Dobra, Will Grigg and Mike Jones all had chances for the Spireites before they took the lead.
Dobra broke the deadlock in the 82nd minute, chipping goalkeeper Mark Cousins from close range.
Michael Jacobs was sent off at the death after picking up a second yellow card as Chesterfield moved three points clear at the top.
The Scots face Croatia at Hampden Park on Friday before taking on Poland in Warsaw three days later in the hope of picking up points in their bid for League A survival.
This will be Armstrong's first appearance for his country since Euro 2024. He played for just 14 minutes in Scotland's loss to Hungary in their final group game of the tournament.
The 32-year-old's inclusion comes after the New York Red Bulls' Lewis Morgan and Torino's Che Adams pulled out, though Clarke confirmed he was happy with his forward options.
Morgan has impressed in the MLS this season, registering 20 goal involvements (13 goals, seven assists) in the regular season for Sandro Schwarz's side.
His 49 chances created is a total only bettered by John Tolkin (59) for the Red Bulls, while he also helped his side in their recent playoff series win over the Columbus Crew.
Adams missed Torino's 2-0 defeat to Juventus last Saturday with a thigh injury, but upon further assessment from the Serie A side, has been ruled out of international duty.
Scotland sit bottom of Group A1 after picking up one point from their first four games, which came in their last Nations League encounter with Portugal.
Clarke's side, however, are both on their longest ever winless run at home (six games – D3 L3) and longest run without a victory in competitive fixtures (10 games - D4 L6).
They could also level their longest overall streak without a win, set in 1998 (nine games – D3 L5 currently), if they fall to defeat on Friday.
Croatia, however, have never won away in Scotland (D2 L1), with this their first trip to Hampden Park since October 2013, losing 2-0 in a World Cup qualifier.
Member of Parliament and chairman of Arnett Gardens, Mark Golding, explained that the partnership is aimed at providing financial stability and a more sustainable future for the club. This as the Dream Team’s expertise is expected to boost the brand and image of the South St Andrew-based club.
“I was seeking a commercial partner to guide strategy and manage the club forward to new revenue and achieve financial sustainability. Arnett has been a leading brand in football, a much-loved and much-supported club not just in the community where it is based, but the wider Jamaica and indeed the diaspora and beyond,” Golding said during a press conference on Monday.
“We were very happy to have met some like-minded business people at Dream Entertainment who have established themselves in the field of entertainment as innovators,” he added.
Like Golding, Scott Dunn, group managing director of Dream Entertainment, pointed out that the partnership will be mutually beneficial, as it provides a greater platform for Arnett to reap success on and off the field of play, as well as an avenue for the Dream Team to expand their influence.
“Football is entertainment, and we believe we can improve upon that entertainment product. The entertainment value of coming to an Arnett Gardens football match is going to be bigger and better.
“Anything I do, I am all in, and my team is definitely the same way. This is not something that is periphery or a side thing for Dream Entertainment, this is now a primary part of our business,” Dunn shared.
He continued: “Arnett Gardens is an iconic community. From Junior Reid singing about Jungle to a million artists thereafter, it is a big community and the surrounding communities as well. Trench Town, in terms of tourism, is a bigger brand than Kingston.
“For the fans in the community, this is something that is going to build the community. For the fans internationally and those who are already with Arnett, this is going to rebuild that excitement and bring in a whole host of new fans.”
St Lucia came storming out of the ages, taking a 1-0 lead just one minute into the match when Shamalyn Albert made a dashing run down the left flank and crossed for Louis, who had an easy finish into net. It was the earliest goal scored by a player at this stage of the tournament.
Guadeloupe had a great chance at pulling level in the 20th on a well-struck left-footed free kick from Jalna Lepante, but Saint Lucia goalkeeper Kenna Lionel did enough to parry it off the post and out of play.
Lepante would get another chance though, this time in the 37th during the run of play and she finished with aplomb, stroking a shot past St Lucia back-up goalkeeper Renala Francis to even the score at 1-1.
Back came St Lucia and it was Louis again finishing an incredible 70-yard run in first half stoppage time for a 2-1 lead.
