Wout Weghorst kept his place in the Manchester United team to face Arsenal as Erik ten Hag backed his newest signing against the Premier League leaders.
The on-loan Dutch striker was retained as the focal point of manager Ten Hag's attack, having made his debut in the 1-1 draw at Crystal Palace on Wednesday.
Weghorst arrived from Burnley after his previous loan at Besiktas was cancelled.
With Casemiro suspended, Ten Hag brought Scott McTominay into his midfield, the only change from the game at Selhurst Park.
It meant Weghorst would be supported by Marcus Rashford, captain Bruno Fernandes and Antony, with McTominay and Christian Eriksen anchoring the visitors' midfield.
Leaders Arsenal's starting XI was unchanged from their 2-0 derby win over Tottenham last Sunday, with Mikel Arteta's team having had their lead clipped to two points after Manchester City's 3-0 victory over Wolves.
The hosts had new recruit Leandro Trossard on the bench, after Arteta brought in the Belgian winger from Brighton and Hove Albion.
This was the first of two games in hand for Arsenal over City, giving them a chance to reassert their early season grip on top spot.
It was a game where fourth-placed United, however, were looking to complete a league double, having beaten Arsenal 3-1 at Old Trafford in September.
United remain the only side to have beaten Arsenal in the league this season.
Arsenal handed another injury blow as White ruled out for 'months'
Mikel Arteta confirmed that Arsenal defender Ben White is facing "months" on the sidelines after sustaining a knee injury.
White had been dealing with several issues all season and has missed five games in all competitions for the Gunners already this term.
After struggling through until the November international break, the decision was taken for him to undergo surgery in order to finally address the ongoing problems.
It serves as a bitter blow for Arteta, with only Thomas Parety (13) making more interceptions than White (11) for Arsenal in the Premier League this campaign.
Though Arteta confirmed that the surgery was successful, White is set for a lengthy spell out of the team.
"It has been different kinds of struggles. It has never been the same thing, but we had to make a decision. He has not improved over the last few weeks, unfortunately," said Arteta.
"We know that Ben is going to push every boundary, but it got to the point where we have to protect the player and we decided to do the surgery.
"He agreed with that and it is going to keep him out for a few months."
Asked for a specific time frame, Arteta added: "We have to see how he reacts post-surgery. I don't expect it to be half a year, but I cannot tell you exactly."
It offers a concern for Arteta in the full-back area, with the Spaniard also revealing on Friday that Takehiro Tomiyasu is "going to be out as well for a bit".
There was, however, some positive injury news for the Gunners ahead of welcoming Nottingham Forest to the Emirates on Saturday.
After not featuring for England during the international break, Bukayo Saka and Declan Rice are expected to be fit to feature against Nuno Espirito Santo's side.
Leandro Trossard will also be available for Arteta despite picking up a hamstring injury during the international break with Belgium.
Defender Riccardo Calafiori is also in contention for Saturday's game after a month out with a knee problem.
'Right guy at the right time' - Amorim confident of changing Man Utd's fortunes
Ruben Amorim believes he is the "right guy at the right time" to turn Manchester United's fortunes around.
The 39-year-old signed a two-and-a-half-year deal earlier this month to keep him at Old Trafford until June 2027, replacing Erik ten Hag after he was sacked in October.
Amorim is the sixth permanent United manager since Alex Ferguson retired in 2013, having left Sporting CP to take charge during the international break.
He won two Primeira Liga titles as Sporting head coach as well as two Taca da Liga trophies, while he led the club to a perfect start in the league this season, winning all 11 of their games.
United sit 13th in the Premier League table ahead of their trip to Ipswich Town on 15 points, though they are just four points behind Chelsea in third.
Amorim recognised the size of the task ahead of him in Manchester but is confident he can make a change.
"I'm a little bit of a dreamer and I believe in myself, and I believe in the club," he said during his first press conference.
"I think we have the same idea, the same mindset and that can help.
"I truly believe in the players; I know you don't believe a lot, but I do. I want to try new things. You guys don't think it's possible, I do.
"Call me naive, but I believe I am the right guy at the right time. I truly believe I am the right guy."
Aged 39 years and 302 days, Amorim will be the youngest to take charge of his first match for the Red Devils since Wilf McGuinness in August 1969 (31y 288d).
United have won just four of their 11 league games so far this season, and have struggled in front of goal, netting just 12 times so far.
Expected to implement his favoured 3-4-3 formation, Amorim admitted it would take time for the club to adapt and has asked for patience as the players get used to his tactics.
"I know at Manchester United we have to win games. We need a lot of time because it's a tough league, we have to improve a lot to try to win the title," he added.
"We have to change the physical aspect of the team. I don't know how long it will take."
Vlahovic out of Juventus clash with Milan
Dusan Vlahovic will miss Juventus' trip to Milan in Serie A this weekend and is also a doubt for the Champions League game at Aston Villa, head coach Thiago Motta has confirmed.
Vlahovic returned from the international break with a muscle problem in his left thigh, and the manager, after he confirmed the Serbian's absence for Saturday's game at San Siro, was asked about his chances of playing on Wednesday at Villa Park.
"I don't know. He definitely won't be there tomorrow. We hope to have him back as soon as possible," Motta told a press conference on Friday.
"Injuries are part of football. Now it's Vlahovic's turn, but we'll keep playing with the same principles, attacking and defending together."
Vlahovic is the latest of Motta's injury problems at Juventus. Argentine winger Nicolas Gonzalez missed the last six league games and is still unavailable, while Poland striker Arkadiusz Milik is a long-term absentee.
Brazilian midfielder Douglas Luiz will also miss the game with Milan and defender Juan Cabal recently suffered an Anterior Cruciate Ligament (ACL) injury, the same issue which will keep fellow defender Gleison Bremer out for the rest of the season.
"I'm really disappointed for Cabal because, like Bremer, he'll be out for a long time," Motta said.
"This is another reason to push ourselves, to commit that bit more so that these absences don't weigh too heavily."
Juventus go into the game as the only unbeaten side in Serie A but find themselves sixth in the standings in what is so far a very tight title race, with just two points separating Motta's side from leaders Napoli.
"It's very balanced and this is good for both us and the public," Motta said.
"We must all try to continue like this. We have to try to get as many positive results as possible."
Milan are one place behind Juve but six points off Motta's side.
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