Despite Medvedev coming into Sunday's decider on a 19-match winning streak, Alcaraz dominated 6-3 6-2 to win in 72 minutes.
Alcaraz's Indian Wells triumph was his third ATP Masters 1000 crown from three finals, not dropping a set in any of those deciders.
The 19-year-old Spaniard went through the Indian Wells Open without dropping a set and reflected that it was a "perfect" fortnight for him.
"It feels amazing to lift the trophy here [and] to recover the number one," Alcaraz told reporters, having reclaimed the top rank from Novak Djokovic due to his victory.
"It has been the perfect tournament. It was a goal for me, this tournament that I really wanted to win. For me, it's amazing."
The lopsided nature of Alcaraz's victory over Medvedev in the final caught many by surprise, hitting 19-4 winners against the in-form fifth seed.
"Honestly I didn’t expect that," Alcaraz said. "I expected a tough match but I played perfect. I said before against Daniil you have to play your best and tactically at your best level as well. I did perfect today. That's why it looks easy but it wasn’t."
Alcaraz added he was delighted to reclaim the number one rank which he had lost after Djokovic won the 2023 Australian Open which he missed due to injury.
Djokovic was unable to participate at Indian Wells due to being unvaccinated for COVID-19, with the pair actually not facing off at any events this year.
Alcaraz returned from abdominal and hamstring injuries last month at the Argentina Open and Rio Open before competing at Indian Wells, while Djokovic was in action at the Dubai Tennis Championships. The next opportunity for the pair to face off as at April's Monte Carlo Masters.
"Novak is one of the best players in the world," Alcaraz said. "That's obvious. I always say, if you want to be the best, you have to beat the best. I really wanted to play against Novak again. We miss him on tour and hopefully to have him back very, very soon."
Alcaraz added: "It feels great to be back on the number one. Of course, every player on the ATP wants to be the number one. For me, it's a dream come true again. Obviously being in front of such great players like Novak, the top player, it's an amazing feeling."
Despite Djokovic being unable to compete at Indian Wells, Medvedev said he felt Alcaraz's return to the top rank was a true number one.
"One hundred per cent," Medvedev said. "It's unfortunate Novak can't play all the tournaments. If you get injured, Rafa is injured for some time, we cannot say if Rafa isn’t injured he would be number one, because we cannot know. Same about Novak.
"For sure if he was able to play last year and this year all the tournaments there is a possibility that the rankings would be different but Carlos is deservedly number one, he won more points than everybody else in the last 52 weeks and he was also year-end number one last year."
Despite Medvedev coming into Sunday's decider on a 19-match winning streak, Alcaraz dominated 6-3 6-2 to win in 72 minutes.
Alcaraz's Indian Wells triumph was his third ATP Masters 1000 crown from three finals, not dropping a set in any of those deciders.
The 19-year-old Spaniard went through the Indian Wells Open without dropping a set and reflected that it was a "perfect" fortnight for him.
"It feels amazing to lift the trophy here [and] to recover the number one," Alcaraz told reporters, having reclaimed the top rank from Novak Djokovic due to his victory.
"It has been the perfect tournament. It was a goal for me, this tournament that I really wanted to win. For me, it's amazing."
The lopsided nature of Alcaraz's victory over Medvedev in the final caught many by surprise, hitting 19-4 winners against the in-form fifth seed.
"Honestly I didn’t expect that," Alcaraz said. "I expected a tough match but I played perfect. I said before against Daniil you have to play your best and tactically at your best level as well. I did perfect today. That's why it looks easy but it wasn’t."
Alcaraz added he was delighted to reclaim the number one rank which he had lost after Djokovic won the 2023 Australian Open which he missed due to injury.
Djokovic was unable to participate at Indian Wells due to being unvaccinated for COVID-19, with the pair actually not facing off at any events this year.
Alcaraz returned from abdominal and hamstring injuries last month at the Argentina Open and Rio Open before competing at Indian Wells, while Djokovic was in action at the Dubai Tennis Championships. The next opportunity for the pair to face off as at April's Monte Carlo Masters.
"Novak is one of the best players in the world," Alcaraz said. "That's obvious. I always say, if you want to be the best, you have to beat the best. I really wanted to play against Novak again. We miss him on tour and hopefully to have him back very, very soon."
