Christopher Nkunku has torn the lateral collateral ligament in his left knee, according to RB Leipzig.
Nkunku was forced to withdraw from France's World Cup squad on Tuesday after getting injured in a training collision with Real Madrid midfielder Eduardo Camavinga.
The 25-year-old was replaced in Didier Deschamps' selection by another player who plies his trade in the Bundesliga, Eintracht Frankfurt's Randal Kolo Muani.
On Saturday, Leipzig confirmed the nature of Nkunku's injury, though were not able to put a timescale on his return.
A statement on the club's website read: "Christopher Nkunku tore the LCL in his left knee while training with the French national team on November 15 in Paris.
"It is not yet clear how long he will be out for and there are different treatment options for this injury. We will provide Christo with the best support so that he can return as soon as possible."
Nkunku has 16 goals in 22 games this season and Die Roten Bullen will be eager to have him back as soon as possible, with Leipzig currently third in the Bundesliga – six points behind leaders Bayern Munich.
Leipzig also announced that Croatian defender Josko Gvardiol will not miss the World Cup despite suffering a broken nose in the recent win over Freiburg, while midfielder Konrad Laimer is back in training after sustaining an ankle injury in September.