Fresh from his move to Camp Nou in the transfer window, Lewandowski will return to familiar surroundings with Barcelona and Bayern Munich – who boast 11 Champions League titles between them – drawn in a tough Group C along with Inter.
And another reunion will see Haaland come up against Borussia Dortmund, whom he left to join Pep Guardiola's Manchester City. They find themselves in Group G alongside Sevilla and Copenhagen.
Another heavyweight clash will take place in Group H, with Paris Saint-Germain and Juventus set to lock horns.
Lukaku and Immobile are two of the form front men in European football, and the duo have earned recognition following their latest goalscoring exploits.
Inter striker Lukaku grabbed both goals in a 2-0 away win at Udinese on Sunday.
And Immobile matched that haul as Lazio thrashed SPAL 5-1, the Italy international's brace taking his 2019-20 league tally to 25 already.
The duo are far from the only big names in this week's selection, however, with Roberto Firmino, Jadon Sancho and Hugo Lloris also among the new in-form cards.
Find the full squad below.
TEAM OF THE WEEK
GK: Hugo Lloris (Tottenham) - 89
CB:Matthijs de Ligt (Piemonte Calcio/Juventus) - 87
LB: Alex Telles (Porto) - 87
CB:Yerry Mina (Everton) - 84
CM: Daniel Parejo (Valencia) - 88
RM: Angel Di Maria (Paris Saint-Germain) - 88
CAM: Jadon Sancho (Borussia Dortmund) - 87
CM: Santi Cazorla (Villarreal) - 86
CF: Roberto Firmino (Liverpool) - 88
ST:Ciro Immobile (Lazio) - 90
ST: Romelu Lukaku (Inter) - 88
SUBSTITUTES
GK:Steve Mandanda (Marseille) - 83
CB:Kaan Ayhan (Fortuna Dusseldorf) - 81
RM:Robert Snodgrass (West Ham) - 81
ST:Francesco Caputo (Sassuolo) - 84
RW:Daniel Ginczek (Wolfsburg) - 82
ST:Kasper Dolberg (Nice) - 81
LW:Oussama Idrissi (AZ) - 81
RESERVES
CM:Alexandru Maxim (Gaziantep) - 79
CM: Alexandru Cicaldau (Universitatea Craiova) - 78
LM: Ahmet Engin (Duisburg) - 76
LM: Nathan Thomas (Carlisle United) - 74
LW: Said Benrahma (Brentford) - 80
Marcus Rashford and Rasmus Hojlund gave the Red Devils a quickfire lead in Portugal, before Pepe and a double from Samu Omorodion looked to have sealed a turnaround.
Bruno Fernandes was then sent off for the second game in a row, but Harry Maguire came off the bench to ensure United left with a point in the Europa League after a 3-3 draw.
It was their second consecutive draw in the competition, having given up a lead in both, leaving them 21st in the league table.
In fact, United are winless in their last five matches in European competitions (D3 L2) despite leading by 2+ goals in three of them.
Ten Hag continues to come under pressure, with his team now winless in four in all competitions, but he believes the squad have what it takes to turn things around.
"We will get there," he told TNT Sports. "Don't judge us in this moment, judge us at the end of the season.
"We are in the process, we will improve. We have had two seasons where we have reached finals, we will continue and fight.
"You see the spirit and the connection between the staff and the team. The players are together, they have a strong spirit, and they want to achieve. We have a good mentality but in some defending parts we have to step up."
Maguire came on as a 78th-minute substitute and scored his first goal of the season, nodding in from Christian Eriksen's corner in the 91st minute.
The former United captain backed the manager to cope with the added noise surrounding his job once again.
"I've played for this club for six years; I know how it works. When you go on a bad spell players come under pressure and also the manager does," Maguire said.
"He's experienced enough and been at this club long enough, so I'm sure he knows how to deal with it. It's part of the privilege you have playing for this club."
United are 12th in the Premier League, having collected just seven points; their joint-fewest after the first six games in a single season (matching their total from 2013-14 and 2020-21).
