Canadian teenager Auger-Aliassime will be seeking his first ATP Tour title after losing all three of his showpiece matches in his breakout campaign last year.
He sealed his place in the final with a 7-6 (7-2) 6-4 victory over Pablo Carreno Busta in a contest lasting one hour and 49 minutes on Saturday.
Unseeded Auger-Aliassime sent down 16 aces, one of which came on match point, and lost only three of his 48 points on first serve, saving all of the four break points he faced in an impressive outing.
"I was serving the best I've ever served in that first set and then played a solid tie-break," he said after reaching his first final on a hard court.
"In the second set, things got interesting with that long third game [when Auger-Aliassime broke]. I was thinking, 'If this goes my way, it might be tough for him'. So, I really pushed to get through."
Monfils is eyeing back-to-back triumphs, having come into this tournament after winning the Open Sud de France on home soil last week.
He defeated Filip Krajinovic in the semi-finals there and repeated the trick against the Serbian this time, winning 6-4 7-6 (7-5) in a display that saw him hit 35 winners.
"It would be great [to win this title again]," said the Frenchman, who like Auger-Aliassime sealed his victory with an ace.
"It would be unbelievable. It would be the first time to win two titles in a row and actually even the first time to win two titles in the same season, so it would be huge for me."
Monfils, who only gave up one break point against Krajinovic, has never played Auger-Aliassime before.
"Felix is a great guy, a humble guy," said Monfils.
"He is very strong, very talented guy. Definitely, I expect a tough match, but a cool match because I think we might see him for a long time in this stage of tournaments."
The Olympic champion claimed more silverware in Vienna, having also triumphed in Madrid, Cincinnati and Acapulco in 2021.
The world number four, who claimed his 300th tour-level career win against Alex de Minaur earlier in the week, is now 25-2 since exiting the fourth round at Wimbledon in July.
Tiafoe was appearing in his first ATP 500 final having defeated Stefanos Tsitsipas, Diego Schwartzman and Jannik Sinner along the way.
The world number 49 stuck with Zverev during a tight opening set, in which breaks were exchanged early on.
However, the German broke again in game 12 to draw first blood, and went on to hit eight aces during the second set.
Tiafoe produced an inspired turnaround from 5-2 down in the second set of his semi-final victory over Sinner.
But there was to be no fairytale finish for the American, who was seeking a second ATP title and first since the 2018 Delray Beach Open.
Zverev subsequently held his nerve to move level with Casper Ruud on five titles for the season, the most on the ATP Tour this year.
Fritz, the third seed, faced sixth seed and world number 15 Frances Tiafoe, and did not allow a single break of serve en route to the 96-minute victory.
He will now face compatriot Tommy Paul in an all-American semi-final after the world number 23 prevailed 6-2 6-2 against Mackenzie McDonald.
The win was Paul's 10th from his past 12 matches, with one of those two losses coming against Novak Djokovic.
Australia's Alex De Minaur is through to the other semi-final after making light work of Japan's Taro Daniel 6-2 6-2 in a surprisingly one-sided contest, considering Daniel was coming off a victory over world number four Casper Ruud.
De Minaur will face Holger Rune after the 19-year-old capitalised on Matteo Berrettini not being at 100 per cent, jumping out to a perfect 6-0 1-0 start before the Italian retired hurt.
Meanwhile, Chile Open second seed Francisco Cerundolo missed out on a potential chance to face his younger brother after going down 6-3 3-6 6-3 against Tomas Martin Etcheverry.
He was one win away from doing his part to set up a quarter-final showdown with Juan Manuel Cerundolo, but the 21-year-old Argentine also did not hold up his end of the bargain, falling 6-2 2-6 7-6 (7-2) to Serbia's Dusan Lajovic.
Laslo Djere ensured it would be a good day for the Serbians with a 7-5 7-5 handling of Italy's Riccardo Bonadio, and he will face third seed Sebastian Baez in the quarter-final after he eliminated hometown hero Cristian Garin 6-4 6-3.
The 24-year-old beat Tiafoe in straight sets, though it was a tight affair as the match was decided via two tie-breaks, Fritz eventually triumphing 7-6 (7-3) 7-6 (7-2) to clinch the ATP 500 event.
Nevertheless, Fritz looked the composed player for much of the contest as he created eight break chances to Tiafoe's three – though the latter managed to hang in for the most part.
The only breaks of serve came in back-to-back games early in the first set, with Tiafoe quickly hitting back before later holding off two set points to force a tie-break.
