Botic van de Zandschulp is the only seeded player remaining at the Winston-Salem Open, advancing to the semi-final after winning a pair of tiebreakers against Benjamin Bonzi 7-6 (8-6) 7-6 (7-1).

Van de Zandschulp, the second seed, is yet to lose a set in the tournament after straight sets wins against Tallon Griekspoor and Jaume Munar, and he used his dominant serve to get the job done against France's Bonzi.

The Dutchman had 15 aces while Bonzi had three, and he posted 50 winners to Bonzi's 24 in a terrific exhibition of power tennis.

Van de Zandschulp, 26, will face Adrian Mannarino in the semi-final as the 34-year-old seeks his second career ATP Tour title, beating Maxime Cressy 6-4 7-6 (7-3).

Fourth seed Cressy was Mannarino's third consecutive seeded scalp, having also defeated ninth seed Emil Ruusuvuori and eighth seed Albert Ramos-Vinolas to make it this far.

Cressy's 10 double faults and 26 unforced errors shot himself in the foot, as the veteran Mannarino played a clean match, posting two double faults and eight unforced errors.

Serbia's Laslo Djere has taken the scenic route to the semi-final, winning his fourth three-set match of the week as he edged past Richard Gasquet 6-4 3-6 7-6 (8-6) in two hours and 43 minutes.

It comes after a three-hour-11-minute marathon against Jason Kubler in the previous round, and a two-hour-50-minute war of attrition against Joao Sousa prior to that.

Djere will hope to have some more gas in the tank when he meets Switzerland's Marc-Andrea Huesler in the semi-final after he upset 13th seed Jack Draper 6-4 6-4.

World number 10 Daria Kasatkina showed why she is the highest ranked player at the Granby Championships, defeating fifth seed Nuria Parrizas-Diaz 6-3 6-2 in convincing fashion.

Kasatkina, who is enjoying a career-high ranking, got the job done in straight sets despite struggling with her serve, committing all nine of the match's double faults.

While she was only able to win a below-par 58 per cent of her service points, she also won 58 per cent of her return points, and it was that ability to deal with the Spaniard's serve that proved to be the difference.

Kasatkina will play France's Diane Parry in the semi-final after she got the better of Germany's Tatjana Maria 6-4 6-7 (6-8) 7-6 (7-4) in a near three-hour tussle.

Parry only had one ace compared to Maria's 10, but she excelled in the longer rallies, with her return success rate jumping up from 16 per cent to 47 per cent when she was able to see a second serve.

Australia's Daria Saville will contest the other semi-final after her 6-3 6-0 domination of China's Xiyu Wang, and she will play Ukraine's Marta Kostyuk after she defeated Canada's Rebecca Marino 6-2 4-6 6-2.

Meanwhile, Liudmila Samsonova continued her terrific run at Tennis in the Land as she beat Magda Linette 6-4 6-3.

Samsonova is yet to lose a set at the tournament, but will face her toughest test next when she meets Bernarda Pera in the semi-final.

Pera, who previously eliminated top seed Barbora Krejcikova in straight sets, came out on top against American compatriot Sofia Kenin 6-2 5-7 6-3, despite creating one fewer break point opportunity.

Alize Cornet is also yet to lose a set on her run to the semi-final, proving too strong for Shuai Zhang 6-4 6-2.

Cornet will play Aliaksandra Sasnovich for a place in the final after the Belarusian pulled away in the second set of her 6-4 6-1 win against American Madison Brengle.

Emma Raducanu is playing better tennis now than when she won the US Open last year, according to six-time major champion Kim Clijsters.

British number one Raducanu enjoyed a meteoric rise at Flushing Meadows last year, becoming the first qualifier to win a grand slam as she claimed an unexpected victory in New York.

She reeled off 10 straight matches without dropping a single set, overcoming the likes of Olympic gold medalist Belinda Bencic and Maria Sakkari before seeing off Leylah Fernandez in the final.