Arnicka Louis then picked up where she left off, completing her hat trick less than two minutes into the second half by tucking away a shot after a deflection in the area to make it 3-1.
Louis then capped off her memorable outing with an excellent finish in the 80th off a long ball from defender Eartha Pond for a 4-1 advantage.
The 5-1 scoreline was completed in the 87th with Eartha Pond again providing service with a long ball and Ellaisa Marquis polishing things off with a goal.
The Gunners bounced back from Cameron Archer's opener to earn their 400th Premier League home win on Saturday, with Kai Havertz, Gabriel Martinelli and Bukayo Saka on target.
Arsenal enter the international break in third, hot on the heels of leaders Liverpool and level on points with Manchester City.
They also continued their impressive record against Southampton, extending their unbeaten run against them in the top flight to 25 matches (W17 D8), but the hosts were made to work for the win.
Arteta's side registered 14 shots in the first half with an expected goals (xG) total of 1.15, though their only shot on target came in stoppage time courtesy of Thomas Partey.
The introduction of Martinelli, Leandro Trossard and Mikel Merino prompted an improvement in attack shortly after Havertz's leveller.
"The start was exceptional, the dominance, the chances. It was unbelievable not to go one, two, three goals up," Arteta said.
"We conceded the goal, and then it was game on.
"I thought the team reacted with a lot of authority, and I am happy the team can react like this - but not happy after the chances we had that we had to go through that.
"The substitutes changed the energy and also the feel in the crowd. We won in the end and I think we deserved it. This team always finds a way.
"The way we started was phenomenal, but we didn't get our reward. We had a difficult context at 1-0 but we did it."
Arteta also lauded Saka's performance after the England international took his goal involvement tally to nine for the season with his strike coming after two assists.
This campaign, only Erling Haaland and Cole Palmer (10 each) have been involved in more goals than Saka.
The 23-year-old has also taken on the role of captain in Martin Odegaard's absence, something Arteta believes Saka is embracing.
"For sure. That's the maturity and steps players have to do. He's been in the team long enough to earn the right to have that role. He believes in that," Arteta said.
"He has the capacity to change and decide games like many other players. If we want to be at the top, sometimes players have to create those moments, and he's certainly done that again today."
Southampton, meanwhile, are now without a win in their last 20 Premier League matches, equalling their longest top-flight winless run (a run of 20 between August and December in 1969).
But they had their moments to level the contest, with Tyler Dibling's deflected effort and Taylor Harwood-Bellis' header striking the woodwork prior to Saka's settler.
"I feel so much more positive and proud of my team than I did on Monday [after a 3-0 defeat at Bournemouth], and we played against one of the best teams in the country," Russell Martin told BBC Sport.
"If we play like that in the next block of games, I'd be very happy. I think we're learning and growing, and we're on a journey. But we're doing it under huge scrutiny and the intensity of the Premier League.
"I have to keep the guys on track and on path. There's a lot to be frustrated about, we don't have enough points on the board and a win yet, but I loved all of our resilience."
Chelsea have won five straight WSL crowns, edging out Manchester City on goal difference last season to give Emma Hayes a triumphant send-off before she joined the United States.
Now under the stewardship of former Lyon boss Sonia Bompastor, Chelsea are the only team in the WSL with a perfect record this term, winning their opening two matches before seeing last week's clash with Manchester United postponed.
Arsenal, on the other hand, have already played out home draws with Man City and Everton, ramping up the pressure ahead of Saturday's game at the Emirates Stadium.
Asked by reporters how it felt to see Arsenal's rivals dominate year after year, full-back McCabe said: "It always hurts.
"You want that to be you. You are in a team sport to be lifting trophies with your team-mates.
"Of course you are envious of them being successful. What we can do is focus on ourselves and put one foot in front of the other. Hopefully, by the end of the season, that will be us."
While Chelsea approach this weekend's headline fixture as favourites, they were trounced 4-1 in this exact game last December, with Alessio Russo scoring twice in one of just three league defeats the Blues suffered all campaign.
Looking back at that victory, McCabe said: "We take those moments as positives and bring it in and really instil that winning mentality into the team.
"We already did it last year, so it's not a new thing for us. It is about controlling ourselves, controlling our gameplan and what we want to do in the game and applying it."