He would have been confident going into it after winning 13 successive singles tie-breaks prior to Sunday, but Fritz blew Tiafoe away in both, with the second coming at the end of a set in which neither player gave an inch.
A third tournament victory of 2022 ensures Fritz will break into the top 10 on Monday and provides a real boost to his hopes of qualifying for the end-of-season ATP Finals.
"Crazy, I don't even think it's set in just how fast the last four or five days have been," Fritz said afterwards.
"It's so crazy, and I couldn't have written it any better. It's exactly what I needed for the race [to Turin for the ATP Finals], for my ranking, to kind of put me in a good position for the end of the year, so it's amazing."
Fritz will be eighth in the world when the new rankings are released, making him the first American man to break the top 10 since Jack Sock did so in 2017.
Fifth seed Garin – winner of the most recent edition in 2020 – exited a second consecutive tournament at the first-round stage after he was humbled by Federico Coria.
Coria had defeated the fifth seed, Dusan Lajovic, at last week's Argentina Open, too, but was particularly impressive on Tuesday.
A stunning 6-2 6-0 win was sealed in an hour and 16 minutes.
Coria fended off two break points midway through the first set and then won the remaining nine games in succession in a dominant victory.
Garin was the only seed to lose in Brazil, however, as Lorenzo Sonego was on the right side of a 6-2 6-0 scoreline against 2019 winner Laslo Djere.
Fabio Fognini also advanced in straight sets, while Spanish pair Albert Ramos-Vinolas and Fernando Verdasco similarly eased through.
At the Delray Beach Open, 2021 runner-up Sebastian Korda defeated Thanasi Kokkinakis in his first match since winning the Australian Open doubles title with Nick Kyrgios.
Former champion Sam Querrey came up short against Denis Istomin.
The Chilean third seed proved too good for qualifier Mager in the decider, winning 7-6 (7-3) 7-5 after one hour, 34 minutes on the clay in Brazil.
The title win was the fourth of Garin's career and second this month, adding to his Cordoba Open success.
But it was his first at ATP 500 level, having earlier beaten fifth seed Borna Coric in the semi-finals.
Mager, who needed almost three hours to win his semi over Attila Balazs, recovered from a break down in the first set before being edged in a tie-break.
The Italian started the second set well, going a break up and appearing set to force a decider.
But Garin came from 5-3 down, winning 16 of the last 20 points and four straight games to clinch the title.
Unseeded Humbert already claimed the scalp of Alexander Zverev earlier in the week and, having seen off Felix Auger-Aliassime to reach the final, came out on top against world number seven Rublev 6-3 7-6 (7-4).
Rublev was appearing in his eighth final since the start of 2020, though it was his first on grass. The Russian was seeking a fifth successive victory in an ATP 500 level final, yet ultimately came up short, meaning Humbert made it three wins from three in his career finals.
The 22-year-old won his first two titles – in ATP 250 events in Antwerp and Auckland – last year.
Humbert's victory took just 87 minutes, with the Frenchman winning 45 of 53 points on his first serve.
The only break of the game went Humbert's way when he struck to make it 5-3 in the first set before holding off two break points in the next game to take the lead.
Neither player offered a single break point in the second set, and it was Humbert who nosed himself in the tie-break to secure a third career triumph, becoming the first player to win the Halle Open on his debut at the tournament since Lleyton Hewitt defeated Roger Federer in 2010.
Humbert's win will also take him up six places in the ATP rankings, from 31 to 25.
Fourth seed Hurkacz, who was beaten in the second round in Melbourne by Adrian Mannarino, saw off wildcard Tsonga 6-4 7-6 (9-7) in one hour and 32 minutes.
"Jo is an amazing player and competitor," Hurkacz said of the former world number five.
"He brought a really high level and it was a really tough match for me and he is definitely on the way back.
"Jo has achieved so much in his career and playing against him you can see why with his shots and his serve. I appreciated playing him and I am happy with the win today."
World number 11 Hurkacz will face either Lorenzo Musetti or Mikael Ymer in the second round.
Sixth seed Cameron Norrie overcame Ugo Humbert 6-2 6-4, while eighth seed Nikoloz Basilashvili was dumped out by American Mackenzie McDonald 6-3 6-2.
McDonald will face Alex de Minaur in the next round after the Australian swatted aside David Goffin 6-0 6-3.
"I think I played really well," De Minaur said. "I played exactly how I wanted to. My coach and I set up a plan about how we wanted to play this match and I managed to execute it.
