The hosts were restricted to 214 all out off 42.4 overs after winning the toss and batting first.
Scott Edwards (68), Max O’Dowd (51) and Vikramjit Singh (46) were the main run getters as Hosein ripped through the Dutch batting line-up with 4-39 off his 10 overs. Alzarri Joseph provided good support with 2-30 from eight overs.
In their chase, the West Indies found themselves in trouble at 99-5 after 23.2 overs before a match-winning and unbroken 118-run partnership between Brandon King and Keacy Carty steered the visitors to a comfortable victory.
The tourists ended up 217-5 with King getting a classy 90-ball 91 that included nine fours and three sixes. Carty was unbeaten on 43 not out off 66 balls. He hit two fours and a massive six that brought an end to the match.
Bas De Leede was the best Dutch bowler on the day with 2-46 from eight overs.
The third and final ODI will be played on Saturday.
The match was reduced to 45-overs per team after a rain delay during the Netherlands’ innings, an innings that saw them accumulate a competitive 240-7 off their 45 overs, leaving the tourists needing a Duckworth Lewis adjusted 247 for victory.
Debutant Teja Nidamanuru (58 not out), Vikramjit Singh (47) and Max O’Dowd (39) were the main contributors for the hosts against 2-29 off nine overs from Akeal Hosein and 2-50 from nine overs from Kyle Mayers.
West Indies openers Shai Hope and Shamarh Brooks then got the reply off to the perfect start, putting on 120 before Brooks was dismissed in the 24th over for a well-made 60 off 67 balls, including three fours and two sixes. That wicket brought Nkrumah Bonner to the crease who lasted for just one delivery, dismissed by Logan Van Beek for a duck.
Captain Nicholas Pooran then made his way to the crease and got to seven before falling to Aryan Dutt to leave the Windies 133-3 off 26.3 overs.
Brandon King then joined Hope at the crease and the pair combined to compile a match-winning 116-run partnership which saw Hope bring up his 11th ODI hundred and King bring up his maiden ODI half-century.
Hope ended up 119 not out off 130 balls, including 12 fours and two sixes, while King ended 58 not out off 51 balls, including five fours and two sixes.
Logan Van Beek took 2-49 from eight overs for the Dutch.
The second ODI will take place on Thursday.
