Manuel Neuer and Thomas Muller – pillars of the Germany national team over the last decade – are battling to prove their fitness with barely three weeks remaining until the World Cup begins.
Bayern Munich boss Julian Nagelsmann confirmed in a press conference on Friday that neither player will be fit enough to feature in Saturday's Bundesliga game against Mainz.
Goalkeeper Neuer remains troubled by a shoulder issue, while attacking midfielder Muller has a hip problem, and Nagelsmann could not say with conviction when both will be back in club action.
The news will inevitably be a worry for Germany boss Hansi Flick, as the former Bayern head coach finalises his plans for the Qatar 2022 finals.
Muller played for half an hour as a substitute in Bayern's 3-0 win at Barcelona on Wednesday, but the 33-year-old will not be risked at all against Mainz, and almost certainly will also sit out the Champions League meeting with Inter next Tuesday.
"He has irritation in his hip again, in the pelvic area," Nagelsmann said. "He won't be able to play, probably not even on Tuesday. We'll probably have to take him out for a week to give him a break.
"Thomas is in good spirits. We talked to a couple of medical professionals yesterday and tried to get a better picture of everything, but the picture didn't really change.
"It's not something that goes away with pain medication either. It feels blocked, and it's difficult to define how the pain is manifesting itself. I decided it would be better just to take him out of action for the time being.
"[Saturday] is the type of game where even for 10 or 15 minutes you have to give absolutely everything, so if we give him that 10 or 15 minutes, he's ultimately going to have to drop out potentially for the next game. We've got to see how it develops and how it reacts.
"The key right now is instead of blindly testing it out constantly, to give it a bit of calm and see how it reacts to that and then see how his recovery goes."
Neuer, the 36-year-old captain of Bayern and Germany, has played no active part since Bayern's 2-2 draw at Borussia Dortmund on October 8.
It is obvious to Nagelsmann that having Neuer fit is not only a priority for Bayern but a matter of national interest.
There are no promises at the moment, but Nagelsmann is hoping Neuer may be able to return next weekend at Hertha Berlin.
"I'm not a mystic that can see into the future," Nagelsmann said. "We put him in the game against Dortmund and maybe that was a game too early, and now he's sat out a couple of games.
"It's very difficult for me to know how the pain will be managed. It's a structural area of the body that needs time to heal and a joint that needs a bit of calm as well, so if you're constantly testing it and putting a burden on it, it can be tough.
"I'm anticipating he will be ready for the World Cup, but I'm not a psychic. We're going to do everything we can to help him be there for the World Cup."
Bayern are the hosts on Saturday against a Mainz team who led at the Allianz Arena last season before slipping to a 2-1 defeat.
However, Mainz have beaten Bayern twice in the past two seasons, both times when having home advantage.
Among sides currently in the top flight, only Augsburg have also taken six points from their last three matches against Bayern – no teams have managed more.
Heading into this meeting, Bayern and Mainz have both won their last two games, each scoring seven goals and conceding none – a league high in this timeframe.
Mainz are also top of the away form table this season with 12 points from six away games, marking them down as a threat.
Bayern nevertheless head into the weekend programme just one point behind early leaders Union Berlin, who must wait until Sunday before tackling Borussia Monchengladbach.
"We're in a good rhythm right now," said Nagelsmann. "Against Barcelona, we looked like a solid unit who all had the same goal in mind. The team have a great connection with one another."
Motta salutes 'solid and concrete' Juventus after derby victory over Torino
Thiago Motta hailed Juventus' "solid and concrete" display on their way to victory over Torino in Derby della Mole.
The Bianconeri claimed bragging rights in the Turin derby, with goals from Timothy Weah and Kenan Yildiz sealing all three points.
Juve climbed to third place - a point behind leaders Napoli - after extending their unbeaten start in Serie A, while earning a ninth clean sheet - the most of any side in Europe's top five leagues.
And Motta paid tribute to his players for their performance levels at the end of a busy seven days.
"It's always important to play with balance, and today, we put in an excellent performance, bringing home three precious points," he said.
"I am happy both for the result and for the level of play expressed in front of our fans, who supported us a lot. We have to thank them, as well as the boys, because it was not easy.
