Mohamed Salah condemned Manchester City to a first Premier League defeat of the season as Liverpool took all three points in a brilliant game at Anfield.
A long ball from Alisson was latched onto by Salah before he fired past Ederson to earn Liverpool just their third league win of the campaign.
Chelsea beat struggling Aston Villa 2-0 and Arsenal secured a 1-0 victory over Leeds United at Elland Road, while Manchester United and Newcastle United played out a hard-fought goalless draw at Old Trafford.
Here, Stats Perform picks out the best facts from the day's Premier League action.
Liverpool 1-0 Manchester City: Salah maintains Reds' unbeaten Anfield record
Liverpool's impressive home form continued as they made it 28 Premier League matches unbeaten at Anfield (21 victories, seven draws) with a win over the champions.
Salah's strike makes it 14 goal involvements for him against City in all competitions, more than against any other opponent, while he is the second player to score in four consecutive Premier League home appearances against the Citizens, after Jimmy Floyd Hasselbaink between 2000 and 2004.
Alisson has now assisted Salah three times in the Premier League, more than any other goalkeeper-outfield player combination in competition history.
The defeat for City means Pep Guardiola has now lost 11 games against Jurgen Klopp, at least four more than against any other coach.
Aston Villa 0-2 Chelsea: Mount double adds to Gerrard pressure
Steven Gerrard's job security was already coming into question before Graham Potter's Blues took victory at Villa Park on Sunday with two Mason Mount goals and an impressive display from goalkeeper Kepa Arrizabalaga.
Since Gerrard took over as Villa head coach in November 2021, only Watford (12) and Norwich (nine) have lost more home Premier League games than the Villans (eight).
Chelsea were fired to victory by Mount, who scored his 25th and 26th Premier League goals for the Blues, becoming the second-youngest player to reach the 25-goal landmark for the club (23y 279d), after Eden Hazard (23y 271d).
Potter's impressive start to life as Chelsea boss continues with his fifth win in six games since taking over (one draw). Those five victories have come in the last five matches, the joint-longest winning run of Potter's managerial career.
7 - Kepa Arrizabalaga made seven saves while keeping a clean sheet against Aston Villa, his most saves without conceding in his top-flight league career. The Spaniard was expected to concede at least two goals based on the placement of the on-target shots he faced. Rejuvenated. pic.twitter.com/RPJNZeqImR
— OptaJoe (@OptaJoe) October 16, 2022Leeds United 0-1 Arsenal: Saka strikes again as Gunners continue strong start
Bukayo Saka's 35th-minute goal at Elland Road was enough for Arsenal to record a ninth win in their opening 10 Premier League games, the first time in their history they have managed this in a top-flight campaign.
Arsenal were forced to ride their luck in the second half though, as Patrick Bamford put a penalty wide for Leeds with their first missed spot-kick in the Premier League since Alan Smith was denied by Brad Friedel against Blackburn in 2002.
The Gunners failed to register a second-half shot on target, while they failed to score after half-time in the Premier League for the first time this season.
Another defeat for Leeds means they are now winless in six Premier League games, losing four of these while drawing the other two as they remain without a top-flight win since August.
Manchester United 0-0 Newcastle United: Red Devils lacklustre in home draw
Manchester United were held by a Newcastle side who may feel disappointed not to have earned victory, having twice struck the woodwork through Joelinton.
The Red Devils went close on a couple of occasions late on but could not prevent the match finishing goalless, United's 76th Premier League game ending in a 0-0 scoreline and their 31st since Alex Ferguson retired in 2013.
Newcastle picked up a point at a stadium where they have struggled in the past, with their 3.6 per cent Premier League win rate (one win in 28 games) at Old Trafford their joint-lowest at any ground where they have played 10 or more times in the competition.
The visitors could have had all three points after an impressive first-half display, but their inability to find a decisive goal means they have now drawn six Premier League games this season, two more than any other side.
Two players with reason to be pleased were the goalkeepers, with David de Gea earning a shutout in his 500th Premier League appearance for United while Nick Pope enjoyed his 50th clean sheet in the top flight, with no English stopper keeping more since Pope's debut in the competition in September 2017 (level with Jordan Pickford).
Aston Villa 2-2 Chelsea: Gallagher caps Blues fightback at Villa Park
Conor Gallagher scored the equaliser as Chelsea fought back from two goals down to clinch a deserved 2-2 draw with Champions League-chasing Aston Villa on Saturday.
Villa looked set to go nine points clear of Tottenham in the race to finish in the Premier League's top four, with Marc Cucurella's own goal and Morgan Rogers' low drive giving them a handsome half-time lead.
Mauricio Pochettino's men dominated much of the first half without reward, but they continued to press after the interval and cultured finishes from Noni Madueke and Gallagher dragged them level.
They almost completed a fine comeback in stoppage time, but there was relief for Villa when referee Craig Pawson disallowed a goal for Chelsea defender Axel Disasi following a VAR review due to an infringement from Benoit Badiashile.