Sunday's 3-0 defeat by Tottenham at Old Trafford provided their latest setback, while increasing the pressure on Ten Hag, whose side face Porto in the Europa League on Thursday before returning to Premier League action against Aston Villa three days later.
Against Spurs, United conceded in the first three minutes of both halves in a single Premier League game for only the second time, while allowing their third-highest xG (4.59) by an opponent since records began in 2009.
Ange Postecoglou's side also created nine big chances, with a team only registering more in five previous games in Premier League history.
The Red Devils also have an xG against of 11.04, a tally only lower than Brentford and the three promoted sides, but Ten Hag is confident the tide will turn.
"We are going to make a success of the season," he told Sky Sports.
"Nothing is easy, but this is nothing for me to panic about. We can sort [the problems] out, this team can sort this out."
The Dutchman also insists he is concerned by the latest speculation surrounding his future at Old Trafford, where he has ended both his previous campaigns with silverware.
"I'm not thinking about it, I'm not anxious," he added. "We created a togetherness in the summer with the ownership and the leadership.
"We made this agreement, and we were all behind it. We know the strategy [is to bring in] young players in a transition period.
"They also know in May in all my last six seasons, there were always trophies, and that is what we are aiming for."
Casillas issued a statement on Tuesday to confirm he is calling time on a playing career that spanned more than 20 years.
The 39-year-old suffered a heart attack during Porto training in May last year and has not played since.
Casillas won five LaLiga titles and the Champions League on three occasions in a glittering Madrid career, while he was also a key part of Spain's greatest period in international football.
He earned 167 senior caps for his country and captained them to back-to-back European Championships in 2008 and 2012 and the World Cup triumph in South Africa in 2010.
Although on the other side of the Clasico rivalry, Messi has no doubt Casillas deserves the highest praise for his career.
"Iker is retiring, but his status as a legend of the game was secured long ago - not just because he was one of LaLiga's best players, but also because he won everything at international level," Messi told AS.
In a message to the former goalkeeper, he added: "You're a fantastic goalkeeper and were a really tough opponent, I have to say.
"Looking back, I think it was a really special rivalry that pushed us to reach new levels every time we came up against each other."
Former Inter boss Mourinho will return to Serie A in 2021-22 after being appointed by Roma following his Tottenham sacking in April.
Mourinho, who guided Inter to an unprecedented treble in 2009-10, replaces Paulo Fonseca in Rome, where the Giallorossi have not won a league title since 2001.
The Portuguese enjoyed stunning success at the start of his managerial career, winning seven league titles and two Champions Leagues in eight seasons across spells at Porto, Chelsea, Inter and Real Madrid.
Since the start of the 2012-13 campaign, however, he has won just one league title – the Premier League with Chelsea in 2014-15.
Indeed, Mourinho won only 51.2 per cent of his matches at Tottenham and left without lifting a single trophy.
In an extract from a new book called 'Stay Crazy and Hungry', reported in Marca, Mourinho thinks his early success contributed to a focus on winning which has not always served him well in recent years.
"I've been a victim of myself and, if I could, it would be one of the things I wouldn't repeat," Mourinho said.
"I won, won and won and I entered into a kind of dynamic where not winning seemed like the end of the world.
"I, myself, because of my personality, made out that the training, the games and the job were all to win, win, win, and then, when I came to situations where it was very difficult to win, which for other coaches is something acceptable, in my case it was never enough.
"Not winning was a failure, but that isn't true."
Mourinho has publicly clashed with many of his players over his illustrious career, notably with Luke Shaw at Manchester United.
Mourinho managed Shaw at United from 2016 until he was sacked in 2018 and he was often critical of the left-back.
Shaw recently launched a scathing criticism of Mourinho and his "strange" personal agenda, with the England full-back insisting "clearly, I'm in his head".
The 58-year-old, however, seemingly has no regrets over his treatment of certain players.
"I always tell the players that, with me, they'll find an honest guy," he added.