"It was the third game of the week, we were able to manage our energy well, and we were solid and concrete for the whole 95 minutes. A well-deserved victory."
Weah became only the second American to score for Juventus against Torino after Weston McKennie in 2020.
Next up for the Bianconeri after the international break is a showdown with AC Milan at San Siro, where Weah's father George played a starring role during the 1990s.
"Today I'm happy," he said. "We have to continue like this, because when we play like tonight, we're strong.
"Now, the match against Milan awaits us. It's important, also for me and for the history of my family."
Slot believes Liverpool have 'many challenges to come' in Premier League title race
Arne Slot envisages "many challenges to come" in Liverpool's Premier League title race, despite his side moving five points clear at the top of the table with victory on Saturday.
The Reds capitalised on Manchester City's slip at Brighton by taking all three points in a 2-0 win over Aston Villa to establish breathing space at the summit.
Darwin Nunez gave the hosts the lead at Anfield as he capitalised after a quick counter, before Mohamed Salah did the same six minutes from time to secure all three points.
While Slot was pleased by the outcome, he is aware the cushion at the top does not guarantee a smooth run in their title challenge.
"It wasn't easy, like most of our games have been now," he told TNT Sport. "Aston Villa were maybe not as aggressive as we thought they would be.
"We were patient. One thing they are very good at is set-pieces. In general, we had control over the game and scored from two counter-attacks, which is maybe not what we would expect.
"If I look at the games that are ahead, they are tough. It will be a tough season in general. Margins are small, we have a margin, but it is small. [There are] many challenges to come for us."
Slot has got off to a fine start since succeeding Jurgen Klopp as manager at the start of the season, as he became just the fourth manager to win as many as nine of his first 11 Premier League games in charge, after John Gregory, Guus Hiddink, and Carlo Ancelotti.
Liverpool now have 28 points in the league. They have only previously equalled this total once after 11 games, in their title-winning season of 2019-20 (31).
Equally, no manager has ever won more points from their first 11 games in the competition than Slot. The Dutchman is not concerned by totals or margins, however, with his focus remaining on the philosophy he wants to instil at Anfield.
"As a manager, if you come into a new club, you don't think about how many points after how many games," he told BBC Match of the Day. "You think about changing the style or keeping it as it was.
"To change the style, you have to do a lot of things on the training ground and in meetings. The only thing I have thought about is how to implement the playing style, and how to make sure the players keep working as hard as they can."
FC Cincinnati 0-0 New York City FC (5-6 on pens): Ilenic sets up Hudson River derby
New York City FC will face the New York Red Bulls for a place in the Eastern Conference final after a 6-5 penalty shootout victory over FC Cincinnati.
In a shootout during which five spot-kicks were missed, Mitja Ilenic kept his cool to slam home and get NYCFC over the line after a 0-0 draw in Ohio.
Cincinnati, last season's Supporters' Shield winners, had the better of the chances at TQL Stadium, though NYCFC did have a goal disallowed midway through the second half, with Alonso Martínez having been flagged offside.
But Nick Cushing, who this week insisted he wanted to stay at NYCFC amid reported interest from Arsenal Women, saw his team get the job done in dramatic fashion.
NYCFC goalkeeper Matt Freese, who made a crucial save to deny Luca Orellano on the half-hour mark, looked set to be the hero until his counterpart Roman Celentano thwarted Thiago Martins.
Freese's save from Gerardo Valenzuela then sparked a remarkable streak of five straight missed penalties, with Kevin O'Toole denied by Celentano, Chidozie Awaziem and Andres Perea blazing over, and Teenage Hadebe kept out by NYCFC's shot-stopper, before Ilenic finally showed how it was done.
NYCFC will now go up against their city rivals next week, while Cincinnati must lick their wounds heading into the offseason.
Data Debrief: Away form a concern for Cushing
While New York can celebrate making the Conference semi-finals, they have now won only one of their last 15 away games in all competitions.
Indeed, NYCFC have won just five of their last 41 road matches in all competitions since the start of the 2023 season.
Their meagre 0.28 expected goals (xG), compared to Cincinnati's 1.13, across the 90 minutes showed they were largely outplayed, and Cushing will be glad next week's semi-final will take place on home turf - with NYCFC the sixth seed, whereas the Red Bulls are the seventh.
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