Difficult form and injuries have prevented the 19-year-old from truly building on the momentum of that triumph, though, with the world number 11 boasting a modest 13-15 record in her first full year on the tour.

Nevertheless, she claimed notable victories over Serena Williams and Victoria Azarenka in Cincinnati last week ahead of her US Open title defence, which begins against Alize Cornet in the opening round.

And former world number one Clijsters empathises with Raducanu, who she feels needs time to adjust to life in the higher echelons of the sport.

"She's already done a lot more in the lead-up to the US Open than she did last year, she has beaten a lot of good players," Clijsters told Reuters.

"She is maturing as a tennis player. I think her tennis is better now than it was when she won the US Open.

"When you have such a life-changing experience – and I'm not talking about what happens on the court, but everything else that gets added to that, even if she doesn't change, people around you change.

"People look at you differently. People on the tour look at you differently, whether she goes to a tournament in Luxembourg, or in Australia. Everybody knows her.

"Those big changes in life take time to get used to. It's so unrealistic the expectations that are on her because when you play a sport, you go out there and you have an opponent who's trying to win just as hard as you."

While Clijsters believes the teenager would do well to successfully defend her title, the three-time US Open winner is confident she will embrace the challenge.

"Is she going to win the US Open? It would be incredible if she did, but there's a lot of other players out there who have just as much chance as her," said Clijsters, whose last US Open success came in 2010.

"So, it will just be a matter of seeing whether she deals with that emotion of being at the slam and the expectations of it? She might be super excited to be there, and then play really free and without any pressure."

Serena Williams will face Danka Kovinic in the first round as the American great begins her final US Open campaign.

It will be a final grand slam for 40-year-old Williams, who has won six singles titles in New York and been a runner-up on four occasions.

Her first singles crown in a major came as a 17-year-old at Flushing Meadows, when she beat Martina Hingis in the 1999 final.

Now the end of a glorious career is beckoning for the 23-time singles major winner, who has also landed 16 doubles grand slam titles.

Kovinic is the world number 80 from Montenegro, with the 27-year-old having only won two matches at the US Open in four previous main-draw appearances.

The winner of that match will likely face Estonian second seed Anett Kontaveit in round two. Kontaveit's first-round opponent will be Romanian Jaqueline Adina Cristian.

Defending champion Emma Raducanu, who was a shock winner last year, faces a tricky first-round assignment against France's Alize Cornet.

Cornet is the tour veteran who beat Iga Swiatek at Wimbledon, ending the Pole's 37-match winning streak, and this will be her 64th consecutive grand slam appearance, a record for WTA Tour players.

World number one Swiatek starts against Italian Jasmine Paolini and could face 2017 US Open champion Sloane Stephens in round two.

Former champion Naomi Osaka, unseeded this year, was paired with Danielle Collins, the 19th seed who was an Australian Open runner-up at the start of the year.

The tournament gets under way on Monday.

Men's defending champion Daniil Medvedev faces American Stefan Kozlov in his opener, while Rafael Nadal, who has not lost a grand slam match all year, faces Australian wild card Rinky Hijikata.

Nadal won the Australian Open and French Open titles before pulling out of Wimbledon ahead of his semi-final against Australian Nick Kyrgios due to an abdominal tear.

That handed Kyrgios a bye through to face Novak Djokovic, who got the better of the Australian, but the Serbian must miss the US Open because his refusal to be vaccinated against the COVID-19 virus meant he would not be allowed to enter the United States.

Djokovic's absence was confirmed shortly before the draw was revealed.

Fast-rising Spanish teenager Carlos Alcaraz begins against Argentina's Sebastian Baez, while fourth seed Stefanos Tsitsipas will face a yet-to-be-determined qualifier.

US Open boss Stacey Allaster said it was "very unfortunate" that Novak Djokovic would have to miss the upcoming grand slam.