"They'll find a guy who will tell you the truth, the things you want to hear and also the things you don't.
"Some may say that I'm a bad coach, that I was a b*******, but no one can say that I wasn't serious or honest."
The 41-year-old played 878 times for club and country, winning 34 trophies along the way, with much of his success coming during his time with Real Madrid.
Having made his name with Porto, Pepe completed a move to the Bernabeu in 2007 and would go on to form one of the best defensive partnerships with Sergio Ramos.
He would win 12 honours during his decade at the Bernabeu, including three Champions League titles, before moving to Besiktas.
Pepe would spend a season in Turkey before returning to Porto, where he would make a further 132 appearances and add another nine honours to his trophy cabinet.
The defender would also enjoy success on the international stage, featuring in all but one of Portugal's seven games in their Euro 2016 triumph.
Pepe was capped 141 times for his country, third on the all-time list behind Joao Moutinho (146) and Cristiano Ronaldo (212).
He played his final ever game in Portugal's penalty shootout defeat to France at Euro 2024, having become the oldest player to ever appear in a European Championship.
In a video shared to Instagram, Pepe said: "I want to thank God for giving me the wisdom to be able to continue my journey.
"I can't help but thank all the presidents who bet on me and believed in me. All the employees of all the clubs I've been to, they are the soul and essence.
"And of the national team. All my teammates and coaches, who helped me grow and compete every day. All the fans, who are the soul of football.
"To Jorge Mendes, to GestiFute, to my mother, who was essential in my journey by letting me fly towards my dream, which was to be a professional footballer.
"To all my friends and family, especially my wife, who was my home in my absence.
"My children for believing in me, for being a fundamental support in my life, for supporting me when I left home to play. They were the support I needed to be able to go with a clear conscience.
"I would like to thank everyone, give them a big thank you and a big hug of gratitude. Thank you all very much."
Samu Omorodion's double looked like it had secured Porto the win, but Maguire came off the bench to score in the 91st minute.
Galeno tested Andre Onana with a powerful first-time shot two minutes in, but Marcus Rashford would open the scoring five minutes later at the other end, cutting inside from the left to drill his low shot under Diogo Costa's leg.
He then set up Rasmus Hojlund for their second in the 20th minute, and Costa again should have done better as the shot went through his hand.
Porto showed their fight soon after, though. Onana sprung brilliantly to keep out Noussair Mazraoui's inadvertent header, but Pepe was alert, stooping to nod home from close range.
Samu got his first in the 34th minute, taking advantage of some slack defending as he leapt high to thump his header over the goalkeeper, and got his second after the break, rifling a powerful shot into the top corner.
It looked like United's hopes of a result were over in the 81st minute as Fernandes received a red card for the second consecutive match. He got his first booking in the first half, receiving his marching orders in the 81st for a high boot in the box.
However, the Red Devils kept pushing for an equaliser, and it came from a corner, with Maguire guiding Christian Eriksen's cross into the top-left corner.
Data Debrief: Ten Hag gets lucky
It was a game that summed up United's season in some ways. They started the game on the front foot, getting two quickfire goals to put themselves in control only to drop their concentration.
Since Erik ten Hag joined the club in 2022, no Premier League club has conceded three or more goals in a match more times in all competitions than United (24).
In fact, they are winless in their last five matches in European competition (D3 L2) despite leading by 2+ goals in three of them.
Fernandes' red card against Tottenham may have been overturned, but this one will stand. Having not received a single red card in any of his first 241 appearances for United in all competitions, he has now received two in his last two.
The Portuguese giants confirmed Conceicao had agreed a deal that will run to 2024.
The 46-year-old had been out of contract after four years with Porto, where he bolstered his reputation as a coach with two Primeira Liga titles.
With runs to the Champions League quarter-finals in 2019 and 2021 – knocking out Juventus earlier this year – Conceicao also made Porto the first Portuguese team this century to reach the last eight of the competition in consecutive appearances.