Alcaraz added: "It feels great to be back on the number one. Of course, every player on the ATP wants to be the number one. For me, it's a dream come true again. Obviously being in front of such great players like Novak, the top player, it's an amazing feeling."
Despite Djokovic being unable to compete at Indian Wells, Medvedev said he felt Alcaraz's return to the top rank was a true number one.
"One hundred per cent," Medvedev said. "It's unfortunate Novak can't play all the tournaments. If you get injured, Rafa is injured for some time, we cannot say if Rafa isn’t injured he would be number one, because we cannot know. Same about Novak.
"For sure if he was able to play last year and this year all the tournaments there is a possibility that the rankings would be different but Carlos is deservedly number one, he won more points than everybody else in the last 52 weeks and he was also year-end number one last year."
Medvedev came into the decider with 19 straight ATP Tour wins, but Alcaraz made light work of the Russian, winning 6-3 6-2 in 72 minutes.
Alcaraz's triumph means he has three Masters titles from three finals, not dropping a set in any, while it ensured he returns to the rankings' summit ahead of 2023 Australian Open champion Novak Djokovic, who did not participate at Indian Wells.
The 2022 US Open champion has won two of three events since returning after three months out with abdominal and hamstring injuries that forced him to miss the Australian Open.
Alcaraz had labelled Medvedev the "best player right now" in the lead-up to the match, but was on top immediately, opening up a 3-0 lead as he hit 10 winners to the Russian's two in the first frame.
The Spaniard's dominance continued, winning the first 10 points of the second set, taking a 4-0 lead before prevailing with his second match point.
Alcaraz finished with 19-4 edge in the winner count, while Medvedev did not manage one ace for the match, marking the first time that has occurred since February 2020 against Gilles Simon in Marseille.
Medvedev had won in Rotterdam, Doha and Dubai recently and was gunning to be the first man to win four titles in five weeks since Andy Murray in 2016, but was completely outclassed by the 19-year-old.
Only John McEnroe has reached a century of victories in fewer matches, the ATP said, with the American getting there from 131 contests while it took Alcaraz 132 to get to that landmark.
Alcaraz made it 10 wins from 11 matches in 2023 by defeating Tallon Griekspoor 7-6 (7-4) 6-3 on Monday at the California tournament.
The Spanish prodigy last year won the US Open and in doing so became the youngest men's world number one, with Novak Djokovic having since clawed back top spot.
Victory over Griekspoor made Alcaraz the third men's tour player born after 2000 to claim 100 tour wins, after Jannik Sinner and Felix Auger-Aliassime, said OptaAce.
The youngster's first tour-level win came against fellow Spaniard Albert Ramos-Vinolas at the 2020 Rio Open, with the then 16-year-old wrapping up a 7-6 (7-2) 4-6 7-6 (7-2) at 3am local time.
The latest victory was his 24th at ATP 1000 level, going past Djokovic on the all-time ranking for wins at that elite tier by players before turning 20.
Alcaraz trails Denis Shapovalov (25) and Rafael Nadal (49), in that regard, but the chances are he will soon only trail Nadal, whom he cannot catch.
With his 20th birthday coming up in May, Alcaraz can substantially add to his ATP 1000 wins before leaving behind his teenage years. He will be looking to go further at Indian Wells and then rack up more victories in Miami, Monte Carlo and Madrid.
He will turn 20 on May 5, during the Madrid tournament where he is the defending champion.
Reflecting on his time on tour so far, Alcaraz said: "A lot has happened since that first ATP win. I'm really proud of myself to have my 100th win on the tour, in like 132 matches.
"I saw I was the second player in history with less matches to be able to get to 100 wins. I'm really proud of myself about that."
Alcaraz has a win percentage of 70.6 at ATP 1000 events in his fledgling career. Only three players with 10 or more matches in ATP 1000 events as a teenager have a higher percentage of success: Andre Agassi (90.9 per cent), Rafael Nadal (84.5) and Jim Courier (72.7).
Standing in the way of Alcaraz making an immediate improvement to his record is another emerging young talent, the 21-year-old British player Jack Draper.
They will meet in round four at Indian Wells on Tuesday, with Draper having sunk the hopes of compatriot and three-time grand slam winner Andy Murray on Monday to reach that stage.
