Christian Eriksen will be out of action for up to three months due to the ankle injury he suffered in Saturday's FA Cup win over Reading, Manchester United have confirmed.
Eriksen was on the receiving end of a heavy tackle from Andy Carroll in the second half, with the Reading forward surprisingly avoiding a yellow card.
Carroll was later sent off for another two forceful challenges.
Eriksen walked away from the incident to play on briefly, but he was soon replaced and later spotted leaving Old Trafford on crutches, with a protective boot supporting his left ankle.
United boss Erik ten Hag offered little insight after the match, but following examinations the club believe it is serious enough to potentially rule him out until May.
A statement read: "Manchester United midfielder Christian Eriksen is expected to be out of action for an extended period because of an ankle injury sustained in our Emirates FA Cup victory over Reading on Saturday.
"While investigations are continuing, initial assessments indicate that Eriksen is likely to be out until late April or early May."
The absence of Eriksen will be a major blow to United and Ten Hag, as the Danish midfielder has been a key component of the side since his arrival on a free transfer in pre-season.
Bruno Fernandes (2,603) is the only outfield player to spend more minutes on the pitch than Eriksen (2,274) across all competitions for United this season.
It is a similar story in terms of chances created, with Eriksen's 53 bettered by only Fernandes' 81, highlighting the Dane's creative importance, particularly from set-pieces.
Eriksen ranks highest in the squad for assists (nine), however, three more than Fernandes.
If the 31-year-old does not play again until the start of May, he will have missed at least 18 matches in all competitions.
That total will increase if United progress in the FA Cup, Europa League and EFL Cup – they are just 90 minutes away from the final of the latter after winning 3-0 away to Nottingham Forest in last week's semi-final first leg.
The return game at Old Trafford on Wednesday will be the first match Eriksen misses.
The absence of Eriksen further stretches United's midfield options after Donny van de Beek was ruled out for the season at the start of January.
It leaves Fernandes, Fred, Casemiro and Scott McTominay as their only recognised senior midfielders, potentially requiring 17-year-old Kobbie Mainoo – who has made two cup appearances but is yet to make his Premier League bow – to step up unless they delve into the transfer market before the window closes on Tuesday.
Sessegnon rejoins boyhood club Fulham after Tottenham departure
Ryan Sessegnon has resigned for Fulham on a free transfer, five years after leaving the club.
The 24-year-old signed a two-year contract with the Cottagers with the option to extend for a further year following his departure from Tottenham last month.
In his first spell at the club, Sessegnon worked his way through the academy over 11 years, scoring 25 goals in 120 first-team appearances.
He then moved to Spurs in a £25million deal in 2019, though struggled to nail down a place in North London, making just 57 appearances in all competitions, and scoring three goals.
"It's amazing to be back. Emotional, as well," he told FFCtv. "It's where it started for me, where everything began, and it's amazing to be back.
"It will always be home for me. I think it had the feeling that it was meant to be, coming back here, so I'm delighted to get it done."
Sessegnon is Fulham's first signing of the transfer window, though they have seen plenty of first-team departures already, with Joao Palhinha, Tosin Adarabioyo and Bobby De Cordova-Reid all leaving the club.
Eriksen in 'no rush' to decide Man Utd future
Christian Eriksen says he is in "no rush" to decide his future despite going into the final year of his contract at Manchester United.
Eriksen joined the Red Devils in 2022, making 28 appearances in the Premier League in his first season, though an injury in January 2023 put a halt to his impressive start to life at Old Trafford.
Following Kobbie Mainoo's breakout season last year, Eriksen dropped down the pecking order at United as he made just 12 starts in his 22 league appearances, scoring just once and assisting two goals.
Some reports suggest Eriksen could be heading out on loan to former club Ajax for the final year of his contract, but he insisted he is satisfied in Manchester.
"I am really happy at United," he said. "I have had two very good years and am going into my third.
"It is a special club and a special place. Also, my family is settled in Manchester, so I am in no rush.
"Obviously, I want to play as much as possible and do everything I can. But that is nothing to do with the club - it is up to you and the manager.
"But in terms of how I feel, I feel very good at United."
Man Utd transformation will not occur 'overnight', says Maguire
Harry Maguire has warned Manchester United supporters their fortunes may not change "overnight" ahead of the Red Devils' first season under the Jim Ratcliffe regime.
INEOS founder Ratcliffe assumed control of football operations when he bought a 25% stake in the club, with his part-takeover being formally ratified earlier this year.
United have since gone about constructing a new football hierarchy, appointing Dan Ashworth as sporting director and Omar Berrada as chief executive.
They were widely expected to part ways with manager Erik ten Hag after finishing eighth in the Premier League last term, but the Dutchman was instead handed a new contract after guiding them to an FA Cup final victory over Manchester City.
United have spent an estimated £88million to bring in striker Joshua Zirkzee and centre-back Leny Yoro ahead of Ten Hag's third season in charge, but Maguire has warned patience will be required as they bid to return to title contention.
"I don't think we will go from finishing eighth in the league to winning all the trophies overnight," Maguire told BBC Sport.
"But I do think we are moving in the right direction now and the decisions that have been made at the top will help this club get back to where it should be."
Yoro's arrival has raised questions about Maguire's future, with Lisandro Martinez also hoping to play a heightened role after an injury-hit 2023-24 campaign.
Maguire was widely expected to leave Old Trafford last year but opted to fight for his place and was ultimately rewarded with regular gametime.
With Martinez, Raphael Varane and Victor Lindelof all enduring disjointed seasons, Maguire managed more Premier League starts (18) and minutes (1,650) than any other United centre-back.
The Red Devils only kept four Premier League clean sheets when Maguire was involved, however, with their 58 goals conceded their most in any league campaign since 1978-79 (63).
He believes he proved his worth, saying: "There was a lot of uncertainty over my future last year but I sat down with the manager, he told me where I was at, said he believed in me and I would get chances.
"I proved last season when I got the chances I took them really well."
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