The only Champions League group with qualifying places still to play for on Tuesday is Group D, with all four teams in with a reasonable chance of progression.
Marseille host leaders Tottenham while Sporting CP take on Eintracht Frankfurt, with each team knowing a win will see them through and defeat will mean third our fourth spot.
It has been a sensational start to the season for Napoli, and they can complete a perfect Champions League group stage on Tuesday.
Luciano Spalletti's men travel to Liverpool looking for a sixth win in six Group A games, and will top the group as long as they avoid defeat by four or more at Anfield.
As the Champions League group stage prepares to draw to a close, Stats Perform takes a look at the Opta numbers behind these and the rest of Tuesday's clashes.
Marseille v Tottenham
Having lost six home matches in a row in the Champions League between March 2012 and November 2020, Marseille have since won two of their last three such matches (L1), including last time out against Sporting. They have not won consecutive home games in the competition since the 2010-11 campaign when they beat MSK Zilina and Chelsea.
Despite currently sitting bottom of Group D, Marseille can still top the standings if results go their way. Only once in 10 previous campaigns have the Ligue 1 side finished top of their Champions League group, which was in 1992-93 when they went on to lift the trophy.
Spurs have failed to win any of their last four away matches in the Champions League. Should they fail to win here, it will be their longest run of games without a win away from home in the competition.
Antonio Conte will be concerned that Tottenham have failed to score in any of their last three away matches in the Champions League; the last English side to go on a longer run without a goal away from home in the competition was Manchester United between October 2004 and November 2005 (five games – a record for an English club).
Sporting CP v Eintracht Frankfurt
In what is their first ever Champions League campaign, Eintracht Frankfurt can still win their group if results go their way. The only German club to win their first group participation in the competition was Kaiserslautern in 1998-99, while the last Bundesliga side to progress to the knockout rounds at the first attempt was Stuttgart in 2003-04.
Sporting are looking to progress to the knockout stages in consecutive Champions League campaigns, having been eliminated during the group stage in seven of their previous eight participations (progressing in 2008-09).
Eintracht's Mario Gotze has recorded an assist in each of his past two appearances in the Champions League; only once before has he set up a goal in three consecutive games in the competition – between November 2012 and March 2013 for Borussia Dortmund.
Sporting have been shown three red cards so far this season in the Champions League – the last team to have more players sent off in a single group stage was Anderlecht in 2013-14 (four).
Liverpool v Napoli
This will be the eighth meeting between Liverpool and Napoli in European competition, with the Italian side (three) edging the Reds (two) in terms of victories so far (two draws). After their 4-1 win in this season's reverse fixture, Napoli could beat Liverpool in consecutive games for the first time.
The Italian side have travelled to face the Reds on three previous occasions in European competition, but are yet to win at Anfield (D1 L2) – losing 3-1 in the Europa League in November 2010 and 1-0 in the Champions League in December 2018, before a 1-1 draw in November 2019, also in the Champions League.
This will be Jurgen Klopp's 100th match as a manager in the Champions League, across spells with Borussia Dortmund and Liverpool. He will become the first German coach to take charge of a century of games in the competition.
Napoli have scored more goals than any other team through the first five matchdays in this season's group stage (20). The only team to score more during a single group stage in the previous four campaigns has been Bayern Munich (twice, 24 in 2019-20 and 22 in 2021-22).
Bayern Munich v Inter
Speaking of which, Bayern and Inter have met on eight previous occasions in European competition, with the German side winning half of those meetings (W4 D1 L3). Indeed, they are unbeaten in the three matches in the Champions League that have taken place in the group stage (W2 D1).
Inter are themselves unbeaten in their previous three away games at Bayern (W2 D1). This makes them the team to have faced the Bavarians away from home on the most occasions without ever losing in European competition.
Bayern have won each of their last 12 group-stage matches in the Champions League, and are looking to become the first side in history to win all six group games in consecutive campaigns. They would also become the first side to do so on three separate occasions, having also achieved perfection in 2019-20.
Inter are unbeaten in three away games in the Champions League, and could go four games without defeat away from home in the competition for the first time since December 2003 to February 2005 (five games).
Bayern have scored in 42 of their last 43 home matches in the Champions League, netting 136 goals across this spell at an average of 3.2 per game. They have scored in each of their last 21 in a row since being held by Sevilla in April 2018.
Other fixtures:
Viktoria Plzen v Barcelona
3 - Viktoria Plzen have lost all three of their previous games against Barcelona in the Champions League, scoring just one goal and conceding 11 times in return.
3 - Barcelona have lost each of their last three away matches in the Champions League, and could lose four in a row for the first time since a run between November 1994 and October 1997.
Rangers v Ajax
5 - Rangers have lost all five of their games in the Champions League this season. No Scottish side have ever been beaten six times within a single campaign in the European Cup/Champions League.
4 - Ajax have lost each of their previous four games in the Champions League; they have not lost five in a row in the competition since September 2004 under Ronald Koeman.
Bayer Leverkusen v Club Brugge
18 - Leverkusen forward Patrik Schick has played 18 times in the Champions League without scoring a goal. His three goals in major European competition have all been scored in the Europa League, where he averages a goal every 138 minutes.
1 - Club Brugge have already qualified for the knockout stage, and could finish top of their group for the very first time in a single edition of the tournament.
Porto v Atletico Madrid
3 - Porto goalkeeper Diogo Costa has saved three of the four penalties he has faced in the Champions League this season. This is already the most ever by a goalkeeper in a single season on record in the competition (since 2003-04).
4 - Atletico are winless in their last four Champions League games (D2 L2). They last had a longer run without a victory in the competition between December 2008 and December 2009, when they went nine games without one prior to head coach Diego Simeone's arrival.