"I know he's a really good player," said Alcaraz, who won his one previous meeting with Draper, a tight three-setter in Switzerland last year.
"I mean, he's playing well. He has beaten great opponents like [Dan] Evans and Andy. I know that I'm going to have to play my best, give my 100 per cent on court. I played against him in Basle [and won] 7-5 in the third, I think. It's going to be a really tough match and I'm going to enjoy it."
Djokovic won his first match back on the ATP Tour since missing the Australian Open on Monday, beating Lorenzo Musetti in the round of 32 at the Dubai Tennis Championships.
The men's world number one had not played a competitive match since early December and was last month deported from Australia on the eve of the Australian Open.
That decision was a result of Djokovic opting not to join the majority of his tennis peers in getting vaccinated against COVID-19 and amid controversy over how he handled getting the virus himself in December.
He showed no signs of rust as he eased to a 6-3 6-3 win over Musetti in just 74 minutes in his first match of 2022, hitting five aces, winning an impressive 71 per cent of his second serves (17 out of 24) and saving all seven break points he faced against his Italian opponent.
However, at a press conference following his victory, Djokovic admitted he is currently unable to enter the United States, and is therefore on course to miss March's prestigious Indian Wells Masters tournament.
"As of today, not. I can't go, I can't enter the United States," he said.
"As of today I'm not able to play. But let's see what happens. I mean, maybe things change in the next few weeks."
Djokovic has been included on the entry list for Indian Wells despite the tournament requiring all players are vaccinated against COVID-19.
Images of Djokovic do not appear in any of the tournament's build-up social media posts nor on the website's promotional announcement, while his entry-list inclusion was little more than a footnote – though did include him.
The statement read: "A power-packed line-up of ATP top-10 players will join [Rafael] Nadal in looking to put together a breakthrough performance in Tennis paradise.
"2021 US Open champion and 2022 Australian Open finalist Daniil Medvedev (world no. 2), 2021 ATP Finals winner Alexander Zverev (world no. 3), and 2021 French Open finalist Stefanos Tsitsipas (world no. 4) will each be in search of their maiden title in the desert.
"Reigning BNP Paribas Open champion Cameron Norrie (world no. 13) will look to replicate his extraordinary 2021 title run, in which he won his first Masters 1000 crown.
"World no. 1 and five-time Indian Wells champion Novak Djokovic is also on the tournament entry list."
After dropping the opening set, two-time Indian Wells champion Azarenka stormed back to outlast the 2017 French Open winner on Friday.
Standing in the way of Azarenka and history is Paula Badosa, who eased past Ons Jabeur in the second semi-final in the Californian desert.
AZARENKA RETURNS TO INDIAN WELLS FINAL
Winner of the Indian Wells Open in 2012 and 2016, Azarenka is back in the decider thanks to a stirring 3-6 6-3 7-5 comeback against fellow seed Ostapenko.
Former world number one Azarenka was down a set and a break before the 27th seed fought back to prevail over Ostapenko in two hours, 20 minutes.
By seeing off 24th seed Ostapenko, two-time grand slam champion Azarenka celebrated her 33rd match win at Indian Wells – only two women have won more matches at the tournament, Lindsay Davenport (47) and Maria Sharapova (38).
"I think my season has been tricky," Azarenka said. "There were parts where I physically couldn't necessarily bring that extra level, extra fight, which was very frustrating. Then there were parts where I felt that I was looking for something to add, and I didn't necessarily know what it was. It was a lot of searching in the season, a lot of kind of stepping into unknown.
"I feel like right now I'm a bit more settled with a bit more structure, a little bit more discipline, which makes it not necessarily easier but a bit clearer what I need to do. So it doesn't take extra energy on that, so I can kind of focus my energy more on the fighting for every ball."
BADOSA UPSTAGES JABEUR
Spaniard Badosa added another scalp to her name by trumping 12th seed Jabeur 6-3 6-3.
Looking to become the first Spanish woman to win the Indian Wells Open, 21st seed Badosa made light work of Jabeur.
Badosa's success means she has beaten four top-20 opponents en route to the final, having stunned Angelique Kerber in the quarter-finals.
Having won her first title earlier this year in Belgrade, Badosa will feature in her second career WTA decider.
First up, world number six Sakkari took on Ukrainian Elena Rybakina, prevailing 7-5 6-4.
