Ollie Robinson has been ruled out of England's series decider against West Indies after failing to recover from a back injury.
The Sussex seamer missed out on the drawn matches in Antigua and Barbados and will play no part in Grenada as England chase a first Test win in nine attempts.
England confirmed their squad on Wednesday, a day before the third Test begins, with Craig Overton recovering from illness to replace Matthew Fisher in the only change.
Robinson was unable to prove his fitness in a net session and skipper Joe Root is hopeful his team-mate can soon put his fitness issues behind him.
"Ollie wasn't as good as we would have liked or he was expecting himself," Root said prior to the squad announcement.
"It's just frustrating for him, as it is for me. He's working very hard but there's something that's nagging away at him.
"I'm not sure exactly of the medical prognosis. He's just got to keep on doing what he's doing and trust in time that he's going to get himself back.
"We all know how effective he has been and how good he's been in his short career up to now so the sooner we can get him back the better."
Root is 116 runs short of reaching 10,000 in Test cricket, a tally only Alastair Cook has previously reached among England players.
The 31-year-old hit centuries in the opening two Tests against West Indies but could not help his side to victory, something he is looking to put right in this winner-takes-all clash.
"I really hope we can take another step forward as a team and get across the line because there's been a lot of good stuff," he told reporters.
"We've played the majority of the cricket up to now and it would be a great way to end the tour. The most pleasing thing is we've not had a nightmare session that's cost us a Test.
"We've looked at each individual session and each hour and looked to win each and every one of them."
England are unbeaten in their last three away Test matches against West Indies, having lost each of the three games prior to that run.
Their most recent meeting at St George's was in April 2015, with England claiming a nine-wicket victory.
Dr. Donovan Bennett defeats Billy Heaven in JCA Presidential election
Dr. Donovan Bennett is the new president of the Jamaica Cricket Association after defeating Wilford ‘Billy’ Heaven at Thursday’s elections at the 20th JCA Annual General Meeting held at the Jamaica Conference Centre in Kingston.
Bennett, who served as JCA vice-president for 11 years, is set for his first term at the helm after a 67-30 victory.
Heaven served as JCA president for the last 10 years and was seeking a fifth term.
Foden: De Bruyne the best in the Premier League
Phil Foden hailed Manchester City team-mate Kevin De Bruyne as the Premier League's best player after the pair both netted in the 4-0 win over Brighton and Hove Albion.
De Bruyne opened the scoring in Thursday's contest at Amex Stadium before Foden took over with a couple of goals of his own before half-time.
Julian Alvarez rounded off the scoring just after the hour in a one-sided contest as an Erling Haaland-less City moved to within a point of leaders Arsenal with a game in hand.
Belgium international De Bruyne now has four goals and six assists in just 13 league appearances for City this season.
Speaking to Sky Sports News after the win over Brighton, Foden said: "I think when he is at it, he is the best player in the Premier League."
Foden's first goal came via a deflected free-kick that he himself won, although replays showed he slipped rather than being fouled.
The England international doubled his personal tally with a composed finish after Brighton were caught in possession at the back.
Asked about playing more centrally, Foden said: "I have always said that I see myself there. This year I have moved inside and it has helped me massively.
"I enjoy it in the middle. It's where I want to be. At the moment, I am just enjoying my football and playing with freedom."
De Bruyne had earlier opened the scoring with a brilliant opener - his first headed goal for City in the Premier League - as City made it 30 games unbeaten in normal time across all competitions.
Alvarez then went on to round off the scoring in a game that not only saw the reigning champions close the gap on Arsenal, but also narrow the goal difference margin to eight.
"It was a good game," De Bruyne said. "I think we played really good in the first half and every game is a lot of pressure. All we can do is prepare as we did today and win the game that is in front of us.
"We just want to win game-by-game and push for the title. We don't get ahead of ourselves. Now the next game is coming quickly. Try to recover and we go again."
Kyle Walker assisted the De Bruyne and Alvarez goals - the first time the defender has set up two goals in a single Premier League game in what was his 390th appearance in the competition.
Reflecting on his rare headed goal, De Bruyne said: "It doesn't happen too much. Kyle gave a good cross and I think the only way I could reach it is by jumping to it. I will take it but it's not something I am good at."
City have rather ominously won four Premier League games in a row and travel to strugglers Nottingham Forest next up at the weekend, knowing victory in their remaining five games will secure an unprecedented fourth straight title.
"I trust my team. All respect to Liverpool and Arsenal, they are amazing," De Bruyne added. "Arsenal are doing what they need to do and we are also needing to do it. Work hard and be humble enough to keep pushing."
New Zealand take unassailable series lead after hard-fought victory over Pakistan
Pakistan slumped to a four-run defeat at the hands of New Zealand despite the efforts of Abbas Afridi and Fakhar Zaman.
The Black Caps took an unassailable 2-1 lead in the five-match T20I series, thanks in the main to Tim Robinson (51) and bowling duo William O'Rourke (3-27) and Ben Sears (2-27) on Thursday.
Set a target of 179 to win, Pakistan looked on their way to victory when Fakhar Zaman got going, but he was eventually dismissed on 61 by Sears.
Abbas took three wickets in New Zealand's innings, yet he could only contribute a single run to Pakistan's cause as the hosts fell just short in Lahore.
Data Debrief
Shadab Khan did not bowl a single delivery for Pakistan, which is the first time that has happened in a completed T20I innings.
He did take an exceptional catch to dismiss Mark Chapman, but it was not enough to inspire Pakistan.
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