"It is a very good feeling. Mentally I thought I was very solid and positive and that is one of the main aspects I am trying to focus on this year."
Medvedev replaced Novak Djokovic as the world number one last Monday, just a day after the Russian fell to a surprise final defeat against Tim van Rijthoven at the Rosmalen Grass Court Championships.
The 26-year-old followed that up with another final appearance in Halle, where he was convincingly beaten 6-1 6-4 by world number 12 Hurkacz.
That made Hurkacz the seventh male player in the Open Era to win his first five career finals, while Medvedev has lost all three showpieces he has contested in 2022.
The US Open success in September was the last trophy Medvedev lifted, but Hurkacz lavished praise on his opponent after the match on Sunday.
"Daniil is an unbelievable player," said Hurkacz. "He's the best player in the world, so it's very tricky to play him.
"All the right shots went my way at the beginning, so I definitely gained a lot of momentum from that.
"I'm super excited. I've been waiting a little for my first [title] this year. I'm happy to win my first ATP 500 title and of course, on the grass it is very special.
"I was serving pretty good today and got a bit of momentum from the first game.
"I saved a couple of deuces on my service game, and then I managed to break Daniil’s serve so I definitely got a bit of momentum. I'm very happy with the win in front of such a great crowd here."
Medvedev boasted a 14-2 record on grass since a first-round exit at Halle last year before meeting Hurkacz, who came in for praise from the world number one.
"Congrats Hubert, great match today, great week. Congrats to you and your team," he said at the post-match ceremony.
"You guys are super nice. Hopefully a lot more matches to play on the biggest stage. Congrats for a great week and the title."
Medvedev was frustrated throughout the match, repeatedly shouting at coach Gilles Cervara, who stormed out of his seat early in the second set.
While he did not address the topic after the final, Medvedev apologised to the crowd for "not making this match longer and more interesting" and acknowledged he was "not easy to be with on the court" this week.
The third seed advanced with a 6-1 6-1 victory, though that does not quite tell the whole story as the second game of the first set lasted a mammoth 24 minutes and 40 seconds.
Martinez saved eight break points in that lengthy game before finally being outdone by Schwartzman, who will now face another Spaniard in Pablo Andujar.
Incredibly, Martinez won 31 points in the first set but just one game.
"It was unbelievable," Schwartzman said. "This was probably the longest game in the history of the tournament
"I don't remember anything like this before. I played an almost perfect match, I played against an opponent that had as much confidence as me."
Andujar beat Albert Ramos-Vinolas 7-5 5-7 6-3, while fourth seed Pablo Carreno-Busta lost 5-7 6-4 6-3 to Fabio Fognini in the shock of the day.
Federico Coria awaits Fognini after following up his surprise win over defending champion Cristian Garin with a 7-6 (7-2) 4-6 6-4 victory against Fernando Verdasco.
At the Delray Beach Open, top seed Cameron Norrie beat Oscar Otte 6-3 7-5 and will face Sebastian Korda, who saw off Andreas Seppi 7-5 6-3, for a place in the semi-finals.
Tommy Paul and Stefan Kozlov are also through to the final eight in Florida after beating Denis Istomin and Steve Johnson respectively in straight sets.
"There is a lot of work, a lot of sacrifice and I think some tears left in my eyes," the 19-year-old said during his on-court interview.
"I'm really proud of myself, but now I'm going to work harder and focus on the next days."
Musetti, whose forehand was excellent, defeated both Stan Wawrinka and Kei Nishikori at the Internazionali d'Italia in Rome last year.
Top seed Stefanos Tsitsipas had no such trouble, easing into the second round, where he will face big-serving American John Isner.
The Greek world number five beat France's Benoit Paire 6-3 6-1, aided by a strong display on serve.
"I didn't know what to expect from Benoit today," Tsitsipas said. "I think it's kind of tricky playing a tournament you haven't played before."
On facing 27th-ranked Isner next up, Tsitsipas added: "He's a guy that serves really well so that's going to be the biggest element and the one thing that I'll really have to resolve during that match."
Fourth seed Milos Raonic sent down 13 aces as he defeated American Tommy Paul 7-6 (8-6) 6-4.
In the late match, fifth seed Grigor Dimitrov got past Adrian Mannarino, who retired when trailing 6-4 3-0.
A memorable week for Krajinovic continued as he saw off fellow Serbian Laslo Djere 6-4 6-2 in his semi-final.
