The only Champions League group with qualifying places still to play for on Tuesday is Group D, with all four teams in with a reasonable chance of progression.
Marseille host leaders Tottenham while Sporting CP take on Eintracht Frankfurt, with each team knowing a win will see them through and defeat will mean third our fourth spot.
It has been a sensational start to the season for Napoli, and they can complete a perfect Champions League group stage on Tuesday.
Luciano Spalletti's men travel to Liverpool looking for a sixth win in six Group A games, and will top the group as long as they avoid defeat by four or more at Anfield.
As the Champions League group stage prepares to draw to a close, Stats Perform takes a look at the Opta numbers behind these and the rest of Tuesday's clashes.
Marseille v Tottenham
Having lost six home matches in a row in the Champions League between March 2012 and November 2020, Marseille have since won two of their last three such matches (L1), including last time out against Sporting. They have not won consecutive home games in the competition since the 2010-11 campaign when they beat MSK Zilina and Chelsea.
Despite currently sitting bottom of Group D, Marseille can still top the standings if results go their way. Only once in 10 previous campaigns have the Ligue 1 side finished top of their Champions League group, which was in 1992-93 when they went on to lift the trophy.
Spurs have failed to win any of their last four away matches in the Champions League. Should they fail to win here, it will be their longest run of games without a win away from home in the competition.
Antonio Conte will be concerned that Tottenham have failed to score in any of their last three away matches in the Champions League; the last English side to go on a longer run without a goal away from home in the competition was Manchester United between October 2004 and November 2005 (five games – a record for an English club).
Sporting CP v Eintracht Frankfurt
In what is their first ever Champions League campaign, Eintracht Frankfurt can still win their group if results go their way. The only German club to win their first group participation in the competition was Kaiserslautern in 1998-99, while the last Bundesliga side to progress to the knockout rounds at the first attempt was Stuttgart in 2003-04.
Sporting are looking to progress to the knockout stages in consecutive Champions League campaigns, having been eliminated during the group stage in seven of their previous eight participations (progressing in 2008-09).
Eintracht's Mario Gotze has recorded an assist in each of his past two appearances in the Champions League; only once before has he set up a goal in three consecutive games in the competition – between November 2012 and March 2013 for Borussia Dortmund.
Sporting have been shown three red cards so far this season in the Champions League – the last team to have more players sent off in a single group stage was Anderlecht in 2013-14 (four).
Liverpool v Napoli
This will be the eighth meeting between Liverpool and Napoli in European competition, with the Italian side (three) edging the Reds (two) in terms of victories so far (two draws). After their 4-1 win in this season's reverse fixture, Napoli could beat Liverpool in consecutive games for the first time.
The Italian side have travelled to face the Reds on three previous occasions in European competition, but are yet to win at Anfield (D1 L2) – losing 3-1 in the Europa League in November 2010 and 1-0 in the Champions League in December 2018, before a 1-1 draw in November 2019, also in the Champions League.
This will be Jurgen Klopp's 100th match as a manager in the Champions League, across spells with Borussia Dortmund and Liverpool. He will become the first German coach to take charge of a century of games in the competition.
Napoli have scored more goals than any other team through the first five matchdays in this season's group stage (20). The only team to score more during a single group stage in the previous four campaigns has been Bayern Munich (twice, 24 in 2019-20 and 22 in 2021-22).
Bayern Munich v Inter
Speaking of which, Bayern and Inter have met on eight previous occasions in European competition, with the German side winning half of those meetings (W4 D1 L3). Indeed, they are unbeaten in the three matches in the Champions League that have taken place in the group stage (W2 D1).
Inter are themselves unbeaten in their previous three away games at Bayern (W2 D1). This makes them the team to have faced the Bavarians away from home on the most occasions without ever losing in European competition.
Bayern have won each of their last 12 group-stage matches in the Champions League, and are looking to become the first side in history to win all six group games in consecutive campaigns. They would also become the first side to do so on three separate occasions, having also achieved perfection in 2019-20.
Inter are unbeaten in three away games in the Champions League, and could go four games without defeat away from home in the competition for the first time since December 2003 to February 2005 (five games).
Bayern have scored in 42 of their last 43 home matches in the Champions League, netting 136 goals across this spell at an average of 3.2 per game. They have scored in each of their last 21 in a row since being held by Sevilla in April 2018.
Other fixtures:
Viktoria Plzen v Barcelona
3 - Viktoria Plzen have lost all three of their previous games against Barcelona in the Champions League, scoring just one goal and conceding 11 times in return.
3 - Barcelona have lost each of their last three away matches in the Champions League, and could lose four in a row for the first time since a run between November 1994 and October 1997.
Rangers v Ajax
5 - Rangers have lost all five of their games in the Champions League this season. No Scottish side have ever been beaten six times within a single campaign in the European Cup/Champions League.
4 - Ajax have lost each of their previous four games in the Champions League; they have not lost five in a row in the competition since September 2004 under Ronald Koeman.
Bayer Leverkusen v Club Brugge
18 - Leverkusen forward Patrik Schick has played 18 times in the Champions League without scoring a goal. His three goals in major European competition have all been scored in the Europa League, where he averages a goal every 138 minutes.
1 - Club Brugge have already qualified for the knockout stage, and could finish top of their group for the very first time in a single edition of the tournament.
