Mohamed Salah condemned Manchester City to a first Premier League defeat of the season as Liverpool took all three points in a brilliant game at Anfield.
A long ball from Alisson was latched onto by Salah before he fired past Ederson to earn Liverpool just their third league win of the campaign.
Chelsea beat struggling Aston Villa 2-0 and Arsenal secured a 1-0 victory over Leeds United at Elland Road, while Manchester United and Newcastle United played out a hard-fought goalless draw at Old Trafford.
Here, Stats Perform picks out the best facts from the day's Premier League action.
Liverpool 1-0 Manchester City: Salah maintains Reds' unbeaten Anfield record
Liverpool's impressive home form continued as they made it 28 Premier League matches unbeaten at Anfield (21 victories, seven draws) with a win over the champions.
Salah's strike makes it 14 goal involvements for him against City in all competitions, more than against any other opponent, while he is the second player to score in four consecutive Premier League home appearances against the Citizens, after Jimmy Floyd Hasselbaink between 2000 and 2004.
Alisson has now assisted Salah three times in the Premier League, more than any other goalkeeper-outfield player combination in competition history.
The defeat for City means Pep Guardiola has now lost 11 games against Jurgen Klopp, at least four more than against any other coach.
Aston Villa 0-2 Chelsea: Mount double adds to Gerrard pressure
Steven Gerrard's job security was already coming into question before Graham Potter's Blues took victory at Villa Park on Sunday with two Mason Mount goals and an impressive display from goalkeeper Kepa Arrizabalaga.
Since Gerrard took over as Villa head coach in November 2021, only Watford (12) and Norwich (nine) have lost more home Premier League games than the Villans (eight).
Chelsea were fired to victory by Mount, who scored his 25th and 26th Premier League goals for the Blues, becoming the second-youngest player to reach the 25-goal landmark for the club (23y 279d), after Eden Hazard (23y 271d).
Potter's impressive start to life as Chelsea boss continues with his fifth win in six games since taking over (one draw). Those five victories have come in the last five matches, the joint-longest winning run of Potter's managerial career.
7 - Kepa Arrizabalaga made seven saves while keeping a clean sheet against Aston Villa, his most saves without conceding in his top-flight league career. The Spaniard was expected to concede at least two goals based on the placement of the on-target shots he faced. Rejuvenated. pic.twitter.com/RPJNZeqImR
— OptaJoe (@OptaJoe) October 16, 2022Leeds United 0-1 Arsenal: Saka strikes again as Gunners continue strong start
Bukayo Saka's 35th-minute goal at Elland Road was enough for Arsenal to record a ninth win in their opening 10 Premier League games, the first time in their history they have managed this in a top-flight campaign.
Arsenal were forced to ride their luck in the second half though, as Patrick Bamford put a penalty wide for Leeds with their first missed spot-kick in the Premier League since Alan Smith was denied by Brad Friedel against Blackburn in 2002.
The Gunners failed to register a second-half shot on target, while they failed to score after half-time in the Premier League for the first time this season.
Another defeat for Leeds means they are now winless in six Premier League games, losing four of these while drawing the other two as they remain without a top-flight win since August.
Manchester United 0-0 Newcastle United: Red Devils lacklustre in home draw
Manchester United were held by a Newcastle side who may feel disappointed not to have earned victory, having twice struck the woodwork through Joelinton.
The Red Devils went close on a couple of occasions late on but could not prevent the match finishing goalless, United's 76th Premier League game ending in a 0-0 scoreline and their 31st since Alex Ferguson retired in 2013.
Newcastle picked up a point at a stadium where they have struggled in the past, with their 3.6 per cent Premier League win rate (one win in 28 games) at Old Trafford their joint-lowest at any ground where they have played 10 or more times in the competition.
The visitors could have had all three points after an impressive first-half display, but their inability to find a decisive goal means they have now drawn six Premier League games this season, two more than any other side.
Two players with reason to be pleased were the goalkeepers, with David de Gea earning a shutout in his 500th Premier League appearance for United while Nick Pope enjoyed his 50th clean sheet in the top flight, with no English stopper keeping more since Pope's debut in the competition in September 2017 (level with Jordan Pickford).
Al-Riyadh 0-1 Al-Nassr: Mane hands visitors bragging rights
Sadio Mane's first-half strike ensured Al-Nassr maintained their unbeaten start to the Saudi Pro League season with a 1-0 win over rivals Al-Riyadh.
He smartly finished from close range in the 41st minute, with his goal enough to seal the three points and move Al-Nassr up to third in the table.
Al-Nassr's threat grew as the first half went on, with Milan Borjan making a fine double stop to deny Ronaldo and Talisca once again before Mohamed Simakan struck the post on the rebound.
