Karim Benzema has suffered an apparent injury setback on the eve of the Qatar World Cup, French media reported on Saturday.
The Ballon d'Or winner and Real Madrid superstar only resumed full training with Les Bleus this weekend but could not complete the session with Didier Deschamps' team.
L'Equipe and RMC Sport reported Benzema was forced out by injury, with no initial indication of how serious the problem might be.
Benzema was troubled by a knee injury earlier this season before missing further fixtures for Madrid after suffering from muscular fatigue in his left quadriceps.
World Cup holders France begin their defence on Tuesday against Australia, before also tackling Denmark and Tunisia in Group D on November 26 and 30 respectively.
Benzema's absence from the tournament, should it come to that, would be a major blow to France, even though coach Deschamps also has the likes of Kylian Mbappe, Antoine Griezmann and Olivier Giroud as forward options.
RB Leipzig's prolific Christopher Nkunku was forced to pull out of the squad this week after suffering knee ligament damage in a training collision with Eduardo Camavinga.