Uncertainty regarding Conceicao had prompted links to Serie A, having played for Lazio in two spells either side of stints with Parma and Inter.
Lazio were one of the sides said to be interested in a busy offseason in Italy, while Inter were also forced to recruit a new coach following Antonio Conte's departure. Lazio are expected to bring in Maurizio Sarri after Simone Inzaghi left the Biancocelesti for Inter.
Conceicao is staying in Porto, having agreed terms following various reports that provided amusement to Pinto da Costa.
"Up until five minutes before it was announced, they were talking on television that it was very difficult for Sergio Conceicao to continue at FC Porto," the president said.
"It was good that we didn't sign immediately, so he got to know Europe... Naples, Rome, Seville or Madrid.
"On May 24, they said that Sergio Conceicao was going to announce to the president that he was not going to continue. They were right, they just didn't get the year right.
"It will be May 24 but many years from now. This is the moment of happiness for both of us."
While Porto lost their title to Sporting CP in 2020-21 and were pipped by Benfica two years earlier, they have collected 14 more points than any other side in the Primeira Liga during Conceicao's tenure.
Porto's tally of 105 wins in 136 games in this time is also clear of Benfica's second-best 100.
Conceicao's league win percentage of 77.2 and return of 2.5 points per game outperforms a host of previous Porto coaches – notably including Champions League winner Jose Mourinho (75.6 and 2.4) – but the terms of his contract have not improved, his president claims.
"I don't know how much [Benfica coach] Jorge Jesus earns and I don't care," Pinto da Costa said.
"But if there is a coach who hasn't renewed for money, that coach is Sergio Conceicao. He won't receive one more euro than he received in the previous contract.
"There was an intention to denigrate the image and to pass on the image that he was staying because we satisfied his [financial] wishes. It's a lie.
"He doesn't get paid because we didn't [offer more]; he doesn't get paid because that was never the subject."
United are still searching for their first Europa League win of the campaign, after Harry Maguire's late header salvaged a 3-3 draw in Porto on Thursday.
After the Red Devils went 2-0 up through early goals from Rashford and Rasmus Hojlund, a strike from Pepe and a brace from Samu Omorodion had put them on the brink of another humiliating defeat.
To cap United's frustrations, captain Bruno Fernandes was shown a red card for a second successive game after also being dismissed in Sunday's 3-0 loss to Tottenham, having never previously been sent off in any of his first 241 games for United.
It was the decision to substitute Rashford for Alejandro Garnacho, though, that dominated post-match talk, with no United player matching Rashford's eight touches in the Porto box or three successful dribbles all game, despite his early withdrawal.
Speaking to TNT Sports after the game, Ten Hag said: "We have to rotate. Garnacho, we didn't start him, but he had a great game not only Sunday but the whole season.
"We go quickly with a turnaround to Villa and they have had a day longer to recover and we have an away game."
Rashford now has 14 goals in the Europa League, moving him outright fourth in the all-time UEFA Cup/Europa League charts among English players, behind only Martin Chivers (22), Alan Shearer (21) and Jermain Defoe (19).
Asked about the substitution again in his post-match press conference, Ten Hag added: "Yeah, but Garnacho was my best player on Sunday by far and also in many other games.
"I think in the season, as I assess it so far, he is bringing us so far the offensive threat by creating chances, assists, also scoring.
"Garnacho we also have to play as well and we have two very good players over that side."
Pushed on whether the decision had anything to do with Rashford's role in Porto's first goal, which came down the England man's flank, Ten Hag said: "I have to watch it back and I think over the left side definitely we didn't defend well tonight.
"Marcus also played a part in this but, as I say, it had to do with Garnacho and nothing against Rashy."
United boss Erik ten Hag is weighing up his goalkeeping options, having stuck with long-term number one David de Gea since taking over.
Reports have emerged that United and De Gea are set for talks on his future, with the 31-year-old's deal to expire in 2023.