Rybakina won the first three games of the match, working her way to an early 4-1 lead, before her Greek opponent rattled off six of the next seven games to claim the first set.
Sakkari again faced adversity early in the second set, coming back from 40-0 down in the second game to hold serve, before breaking the very next game to pinch the match-winning lead.
Azarenka, also a winner in 2012 and 2016, had to come back from a set and a break down in the semi-final, and for a while looked like good preparation for the battle that Badosa provided.
But in the end Badosa prevailed 7-6 (7-5) 2-6 7-6 (7-2) after three hours, four minutes on court, securing only her second title in what was just her second final of the season while becoming the first Spanish woman to claim the title in Indian Wells.
A highly competitive start saw a combined total of nine break points go to waste in the first four games alone, and when Azarenka did finally lose a service game to go 4-3 down, she emphatically hit back at the first time of asking.
She had no option but to repeat that feat soon after when Badosa broke again to take a 6-5 lead, and she duly obliged to set up a tie-break.
But Badosa got the better of two-time grand slam champion Azarenka in the tie-break, despite the latter overturning a four-point deficit to go level at 5-5.
Azarenka appeared re-energised at the start of the second set, though, charging into a 3-0 lead inside 11 minutes, her level of intensity suddenly leagues ahead of her opponent's.
Badosa only showed brief glimpses of her ability and Azarenka had few issues levelling the match, her class on full display in the fifth game as she read a wide drop shot and replied with a sensational cross-court effort.
After such a colossal fight to get back on level terms it was perhaps to be expected that Azarenka would drop off a little early on in the decider, but a bad miss from Badosa allowed the Belarussian to recover from a break and she consolidated to tie the set at 2-2.
The pair continued to slog it out thereafter with neither woman giving an inch, Badosa's often-brutal power countered nicely by Azarenka's athleticism.
But Badosa was her own worst enemy as she overhit two shots to allow Azarenka to get what looked likely to be the decisive break, but the 32-year-old failed to serve out the match and, perhaps predictably, a tie-break ultimately beckoned.
Badosa's energy reserves suddenly looked far deeper than her opponent's as she moved her around the court with almost surgical precision, her eventual 7-2 win in the tie-break speaking to the ferocity she displayed to win the comfortably biggest title of her career to date.
The Italian sixth seed had to fight from 2-5 down in the second set and saved three set points, before powering through to triumph 6-4 7-5 over Lloyd Harris.
"I got a little bit nervous," Berrettini said post-match. “I didn’t like how I handled the start of the second set. I let the anger get out a little bit, which helped. I found the right balance in order to break him in the important moment and then I had the momentum.”
The world number six found another level in reeling off five straight games, and will now face unseeded Miomir Kecmanovic, who accounted for Botic van de Zandschulp 7-6(6-3) 7-5.
Taylor Fritz was also pushed by Spanish qualifier Jaume Munar, taking a third-set tiebreaker to progress to the fourth round.
The 20th-seeded was made to work for it in a match that lasted just under three hours, but Munar feel short in the clutch, with two unforced forehand errors in the closing tiebreak to give Fritz a three-point gap.
In Tuesday's last game, Andrey Rublev showed rare composure to progress past Frances Tiafoe 6-3 6-4.
Neither got off to the best of starts, with Rublev and Tiafoe sharing service breaks in the opening four games of the first set. The characteristically volatile Rublev managed to regroup, though, and stayed calm even when Tiafoe got his home crowd on side.
Despite a low 67 percent on first serve, Rublev won 83 percent of those points, while Tiafoe did himself no favours with an even lower 58 percent first-serve rate.
Last-year’s semi-finalist will face 29th-seeded Alex de Minaur, who defeated Tommy Paul 7-6(6-2) 6-4.
The Australian world no. 31 faced immediate difficulty on service, with only his second service game going to eight consecutive deuces, after five saved break points. He eventually saw the match through, after breaking for 4-3 in the second set.
Fellow seeds Hubert Hurkacz and Grigor Dimitrov both went through relatively unscathed, with respective wins over Steve Johnson and Alexander Bublik.
Dimitrov will face John Isner, who saw past Diego Schwartzman 7-5 6-3 in Tuesday’s other result.
Clijsters remains winless since coming out of retirement on the WTA Tour, falling 6-1 2-6 6-2 to Katerina Siniakova on Thursday.
