Chelsea will host Milan on Wednesday in what could well be a must-win fixture for the Blues, who sit last in Champions League Group E.
England has not been a happy hunting ground for Milan, but the group leaders and reigning Serie A champions will be hoping for a change of fortune when they roll into Stamford Bridge.
Meanwhile, Mykhaylo Mudryk will get a chance to show why he is considered one of the top young talents in Europe as Shakhtar Donetsk head to the Santiago Bernabeu to take on Real Madrid.
Paris Saint-Germain will look to change their poor historical record against Benfica, with Kylian Mbappe on the brink of becoming the club's record European goalscorer.
Stats Perform has dug up the most interesting facts and angles for each contest on Wednesday.
Chelsea v Milan
This is the first time these two teams will meet in the Champions League since they were in the same group in 1999, with both of those matches ending in draws. They have not met in a competitive game since, with all four of their 21st-century contests coming in the International Champions Cup (Chelsea won three of those with Milan recording one victory).
Chelsea have only lost twice at home to Italian teams in continental competition, collecting eight wins and three draws. They lost to Lazio 1-2 in 2000, and to Inter 1-0 in 2010.
Milan's record in England also gives no reason for optimism, with only one win from 20 tries in European play (D7 L12).
Olivier Giroud was subbed off in Milan's dramatic 3-1 win over Empoli on Saturday. The France striker could become the 10th player to score for and against Chelsea in the Champions League, and first since Loic Rémy for Lille in December 2019, should he net in this meeting.
Real Madrid v Shakhtar Donetsk
This is the third consecutive season these sides have met in the group stages. It is the fifth time teams have ever been paired together in three consecutive seasons, and Shakhtar was involved in the most recent occasion as well, against Manchester City from 2017-18 through to 2019-20.
Over the past two seasons, they have split the wins evenly, with Shakhtar winning both games in the 2020-21 campaign, before Madrid triumphed in both fixtures last season.
After a win and a draw in the first two matchdays, Shakhtar boast the highest shot conversion rate in the competition, scoring with five of their 10 shots, including two goals from 21-year-old rising star Mudryk.
On the other side, Vinicius Junior leads the Champions League with 33 chances created and seven assists from open play since the start of last season, and he shares the mantle for most goal involvements at 18 with Barcelona's Robert Lewandowski.
Benfica v Paris Saint-Germain
Benfica are looking to extend their surprisingly strong record against Paris Saint-Germain, having won three of their six previous meetings (1D 2L) in European competitions, including the past three in a row. Their last fixture came in the 2013-14 season, with Benfica winning 2-1 at home.
In fact, Benfica have enjoyed plenty of success while hosting French sides, with five consecutive home wins – twice against Lyon, as well as beating Lille, Monaco and PSG.
However, PSG are a different beast now then they were back in 2014, and have only lost one of their past 11 matches in the group stage (8W 2D).
At only 23, Mbappe can become the club's all-time leading scorer in European competitions with one more goal. He is currently tied at 30 with Edinson Cavani.
RB Leipzig v Celtic
These sides both won their home fixtures when they were matched up in the 2018-19 group stage, and they will be desperate for a result as they enter Wednesday's game with only one point between them in Group F.
Celtic will be looking to make history as they have never won a European game away in Germany (10L 3D), failing to score on nine of those 13 occasions.
But it might be a case of a stoppable force meeting a movable object, as Leipzig have not kept a clean sheet in their last seven home games in the competition. They have only shut out their opponents twice from 15 Champions League home games.
Jota will be the key for Celtic's chances, with his six chances created trailing only Napoli's Piotr Zielinski (eight), while only Madrid star Vinicius is credited with more take-on dribbles (11) than Jota's nine.
Other fixtures:
Manchester City v FC Copenhagen
23 – Manchester City are two games away from tying Manchester United's record of 23 consecutive Champions League home fixtures without a loss. They are unbeaten at home in the competition since 2018.