Mane would eventually break the deadlock in the 41st minute though, darting in front of his marker to meet Abdulrahman Ghareeb's low cross and rifle it into the roof of the net.
The Senegalese striker arguably should have doubled his tally before the break, but was denied by Borjan's stretching save when one-on-one with the Canadian.
Talisca should have wrapped up the points in the final three minutes, but he blazed over an empty net from close range, before having a late goal disallowed for offside.
Data Debrief: Derby delight for Al-Nassr
After drawing their last two matches, this win was a welcome result for Al-Nassr as they racked up their sixth victory of the season to close the gap at the top of the table to six points.
It is just the second time Al-Nassr have avoided defeat in their first 10 matches of a Pro League campaign, last doing so in 2013-14, when they won the league title.
They are now unbeaten in their last seven Pro League derbies (W4 D3), their longest such streak since a run of nine between 2018 and 2020.
This is the first time in eight such games that they have kept a clean sheet though, and limited their opponents to just five shots throughout.
Luis Enrique confirms PSG squad rotation for Angers encounter
Paris Saint-Germain manager Luis Enrique confirmed he will rotate his squad for their trip to the Stade Raymond Kopa to face Angers in Ligue 1 on Saturday.
The Parisiens' stuttering start to their Champions League continued in midweek, losing late on to Atletico Madrid to leave them 25th in the new 36-team league table.
PSG have lost five of their last eight games in the Champions League (W2 D1), as many as in their previous 19 games in the competition.
However, Luis Enrique's side have been impressive in the league and are currently six points clear of Marseille at the summit of the standings.
They also boast an impressive record against this weekend's hosts, winning 19 of their 20 encounters in all competitions (D1) against Angers.
"The most important match is tomorrow. Tomorrow, we'll rotate," Luis Enrique confirmed.
"I feel that with so little rest I need players. Angers are a highly motivated opponent who play at home.
"They can defend well and create problems in transition thanks to their wingers. I need all the players ready."
PSG will, however, be without William Pacho, who travelled to Ecuador on Thursday ahead of the international break and did not take part in Friday's training session.
Luis Enrique also insisted there had been a "blockage in finishing" in their recent fixtures in Europe, though they have not been shy of goals in Ligue 1.
In their midweek defeat, the Parisiens registered 22 shots compared to their opponents' four, ending the contest with an expected goals (xG) of 2.12 to Atletico's 0.67.
However, PSG have scored a division-high 29 goals from their 10 games so far, and Luis Enrique is relishing the chance of rediscovering their clinical edge this weekend.
"After a match like Wednesday's, and I've been through others in my career, it's difficult. Emotions are going to absorb everything," he added.
"The result will make you see everything in a negative light.
"How am I feeling? Perfectly. The more difficult it is, the better. We're aware that there's a blockage in the finishing.
"There's no denying it, it's a general problem. We need to overcome that, through confidence, by trying to create clearer chances, and collectively.
"I know it's a medium to long term project, and there will be ups and downs."
Al-Hilal 3-1 Al-Ettifaq: Champions return to the summit with dominant win
Al-Hilal surged back to the Saudi Pro League summit with a convincing 3-1 triumph over 10-man Al-Ettifaq on Friday.
The defending champions are now one point clear of Al-Ittihad in the standings, with their latest victory piling more misery on Al-Ettifaq boss, Steven Gerrard.
Al-Hilal struggled in the early exchanges at the Kingdom Arena, registering their first effort on Marek Rodak's goal in the 38th minute courtesy of Marcos Leonardo.
But the hosts would take the lead in the second minute of first-half stoppage time, with Mitrovic on hand to steer Renan Lodi's delivery into the net from close range.
Al-Hilal then doubled their advantage nine minutes from time when Malcolm collected the ball from Abdullah Al Hamddan, before rounding Rodak and finishing into an empty net.
However, hopes of a comeback from the visitors were revived in second-half stoppage time when Joao Cancelo gave away a penalty after a handball inside the box.
Vitinho stepped up and fired home the spot-kick, but Al-Hilal confirmed the win two minutes later through Mohammed Al Qahtani, with visiting forward Abdullah Radif shown a late red card for violent conduct.
Data Debrief: Happy Friday!
Al-Hilal continued their quest for a 20th Saudi Pro League crown with a dominant display against Al-Ettifaq, extending their unbeaten run against their opponents in the process.
They have now not lost their last 13 league encounters against Al-Ettifaq (W12 D1), surpassing their longest unbeaten streak against them in the competition (12 matches between 2008 and 2013 - W8 D4).
Al-Hilal have now lost only three matches when hosting teams on a Friday in the Pro League out of 55 matches (W46 D6 L3).
Lodi also took his goal contribution tally to eight this season in all competitions (three goals, five assists). During his European career with three different clubs, he only notched more goal involvements (nine) in the 2021-22 campaign with Atletico Madrid.
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