TOP STORY – MAN UTD EYE COSTA AS DE GEA REPLACEMENT
Manchester United's goalkeeper situation is in flux, with the club interested in Porto custodian Diogo Costa, according to Metro.
United have sent scouts to watch the 23-year-old goalkeeper, who has seven caps for Portugal.
The Red Devils are looking for De Gea's successor, with the Spaniard seemingly not suiting Ten Hag's possession-based style.
United also have 25-year-old England international Dean Henderson out on loan at Nottingham Forest.
ROUND-UP
– O Jogo claims former Olympiacos manager Pedro Martins could be the latest Portuguese coach to take over at Wolves, following Bruno Lage's dismissal on Sunday. The Telegraph reports that under-fire Sevilla boss Julen Lopetegui may be considered and Celtic manager Ange Postecoglou has also been discussed.
– Juventus and Real Madrid will rival Liverpool in the race to sign Belgian midfielder Youri Tielemans from Leicester City, claims Calciomercato.
– LaLiga pair Sevilla and Valencia are both interested in Manchester United forward Anthony Martial, reports Todofichajes.
– Tottenham and Juventus target Nicolo Zaniolo is set to pen a new deal with Roma, re-committing on a €4million per-year deal until 2027, according to Calciomercato.
– Everton's Venezuela international striker Salomon Rondon has interest from UAE club Sharjah FC but is likely to stay with the Toffees, reports Liverpool Echo.
The Portuguese only took over in June but his side are eighth in the Premier League with five losses already.
Spurs were humbled 3-0 at home by under-pressure Manchester United on Saturday.
Supporters made their feelings known at full-time as boos rung out around Tottenham Hotspur Stadium.
TOP STORY – SPURS READY TO REPLACE NUNO
Tuttomercato claims that Tottenham are working on a deal to have ex-Inter boss Antonio Conte replace Nuno Espirito Santo as manager.
Football Insider also reports that Spurs will sack Nuno this week, with Ryan Mason to be installed as their interim boss again.
The Standard claims that Porto head coach Sergio Conceicao is also under consideration for the job.
ROUND-UP
- Le Parisien reports that Paris Saint-Germain could sensationally walk away from their contract with off-season signing Sergio Ramos, who is yet to debut for the club due to ongoing injury issues from his time at Real Madrid. PSG are said to believe they were misled about his injury status.
- Barcelona are interested in a loan deal for Manchester United's wantaway Dutch midfielder Donny van de Beek, reports Sport.
- Real Madrid are considering moves for Manchester United's Paul Pogba and Chelsea's Antonio Rudiger, claims Marca.
- Theo Hernandez will ignore Manchester City 's advances and pen a new deal with Milan, reports Calciomercato.
- Tuttosport reports hot property Fiorentina forward Dusan Vlahovic wants to join Juventus amid interest from Tottenham, among others.
Real Madrid great Casillas confirmed his intention to stand for the position in February, but his withdrawal means Luis Rubiales is expected to be re-elected unopposed in August.
Casillas, who won Euro 2008 and 2012 alongside the 2010 World Cup with Spain, explained via a Twitter post his decision was in part due to "the exceptional social, economic and health situation that our country is suffering".
"This makes the elections take a back seat," he added. "I think it is time to add and not divide."
The former Madrid goalkeeper, who made 167 senior appearances for his country, insists the decision to pull out does not mean a "closed door for the future" and said he could opt to run for the position further down the line.
"I wanted a fair, transparent and truly participatory electoral process, looking for the best for Spanish football," he said.
"I hope that in the next elections it can happen with me or with other candidates."
Spain has been one of the worst-affected countries of the pandemic, with over 290,000 confirmed cases of COVID-19. Of those returning a positive test, 27,136 people have died.
Casillas won five LaLiga titles and three Champions Leagues with Madrid before departing his boyhood club for Porto in 2015.
The 39-year-old suffered a heart attack in May 2019 and was later added to the club's backroom team, with Porto president Jorge Nuno Pinto da Costa announcing Casillas had retired from playing in February.