62 – City's Erling Haaland averages a goal every 62 minutes in the competition, netting 26 goals in 21 appearances. He is well clear of second-placed Mario Gomez, who scored his 26 goals on an average of every 102 minutes.
Sevilla v Borussia Dortmund
1 – Borussia Dortmund have only won one of their past 11 trips to Spain in the Champions League (L7 D3), but that win came from their most recent opportunity, against Sevilla in February 2021.
3 – Sevilla have failed to score in each of their past three Champions League games. They have never gone four consecutive games in European competition without scoring.
Juventus v Maccabi Haifa
29 – It has been 29 years since Maccabi Haifa defeated an Italian team in European competition (3L 1D), with their only victory coming in 1993 against Parma.
8 – The Israeli side have lost all eight of their Champions League fixtures since 2002, by a combined aggregate score of 13-1.
Salzburg v Dinamo Zagreb
6 – Salzburg can become the first Austrian team to ever go six games unbeaten in the Champions League if they can avoid defeat against Dinamo Zagreb, with three wins and two draws from their past five.
23 – The last time Zagreb kept a clean sheet away from home in this competition was 23 years ago, drawing 0-0 against United at Old Trafford in 1999. Since then, they have conceded 52 goals in 18 away games (2.9 per game).
Hurtig the hero after late goal sends Arsenal into Champions League quarters
Lina Hurtig's 89th minute winner ensured Arsenal progressed to the quarter-finals of the Women's Champions League after edging Juventus 1-0 on Thursday.
After being frustrated for large parts of the encounter, Hurtig bundled home from close range after Martina Lenzini's poor clearance to book the Gunners' place in the last eight.
Despite Arsenal dominating the early exchanges, it was Juventus who had the first sight of goal, though Eva Schatzer's effort was easy for Daphne van Domselaar to gather.
In a first half that saw just two shots on target, both coming from the visitors, Renee Slegers' substitutes proved to be the difference for Arsenal.
Slegers introduced Beth Mead, Stina Blackstenius and Hurtig late on, with the latter somehow putting Kim Little's cross over the bar from five yards out.
However, the Swede would atone for her earlier error, combining with fellow substitute Blackstenius to net against her former club and send them out of the competition with two group games remaining.
Meanwhile, in Group D, Barcelona edged closer to the quarter-finals of the competition with a convincing 4-1 victory over St. Polten at the Generali Arena.
The reigning champions are still three points behind Manchester City following their 2-1 win over Hammarby, and know a win against the Swedes next month will see them progress.
Kika Nazareth opened the scoring in the 20th minute after capitalising on a mistake by Kamila Dubcova, notching her second nine minutes later from close range.
Barca found themselves three goals up at the break when Vicky Lopez netted her first goal in the competition to put the result beyond doubt.
There was also a landmark moment for Alexia Putellas, who netted her 200th goal for the club with a well-taken effort into the far corner.
Valentina Madl took some of the shine off an otherwise impressive display from the visitors, who have now taken their tally to 20 goals from their four matches in the competition.
Guardiola agrees two-year contract extension with Man City
Pep Guardiola will be Manchester City manager for at least two more seasons after 2024-25, after he signed a two-year contract extension on Thursday.
The 53-year-old was coming to the end of his City deal, which was due to expire at the end of the current campaign, but he has opted to remain at the Etihad Stadium.
The deal itself will take Guardiola's tenure at the club to over a decade, making him City's longest-serving manager since Les McDowall in 1963.
There had been suggestions that he may leave at the end of the season following the announcement that director of football Txiki Begiristain was on his way out.
Guardiola was strongly linked with the England job after Gareth Southgate resigned in the wake of their Euro 2024 final defeat, but the Football Association appointed Thomas Tuchel last month.
“Manchester City means so much to me," Guardiola said. “This is my ninth season here; we have experienced so many amazing times together. I have a really special feeling for this football club.