A four-time grand slam champion, the 38-year-old Clijsters has lost all five of her singles matches since her return last year.
"I think overall, there's definitely moments where I'm feeling really good out there, and there's moments where I feel too inconsistent," Clijsters – a winner at Indian Wells in 2003 and 2005 – told reporters.
"That's part of this process in general, it's not going to be a smooth ride, and that's what I'm going to try to improve every time I'm out there."
World number 53 Siniakova converted six of nine break points on Clijsters' serve and moved on to face 10th seed Angelique Kerber at the WTA Premier 1000 event.
GOLUBIC HOLDS OFF VONDROUSOVA
The day's only duel between top-50 players saw world number 46 Viktorija Golubic outlast 37th-ranked Marketa Vondrousova 6-1 4-6 6-3.
Both players struggled with their own service games, combining for three aces and 17 double faults, but it was the Swiss who managed to convert on eight of 14 break-point chances and come out on top.
It was Golubic's first win against a player in the top 50 since joining those ranks herself in July; she had been 0-3 against them since then.
GARCIA RALLIES PAST FLIPKENS, RISKE GETS RARE INDIAN WELLS WIN
Caroline Garcia fought back to defeat Kirsten Flipkens 5-7 6-4 6-0 in a match that took two hours, nine minutes to complete, firing seven aces and winning 71.2 per cent of points on her first serve.
The Frenchwoman, who had been upset by qualifiers at her two previous tournaments in Ostrava and Chicago, meets 15th seed Coco Gauff in the second round.
Alison Riske celebrated a victory for just the second time in seven trips to Indian Wells, cruising past qualifier Liang En-shuo 6-2 6-2 to set up a second-round matchup against 16th seed and former US Open champion Bianca Andreescu.
The four-time grand slam champion is on the comeback trail after reversing her 2012 retirement last year.
Clijsters, 36, earlier this month was beaten in straight sets by Garbine Muguruza at the Dubai Tennis Championships on her return to the court.
The Belgian is a two-time Indian Wells champion and is also set to play at Monterrey before heading to California.
It was also announced by tournament organisers on Thursday that both Novak Djokovic and Rafael Nadal have been given wild cards to play doubles at Indian Wells.
World number one Djokovic is set to team up with Viktor Troicki after they were part of Serbia's ATP Cup-winning squad at the start of the year.
Nadal, second behind Djokovic in the singles rankings, will play with compatriot Marc Lopez, with whom he won gold at the 2016 Olympic Games.
The former world number one was revealed as an automatic qualifier for the BNP Paribas Open at Indian Wells last month, though uncertainty surrounded his possible participation.
Djokovic was deported from Australia ahead of the Australian Open in January due to not meeting the country's COVID-19 vaccination requirements, with the Serbian choosing not to be jabbed.
After testing positive for – and recovering from – coronavirus the previous month, it was at one stage thought Djokovic might have been allowed entry to Australia on the grounds of having post-virus antibodies.
But he was ultimately ordered to leave the country and it quickly became clear the 34-year-old was likely to run into similar problems down the line.
Djokovic was included in the draw for the upcoming BNP Paribas Open, setting up a second-round clash with David Goffin or Jordan Thompson, and organisers said on Wednesday that talks were ongoing as they looked to determine the superstar's eligibility.
But America's Centers for Disease Control and Prevention (CDC) states all non-US citizens travelling to the country "must be fully vaccinated with the primary series of an accepted COVID-19 vaccine", with "only limited exceptions" applying.
Unsurprisingly, Djokovic has not been granted entry.
Confirming his situation, Djokovic tweeted: "While I was automatically listed in BNP Paribas Open and the Miami Open draw, I knew it would be unlikely I'd be able to travel.
"The CDC has confirmed that regulations won't be changing so I won't be able to play in the US. Good luck to those playing in these great tournaments."
Djokovic has lost his place atop the ATP rankings to Daniil Medvedev and his inability to feature at the Australian Open meant Rafael Nadal set a new record for the most grand slam men's singles titles, as the Spaniard claimed his 21st success.
It is unclear whether Djokovic will be able to add to his 20 at Wimbledon or Roland Garros, while it seems he will also miss the US Open unless the CDC changes its regulations in the meantime.
