Ollie Robinson has been ruled out of England's series decider against West Indies after failing to recover from a back injury.
The Sussex seamer missed out on the drawn matches in Antigua and Barbados and will play no part in Grenada as England chase a first Test win in nine attempts.
England confirmed their squad on Wednesday, a day before the third Test begins, with Craig Overton recovering from illness to replace Matthew Fisher in the only change.
Robinson was unable to prove his fitness in a net session and skipper Joe Root is hopeful his team-mate can soon put his fitness issues behind him.
"Ollie wasn't as good as we would have liked or he was expecting himself," Root said prior to the squad announcement.
"It's just frustrating for him, as it is for me. He's working very hard but there's something that's nagging away at him.
"I'm not sure exactly of the medical prognosis. He's just got to keep on doing what he's doing and trust in time that he's going to get himself back.
"We all know how effective he has been and how good he's been in his short career up to now so the sooner we can get him back the better."
Root is 116 runs short of reaching 10,000 in Test cricket, a tally only Alastair Cook has previously reached among England players.
The 31-year-old hit centuries in the opening two Tests against West Indies but could not help his side to victory, something he is looking to put right in this winner-takes-all clash.
"I really hope we can take another step forward as a team and get across the line because there's been a lot of good stuff," he told reporters.
"We've played the majority of the cricket up to now and it would be a great way to end the tour. The most pleasing thing is we've not had a nightmare session that's cost us a Test.
"We've looked at each individual session and each hour and looked to win each and every one of them."
England are unbeaten in their last three away Test matches against West Indies, having lost each of the three games prior to that run.
Their most recent meeting at St George's was in April 2015, with England claiming a nine-wicket victory.
Matthews takes 2-21, hits 41 as Melbourne Renegades get first win of the season in WBBL
West Indies captain Hayley Matthews produced a strong all-round performance to help the Melbourne Renegades get their first win of the season on the Women’s Big Bash League in Australia, a six-wicket win over the Perth Scorchers at the Junction Oval in Melbourne on Saturday.
The Scorchers were bowled out for 140 in 19.4 overs after winning the toss and batting first.
Opener Beth Mooney led the way with 36 while Alana King (26) and captain Sophie Devine (22) also made valuable contributions.
Sophie Molineux was the outstanding bowler on the day for the Renegades with 4-17 from her four overs and was well supported by Alice Capsey (2-15 from three overs), Matthews (2-21 from 2.4 overs) and Georgia Wareham (2-35 from four overs).
The Renegades then needed just 17.4 overs to reach 145-4 and secure their first win in three tries this season.
A 102-run opening partnership between Matthews and Courtney Webb set up the chase beautifully.
Webb led the way with 61 off 40 balls including nine fours and a six while Matthews made 41 off 27 balls including seven fours and a six.
Deandra Dottin hit a six to seal the win off Alana King who took 2-35 from 3.4 overs.
Jadeja and Ashwin boost India hopes of avoiding series whitewash
India boosted their hopes of avoiding a series whitewash by taking control on day two of the third Test against New Zealand in Mumbai.
Ravindra Jadeja (4-52) and Ravichandran Ashwin (3-63) led the hosts' charge, as they reduced the tourists to 171-9 at the close.
Following their late 10-minute collapse on Friday, which left them at 84-4, Rishabh Pant (60 off 59 balls) and Shubnam Gill (90 from 146 deliveries) ensured India made a progressive start to the second day.
Washington Sundar also chipped in with 38 from 36 balls, but Jadeja and Sarfaraz Khan went in quick succession as New Zealand claimed three wickets in the space of 10 overs after lunch.
The Black Caps trailed by 28 after bowling their opponents out for 263, but lost Tom Latham in the opening over, with Devon Conway and Rachin Ravindra following soon after to leave them at 44-3.
Will Young (51 off 100) chalked up his second 50 of the Test, though it proved a false down for the tourists, as Jadeja and Ashwin took a combined seven wickets to keep their side's deficit down to just 143 with one wicket remaining.
Data Debrief:
India are desperately trying to prevent New Zealand from inflicting their first-ever home whitewash in a series of three or more Tests.
Pant certainly did his bit by taking just 36 balls to notch up India's fastest Test 50 against the Black Caps, for whom Patel (5-103) took his second five-wicket haul in the city of his birth, as well as his sixth overall in Test cricket.
Jadeja was also inspired in the field, though, as he took his wicket tally for the Test to nine.
Webster hits 95* as defending champions Red Force move to two wins from two with seven-wicket victory over Volcanoes at Brian Lara Cricket Academy
Hosts and defending champions Trinidad & Tobago Red Force comfortably defeated the Windward Islands Volcanoes by seven wickets at the Brian Lara Cricket Academy on Friday to move to two wins out of two this season.
The Red Force first restricted the Volcanoes to 182 all out off 45 overs after winning the toss and bowling first.
Joshua James, Yannic Cariah and Anderson Phillip all took two-wicket hauls for the Red Force while Jeremy Solozano and Sunil Ambris each made 47 for the Volcanoes.
The Red Force then needed only 38 overs to reach 186-3 and secure their second win in as many games this season.
Tion Webster led the way with the bat with 95* off 115 balls including 14 fours and one six while Amir Jangoo hit 31.
Captain Joshua Da Silva finished 21* alongside Webster.
Full Scores:
Windward Islands Volcanoes 182 off 45 overs (Sunil Ambris 47, Jeremy Solozano 47, Joshua James 2-15, Anderson Phillip 2-21, Yannic Cariah 2-35)
Trinidad & Tobago Red Force 186-3 off 38 overs (Tion Webster 95*, Amir Jangoo 31)
The Red Force will next play the Leeward Islands Hurricanes at the same venue on Sunday while the Volcanoes will next play the Jamaica Scorpions at the Queen’s Park Oval on Tuesday.
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