Greek world number three Tsitsipas revealed last month he would not get a jab due to concerns over side effects.
The ATP Tour has persisted in encouraging players to get vaccinated, with Novak Djokovic the most high profile to have stated he was opposed to it, and Tsitsipas has now backtracked on his original stance.
"I will get vaccinated this year," the 23-year-old told Greek outlet Antenna TV. "So I can go to restaurants and shops. I support all those who get vaccinated.
"I am not a doctor; I am a tennis player, so I may not have the most substantiated opinion when it comes to medical issues."
The French Open runner-up was subject to backlash in his homeland following his initial comments on the vaccine, with a series of top figures questioning his thought process.
"The COVID-19 vaccine has not been tested enough because it is new and has some side effects," said Tsitsipas.
"I know some people who've had them. I'm not against it, I just see no reason for someone in my age group to be vaccinated [yet].
"For us young people I think it's good to pass the virus because we'll build immunity.
"I don't see it as something bad. As I said, it isn't obligatory, everyone has freedom to decide for themselves what's right and what's not. At some point we should all do it, I'm not saying the opposite.
"The time will come when we will not be given many options, but until then I want to see a better version of the vaccine that gives us more pluses than minuses."
Tsitsipas is set to play for Team Europe at the Laver Cup this week after missing Greece's Davis Cup tie with Lithuania due to a foot injury.
Federer has not played competitively since losing to Hubert Hurkacz in the Wimbledon quarter-finals last year, and has since undergone his third knee surgery in two years.
But the 41-year-old is hopeful of returning to the court for this month's Laver Cup, where he is set to team up with Rafael Nadal, Andy Murray and Novak Djokovic for Team Europe.
Federer recently shared an encouraging video of a practice session on social media after stepping up his rehabilitation.
With tennis set to lose one legend after Williams' final US Open campaign was ended by Ajla Tomljanovic on Friday, the return of Federer would represent a major boost for the sport.
Speaking after beating Murray in the third round at Flushing Meadows, Berrettini said: "I think I said it so many times. Probably it's never going to be enough. One of the reasons why I'm here now is Roger.
"He was my idol when I was growing up. I was cheering for him, so I want him back really badly.
"He's just like Serena, I guess, one of a kind, you know?
"I wish him a really speedy recovery in whatever he's doing to come back. I wish I could play one more time against him."
Berrettini has lost each of his two tour-level matches against Federer, including a straight-sets defeat at Wimbledon in 2019.
Djokovic announced he would not be making the trip to New York on Thursday, due to visitors to the United States being required to display proof of vaccination against COVID-19.
The US Open will represent the second grand slam Djokovic has missed this year, after his unvaccinated status saw him deported from Melbourne ahead of the Australian Open in January.
Nadal is one of the most likely players to benefit from Djokovic's absence as he bids to win a 23rd grand slam title, but the Spaniard expressed sympathy for his rival as he prepared to begin his US Open campaign against Rinky Hijikata next week.
"From my personal perspective, it's very sad news," Nadal said. "It's always a shame when the best players in the world are not able to play a tournament because of injuries or because of different reasons.
"It's tough for the fans, tough for the tournament. In my opinion, tough for the players, too, because we want to have the best field possible."
Nadal's clash with Hijikata will represent his first outing at Flushing Meadows since he beat Daniil Medvedev to win the 2019 title, and injuries have caused him to miss four of the last 10 editions of the tournament.
Roger Federer, another of Nadal's great rivals, will also miss the competition after undergoing three knee operations in two years, but the Spaniard believes the major championships can cope with the absences of tennis' aging stars.
"The world of tennis [will] keep going, even if it is not good news for everyone," he added. "The world continues and the tennis will continue after me, after Novak, after Roger.
"Without a doubt, Novak is one of the most important players of the last 20 years, [in] the history of our sport. In a personal way, I feel sorry for him that he's not able to travel here."
Meanwhile, Federer is hoping to return to the court for September's Laver Cup, where he will join Nadal and Djokovic in a star-studded Team Europe line-up, and the Swiss maestro's old foe is desperate to see him make his long-awaited comeback.
"I'm super excited to see Roger again on court, of course," Nadal said. "I hope he's healthy enough to make that happen.
"It has been a long period of time without Roger on court so I really hope that he can manage to be back.
"The most important thing at this stage of his career is the health and the happiness, no? If he's healthy enough and happy enough to be back on the tennis tour, it will be amazing.
"If not, we can say thanks to him for everything that he achieved. I am confident that we will keep having Roger for a while."
The Swiss superstar contested his final match on Friday night in London, as he bowed out at the age of 41, accepting knee trouble in recent years would not allow him to carry on.
Zidane's last match as a player famously ended in a headbutt, a red card and crushing disappointment in the 2006 World Cup final, as France lost out to Italy on penalties in Berlin.
That was a far cry from the celebratory scenes at the O2 where 20-time grand slam winner Federer exited in a hail of adulation and high emotion, as the man from Basle broke down in a flood of tears on court.
The poignancy came after Federer lost alongside Rafael Nadal in a Laver Cup doubles clash with Jack Sock and Frances Tiafoe, a low-stakes occasion compared to Zidane's swan song.
Both Zidane and Federer played their sport with maverick and artistic tendencies that set them apart from many of their peers, while also winning a stack of trophies.
Zidane had two spells as Real Madrid boss after hanging up his boots following a playing spell at the Santiago Bernabeu, and he hopes there are great opportunities awaiting Federer too.
"Today you are stepping into another world. I wish you a second part of life as rich as the first," Zidane wrote on Instagram.
"Thank you Roger, you made the whole world dream! And you remained profoundly the same. Thank you Roger, the great class."