“That is why I am so happy to be staying for another two more seasons.
“Thank you to everyone for continuing to trust and support me – The Owner, The Chairman Khaldoon, Ferran, Txiki, the players and, of course, the fans… everyone connected to Manchester City. It has always been an honour, a pleasure and a privilege to be here.
“I have said this many times before, but I have everything a manager could ever wish for, and I appreciate that so much.
“Hopefully, now we can add more trophies to the ones we have already won. That will be my focus.”
Having been appointed in 2016, Guardiola is by some distance Manchester City's most successful manager of all time, having won 18 major trophies during his time at the club.
That list includes their first-ever Champions League triumph in 2023 and six Premier League titles, including an unprecedented four on the spin.
He also boasts a 72.04% win percentage across all competitions, which is unsurprisingly the highest of any full-time City manager in history.
McKenna fired up for 'biggest game in world football' against Man United
Kieran McKenna believes Ipswich Town's Premier League clash with Manchester United will be the "biggest game in world football" this weekend.
United are in action under new manager Ruben Amorim for the first time since the Portuguese officially replaced Arne Slot as head coach.
While plenty of focus is on the visitors at Portman Road, Ipswich are fired up after beating Tottenham 2-1 before the international break.
That was Ipswich's first league win of the season – and their first in the Premier League in 22 years – and now attention turns to facing United.
McKenna, who previously coached United, said at a fan event this week: "Sunday, what a game. It's one we're really, really looking forward to.
"Not for the personal connection, but as manager of Ipswich Town, to be on that stage, it's what we've worked so hard for.
"It's the biggest game in world football anywhere this weekend, the biggest game in the world in the biggest sport in the world and it's at Portman Road."
Ipswich's surprise win at Tottenham last time out moved them up to 17th, while United are 13th after beating Leicester City 3-0 in Ruud van Nistelrooy's final game in caretaker charge.
Amorim took his first training session on Monday, albeit with many first-team stars away on international duty, and the former Sporting CP boss believes his style of play will be clear to see from the off.
"I think you will see an idea," he told the club's website. "You could like it or not, I don't know, but you will see an idea.
"You will see a positioning. You will see something that we want to reach that kind of level. You will feel that.
"We have to know it's [only] two trainings before the first match. This is the best league in the world. But if I have to say something to you, [it's that] you will see an idea. This I can guarantee."
PLAYERS TO WATCH
Ipswich Town - Liam Delap
Delap scored what proved to be Ipswich's winner against Tottenham and has now netted six of his side's 12 Premier League goals this term.
That makes the Manchester City academy product one of only three players to have scored at least half of his side's goals in the competition this season, along with Erling Haaland at City (55%) and Chris Wood at Nottingham Forest (53%).
Manchester United - Alejandro Garnacho
Garnacho was among the scorers against Leicester two weeks ago and has now been directly involved in 20 Premier League goals for United (13 goals and seven assists).
The Argentina international is one of only two non-British players to reach that figure for United before turning 21, along with Cristiano Ronaldo (25 goals).
MATCH PREDICTION: MANCHESTER UNITED WIN
Ipswich are seeking back-to-back Premier League wins for the first time since February 2022, with that run also beginning with a 2-1 victory against Tottenham.
The Tractor Boys are the only side in the competition without a home win this season. Only five newly promoted clubs have failed to win any of their first six home matches, all of whom went back down.
United have won 17 of their past 19 Premier League games against newly promoted opponents, meanwhile, including nine wins in a row in away fixtures.
The Red Devils were 1-0 winners on their most recent league trip to Portman Road in April 2022, but only once have they won successive league games away to Ipswich.
However, the Tractor Boys have lost four of their past five league matches against Man United, failing to score in each of those losses.
OPTA WIN PROBABILITY
Ipswich Town - 22.2%
Draw - 23%
Manchester United - 54.8%
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