Super Bowl LVI: Tyler Higbee out for Rams after MCL sprain
Higbee will not face the Cincinnati Bengals after he and offensive tackle Joseph Noteboom were placed on injured reserve on Friday.
Running back Darrell Henderson Jr. and nose tackle Sebastian Joseph-Day were both activated ahead of Sunday's game, but Higbee's absence comes as a blow – albeit one that was expected.
The former fourth-round pick suffered an MCL strain in the NFC Championship Game win over the San Francisco 49ers.
Higbee had 61 catches for 560 yards and five touchdowns in the 2021 regular season, adding nine receptions for 115 yards in the playoffs.
He has been targeted 14 times in the postseason, third-most on the Rams behind superstar wide receivers Cooper Kupp (32) and Odell Beckham Jr. (23).