The Dutchwoman has won five and drawn one of her six games since taking over after Jonas Eidevall's departure in October.
Arsenal sit second in their Champions League group and have won each of their last two games in the competition, scoring exactly four goals on both occasions – the Gunners are aiming to win three in a row in the group stage for just the second time after doing so in 2021-22 (W3).
They face Juventus on Thursday in their final game before the international break, and Fox is hopeful their growing confidence will show through in the result.
"I think right now we are all very confident in each other and ourselves. With the entire team, we feel together," said Fox.
"Each game has been very difficult, and we have been learning from each other. We're learning from the hiccups at the start of the season.
"Renee brings a lot of confidence, is very even-keeled and is just straightforward. I think with that, you have clarity and also freedom.
"As a team, we all want to do better. It’s never just one person or one reason why we're doing bad.
"It's a collective responsibility and accountability to come together and make things work to be better."
Arsenal have had off-the-field issues in the Champions League this season though, as a fixture clash with the men's team has forced the team to get "special dispensation" from UEFA to play their tie against Bayern Munich at Meadowpark instead of the Emirates Stadium.
Slegers admitted it was a "challenge", but believes Arsenal are still in a good position as a club to keep pushing women's football forward.
"I was playing for Arsenal's academy in 2006, so I know how big Arsenal have been over time in women's football. That's why I came to England," Slegers said.
"So historically, Arsenal has been leading in pushing the development of women's football and I think it will do that in the future as well. This was a bump in the road, which will always happen.
"It's like player development, you will not go up in a straight line, there will be challenges on the way. This is a challenge, but we're all very proud of what Arsenal tries to do to push women's football forward."
The loss meant Arsenal were eliminated at the third-round stage of the competition for only the second time in 26 seasons.
Arteta was back on the bench after a bout of coronavirus forced him to miss arguably their best performance of the season in the 2-1 defeat to Manchester City last weekend.
But he was not happy with what he saw at the City Ground, with substitute Lewis Grabban getting the winner for Forest, who were also the last team to beat Arsenal at this stage of the FA Cup.
Speaking after the game, Arteta told ITV Sport: "We are out of the competition and we have to apologise.
"When you have nine players out, that's a big explanation, but still I don't want to use excuses.
"The team we put out, I expected them to play better and to compete better than we did.
"When you don't do that in a cup against any opponent, you're out.
"What we've done today is nowhere near the standard required."
The 34th-minute withdrawal of left-back Nuno Tavares after a very sloppy start was the first indicator of potential frustration on Arteta's part.
Yet he opted against criticising the youngster, putting it down to a desire to simply change the level of the team.
Asked if it summed up his frustration, Arteta added: "No, it was a decision you have to make in certain moments to try improve the performance of the team, and that's what I did."
Arsenal will look to get this defeat out of their system as soon as possible, with an EFL Cup semi-final first leg against Liverpool and a north London derby trip to Tottenham on the horizon.
Jordan Pickford was in fine form between the sticks for the Toffees, who also defended excellently to frustrate their hosts on Saturday.
Martin Odegaard and Bukayo Saka came closest for the Gunners but were both brilliantly denied by England's goalkeeper.
Gabriel Martinelli also had two efforts blocked after Abdoulaye Doucoure had gone closest for Everton early on.
And other than a late penalty shout for a tackle by Vitalii Mykolenko on Thomas Partey, which was waved away by the referee and the decision upheld by VAR, Everton were able to keep any late drama to a minimum.
The draw leaves Arsenal in third position, behind Liverpool, who could only draw with Fulham, and Chelsea, while Everton are 15th.
Maanum netted the only goal of the game in the 19th minute after Caitlin Foord saw her cross spilled by Rugile Rulyte, with Maanum on hand to finish from close range.
The Gunners could have made the encounter more comfortable as Alessia Russo's header came back off the crossbar to conclude a dominant first half.
Arsenal struck the woodwork a further two times after the interval, through Russo and Kyra Cooney-Cross, with Leah Williamson also seeing her header cleared off the line.