The former world number one was handed a second-round clash against either David Goffin or Jordan Thompson.
All 32 seeds receive a first-round bye, so although the men's singles begins on Thursday at the California desert event, Djokovic is not due to be in action until the weekend.
However, it remains to be seen whether he is allowed into the United States, given he has declared he has not received any vaccination against the COVID-19 virus.
Tournament organisers admit they do not know whether Djokovic will play.
They said in a statement on the event's official Twitter feed: "Novak Djokovic is on the tournament entry list, and therefore is placed into the draw.
"We are currently in communication with his team; however, it has not been determined if he will participate in the event by getting CDC approval to enter the country.
"We will provide updates in the future as we learn more."
The CDC is America's Centers for Disease Control and Prevention, which lays down requirements for non-US international citizens travelling to the United States.
Within its rules, it is stated that all non-US citizens travelling to the US "must be fully vaccinated with the primary series of an accepted COVID-19 vaccine", adding that "only limited exceptions apply".
Djokovic tested positive for COVID-19 in December, and at one stage it appeared that recovering from that, and having post-virus antibodies, would be enough to allow him to travel to Melbourne and play in the Australian Open.
That proved not to be the case, with Djokovic twice detained after arriving in Australia before being deported.
He has since made his return to tennis at the Dubai Tennis Championships, where he surprisingly lost in the quarter-finals to Jiri Vesely.
The 34-year-old Serbian has been overtaken for the rankings top spot by Daniil Medvedev, the Russian who will be playing under a neutral flag while his country's military invasion of Ukraine continues. Medvedev will begin against Alexei Popyrin or a qualifier at Indian Wells.
Last month, the world number one and 20-time grand slam winner was deported from Australia on the eve of the Australian Open after his entry visa to the country was cancelled due to him not being vaccinated against coronavirus.
Djokovic believed he was still eligible to enter the country and compete after testing positive for coronavirus in December and making a full recovery.
The Serbian was subsequently sent home as he lost the legal battle that dominated much of the sports news agenda during the early weeks of 2022.
Djokovic is set to make his return to the court at the Dubai Duty Free Tennis Championships later this month, with vaccination not a requirement.
But it is at Indian Wells, where the five-time champion has been announced as a competitor, prompting curiosity about whether more legal battles await or if Djokovic has since been jabbed.
An Indian Wells statement read: "With health and safety as the tournament's top priority, the BNP Paribas Open will require valid proof of full vaccination to enter the Indian Wells Tennis Garden for the tournament.
"For the second consecutive year, the BNP Paribas Open has partnered with CLEAR, the secure identity company, to facilitate the implementation of the venue's mandatory vaccination policy ahead of the 2022 tournament.
"The guidelines for the players are governed by the protocols established by their respective governing bodies, the WTA and ATP, as well as any restrictions established by the United States of America in regard to the vaccination status of international travellers entering the country."
Images of Djokovic do not appear any of the tournament's build-up social media posts nor the website's promotional announcement, while his entry-list inclusion is little more than a footnote – but, crucially, it does include him.
The statement continued: "A power-packed line-up of ATP top-10 players will join [Rafael] Nadal in looking to put together a breakthrough performance in Tennis paradise.
"2021 US Open champion and 2022 Australian Open finalist Daniil Medvedev (world no. 2), 2021 ATP Finals winner Alexander Zverev (world no. 3), and 2021 French Open finalist Stefanos Tsitsipas (world no. 4) will each be in search of their maiden title in the desert.
"Reigning BNP Paribas Open champion Cameron Norrie (world no. 13) will look to replicate his extraordinary 2021 title run, in which he won his first Masters 1000 crown.
"World no. 1 and five-time Indian Wells champion Novak Djokovic is also on the tournament entry list."
The 22-time grand slam winner withdrew from the Indian Wells Open as he is unable to play in the United States.
He is not vaccinated against COVID-19, which remains a requirement of international travellers, but Djokovic had hoped to be granted special permission to enter the country.
US tennis authorities and a number of politicians also expressed support for an exception being made for the 35-year-old Djokovic, with US president Joe Biden urged to reconsider policy.
Even last week, Serbian superstar Djokovic was clinging to hopes of playing the Miami Open, which he has won six times.
However, tournament director James Blake told Tennis Channel there is no chance of that happening, despite extensive efforts.