Shortly before the draw announcement, it was confirmed that three-time Flushing Meadows champion Djokovic would be absent.

His stance on refusing a COVID-19 vaccination meant he would be prevented from entering the United States, denying the 35-year-old another shot at glory in New York.

Tournament director Allaster said: "Novak is a great champion and it is very unfortunate that he will be unable to compete at the 2022 US Open, as he is unable to enter the country due to the federal government's vaccination policy for non-US citizens.

"We look forward to welcoming Novak back at the 2023 US Open."

The tournament begins on Monday, with Russian Daniil Medvedev defending the title he secured by beating Djokovic in last year's final, when entry requirements to the US were not so restrictive.

Serbian Djokovic has won 21 grand slam titles, one fewer than Rafael Nadal who has already arrived in the Big Apple ahead of the final major of the year.

Nadal moved ahead of Djokovic and clear at the top of the men's all-time list by winning the Australian Open and French Open titles this year, before having to withdraw from a Wimbledon semi-final against Nick Kyrgios because of an abdominal tear.

Djokovic was not allowed to play at the Australian Open at the start of the year, when issues surrounding his visa ended with him being deported from Melbourne on public health grounds due to not taking the vaccine.

Novak Djokovic will play no part in the US Open, the second grand slam he will have missed this year because of his stance on refusing a COVID-19 vaccination.

The Wimbledon champion announced on Thursday, shortly before the draw in New York, that he would not be making the trip to Flushing Meadows.

He posted on social media: "Sadly, I will not be able to travel to NY this time for US Open."

The 35-year-old Serbian, who has won 21 grand slam titles, added: "Good luck to my fellow players! I’ll keep in good shape and positive spirit and wait for an opportunity to compete again. See you soon tennis world!"

Djokovic, who lost to Daniil Medvedev in last year's final in New York, had his route to the United States blocked by red tape this time around.

US authorities are refusing to allow unvaccinated foreign visitors to enter the country. Djokovic, a three-time US Open winner, has been steadfast on his position regarding the vaccine.

The United States Tennis Association (USTA) pledged to adhere to government rulings surrounding coronavirus protocols, despite including Djokovic on the US Open entry list last month.

However, he had first to be allowed to enter the country before he could consider competing, and that was out of the USTA's hands.

In late July, Djokovic said he was "preparing as if I will be allowed to compete"; however, he was unable to travel for the build-up tournaments, and now he will miss the major too.

"Thank you #NoleFam for your messages of love and support," he told his fans on Thursday.

Djokovic was not allowed to play at the Australian Open at the start of the year, when issues surrounding his visa ended with him being deported from Melbourne on public health grounds due to not taking the vaccine.

American great John McEnroe said it was "a joke" that Djokovic should have to miss the US Open too, and called for a solution to be found, but that has not come about.

The current entry rules for international travellers to the United States were not in place when Djokovic was toppled by Medvedev in last year's men's singles final, the result that ended his hopes of a calendar Grand Slam.

Iga Swiatek is still a standout candidate to win the US Open, even if the WTA field has plenty of strength in depth, so says Laura Robson.

The latest iteration of the season's final grand slam gets under way on August 29, with Emma Raducanu looking to mount a successful defence at Flushing Meadows.

But with six different winners in the last eight WTA majors, the race is wide open to take glory in New York, particularly after three-time major winner Ash Barty called time on her career following this year's Australian Open.

That leaves former British number one Robson feeling any title fight is too tough to call, though she believes the strength of the field makes it all the more thrilling and unpredictable.

"I think it just shows that there's a lot of depth on the WTA side," she told Stats Perform. "You've got 15 players in any given slam [who could win], which for me makes it more exciting.

"I'm pumped when I see the draw come out, because things can open up so quickly. Had Ash Barty not retired earlier this year, then she probably would have been the front runner going into the rest of the season.

"It really could be anyone. Ons Jabeur is playing great tennis, [Elena] Rybakina and then [Paula] Badosa, on hardcourts is playing great as well."