But Jonas Eidevall's side were able to restrict their opponents to very little, with the hosts ending the contest with 30 shots, though only five of those were on target.
Arsenal go through to the next stage of the next stage of the competition, which is a knockout tie played across two legs.
In an end-to-end encounter that the Gunners dominated for the majority, goals from Mayra Ramirez and Sandy Baltimore sealed a sixth victory of the season for Chelsea.
The Blues opened the scoring in the fourth minute after Arsenal failed to clear Baltimore's corner, with Millie Bright flicking the ball on to Ramirez, who hooked it over her shoulder and in.
A dominant start was further rewarded 12 minutes later when Lauren James skipped to the byline before standing the ball up at the back post for Baltimore to nod beyond Daphne van Domselaar from close range.
But Arsenal grew into the contest after going two goals down, claiming their just rewards two minutes before the interval when Caitlin Foord broke into the Chelsea box before curling an effort in off the far post to hand the hosts a lifeline.
The Gunners felt they should have had a penalty early in the second half when James barged Lotte Wubben-Moy off the ball as they continued to mount pressure on the Blues' backline.
And they almost snatched a point late on when Katie McCabe picked out Stina Blackstenius, with the Swede sending a strike crashing off the crossbar as Chelsea held on in the closing stages to seal an already huge victory in the title race.
Data Debrief: Blues not brilliant, but win again
Chelsea continued their excellent start under Bompastor in the Women's Super League but struggled in the second half against Arsenal's endless wave of pressure.
The Blues ended the contest with an expected goals (xG) total of 0.98 from their 11 shots compared to Arsenal's 2.74 from their 20 attempts on Hannah Hampton's goal.
Arsenal's Alessia Russo was perhaps the most guilty of spurning her side's best opportunities, ending the encounter with more shots on target (four) and touches in the opposition box (12) than any other player on the pitch.
After being frustrated in the first half by United, the hosts found the breakthrough when Jurrien Timber glanced Declan Rice’s corner beyond Andre Onana in the 54th minute.
Arsenal doubled their lead in similar fashion, this time from the opposite side when Bukayo Saka’s back-post delivery was headed back across by Thomas Partey, with William Saliba providing the finishing touch.
Kai Havertz almost put the hosts further in front but was thwarted by Onana, with substitute Mikel Merino also nearly scoring from another corner moments later.
Despite victory, Arsenal drop to third after Chelsea’s 5-1 thrashing of Southampton, but they closed the gap to leaders Liverpool to seven points, while United are 11th.
Data Debrief: Corner Kings
Arsenal are known for the threat they possess from set-pieces, especially corners, and that weapon proved crucial in getting a much-needed win to keep their title hopes alive.
The Gunners have now scored more goals from corners (22) than any other team in the Premier League since the start of last season, with both of their goals on Wednesday coming this way. 10 of those have opened the scoring in a match, which is also a league-high figure in this period.
It was also a happy 50th Premier League appearance for Arsenal for Rice after he notched the assist for the opener. Since the start of last season, no player has recorded more assists from set plays than Rice (seven, level with Saka).
For Amorim, meanwhile, he suffered his first league defeat since December 2023 (Sporting CP 2-3 Vitoria Guimaraes), with the defeat at the Emirates ending a 34-game unbeaten run for the Portuguese coach in league competition (W31 D3).
The holders were poor for much of normal time, which looked to be coming to an end with Smith Rowe sent off for a foul on Sean Longstaff.
However, the VAR advised referee Chris Kavanagh to revisit that decision, which was overturned, allowing Smith Rowe to make the most of his reprieve by punishing a wasteful Newcastle side with a 109th-minute goal.
Pierre-Emerick Aubameyang's simple strike added a second and, while there is concern for Arsenal over Gabriel Martinelli, who suffered an ankle injury in the warm-up, Mikel Arteta's men will be thankful to have kept their defence alive following a below-par display.
The Gunners had struck first after nine minutes on home turf on Sunday when Bukayo Saka took down Ben White's excellent long ball in the area, turned Andrew Robertson, and rifled past Caoimhín Kelleher at his near post.