It meant Villa boss Unai Emery was unable to celebrate his new long-term contract with three points, with his team now seven points clear of fifth-placed Spurs, who have three games in hand on their rivals.
Chelsea stay ninth and are five points adrift of the top seven, but with a game in hand to come, their European hopes are not yet over.
Villa made a flying start and were ahead within four minutes, albeit in somewhat fortunate circumstances. John McGinn didn't get a clean connection on Lucas Digne's left-wing cutback, but his shot bounced off Cucurella and into the net.
Chelsea thought they were level after 16 minutes as Nicolas Jackson raced clear to finish into the roof of the net, but his strike was disallowed for offside after a VAR review, with replays showing he was leaning beyond Matty Cash.
Jackson should then have equalised when found by Cucurella six yards out, but he could only send his header against the foot of the post and wide.
Villa then doubled their lead against the run of play shortly before half-time, with Djordje Petrovic powerless as Rogers squeezed his shot through Trevoh Chalobah's legs and in.
A hamstring injury saw Villa goalkeeper Emiliano Martinez withdrawn at half-time, and his replacement Robin Olsen was beaten after 62 minutes, Madueke stroking home after Gallagher forced a high turnover.
Olsen stuck out an arm to deny Madueke a second with 71 minutes gone, but he had no chance as the Blues levelled with nine minutes to play, Gallagher rifling a left-footed finish into the top-left corner.
Chelsea thought they had won it when Disasi headed home five minutes into stoppage time, but referee Pawson disallowed the goal following a VAR review, with Badiashile adjudged to have fouled Diego Carlos in the build-up.
Villa throw it away
Villa could hardly have wished for a stronger position at half-time. Despite Chelsea carving out several good openings, they found themselves 2-0 up and primed to exploit their opponents further through the pace of Ollie Watkins and Leon Bailey.
Chelsea had lost 16 of their previous 18 Premier League games when trailing at half-time (one win, one draw), losing their last eight when two or more goals behind at the break.
However, Emery's men simply didn't get going after the restart, and only a late VAR review saved them from a crushing defeat, with Disasi's potential winner chalked off for a foul by fellow defender Badiashile.
Gallagher leads from the front
Gallagher has polarised opinion at times this season, but Chelsea's stand-in skipper produced a talismanic display just when his team needed him most at Villa Park.
The England international is known for his tenacious work out of possession, and he forced a turnover on the corner of the Villa box in the build-up to Madueke's goal.
Gallagher's own strike, which flew into the top corner to stun the home faithful, took him to double figures for Premier League goal involvements for the season (four goals, six assists). He has only achieved that feat in one other campaign in the competition, scoring eight goals and adding three assists on loan at Crystal Palace in 2021-22.
Four of his seven Premier League goals for Chelsea, meanwhile, have now come from outside the area.
Al-Khaleej 0-1 Al-Nassr: Ronaldo misfires on return as Laporte nets winner
Cristiano Ronaldo returned from suspension but failed to find the net as Al-Nassr secured a 1-0 win over Al-Khaleej on Saturday, with Aymeric Laporte coming up with the decisive goal.
Ronaldo was in action for the first time since being sent off for an elbow in a 2-1 Saudi Super Cup loss to Al-Hilal earlier this month, with his initial two-match ban being reduced to one on appeal.
He missed three good chances as Al-Nassr threatened to fall further behind runaway Saudi Pro League leaders Al-Hilal, but former Manchester City defender Laporte spared his blushes by nodding Marcelo Brozovic's deep free-kick into the bottom-left corner with 68 minutes gone.
Al-Nassr remain nine points adrift of Al-Hilal at the summit in spite of their win, with Jorge Jesus' team unbeaten through 28 games this season as they close in on a record-extending 18th title.
Data Debrief: Ronaldo misfires on return
Ronaldo was presented with the Saudi Pro League's Player of the Month award for March ahead of kick-off, having scored four goals in three league appearances last month.
However, his sights were off on Saturday as he failed to net despite three of the visitors' four big chances, as defined by Opta, falling his way. He led all players on the pitch for expected goals (1.27 xG), shots (five), shots on target (three) and touches in the area (nine) without reward.
Huddersfield all but relegated from Championship while League Two play-off spots decided
Huddersfield Town saw their relegation from the Championship all but confirmed after a 1-1 draw with fellow strugglers Birmingham City on Saturday.
The Terriers avoided a defeat that would have seen them relegated on Saturday, but even a win on the final day over promotion hopefuls Ipswich Town will not be enough unless they overcome a huge goal difference of 15 goals with Plymouth Argyle.
Birmingham remain in the other relegation place and now must beat Norwich City to stand a chance of staying up with Sheffield Wednesday, Plymouth and Blackburn Rovers also still in danger.
At the other end of the table, the Canaries dropped points in a 2-2 draw with Swansea City, leaving the door open for Hull City, who face Ipswich Town later today.
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