Sixth seed Krajinovic defeated Stefanos Tsitsipas in the quarter-finals and ensured he followed up on that surprise victory with a dominant display against Djere on Saturday.
The victor committed only seven unforced errors in the match, while conceding just two break points in the contest.
Second seed Carreno Busta has not dropped a set all week and kept that run going with a 7-6 (7-2) 6-3 win over Federico Delbonis.
Carreno Busta needed just under two hours to see off a battling Delbonis, with neither player offering up a single break point in a first set that went the distance.
The Spaniard won five straight points to take the tie-break and continued that momentum into the second set when he broke Delbonis twice.
Neither Carreno Busta nor Krajinovic has ever won a tournament at ATP 500 level or above.
Carreno Busta has five career titles, but all of those are at ATP 250 level, losing to Dominic Thiem in his only showpiece appearance at this level at the Rio Open back in 2017.
Krajinovic, meanwhile, has lost all three of the career finals he has reached.
"I enjoy playing here, I feel comfortable here," Carreno Busta said. "It is my most important match this year on Sunday - I need to be really focused until the end.
"[Delbonis] is a really tough player and my level was very good. I probably played better in the second set, but I continued fighting all the time."
At the Nordea Open in Bastad, Sweden, top seed Casper Ruud was comfortable as he defeated Roberto Carballes Baena 6-1 6-4 to earn a place in the final.
Ruud needed just 79 minutes to do the job, breaking Carballes Baena on five occasions.
He has only played two matches – both comfortable wins – to reach the final after a walkover against Henri Laaksonen in the quarters.
Rising star Ruud will bid for his second ATP title of the year and the third of his career against Federico Coria on Sunday.
Coria also had a comfortable last-four tie, seeing off Germany's Yannick Hanfmann 6-2 6 -1, with the win meaning the 29-year-old reached his maiden career tour final.
"I am very happy - it is my first final," said world number 77 Coria, who beat second seed Cristian Garin in the last eight.
"I played the best tennis of my life in this match. It is amazing here in Bastad, it is beautiful."
Kyrgios suffered a disappointing semi-final defeat to Andy Murray in Stuttgart last week, but looked greatly improved against Tsitsipas as he recovered from a set down to win 5-7 6-2 6-4.
It was the second serve of both men where Kyrgios shone, winning 76 per cent (28 of 37) of points on his second serve, and 58 per cent (23 of 40) on his opponent's.
"Stef is one of the best players in the world at the moment and he's going to have some amazing results and I'm sure many, many grand slams," Kyrgios said following his win.
"I don't know if I can say the same for me, but I'm happy to still be able to produce this level with the tournaments I play. It is a testament to how hard I do work when I'm not playing."
He will face Pablo Carreno Busta in the quarter-finals after the Spanish sixth seed beat Sebastian Korda 6-4 0-6 6-3.
Elsewhere, Hubert Hurkacz will face Felix Auger-Aliassime in the last eight after defeating Ugo Humbert 7-6 (7-5) 6-3, while the Canadian also won in straight sets against Mackenzie McDonald 7-6 (9-7) 6-1.
The one remaining first round match saw number one seed Daniil Medvedev beat David Goffin 6-3 6-2 to set up a second round clash with Ilya Ivashka.
At the Queen's Club Championships, sixth seed Denis Shapovalov was eliminated by Tommy Paul 6-4 2-6 6-4, with the American now scheduled to face Stanislas Wawrinka in the second round.
It means that six of the eight seeds in west London were knocked out in the first round, with Matteo Berrettini and Marin Cilic the only remaining seeds. The latter sealed his place in the quarter-finals on Wednesday with a 7-6 (8-6) 7-5 win over Alexander Bublik.
Cilic will play Finland's Emil Ruusuvuori in the last eight after he beat home favourite Jack Draper 6-2 7-6 (7-2).
The best contest of the day came between Alejandro Davidovich Fokina and Alex de Minaur, with the former coming from behind to win 4-6 6-4 7-5 to set up a quarter-final with Botic van de Zandschulp, who beat Grigor Dimitrov 7-6 (7-5) 6-3.
Zverev and Brazil's Marcelo Melo were in a super tie-break against Lloyd Glasspool and Harri Heliovaara when they were angered by a call made by the umpire.
A return on Melo's serve seemed to be called out by a line judge, but the umpire overruled the decision to put Glasspool and Heliovaara 9-6 up and give them match point, a subsequent ace ending the match in their favour.