"Obviously, we're one of the premier tournaments in the world, we'd like to have the best players that can play," said Blake, a former world number four.
"We did all that we could. We tried to talk to the government, but that's out of our hands. We tried and he wasn't able to play."
Blake said he was in the same position as Indian Wells tournament director Tommy Haas, being unable to influence government-level decisions.
"We tried to get Novak Djokovic to be allowed to get an exemption, but that wasn't able to happen," Blake said. "We'd love to have him, and he’s our greatest champion, won it six times here.
"Unfortunately, that's way above my pay grade."
Blake added: "We exhausted all the options we knew of. Hopefully Novak will be back this year and hopefully he will be back for all the later events in the States including Cincinnati and the US Open."
World number one Djokovic was set to return to action at the rescheduled event after losing the US Open final to Daniil Medvedev in straight sets.
However, the Serbian – one of two five-time winners of the competition alongside Roger Federer – has decided to pull out for an unspecified reason.
"I am sorry I won't get to see my fans in Indian Wells and play in the desert, my favourite place to go. I hope to see you next year!" Djokovic said in a statement.
Tournament director Tommy Haas added: "We are disappointed that Novak will not be able to joins us at the BNP Paribas Open this fall.
"We hope to see him back in Tennis Paradise next March to contend for a record-setting sixth title in the desert."
Djokovic's defeat against Medvedev in Flushing Meadows ended his hopes of claiming a record-breaking 21st major title, the 34-year-old having already won the Australian Open, French Open and Wimbledon in 2021.
He fell short in his aim to become the first man since Rod Laver in 1969 to win all four majors in a single season but has already booked his place at this year's ATP Finals.
Osaka was reduced to tears as she crashed out with a 6-0 6-4 third-round defeat to 21st seed Veronika Kudermetova at Indian Wells on Saturday.
A member of the crowd could be heard shouting "Naomi, you suck" after the four-time grand slam champion had been broken in the first game of the match.
Osaka approached the chair umpire to report the incident and held further discussions with the court supervisor after being insulted again.
Serena and Venus Williams were subjected to verbal abuse at the prestigious tournament in the Californian desert back in 2001.
The legendary siblings' father, Richard Williams, claimed he had been racially abused at Indian Wells, while Venus Williams said she "heard whatever he heard".
Former world number one Osaka said while trying to hold back the tears after her exit: "I've been heckled before and it didn't really bother me.
"But being heckled here... I've watched videos of Venus and Serena get heckled here and if you've never watched it, you should watch it.
"I don't know why, but it went into my head and got replayed a lot. I just want to say thank you and congratulations [to Kudermetova]."
Serena Williams boycotted the competition for 14 years before making her Indian Wells return in 2015.
Azarenka – a two-time Indian Wells champion in 2012 and 2016 – accounted for Pegula at the WTA Premier 1000 event in the desert on Wednesday.
The former world number one will play 2017 French Open winner Jelena Ostapenko in the semi-finals after she got past American Shelby Rogers.
AZARENKA FLEXES TO BOOK SEMI-FINAL SPOT
Two-time Australian Open champion Azarenka won 6-4 6-2 over Pegula, who had beaten fourth seed Elina Svitolina in the fourth round.
Pegula hit 27 winners compared to Azarenka's 21 but the American had 30 unforced errors, with her 27th-seeded opponent also winning 81 per cent of first-service points to claim the edge.
"I started going for my shots from the beginning. I knew I have to apply pressure on her," Azarenka told her post-match news conference.
"I will have the moment where I will have opportunity. I think in the beginning of the match we had a lot of great rallies, a lot of points where I was like, 'Oh, maybe I got this one,' and she got me. I felt that I really just stuck to being aggressive and being consistent. I got my opportunities."
She added: "I felt that I really played well in the crucial moments. I felt like I stepped up a lot to the occasion. That's what I'm really happy with today."
OSTAPENKO FINISHES STRONG OVER ROGERS
Ostapenko earned her final-four spot with a see-sawing 6-4 4-6 6-3 win in two hours, 15 minutes over Rogers.
In a match that included 15 breaks of serve, Ostapenko won the final five games as she rallied to secure victory and her third semi-final of the year.