Robson acknowledged it is tough to look past world number one Swiatek, though. The Pole claimed her second French Open crown earlier this year and has won 50 matches in 2022.

"She just looked like she was on fire," Robson added, before suggesting Swiatek's defeat at Wimbledon to Alize Cornet came merely because "she just ran out of gas".

"I think she's going to transition a little slower on to the hard courts then at the US Open. They're not quite the same surface that works best for her game.

"But at the same time, you know, she's got so much confidence at the moment that you can't really bet against her."

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Dominic Thiem's run at the Winston-Salem Open came to a halt as Jack Draper claimed a comfortable straight sets victory on Wednesday.

In the first meeting between Draper and Thiem, it was the 20-year-old Brit who sealed his place in the last eight with a routine 6-1 6-4 victory.

Draper charged ahead in the first set, creating five chances to break and taking two of them, while his sole successfully converted break point in the second set paved the way for the Winston-Salem debutant to serve out the match.

World number 55 Draper has now reached three Tour-level quarter-finals this season, while 2020 US Open champion Thiem had been on a run of making it to the last eight in his last three tournaments, in Bastad, Gstaad (where he made the semis) and Kitzbuhel.

Draper did not offer up a single break opportunity, and said: "I was really good behind serve, really solid. In the second set it was tough because he was coming up with some amazing shots. It was a real honour to be on court with Dominic. He's an amazing player.

"I started confidently, I started well. I was hitting through the ball, felt good in the conditions. It was a difficult start because I felt like everyone was supporting Dominic and I knew that I needed to come out confidently and sharp, and that's what I did."

Draper will meet Marc-Andrea Huesler in the quarter-finals, after the world number 102 overcame Ilya Ivashka.

Botic van de Zandschulp is the favourite after Grigor Dimitrov's retirement due to illness with the Dutchman progressing to the last eight by defeating Spain's Jaume Munar in straight sets. He will face Benjamin Bonzi after the Frenchman's 7-5 6-2 defeat of Thiago Monteiro.

Maxime Cressy will face Adrian Mannarino after coming from a set down to beat Lorenzo Sonego 6-7 (4-7) 6-2 7-6 (7-3), while Richard Gasquet and Laslo Djere make up the other quarter-final tie after respective victories over Steve Johnson and Jason Kubler.

Bernarda Pera stunned former French Open champion Barbora Krejcikova at Tennis in the Land as the top three seeds tumbled out in Cleveland.

Pera has enjoyed an excellent 2022, winning her first career WTA title in Budapest and then following that up with her second at the Hamburg European Open.

And the Croatian-born American is two wins away from a third final after thrashing top seed Krejcikova 6-4 6-1.

It sets up an enticing last-eight clash with another former grand slam champion in compatriot Sofia Kenin.

Second seed Martina Trevisan from her clash with Zhang Shuai, while third seed Ekaterina Alexandrova lost 3-6 7-5 7-5 to Maidson Brengle.

Some high seeds also tumbled out at the Granby Championships.

Third seed Jasmine Paolini surrendered a lead in a three-set loss to Rebecca Marino and there were also defeats for fourth seed Anna Bondar and eighth seed Tereza Martincova to Tatjana Maria and Diane Parry respectively.

Marta Kostyuk, the 10th seed, had to come from a set down to beat Marina Stakusic but ninth seed Daria Saville lost just one game in her demolition of Katherine Sebov, winning 6-1 6-0.

Victoria Azarenka will not play in the Tennis Plays for Peace Exhibition at Flushing Meadows on Wednesday, the United States Tennis Association (USTA) has announced.

The former world number one was due to participate in the charity event set up in support of Ukraine ahead of next week's US Open.

The Belarusian's involvement in the exhibition came under scrutiny from Ukrainian player Marta Kostyuk, who subsequently declined the opportunity to compete alongside the likes of Rafael Nadal, Iga Swiatek and John McEnroe.