Saka consequently became the youngest Arsenal player to reach 50 Premier League goals but Liverpool restored parity when Trent Alexander-Arnold's corner was flicked on by Luis Diaz at the near post and nodded home by Virgil van Dijk.
Mikel Merino missed a great chance from one Declan Rice set-piece but restored Arsenal's lead from the England international's wicked free-kick shortly before half-time.
Arsenal lost Gabriel Magalhaes and Jurrien Timber to injury in the second half and the loss of the defensive duo saw them noticeably penned further in their own half.
The pressure eventually told when Alexander-Arnold played a superb long ball forward that Darwin Nunez controlled and he had the wherewithal to tee up Salah to coolly slot home the equaliser nine minutes from time.
Arne Slot's men are consequently second in the table, just a point behind leaders Manchester City, while Mikel Arteta's Gunners are five off top spot in third.
Data Debrief: New ground for Saka as Slot has no travel sickness
Saka was awarded the Man of the Match for an industrious display and his excellent opener saw him become the youngest Arsenal player to 50 Premier League goals, beating Thierry Henry and also seeing him become the seventh youngest player to a half century of goals in the Premier League.
Liverpool were rewarded for a much-improved second-half performance, though, and Arne Slot is now the first Liverpool manager to not lose any of this first seven away matches in charge since William Connell in February 1923.
Van Dijk grabbed the first equaliser and he now has 17 headed goals in the Premier League, a tally bettered only by John Terry among defenders (27). Indeed, 15 of his last 18 Premier League goals have come via his head.
Merino's first Gunners goal also came via his head and it marked Arsenal's 27th goal from set-pieces (excluding penalties) since the start of last season, the most in the competition.
The WSL's all-time top scorer Vivianne Miedema marked her City debut with a goal against her former club at the Emirates Stadium, where Beth Mead snatched a share of the spoils late on.
Miedema's deflected effort in the 42nd minute cancelled out Frida Maanum's early opener.
Maanum's close-range strike came just 45 seconds after Miedema had arrowed a shot wide after capitalising on slack play from her former team.
Caitlin Foord had a goal narrowly disallowed for offside early in the second half, and Arsenal's frustrations were compounded when Jessica Park put City ahead with a stunning effort from the edge of the box, with the ball clipping in off the underside of the crossbar.
Yet Arsenal fought back in the 81st minute as Mead nudged in on the rebound after Rosa Kafaji struck the woodwork.
Data Debrief: Sweet sixteen for Miedema
It just had to be her. Former Arsenal heroine Miedema has now scored against all 16 of the opponents she has faced in the WSL, with Bethany England (18/18) the only player to hold a better 100% such record in the competition.
But Mead had the final say. She is the leading goalscorer in the history of the WSL when it comes to the opening weekend, having now netted eight such goals.
Mikel Arteta's side began the fixture outside the top eight in the expanded league stage but jumped up to third with Saka again the catalyst.
He tucked in a Gabriel Jesus cross at the far post in the 34th minute. though Arsenal should have been out of sight before the interval.
The Brazilian missed two glorious opportunities while one-on-one with Radoslaw Majecki, with Martin Odegaard and Gabriel Martinelli also guilty of wasting chances.
Monaco threatened to make Arsenal pay for that profligacy after the interval, but the visitors gifted Saka his second goal in the 78th minute, as Majecki's rushed clearance fell straight to his feet.
Substitute Kai Havertz then rubber-stamped the victory with a close-range third 10 minutes later, though the final touch on Saka's low cross could have come off Thilo Kehrer, leaving Monaco in 16th.
Data Debrief: Leading from the front
As he has so many times before this season, Saka was once again at the heart of the action as he gave Arsenal's hopes of clinching automatic qualification a huge boost.
Only Mohamed Salah (28) has been involved in more goals in all competitions among Premier League players than Saka this season (nine goals, 12 assists).
Since the start of last season, only Harry Kane (18), Vinicius Junior (16) and Antoine Griezmann (13) have been involved in more Champions League goals than Saka (eight goals, six assists).
While Arsenal's attacking play has caught the eye often, their defensive work should also be credited. Since the start of last season, the Gunners have won seven of their eight Champions League home matches (D1), keeping a clean sheet in every single victory.
