Cristiano Ronaldo faces an uncertain Manchester United future, but he stands to pass a string of landmarks if he stays and plays for Erik ten Hag this season.
Tottenham's Harry Kane, set to captain England at the World Cup later in the year, is chasing a significant club landmark.
And guess who will join Mohamed Salah in bidding to set an opening-day career goals record.
Of course, it's...... Jamie Vardy.
As the new season gets under way on Friday, Stats Perform looks at the records and milestones coming into view.
KANE, RONALDO, HAALAND: TARGETS IN THE CROSSHAIRS OF THE BIG GUNS
What role Ronaldo has to play remains in the balance, given he appears keen to leave United for a second time.
But if the 37-year-old features for the Red Devils, he can begin to chase down landmarks. For starters, he is just four victories short of having had a hand in 150 United wins in the Premier League, having drawn 43 times and lost 37 while a member of the team across his two Old Trafford spells.
Ronaldo is a mere six goals away from becoming the first player to amass 500 goals in Europe's top five leagues. His record 494 goals to date have come from 616 league matches. On his heels, however, is perennial rival Lionel Messi, once of Barcelona and now at Paris Saint-Germain (480 goals in 546 league games).
Kane is 17 away from hitting the 200-goal mark in the Premier League, a total only ever achieved by Alan Shearer (260) and Wayne Rooney (208). Sergio Aguero (184) and Andy Cole (187), third and fourth on the Premier League era list, are poised to be knocked down a peg as Kane continues his assault on the league record.
Both Leicester City's Vardy and Liverpool's Salah will be looking to equal or break the Premier League matchday one goals record, which is currently held jointly by Shearer, Frank Lampard and Rooney (eight goals). Vardy and Salah have seven each, like the retired Teddy Sheringham and Aguero.
Manchester City new boy Erling Haaland has caused a sensation with his goalscoring wherever he has played, dazzling for Molde, Salzburg, Borussia Dortmund and Norway. He could become the seventh Norwegian to score on his Premier League debut, and the third to do so in the opening game of a season, after Tore Andre Flo for Chelsea in 1997-98 and Adama Diomande in 2016-17 with Hull City.
DESERVES A LONG SERVICE MEDAL
Liverpool's James Milner, fresh from signing a new one-year contract, is 12 short of reaching 600 Premier League games. Only three players have reached that mark to date: Gareth Barry (653), Ryan Giggs (632) and Lampard (609).
Milner made his Premier League debut for Leeds United as a 16-year-old in November 2002, so a 20-year anniversary is approaching for the former England midfielder.
David Moyes was already a Premier League manager by the time Milner made his first appearance. At Everton then, he has done the rounds since and is a mere two games away from completing 1,000 matches in all competitions as a manager in English football.
Now at West Ham, Moyes looks to be at the opposite end of his touchline career to Mikel Arteta, the Arsenal manager who is one away from bringing up his first 50 wins as a Premier League boss.
STICK AROUND LONG ENOUGH...
Only six teams have been constant members of the Premier League since its first year in 1992-93. Completing the first 30 seasons without suffering the indignity of relegation have been Manchester United, Liverpool, Chelsea, Tottenham, Everton and Arsenal. Sooner or later, all sorts of landmarks arrive for these league lynchpins.
Arsenal have lost 249 Premier League games and headed into Friday night's season opener against Crystal Palace under threat of becoming the 13th side to lose 250. They would have had the longest wait to lose 250, however, having already played four games more than Chelsea, who took the longest (1,148 games) of those to have reached the not-so-desirable milestone.
Tottenham, another of those stalwart sides, are just five away from becoming the fifth team to score 1,000 goals at home in the competition (Manchester United 1,214, Liverpool 1,156, Arsenal 1,154, Chelsea 1,121).
Chelsea are 27 shy of 2,000 goals, home or away, having plundered 1,973 in their 1,152 games to date.
Aston Villa and Newcastle United are both 12 short of losing 400 Premier League games. Only West Ham (408) and Everton (414) have lost more games than those sides, who will hope to avoid spilling over that barrier this season.
West Ham are four away from reaching 1,000 Premier League games, while promoted Nottingham Forest are two away from 200.
MAKING UP THE NUMBERS
Liverpool left-back Andy Robertson needs one assist to become only the second defender to register 50 Premier League assists, after Leighton Baines (Wigan, Everton). Robertson has 49, with Baines managing 53 across his career.
Aston Villa veteran Ashley Young and Tottenham new arrival Richarlison are two shy of reaching 50 Premier League goals, while Newcastle's former Burnley goalkeeper Nick Pope is four away from 50 clean sheets in the competition.
Brighton and Hove Albion are two away from 50 wins, with Aston Villa four short of 300 draws, a tally that only Everton (320) have reached.
Southampton need four victories to reach 100 away wins, and Aston Villa want four three-pointers on the road to reach their 150 wins. Leicester, on the other hand, are four away from 150 Premier League away defeats. Brendan Rodgers will hope to fend off that landmark until well into the new campaign.
St. Louis City v LA Galaxy: Reus sets sights on silverware after dream start
Marco Reus is desperate to bring silverware to the LA Galaxy after making a flying start to his time in MLS, with St. Louis City the destination for his first road game on Sunday.
Reus registered a goal and an assist on debut last week as the Galaxy beat Atlanta United 2-0, maintaining their grip on top spot in the Western Conference.
The Galaxy are five points clear of local rivals Los Angeles FC at the top of the standings ahead of Sunday's trip to St. Louis, who are 13th and 10 points adrift of the playoff picture.
