Marcus Rashford remains "under consideration" for an England recall, though Gareth Southgate conceded the lack of game-time for several key players is "not ideal".
In the last national squad before the Qatar 2022 World Cup, there was no place for Manchester United attacker Rashford and club-mate Jadon Sancho.
Rashford is, however, struggling with a muscular problem. The 25-year-old has been in strong for this season, scoring three Premier League goals in six appearances.
A maiden call-up for Brentford attacker Ivan Toney and a recall for Tottenham's Eric Dier were among the more eye-catching inclusions by Southgate, who stressed the door is not shut for those others seeking a return to the fold in time to make the World Cup squad.
"There were certain players we wanted to keep involved this time, but that said, it doesn't mean that this is the end for some of the others who aren't involved," he stated.
"Marcus Rashford, for example, has shown some encouraging signs recently. He is a player we know well so if he can perform at a high level in the next few weeks, he of course will be under consideration."
Several of Southgate's regular squad members made the cut, such as United duo Harry Maguire and Luke Shaw, alongside Manchester City midfielder Kalvin Phillips, all of whom have struggled for minutes this season.
Their crucial impact on last year's Euro 2020 campaign, however, has swayed Southgate, though he acknowledged it is not a "perfect situation".
"Clearly, we have a number of players including Ben Chilwell, Luke Shaw, Harry Maguire and Kalvin Phillips who are not playing a lot of minutes with their club," he added.
"It is not ideal, but we feel they have been, and can be, important players for us. It is not a perfect situation, but there is still a lot of football to be played before Qatar.
Tottenham defender Dier ends a two-year absence from the national set-up, having been a member of the team that travelled to the 2018 World Cup, with Toney a new face altogether.
"With Eric, he has been playing well for a period of time," Southgate added. "We think it is a really close call across our centre-backs, and he has deserved to be picked back in the group.
"We know what a good character he is. He fits in with the culture and has great international experience and leadership qualities.
"With Ivan Toney, we have been tracking him for a long time. I had a good chat with Thomas Frank about him last season.
"His form and his qualities – not only his goalscoring but his technical ability, build-up play and aerial prowess – gives us a different threat to some of the other players we could pick."
England travel to Italy in a Euro 2020 final rematch before returning to Wembley to face Germany in their two Nations League encounters before the World Cup.
Stokes out of first Pakistan Test through injury
England captain Ben Stokes is out of their first Test against Pakistan having failed to recover from a hamstring tear in time.
Stokes suffered the hamstring injury in August playing in The Hundred and has not played since, missing England's three-match series against Sri Lanka last month.
England said last week that the 33-year-old was "on track" to participate in the tour and trained away from the rest of the team in their first session.
Stokes confirmed he will miss the first Test, which begins on Monday in Multan, and Ollie Pope will continue to deputise as captain in his absence.
"I tried my hardest to get myself fit for this game but have taken the call to miss this one because I've not quite managed to get game-ready," Stokes told BBC Sport.
"There is a lot that has to go into my rehab programme. We got to a certain point, but looking at the picture of what we've got coming up and physically where I'm at, I'm not quite ready to play.
"It's always frustrating to miss out. I've got some good things to focus on, so even though I'm not playing, I've got a goal in mind."
The second Test starts on October 15, but the all-rounder admitted he was not sure whether that was a realistic target for his return.
"I've pushed myself incredibly hard and worked really hard with the medical team to get to where I'm at now. I think I'm further ahead than what we expected," he added.
"I'll be working just as hard over the next 10 days to try to get myself fit for the second Test."
In his absence, Durham seamer Brydon Carse will make his England Test debut.
He has previously played 19 ODIs and four T20s for England and will make his red-ball bow just over a month after completing a three-month ban for historical gambling offences.
England XI for first Test against Pakistan: Zak Crawley, Ben Duckett, Ollie Pope (captain), Joe Root, Harry Brook, Jamie Smith, Chris Woakes, Gus Atkinson, Bryson Carse, Jack Leach, Shoaib Bashir.
Gabbia, Pisilli and Maldini named in Italy's Nations League squad
Luciano Spalletti has handed four players their senior call-up to the Italy national team ahead of their Nations League fixtures next week.
Italy take on Belgium and Israel in the next round of games, hoping to build on their impressive start in Group A2 after winning their opening two games which included a 3-1 win over France.
Milan defender Matteo Gabbia has been included after an impressive run of performances at centre-back under new head coach Paulo Fonseca.
Gabbia is also the first player from the Rossoneri to be named in the Italy squad in almost 600 days, with Sandro Tonali, who joined Newcastle in 2023, the last Milan representative to feature for the Azzurri.
There was also a place in the squad for Monza's Daniel Maldini, who could follow in the footsteps of his father Paolo, and grandfather Cesare, both former Italy captains.
Maldini has one goal and one assist in seven appearances in all competitions this season, and comes in for Lazio's Matteo Zaccagni.
Juventus goalkeeper Michele Di Gregorio has also been given a first call-up to the senior side, replacing the injured Alex Meret of Napoli.
Roma's Niccolo Pisilli was also named in the squad, replacing Atlanta's Marco Brescianini, who has also suffered a recent injury set-back.
There were five Premier League representatives named in Spalletti's 23-man squad on Friday, with Guglielmo Vicario, Riccardo Calafiori, Caleb Okoli, Destiny Udogie and Tonali also included.
However, there was no space for Liverpool's Federico Chiesa, who did not feature in the Reds' Champions League win over Bologna in midweek.
Italy squad: Michele Di Gregorio (Juventus), Gianluigi Donnarumma (PSG), Guglielmo Vicario (Spurs), Alessandro Bastoni (Inter), Raoul Bellanova (Atalanta), Alessandro Buongiorno (Napoli), Riccardo Calafiori (Arsenal), Andrea Cambiaso (Juventus), Giovanni Di Lorenzo (Napoli), Federico Dimarco (Inter), Matteo Gabbia (Milan), Caleb Okoli (Leicester), Destiny Udogie (Tottenham Hotspur), Nicolo Fagioli (Juventus), Davide Frattesi (Inter), Lorenzo Pellegrini (Roma), Niccolo Pisilli (Roma), Samuele Ricci (Torino), Sandro Tonali (Newcastle United), Moise Kean (Fiorentina), Daniel Maldini (Monza), Giacomo Raspadori (Napoli), Mateo Retegui (Atalanta).
Bayern confirm Musiala 'sidelined for the time being' with hip injury
Bayern Munich have confirmed that midfielder Jamal Musiala will be out "for the time being" after picking up a hip injury in their Champions League defeat to Aston Villa.
Musiala, who played in the second half of the 1-0 loss at Villa Park, has been ruled out for Bayern's upcoming Bundesliga fixture against Eintracht Frankfurt on Sunday.
He will also miss Germany's Nations League fixtures against Bosnia and Herzegovina and the Netherlands, with Julian Nagelsmann replacing the 21-year-old in his squad with Stuttgart's Jamie Leweling.
Musiala has been in fine form for Vincent Kompany's side, scoring three goals and laying on three assists in eight appearances in all competitions.
The midfielder also has the joint-most completed dribbles in the Bundesliga this season (seven), while only Michael Olise (14), Joshua Kimmich (13) and Harry Kane (10) have created more chances for Bayern than Musiala (seven).
He has also impressed for Germany on the international stage, scoring six times in 36 games for his country, playing a starring role in their Nations League opener against Hungary last month, scoring once and providing three assists in the 5-0 victory.
"Following an examination by the club's medical staff, Jamal Musiala will be sidelined for the time being with a hip problem," Bayern said on their social media accounts.
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