Azarenka had called for player unity following Russia's Belarus-assisted invasion of Ukraine earlier this year, with the two-time Australian Open winner saying Wimbledon's ban on Russian and Belarusian players made no sense.

Following the recent criticism led by Kostyuk, who was bemused by the presence of Azarenka, the USTA decided it would be in the best interest of the event if she was not involved.

In a statement, the governing body said: "In the last 24 hours, after careful consideration and dialogue with all parties involved, Victoria Azarenka will not be participating in our 'Tennis Plays for Peace Exhibition' this evening [Wednesday].

"Vika is a strong player leader and we appreciate her willingness to participate. Given the sensitivities to Ukrainian players, and the ongoing conflict, we believe this is the right course of action for us."

Emma Raducanu is making a "natural transition" to the WTA Tour, says former British number one Laura Robson.

Raducanu became a grand slam winner in just her second major appearance when she defeated fellow teenager Leylah Fernandez in last year's US Open final, and the first qualifier to win the women's singles at Flushing Meadows.

Since then, the 19-year-old has cracked the top 10 of the WTA Rankings, but has otherwise endured a mixed run of form, with a last-16 exit in the Western and Southern Open her latest result ahead of a return to New York, while she has also changed coaches in a season that has so far failed to produce a trophy.

But Robson thinks they are mere teething troubles for Raducanu, arguing that her difficulties have been blown out of proportion.

"I wouldn't say she struggled," Robson told Stats Perform. "I think she's making it a natural transition to the main tour.

"Emma came through so quickly, then struggling to catch up to the day-to-day life of being a professional tennis player, which is a lot of time away from home, a lot of training weeks, a lot of travel.

"She hasn't been able to put that time in. I thought she played great last week in Washington, and unfortunately, had a very tough draw against Camila Georgi in the first round last night.

"But I think she's playing some great tennis. So, I feel when she's back on the courts at US Open, they really suit her and hopefully some positive vibes will help as well."

Robson, a former Junior Wimbledon champion in 2008, won the WTA Newcomer of the Year prize in 2012 after claiming a silver medal alongside Andy Murray in the mixed doubles at London 2012, but ultimately struggled with a succession of injuries before her retirement this year.

She is loathe to draw parallels between her own experiences and those of Raducanu but hopes time can be afforded to the youngster.

"I mean, I wouldn't even compare my situation to hers, because Emma came through so quickly that it feels like she's only just catching her breath," she added.

"She just needs time to manage her own expectations. I hope she's not even thinking about anyone else's expectations because they really don't matter in the grand scheme of things.

"I think she just needs a good amount of training work, which I know she has been doing anyway. And the results will come because they think she's an incredible ball striker and a great athlete as well."

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Three-time grand slam champion Angelique Kerber has announced she is pregnant and will miss the US Open as "two against one just isn't a fair competition."

The former world number one on Wednesday revealed she will not be around on the WTA Tour "for a while", as she is expecting her first child.

Kerber, 34, says she is "nervous and excited" by the "new path" she is heading in.

The German posted on Instagram: "I really wanted to play the @usopen but eventually I decided that two against one just isn't a fair competition.

"For the next months, I will take a break from traveling the globe as a tennis player but then again, I believe it’s for the best possible reason! I will miss all of you.

"New York has often been a turning point in my career and it feels like this year will be no different in some way! From restarting my career in 2011 to winning the title in 2016 and becoming #1 in the world… the @usopen have a special place in my heart and I wish I could have said goodbye to all of you on court before not being around on tour for a while.

"Being a professional athlete means everything to me but I'm grateful for the new path I'm heading to. To be honest, I'm nervous and excited at the same time. Thanks for your continued support - it means everything to me "

Kerber's announcement came just five days before the US Open gets under way at Flushing Meadows.

The left-hander was crowned champion in New York six years ago after also winning the Australian Open in 2016 and she went on to take the Wimbledon title in 2018.