Saka scored one and set up another to cap a fine individual display in what was an excellent team performance from the Gunners.
Having danced into the box to drill home a crisp finish for the opener, Saka turned provider for Thomas Partey early in the second half, with the midfielder curling the ball into the left-hand corner.
Ethan Nwaneri combined with fellow substitute Raheem Sterling to slide home his first Premier League goal and add further gloss late on.
Arsenal’s victory saw them go level with Chelsea on 22 points, but they remain in fourth place, while Forest drop down to sixth after back-to-back league defeats.
Data Debrief: Gunners reach landmark triumph
Arsenal have often relied on Saka to produce moments of magic since his integration into the first-team, and it seemed fitting that his display would help the Gunners to their 2,000th victory in English top-flight history.
Only Liverpool's Mohamed Salah (14) has been involved in more Premier League goals this season than Saka (12 – four goals, eight assists), with his impressive performance backed up by the match statistics.
The England international registered more shots (six) and more touches in the opposition box (13) than any of his team-mates, while his four chances created was a total only bettered by Martin Odegaard (six).
But there was also a special moment for substitute Nwaneri. At 17 years and 247 days, he is now Arsenal's second-youngest Premier League goalscorer, behind only Cesc Fabregas against Blackburn Rovers in August 2004 (17y 113d).
Cameron Archer stunned the hosts in the 55th minute, firing a low effort into the bottom corner after being picked out by Mateus Fernandes’ raking pass.
But the Gunners responded three minutes later through Kai Havertz, who continued his scoring streak at the Emirates with a fierce strike beyond his former team-mate Aaron Ramsdale.
The comeback was complete 10 minutes later when Bukayo Saka’s teasing delivery to the back post found substitute Gabriel Martinelli.
Saka himself then sealed the triumph with a fine first-time finish, with Arsenal remaining third, behind Liverpool and Manchester City, while Southampton sit in 19th.
Data Debrief: Saka the king of Fortress Emirates
Arsenal's triumph saw them secure their 400th home Premier League victory, becoming just the second side to reach the milestone after Manchester United (428 home wins).
But the comeback win was largely down to the performance of Saka, who has now assisted in six of Arsenal’s seven Premier League games this season, (seven in total – three more than any other player in 2024-25), while he provided two assists in a single league game for just a second time.
Only Manchester City's Erling Haaland and Chelsea's Cole Palmer (10 each) have more Premier League goal involvements than Saka this term (nine – two goals and seven assists).
Havertz's equaliser also saw him become the first player to score in seven consecutive home appearances for Arsenal in all competitions since Robin van Persie between December 2011 – March 2012 (also a run of seven).
Leicester looked set to claim a point against the odds thanks to an unlikely James Justin double in the opening 18 minutes of the second half.
Arsenal had been in complete control in the opening exchanges, with Gabriel Martinelli opening his account for the season with an instinctive finish inside the box.
The Gunners then doubled the hosts' advantage before the break, marking his return from suspension with a goal after firing home Martinelli's cutback.
Yet Justin – whose second was an eye-catching volley – turned the match on its head until Mikel Arteta’s side came good again in the closing stages.
Trossard was again involved, seeing his effort deflect beyond Mads Hermansen by the unfortunate Wilfried Ndidi in the fourth minute of injury-time.
The win was sealed five minutes later, with Justin rounding off his eventful encounter with an unfortunate assist as his attempted clearance cannoned in off Kai Havertz to move Arsenal level on points with Manchester City at the summit.
Data Debrief: Gunners eventually down plucky Foxes
The Gunners are now unbeaten in 40 Premier League home games against promoted sides (W35 D5), winning each of the last 11 in a row.
Arsenal had 36 shots in this match, their joint-most on record (since 2003-04) in a single Premier League game (also 36 v Sunderland in May 2017).
With a goal and an assist, Martinelli has now been involved in 51 Premier League goals for Arsenal (33 goals and 18 assists). Against no side has the Brazilian been involved in more than his five against Leicester (three goals and two assists).
Havertz's late goal also brought up a Premier League milestone, notching his 50th goal involvement (35 goals and 15 assists) in the division, with 24 of those coming in 43 games for the Gunners.