Porto v Atletico Madrid
3 - Porto goalkeeper Diogo Costa has saved three of the four penalties he has faced in the Champions League this season. This is already the most ever by a goalkeeper in a single season on record in the competition (since 2003-04).
4 - Atletico are winless in their last four Champions League games (D2 L2). They last had a longer run without a victory in the competition between December 2008 and December 2009, when they went nine games without one prior to head coach Diego Simeone's arrival.
Carragher says Liverpool may need to move on from Salah and Nunez
Jamie Carragher believes Liverpool's next manager has a big decision to make regarding Mohamed Salah's future, adding the Reds definitely need to move on from Darwin Nunez.
Liverpool's title hopes suffered a potentially fatal blow at Goodison Park on Wednesday, as goals from Jarrad Branthwaite and Dominic Calvert-Lewin handed Everton a memorable 2-0 win.
The defeat – Liverpool's first at Goodison since 2010 – means they are three points behind Premier League leaders Arsenal and one clear of Manchester City, who have two games in hand.
Jurgen Klopp now looks likely to end his final season at the helm with just February's EFL Cup triumph to show for his efforts, with Carragher declaring Liverpool's title hopes to be over on Wednesday.
He also believes Klopp's successor – which could be Feyenoord's Arne Slot if reports are to be believed – may need to shake up Liverpool's frontline.
"Mo Salah is Liverpool's goalscorer and he's gone off the boil. That's shone a light on others," Carragher told Sky Sports.
"There is a real discussion for the new manager about what the future holds for Mo Salah – it's the first time we've asked that question. He only has a year to go on his deal.
"He's looked a shadow of himself for a lot of this season but especially since he's come back from injury. He is Liverpool's legend, superstar, one of the all-time greats, but he's been so far off it."
Salah has 17 Premier League goals this season, but 14 of those came before he went to the Africa Cup of Nations with Egypt in January.
Prior to that tournament, Salah boasted a shot conversion rate of 21.54 per cent for 2023-24, netting with 14 of his 65 total attempts in the competition. Since returning, he has only converted 8.57 per cent of his 35 efforts.
Salah's strike partner Nunez has also come in for criticism, with only Erling Haaland (30) missing more big chances than the Uruguayan's 26 this term. Haaland has, however, converted 34.78 per cent of his big chances to Nunez's 18.75 per cent.
Carragher does not believe Nunez is capable of further improvement after two up-and-down campaigns on Merseyside, saying: "I think I'm at the stage with Nunez where I'm not sure there's a question to ask.
"You want him to do well because he gives everything, he causes trouble, he gets the odd goal.
"But after two years, when Liverpool are going for the title or in big games, you need your man to score at Old Trafford or at Goodison Park. This is the business end, the time to win.
"He's ground to a halt. After two years there's going to be no improvement in him. This is what he is.
"He can cause trouble but he's erratic with his finishing – it's not enough to win you trophies so there's a big decision to be made on him. It's not acceptable when you're going for a title."
Guardiola insists Man City share same title hunger as challengers
Pep Guardiola insists Manchester City share the same hunger to lift the Premier League trophy as their title rivals, warning perfection may still be needed for the champions to retain their crown.
It has been a mixed week for City's rivals thus far, with Arsenal thrashing Chelsea 5-0 on Tuesday before Liverpool suffered a surprise 2-0 defeat in Wednesday's Merseyside derby at Everton.
Those results mean the Gunners sit four points clear of City and Liverpool lead the champions by one, but with two games in hand, the title race is still very much in City's hands.
They go to Brighton and Hove Albion on Thursday before facing Nottingham Forest on Sunday, and Guardiola still thinks even the slightest slip-up could prove costly.
Asked whether City need to win their six remaining games to win the title, Guardiola said: "Yes, absolutely. They gave us a chance, with the fact they lost last week to Aston Villa and Crystal Palace.
"But we knew what we had to do before those games, and now we have to win all games so that at the end, we have it in our hands to retain our title.
"Nothing changes. The fact is, we knew what we had to do before, and now nothing has changed."
Guardiola was then asked whether City are as motivated to win the title as their rivals, having lifted the trophy in five of their seven seasons under him to date.
He said: "I would not be here [if not]. There are so many games, and to be in this position after what we have done in the past, it would not be possible [without the desire].
"We know the difficulty is extreme, and it will remain difficult because we have tough games coming up. We go one game at a time, and we know that if we lose, it will be so tough to retain the title.
"Last Saturday proved the many difficulties we have, especially the schedule and recovery time after the game against [Real] Madrid. The players were unbelievable."
Guardiola hit out at the busy nature of the schedule after Saturday's FA Cup semi-final win over Chelsea, saying he couldn't understand how his players had managed to perform just three days after their penalty shoot-out defeat to Madrid.
Those comments have sparked renewed debate about the football calendar, and Guardiola was asked whether elite clubs had a right to complain while organising money-spinning pre-season tours around the globe.
"Yeah, but we have to do it," he said. "We have to pay the salaries of the players and the manager, and the club has fans all around the world who want to see us. They are an income for us.
"It's not easy, but we have to get resources. I would love to say don't go to another continent to play, have another week of holiday, and then train here. But we have to understand the club.
"It's not just Man City. Every club needs those financial resources to be sustainable. Now that we've won a lot, for many years, we have a lot of supporters. That's why it's necessary to do, and you have to adapt.
"But that is not the reason why [he complained]. The reason is that the schedule is so tight. I'm sorry, it's not."
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
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