Reus' arrival in Los Angeles has caused plenty of fanfare, but he is focused solely on the team's collective aims.
"It's not about me, it's about the team," he said. "We want to be champions. So we take it game by game.
"Besides the traffic, it's really amazing. The people are so friendly. The weather, it's really nice. When you wake up in the morning and the sun is shining, you start the day differently.
"So I'm really, really happy every morning I come into the dressing room. I'm just happy and excited."
St. Louis played out a thrilling 4-4 draw with the Portland Timbers last week, twice throwing away a two-goal lead to leave interim coach John Hackworth bewildered.
"Really don't know what to say," Hackworth said. "It's hard to imagine coming to a place like this and scoring four goals, being up, and then just losing one-versus-one defensive battles.
"Sometimes, the number of goals you give up, or the number of goals you score, can hide a lot of the transition moments.
"An easy way to prevent some of these defensive miscues from happening is to just be better with the ball."
PLAYERS TO WATCH
St. Louis City – Eduard Lowen
Lowen scored his fourth goal of the MLS season last time out, converting from the penalty spot as St. Louis drew 4-4 with the Timbers.
Only Joao Klauss, with five goals, has outscored him for St. Louis this term.
LA Galaxy – Marco Reus
Reus is one of 20 players in MLS history to record a goal and an assist on his regular-season debut.
He is also the fifth Galaxy player to do so, after Steven Gerrard, Andreas Herzog, Giovani dos Santos and Sasha Victorine. No other team have had more than two players achieve the feat.
MATCH PREDICTION – DRAW
The Galaxy have won 10 of their last 13 regular-season matches, the first time they have done so in a single season since 2011. LA have not recorded 11 wins in a span of 14 matches within a single regular season in the post-shootout era (since 2000).
It would be no surprise to see the points shared in this one, though. All three meetings between St. Louis and the Galaxy have ended level, all with different scorelines (1-1, 2-2, 3-3).
St. Louis have only won one of the last six matches in which they have held the lead in regular-season play dating back to the beginning of June (four draws, one defeat).
OPTA WIN PROBABILITY
St. Louis City – 35.8%
LA Galaxy – 38.1%
Draw – 26.1%
Raphinha hails Barcelona after statement win over Valladolid
Barcelona forward Raphinha believes the team have laid down a statement of their intent by starting the season with four straight wins in LaLiga.
Raphinha scored the first hat-trick of his career and also delivered two assists on Saturday, as Barca crushed Real Valladolid 7-0 at Camp Nou.
Hansi Flick's side already possess a four-point cushion at the top of the table after also recording victories over Valencia, Athletic Bilbao and Rayo Vallecano.
Raphinha believes their results have demonstrated the club got things right in the transfer market, telling Movistar: "Today's game has shown that there is no need for anyone else to come. We are very happy because of that.
"We are in very good shape. The team is working hard. Today's result shows what we are working for.
"We saw that the coach was on the sidelines asking for more goals and that's our mentality.
"We are hungry and want to score as many goals as we can. When we are dominant like we have been, the best way to respect our rivals is not taking the foot off the gas."
Raphinha was one of the players who faced criticism during Barca's trophyless 2023-24 campaign and was rumoured to be on his way out ahead of the new season.
The Blaugrana again battled financial restrictions throughout the window, allowing Ilkay Gundogan to leave in order to secure the registration of new arrival Dani Olmo.
With his future now certain, Raphinha is keen to nail down a starting spot and contribute on a regular basis.
"I don't know if today's was my best game, but it's certainly among my best. I will try to play even better and as much as I can," the Brazilian said.
"I'm very happy to be able to help the team. I feel good. I knew that this season would be very important for me. I'm looking for my best version to help my team-mates and be more confident."
Lazio 2-2 Milan: Leao salvages draw but Rossoneri still winless
Rafael Leao came off the bench to earn Milan a 2-2 draw with Lazio at the Stadio Olimpico on Saturday, but Paulo Fonseca's side are still without a Serie A win this season.
Milan were in front at the break through Strahinja Pavlovic's eighth-minute goal, the Serbian rising highest to power home a header from Christian Pulisic's corner.
However, Lazio hit back in the second half with Valentin Castellanos and Boulaye Dia scoring in quick succession.
Nuno Tavares' first-time ball into the centre was met by the unmarked Castellanos to level in the 62nd minute, then Dia tapped another Tavares cutback home to put the Biancocelesti ahead four minutes later.
Fonseca reacted by sending on four substitutes, and those changes had a swift impact as three of them combined for the leveller.
Theo Hernandez – who joined Leao in being dropped from the start – picked out Tammy Abraham, and his lay-off allowed Leao to escape Tavares to fire past Ivan Provedel.
The game was preceded by an emotional tribute to the man who led Lazio to their last league title, Sven-Goran Eriksson, who died at the age of 76 on Monday.
A Lazio shirt bearing the Swede's name was displayed on the home bench, while a banner held up by the home fans read: "You brought us to the top of the world... Have a good trip Mr. Sven."
Data Debrief: Milan's slow start continues
New Milan boss Fonseca is already under pressure after overseeing a return of two points from his first three league games at the helm.
It is the first time the Rossoneri have drawn two of their opening three matches in a Serie A season since 2011-12, when they also drew two and lost one,
They went on to finish second that season, just four points adrift of champions Juventus. If a title challenge is to take place this term, rapid improvements are needed.
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