"I'm really happy to be in the semi-final. It's been a tough year for me, I've been up and down," Ostapenko – the 24th seed – said during her on-court interview. "I feel like my tennis is getting better and more consistent. Today I was trailing 3-1 in the third set and I was fighting to the last point."
Former world number five Ostapenko trailed 3-1 in the final set before finishing strong to set up a showdown with Azarenka.
"She's a great player, great champion, such a fighter," Ostapenko said about Azarenka. "Hopefully I can just enjoy it."
Halep, who is aiming to rebuild her ranking in 2022 after an injury-hit second half of last year, was excellent with her return, particularly on Gauff's second serve to gain the edge.
The Romanian saved all four break points generated by Gauff, while she converted three of the nine break points that she created.
Halep, who started the year with victory at the Melbourne Summer Set 1 before a last-16 loss to Alize Cornet at the Australian Open, needed only one hour and 16 minutes to seal her progress.
She will next play Romanian compatriot Sorana Cirstea after the 26th seed won 5-7 6-1 6-0 against lucky loser Anna Kalinskaya.
Last year's US Open champion and British 11th seed Emma Raducanu was bundled out by Croatian world number 79 Petra Martic 6-7 (3-7) 6-4 7-5.
Raducanu had served for the match in the final set but the Croatian won the final three games. Martic triumphed in two hours and 46 minutes, reaching the last 16 at Indian Wells for the second time in her career.
Martic will face 28th seed Liudmila Samsonova who triumphed 6-4 7-6 (7-4) over Danka Kovinic.
Third seed Iga Swiatek came from a set down to win 6-7 (3-7) 6-2 6-1 over Clara Tauson in two hours and 18 minutes.
Swiatek has won seven straight matches and is unbeaten at WTA 1000 events this season, having triumphed in Doha last month.
The Pole will take on three-time major winner Angelique Kerber in the last 16 after the German won comfortably over Daria Kasatkina 6-2 6-1.
American 25th seed Madison Keys got past countrywoman Alison Riske 7-6 (7-4) 6-1, setting up a fourth-round meeting with British qualifier Harriet Dart who beat Kaia Kanepi in straight sets.
The 18-year-old achieved stunning success at the US Open, winning the grand slam event as a qualifier without dropping a set.
Raducanu will play her first match since that famous Flushing Meadows triumph when she takes on Aliaksandra Sasnovich at the Indian Wells Open on Friday.
The youngster has been rated as favourite to win the tournament, which is seen as one of the most prestigious outside of the four majors.
There is already talk of her qualifying for the lucrative season-ending WTA Finals and triumphing at Wimbledon next year, having burst onto the scene in 2021 by reaching round four at All England Club.
But fellow Briton Henman urged fans to show caution with what they expect from Raducanu before her first match in 27 days against seasoned pro Sasnovich.
Raducanu has regularly discussed her lack of experience at tour level while she searches for a new coach to show her the ropes and Henman did not want to entertain discussions of her winning Wimbledon in 2022.
"I think that is probably getting a little ahead of ourselves," Henman said to talkSPORT.
"She has shown her enormous potential by what she did in New York, but she is still so young and so inexperienced.
"She has played so few events on the tour, let alone at grand slam level. I think it’s very easy to get ahead of ourselves.
"Regarding some of the young up and coming players, to really understand where they are at and their development, for me you get a very good insight once they have played every tournament twice.
"To put it into context, she has never played the clay court swing, she’s never played Roland Garros, she has never played the Australian Open.
"Once she has played all those events twice, then we will be able to assess where her game is at.
"Right now, it is as much about the process as the outcome and keep developing her game."
Henman, though, was in no doubt that Raducanu is a prodigious talent.
He added: "What is exciting is that she can improve in so many areas.
"It is easy to focus on her tennis game, but she can get fitter, stronger, faster and gain experience playing at the highest level and continue improving her tennis game.
"If she does that then I think she will go on and win more tournaments in the future.
"It was a privilege to be on the side of the court for all her main draw matches and just see the quality of her tennis at close quarters.
"Her resilience mentally, her composure and the consistency was incredible. To win 20 straight sets to qualify and win a grand slam is unprecedented in our sport, it was a real pleasure to watch."
While Raducanu received a first-round bye, Sasnovich had an easy opener as she beat Maria Camila Osorio Serrano in straight sets.
The Belarusian has never won a WTA Tour event or reached the last eight of a major.