Top overall seed at the Winston Salem Open, Grigor Dimitrov, won the first set of his opening match against Dominic Thiem 6-0 before being forced to retire due to illness symptoms while trailing 4-2 in the second.

The first set was total domination from the Bulgarian, winning 80 per cent (12-of-15) of the points against Thiem's serve as he breezed through the opening frame in 25 minutes, but after experiencing dizziness and shortness of breath in the second set, he decided to pull the plug on his match after a visit from the doctor.

Thiem will play England's Jack Draper in the next round after he was too strong down the stretch for Italy's Fabio Fognini, winning 6-2 4-6 6-1.

Meanwhile, it was relatively smoother sailing for second second Botic van de Zandschulp in his all-Dutch matchup against Tallon Griekspoor, converting both of his two break point opportunities to win 7-6 (7-5) 6-3.

Earlier in the day, in-form Belarusian and 11th seed Ilya Ivashka used his powerful serve to overwhelm Germany's Peter Gojowczyk 6-4 6-2. 

Ivashka will meet Switzerland's Marc-Andrea Huesler next after the world number 102 passed a stiff test against Sweden's Mikael Ymer, with his 6-4 6-4 win likely elevating him into the top-100 when the next rankings are released.

Richard Gasquet at 36 years young upset 20-year-old Italian Lorenzo Musetti 7-6 (7-5) 4-6 6-1, and he will play Steve Johnson next after the big American defeated Spain's Pedro Martinez 7-6 (7-2) 6-2.

Serbia's Laslo Djere needed almost three hours to get the better of Portugal's Joao Sousa 4-6 6-3 7-6 (7-5), and Djere will play Australia's Jason Kubler after he handled South Korea's Kwon Soon-woo 7-5 6-2.

The other two Aussies in action were less successful, as John Millman fell 6-4 6-4 to Spain's Albert Ramos-Vinolas, and James Duckworth went down 6-3 6-3 against Maxime Cressy.

Finland's rising star Emil Ruusuvuori was disappointing in his 6-4 6-1 loss to France's Adrian Mannarino, and fellow Frenchman Benjamin Bonzi also got the job done against England's Kyle Edmund 6-4 7-6 (7-5).

In the late session, 15th seed Jaume Munar defeated Tseng Chun-hsin 6-3 6-4, and in the last match of the night, Lorenzo Sonego beat Alejandro Tabilo 7-5 6-1.

Aliaksandra Sasnovich was the top seed to advance in Tuesday's action at Tennis in the Land, treating the Cleveland crowd to a two-and-half-hour battle before prevailing 4-6 6-3 6-3 against Sara Sorribes Tormo.

In a close contest, Belarus' Sasnovich took advantage in the big moments, winning five of her 10 break point opportunities, while Sorribes Tormo could only convert two-of-nine.

While seventh seed Sasnovich was the highest-seeded winner on the day, fifth seed Irina-Camelia Begu fell victim to a shock 6-3 6-2 upset from world number 415 Sofia Kenin.

Kenin, a wildcard, now advances to the quarter-finals after winning two matches in a row for the first time since January, and prior to this week she had lost her previous nine matches.

Alize Cornet will likely meet second seed Martina Trevisan in the quarter-final after a strong 6-3 7-6 (7-1) triumph against Denmark's rising 19-year-old talent Clara Tauson.

Liudmila Samsonova needed only 59 minutes to breeze past Iryna Shymanovich 6-1 6-0, and it was similarly smooth sailing for Magda Linette as she defeated Sorana Cirstea 6-4 6-2.

Meanwhile, at the Granby Championships in Canada, only one match was able to finish before the rain halted the rest of the day's play.

Spain's Nuria Parrizas-Diaz was too much for England's Harriet Dart, winning 6-2 6-4, while top seed Daria Kasatkina will just need to add the finishing touches when she resumes her match against Magdalena Frech, leading 6-3 5-0.