India captain Rohit Sharma has been ruled out of the first Test with Bangladesh, with Mohammed Shami and Ravindra Jadeja both out of the tour entirely.
The two nations begin their two-match encounter on Wednesday, following a trio of ODI encounters that saw the hosts take a 2-1 series win.
Rohit suffered a left thumb injury during the second game, with KL Rahul skippering the side during his absence in Saturday's dead-rubber victory.
Though the BCCI has ruled him out of action for the opener in Chittagong, it did confirm he could be assessed to feature in the second and final match in Mirpur.
Shami and Jadeja are continuing to struggle with shoulder and knee injuries that have forced their exclusion, with India forced to include a slate of fresh faces.
Abhimanyu Easwaran, Navdeep Saini and Saurabh Kumar, who have all been with the nation's A team, have been drafted in as replacements.
In addition, fast bowler Jaydev Unadkat has been called up for the red-ball series too, though there is no room for record breaker Ishan Kishan.
The wicket-keeper-batsman, who posted the fastest double-century in ODI history in India's win over Bangladesh, has not played Test cricket for his country before.