Debutant Joao Felix's red card proved costly as Carlos Vinicius earned Fulham a 2-1 win over west London rivals Chelsea that piles even more pressure on head coach Graham Potter.
Joao Felix was named in injury-hit Chelsea's starting line-up, a day after joining on loan from Atletico Madrid, and saw red for a lunge on Kenny Tete shortly before the hour mark.
Chelsea had fought their way back into the match at the time of that dismissal after Kalidou Koulibaly's close-range finish cancelled out former Blues winger Willian's first-half opener at Craven Cottage.
Fulham were without suspended top scorer Aleksandar Mitrovic, but Carlos Vinicius headed in his first Fulham goal in the 73rd minute to land his side a rare win in this fixture and make it six defeats in eight for Chelsea.
Bernd Leno did well to keep out an early Lewis Hall strike in a bright start from Chelsea, with Joao Felix looking particularly lively in the final third.
Fulham soon grew into the game and struck the crossbar through a powerful Bobby Decordova-Reid effort, shortly after Carlos Vinicius had a penalty shout rejected.
However, Willian gave Fulham the lead when Chelsea's defence backed off and allowed the winger to fire away a shot that deflected off Trevoh Chalobah on its way through.
Leno continued to frustrate Chelsea, but he was almost caught out by a Mason Mount free-kick that struck the right-hand post and landed nicely for Koulibaly to squeeze over the line.
Chelsea lost another player to injury when Denis Zakaria hobbled off and then had Joao Felix dismissed for a studs-up challenge on Tete.
More misery was to follow for Chelsea and Potter as Andreas Pereira played in a delightful cross for Carlos Vinicius to get above Chalobah and power home a winning goal at the back post.
Leipzig have 'everything you would want' – Celtic boss Rodgers
Celtic may be four points clear of RB Leipzig in the Champions League, but Brendan Rodgers is not underestimating the challenge that his side face on Tuesday.
The Hoops welcome Leipzig to Celtic Park on matchday four, for what will be the fifth meeting between the sides.
Leipzig have won three of the previous four encounters, with Celtic winning 2-1 in a Europa League match in November 2018.
While Leipzig, who are second in the Bundesliga, have lost all of their Champions League matches this term, Celtic bounced back from their heavy defeat to Borussia Dortmund by holding Atalanta to a 0-0 draw in their last European outing.
Rodgers' team come into Tuesday's clash on the back of a resounding 6-0 defeat of Aberdeen in the Scottish Premiership, but Rodgers knows his side are in for a stern test.
"Leipzig are no different to Borussia Dortmund and Atalanta," said Rodgers. "A top team. They have everything you would want - speed, power, technique.
"It's a brilliant challenge for us."
After conceding seven goals against Dortmund on MD2, Rodgers explained Celtic knew they had to step up.
"You always have to learn and be better and we were against Atalanta, a really outstanding team," said Rodgers, who were perhaps fortunate not to concede against the Serie A side, given they conceded 2.4 expected goals (xG).
"We'll look to bring our energy to the game but we also know we'll have to defend for good periods of the game, play with concentration and commitment like we did against Atalanta," he said.
"There will be moments when we press with aggression and moments where we have to be controlled. Top teams will push you back and you have to have resilience."
After a run of 12 home games without a win at Celtic Park in the Champions League between 2013 and 2023 (D3 L9), Celtic have won their last two home games. They last had three wins in a row back in November 2007 under manager Gordon Strachan.
"Home games are very important at this level and when you want the result the supporters can bring you closer to that," said Rodgers.
"What the noise generates here is absolutely incredible.
"We will also need that bit of patience as well because we have to be educated in our pressure.
"We've got ourselves into a really good position after three games and now we have another opportunity to show we can pick up a result against a top team."
Neymar does not believe latest injury is serious
Neymar does not feel his latest injury is anything to be overly worried about.
The Brazilian star had to be substituted off late on in Al-Hilal's 3-0 win over Esteghlal in the AFC Champions League Elite on Monday.
Aleksandar Mitrovic's hat-trick propelled Saudi Pro League giants Al-Hilal to a comfortable win, though it was soured when Neymar clutched his right thigh and left the field just 29 minutes after coming on as a second-half substitute.
It was only the 32-year-old's second appearance since he returned from a year-long lay-off due to a serious knee injury.
However, the former Paris Saint-Germain and Barcelona attacker allayed fears over a serious injury.
"It felt like a cramp, only very strong!" Neymar posted on Instagram. "I'm going to have some tests and I hope it's nothing too serious.
"It's normal for this to happen after a year, the doctors had already warned me, so I have to be careful and play more minutes."
Neymar has played only seven games for Saudi Arabia's Al-Hilal since joining from PSG in a blockbuster transfer last year.
Fonseca targets statement Milan win over Real Madrid
Milan have no need to fear Real Madrid and their coach Paulo Fonseca is targeting a statement win in the Champions League.
Despite having won more Champions League/European Cup titles (seven) than any other club apart from Madrid (15), it has been 17 years since Milan last lifted the trophy in 2007.
On the other hand, holders Madrid have won the Champions League six times since 2013-14.
But Fonseca sees no reason to fear Los Blancos at the Santiago Bernabeu, where Carlo Ancelotti's side were recently hammered 4-0 by Barcelona.
"We're playing against a team that aspires to win the Champions League every year and for us it's a great opportunity to grow," Fonseca said.
"We'll play without fear of anything, with courage, because we believe we can play a great game and do great things.
"I always transmit to my team the desire to win and tomorrow will be no different. Real Madrid are a great team, but we will go out there thinking about winning. After that, anything can happen, but that's the mentality.
"To win a match like this, we have to defend well, have possession of the ball and create dangerous situations. A match against Real Madrid is a chance to show the world our quality and the way we are growing."
Madrid are 12th in the 36-team Champions League table with six points, while Milan are languishing in 25th spot – just outside the play-off places – with three points after three games.
Fonseca explained Milan had carefully studied Barcelona's 4-0 win over Madrid in last month's Clasico.
"I saw the derby, it's impossible not to watch it. They are teams I like to watch and I paid close attention to the game," Fonseca said.
"We are different from Barcelona but it was important to see Real Madrid's intentions against them because Barca have a similar way of defending with us. We made the whole team watch the game.
"It is the match between the two clubs that have won the Champions League the most. There are many games in the continent that are big, but this one is obviously something special, a match between two clubs that are attractive.
"We hope to put on a good show for people who enjoy good football."
Milan are winless in their last three Champions League games against Madrid (D2 L1) since they won 3-2 in October 2009 with goals from Andrea Pirlo and Alexandre Pato.
Madrid have won five of their seven home matches against Milan in the competition (D1 L1), beating them 2-0 in the most recent such match in October 2010.
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