Juventus' hopes of progressing to the Champions League last 16 suffered a massive blow as they were stunned 2-0 by Maccabi Haifa.
The Bianconeri went into their third Group H encounter trailing pacesetters Paris Saint-Germain and Benfica by four points.
And their deficit to at least one of that duo will grow after they were outplayed by the Israeli champions on Tuesday at Sammy Ofer Stadium.
Omer Atzili's first-half double was the difference, but the margin of victory could have been greater for Maccabi as they claimed a famous win that will increase the scrutiny on under-fire Juve coach Massimiliano Allegri.
Frantzdy Pierrot had Wojciech Szczesny scrambling to make a diving save in the fourth minute, but the goalkeeper could do nothing to deny the hosts soon after when Atzili flicked home Pierre Cornud's left-wing cross.
Tjaronn Chery then struck the top of the crossbar with a free-kick before Atzili forced Szczesny into action once more at the end of a rapid counter-attack as Maccabi continued to pile pressure on Juve.
That pressure told again in stunning fashion just before half-time, Pierrot laying off for Atzili to shape a superb finish into the top-right corner after Juve had been dispossessed in their own half.
Juve eventually threatened a response, but Joshua Cohen was equal to Dusan Vlahovic's header to preserve Maccabi's two-goal advantage at the break.
Having replaced the injured Angel Di Maria with Arkadiusz Milik in the first half, Allegri threw on Filip Kostic and Manuel Locatelli at the start of the second half.
But neither had the desired impact as Maccabi hung on with relative comfort to leave Allegri's men facing the legitimate prospect of a group-stage exit.
Real Sociedad 0-1 Real Madrid: Los Blancos edge closer to LaLiga title with win
Arda Guler scored in the first half to earn a second-string Real Madrid side a 1-0 win at Real Sociedad on Friday, moving the LaLiga leaders a step closer to a record-extending 36th Spanish title.
With five games remaining, Madrid climbed to 84 points and extended their lead to 14 points over second-placed Barcelona, who have a game in hand and host Valencia on Monday.
Madrid manager Carlo Ancelotti rested several key players ahead of their Champions League semi-final against Bayern Munich, but his side did just enough to secure the three points.
The winner came from 19-year-old Turkish midfielder Guler, making his first start for Madrid after signing from Fenerbahce, when he turned home Dani Carvajal's cross in the 29th minute.
Minnesota United v Sporting Kansas City: ‘It’s what I’ve waited for’ - Oluwaseyi
Minnesota United forward Tani Oluwaseyi is relishing his chance in the first team ahead of their clash with Sporting Kansas City.
The Loons have enjoyed a strong start to the MLS season and sit fifth in the Western Conference.
Sporting KC, meanwhile, sit three points below them in 10th having won just two of their opening nine matches.
Oluwaseyi scored the opening goal in Minnesota’s 3-0 win over Charlotte last weekend, which ended a run of three games without a victory.
Asked how it feels to break into the starting line-up after spending his first year at the club on loan, Oluwaseyi, who has scored a joint-high three goals, said:
“It's something that I've been waiting for, for I guess the last three years.
“I hoped that I could do it in year one, and that was kind of the goal going in, but everyone has a different journey, which is very evident in the game.
“So it took a couple of years, but I think being here now, being given the opportunity, the biggest thing for me is just grabbing an opportunity and making the most with it.”
‘We can’t control the Opta supercomputer’ – Eidevall says Arsenal’s destiny is in their own hands
Jonas Eidevall insists Arsenal are still focused on their title push despite being given a 0 per cent chance of winning the Women’s Super League by the Opta supercomputer.
The Gunners sit in third place ahead of Sunday’s match against Everton and are six points behind leaders Manchester City.
Chelsea occupy second place, three points ahead of Arsenal, but with a game in hand on the teams around them.
Asked if he thought his side could do something special despite the Opta supercomputer’s prediction, Eidevall did not rule his team out of the race.
He said: “It's about for us focusing on what we can control.
"The Opta supercomputer is definitely one of the things that we can't control. So, they can make their calculations, but we have to focus on our performances.”
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