Cristiano Ronaldo faces an uncertain Manchester United future, but he stands to pass a string of landmarks if he stays and plays for Erik ten Hag this season.
Tottenham's Harry Kane, set to captain England at the World Cup later in the year, is chasing a significant club landmark.
And guess who will join Mohamed Salah in bidding to set an opening-day career goals record.
Of course, it's...... Jamie Vardy.
As the new season gets under way on Friday, Stats Perform looks at the records and milestones coming into view.
KANE, RONALDO, HAALAND: TARGETS IN THE CROSSHAIRS OF THE BIG GUNS
What role Ronaldo has to play remains in the balance, given he appears keen to leave United for a second time.
But if the 37-year-old features for the Red Devils, he can begin to chase down landmarks. For starters, he is just four victories short of having had a hand in 150 United wins in the Premier League, having drawn 43 times and lost 37 while a member of the team across his two Old Trafford spells.
Ronaldo is a mere six goals away from becoming the first player to amass 500 goals in Europe's top five leagues. His record 494 goals to date have come from 616 league matches. On his heels, however, is perennial rival Lionel Messi, once of Barcelona and now at Paris Saint-Germain (480 goals in 546 league games).
Kane is 17 away from hitting the 200-goal mark in the Premier League, a total only ever achieved by Alan Shearer (260) and Wayne Rooney (208). Sergio Aguero (184) and Andy Cole (187), third and fourth on the Premier League era list, are poised to be knocked down a peg as Kane continues his assault on the league record.
Both Leicester City's Vardy and Liverpool's Salah will be looking to equal or break the Premier League matchday one goals record, which is currently held jointly by Shearer, Frank Lampard and Rooney (eight goals). Vardy and Salah have seven each, like the retired Teddy Sheringham and Aguero.
Manchester City new boy Erling Haaland has caused a sensation with his goalscoring wherever he has played, dazzling for Molde, Salzburg, Borussia Dortmund and Norway. He could become the seventh Norwegian to score on his Premier League debut, and the third to do so in the opening game of a season, after Tore Andre Flo for Chelsea in 1997-98 and Adama Diomande in 2016-17 with Hull City.
DESERVES A LONG SERVICE MEDAL
Liverpool's James Milner, fresh from signing a new one-year contract, is 12 short of reaching 600 Premier League games. Only three players have reached that mark to date: Gareth Barry (653), Ryan Giggs (632) and Lampard (609).
Milner made his Premier League debut for Leeds United as a 16-year-old in November 2002, so a 20-year anniversary is approaching for the former England midfielder.
David Moyes was already a Premier League manager by the time Milner made his first appearance. At Everton then, he has done the rounds since and is a mere two games away from completing 1,000 matches in all competitions as a manager in English football.
Now at West Ham, Moyes looks to be at the opposite end of his touchline career to Mikel Arteta, the Arsenal manager who is one away from bringing up his first 50 wins as a Premier League boss.
STICK AROUND LONG ENOUGH...
Only six teams have been constant members of the Premier League since its first year in 1992-93. Completing the first 30 seasons without suffering the indignity of relegation have been Manchester United, Liverpool, Chelsea, Tottenham, Everton and Arsenal. Sooner or later, all sorts of landmarks arrive for these league lynchpins.
Arsenal have lost 249 Premier League games and headed into Friday night's season opener against Crystal Palace under threat of becoming the 13th side to lose 250. They would have had the longest wait to lose 250, however, having already played four games more than Chelsea, who took the longest (1,148 games) of those to have reached the not-so-desirable milestone.
Tottenham, another of those stalwart sides, are just five away from becoming the fifth team to score 1,000 goals at home in the competition (Manchester United 1,214, Liverpool 1,156, Arsenal 1,154, Chelsea 1,121).
Chelsea are 27 shy of 2,000 goals, home or away, having plundered 1,973 in their 1,152 games to date.
Aston Villa and Newcastle United are both 12 short of losing 400 Premier League games. Only West Ham (408) and Everton (414) have lost more games than those sides, who will hope to avoid spilling over that barrier this season.
West Ham are four away from reaching 1,000 Premier League games, while promoted Nottingham Forest are two away from 200.
MAKING UP THE NUMBERS
Liverpool left-back Andy Robertson needs one assist to become only the second defender to register 50 Premier League assists, after Leighton Baines (Wigan, Everton). Robertson has 49, with Baines managing 53 across his career.
Aston Villa veteran Ashley Young and Tottenham new arrival Richarlison are two shy of reaching 50 Premier League goals, while Newcastle's former Burnley goalkeeper Nick Pope is four away from 50 clean sheets in the competition.
Brighton and Hove Albion are two away from 50 wins, with Aston Villa four short of 300 draws, a tally that only Everton (320) have reached.
Southampton need four victories to reach 100 away wins, and Aston Villa want four three-pointers on the road to reach their 150 wins. Leicester, on the other hand, are four away from 150 Premier League away defeats. Brendan Rodgers will hope to fend off that landmark until well into the new campaign.
Klopp returns to football as Red Bull's head of global soccer
Jurgen Klopp has landed his first role since leaving Liverpool, with the German announced as the new global head of soccer at Red Bull.
Klopp, who ended his nine-year stint at Anfield earlier this year, has signed a long-term deal with the energy drinks brand, believed to be a five-year contract.
He will be responsible at the strategic management level for Red Bull's international network of clubs, which includes RB Leipzig, New York Red Bulls, Red Bull Bragantino and Red Bull Salzburg, who are managed by former assistant, Pep Lijnders.
Red Bull says Klopp will not be involved in day-to-day operations but will advise teams on playing philosophy, transfer strategy and coaching development.
Klopp will officially begin in the role at the start of next year.
"A few months ago I said I don't see myself on the sidelines any more and that is still the case," Klopp said on Instagram.
"But I still love football, I still love working, and Red Bull gives me the perfect platform for that."
Klopp has been on a break since leaving Liverpool at the end of last season, after a successful reign at Anfield.
During his time on Merseyside, Klopp won eight major honours, including ending the Reds' 30-year wait for a first Premier League title four years ago.
The German took charge of 489 games, winning 304 (D100 L85), with only Bill Shankly (729) and Bob Paisley (532) overseeing more matches than Klopp.
After leaving, the 57-year-old said he did not want to take a coaching role for the foreseeable future, but is understood to have secured an exit clause that especially applies to the Germany national team.
But for the time being, Klopp wants to use his experiences in his new role ahead of a potential return to the dugout.
"I want to share the experiences I have collected over the years," said Klopp.
"We all know there are more successful managers out there but in my career I have fought for promotion, fought for titles and I have fought for trophies.
"Sometimes we failed, sometimes we succeeded and dealing with that is not easy, but it is possible.
"Then I want to learn again. Because when you are in the job, and you have to play every three days, you barely have the time.
"I want to see, feel and figure out what is useful for football, developing football a little bit as well."
Root targets 'many more runs' as Cook backs England great to set all-time record
Joe Root is targeting "many more runs" after overtaking Alastair Cook as England's all-time leading Test run-scorer.
The 33-year-old surpassed Cook's previous high of 12,472 on day three of the first Test against Pakistan on Wednesday.
Root reached the mark by piling on 71 runs in the blistering Multan heat and reached 176 not out at the end of play with England 492-3.
"I'm obviously proud but still feel there is plenty more left to do, and many more runs left to get," Root is quoted as saying by BBC Sport.
"More than anything, the way we played as a team is what stands out - we've got ourselves back in a really good position."
Root's 12,578 runs consist of 35 centuries, 1,355 fours and 44 sixes, coming across 146 matches.
He is now fifth on the all-time list of run-scorers across all nations, with only Rahul Dravid (13,288), Jacques Kallis (13,289), Ricky Ponting (13,378) and Sachin Tendulkar (15,921) ahead of him.
And with time still on his side age-wise, Cook has backed the man who took his England record to overtake each of those legendary names.
"I would be betting on Root to do it," Cook told Test Match Special. "I don't see Root losing that hunger and ability to keep driving himself forward for the next couple of years.
"He's just this consistent run-scoring machine. There are other geniuses who can play genius innings, but Root is a genius with consistency."
England have never conceded as many as Pakistan's 556 and gone on to take a first-innings lead, but they trail by just 64 runs heading into day four.
"We've still got an opportunity to win the game, which is really exciting," Root added. "Hopefully we can kick on tomorrow."
Duckett leads tributes to 'extremely humble' Root after making England history
Ben Duckett hailed "extremely humble" Joe Root after watching his team-mate become England's all-time leading Test run-scorer on day three against Pakistan.
Root needed 39 entering Wednesday's play in Multan to break Alastair Cook's record, and he surpassed that target with ease, ending the day unbeaten on 176 alongside Harry Brook.
In his 147th Test outing, Root drilled Aamir Jamal's delivery in the blistering heat to overtake Cook's previous record of 12,472 as England closed to within 64 runs of Pakistan on 492-3.
Duckett partnered Root for the historic moment and led the tributes at the end of play.
"He is extremely humble," Duckett, who recovered from a broken thumb to make 84, told Test Match Special. "It doesn't feel like you're sat around greatness.
"He's just hungry for runs every time he goes out bat for England. It's incredible to be in the same dressing room as him and long may it continue."
Root now has 12,578 runs in 146 matches, which has seen him bat in 268 innings in total, with his tally consisting of 35 centuries, 1,355 fours and 44 sixes.
The 33-year-old is up to fifth on the all-time list of run scorers across all nations, with only Rahul Dravid (13,288), Jacques Kallis (13,289), Ricky Ponting (13,378) and Sachin Tendulkar (15,921) ahead of him.
England batting coach Marcus Trescothick added to Sky Sports: "We're lucky enough to sit and watch history being made as a man goes on to be the leading run scorer in his country.
"The way he goes about it, the work he puts in and continues to strive for greatness all the time. He's been superb and think will continue to be superb for a number of years yet."
Amid all the fanfare for Root, England will enter day four looking to create some history of their own.
The tourists have never conceded as many as Pakistan's 556 and gone on to take a first-innings lead.
"The pitch is not doing a great deal at the moment and to be in a position where we can say we can get [a lead of] 150-200 is an incredible effort," Duckett added.
"The morning session will be important and if we can limit the damage, we can kick on in the afternoon."
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