As the pairs shook hands at the net afterwards, Zverev quickly walked off and smashed his racquet against the umpire's chair three times.
He then shouted at the umpire that he had "destroyed the whole f****** match" before striking the chair once more.
Zverev was due to face Peter Gojowczyk in the second round of the singles, but the ATP Tour confirmed the Olympic champion has been removed from the draw.
A brief statement read: "Due to unsportsmanlike conduct at the conclusion of his doubles match on Tuesday night, Alexander Zverev has been withdrawn from the tournament in Acapulco."
Down a set when forced off on Friday, top seed Thiem failed to stave off a quarter-final loss once play resumed on Saturday.
Italian qualifier Mager turned his overnight advantage into a 7-6 (7-4) 7-5 victory before again taking to the court later in the day for his semi-final.
The 25-year-old's opponent, lucky loser Attila Balazs, earlier beat Pedro Martinez 2-6 6-4 6-2 but was left clinging onto a place in the tournament when the rain returned, the Hungarian trailing 7-6 (7-4) 3-3 against Mager.
The winner will likely face Cristian Garin in the final after the Chilean third seed opened up a 6-4 4-4 lead over Borna Coric in the other postponed semi-final.
Poor conditions also interrupted the Delray Beach Open, where Milos Raonic was unable to get underway against Reilly Opelka.
The big servers had their semi-final rescheduled for Sunday and will compete for a spot in the decider against Yoshihito Nishioka, who battled from a set down to defeat Ugo Humbert 1-6 6-4 6-0.
Nishioka has reached the final despite dropping the opener in three of his four matches at the ATP 250 event.
"After the first set I just figured out how to play against him and just kept trying to do it and then it worked," he said, as quoted by the ATP Tour.
"If I lose the first set it's okay, I just figure out how he's going to play, how I have to play against him and then from the second set I say, 'Okay, let's do it this way.'"
The top seed broke early and late in both sets as he cruised through the opening round a 6-2 6-2 winner.
Next up for Medvedev is a clash with former US Open champion Thiem, who beat him in the semi-finals on the way to triumphing at Flushing Meadows two years ago.
Stefanos Tsitsipas overcame local wildcard Dennis Novak 7-6 (7-2) 6-2 as the Greek ace seeks a third final in as many weeks, having lifted the title in Astana and finished as runner-up to Holger Rune in Stockholm.
Jannik Sinner also advanced in straight sets against Cristian Garin, but Taylor Fritz's ATP Finals hopes suffered a blow after the fourth seed was beaten 6-1 4-6 6-3 by Denis Shapovalov.
Over in Basel, world number one Carlos Alcaraz sailed through to his 11th quarter-final of the season after a commanding 6-4 6-2 win over Botic van de Zandschulp.
Meanwhile, Felix Auger-Aliassime recovered from losing the opening set to deny Marc-Andrea Huesler. The third seed claimed a career-best ninth successive ATP Tour victory, as he looks to complete a hat-trick of titles in as many weeks having recently reigned in Florence and Antwerp.
Stockholm champion Rune built on his recent momentum with a 6-2 7-5 success over Alex de Minaur, but Naples winner Lorenzo Musetti was ousted in a deciding set by Albert Ramos-Vinolas.
Rublev – defeated by Medvedev in the Australian Open quarter-finals – booked his place in the last eight with a clinical 7-5 6-2 victory over the former world number one.
The world number eight hailed Murray as a "true legend" ahead of the clash, with the Russian and Scot having previously met only once before.
Murray, then at the peak of his powers, came out on top in the second round of the 2017 Australian Open, thought it was a far different story this time around, Rublev dispatching his opponent with relative ease.
Rublev saved all three break points that Murray managed to create during proceedings, breaking twice in the second set before wrapping up the win at the first opportunity.
Dusan Lajovic put in an impressive display as he registered a 7-6 (7-4) 6-4 victory over Medvedev.
A run to the Rotterdam final would have moved Medvedev up to world number two, yet the Australian Open runner-up was well shy of his best.
The Russian led by a break in the first set, only for Lajovic to hit back to square things up at 3-3, with the Serbian winning the tie-break when Medvedev double-faulted.
Lajovic looked to have the odds stacked against him early in the second set, yet ultimately fought back again following another unforced error from the world number three to claim his second career win over Medvedev.
Lajovic will now face Borna Coric to tee up a tie with Kei Nishikori, who followed up his opening win over Felix Auger-Aliassime by beating Alex de Minaur 6-3 2-6 7-5 to clinch a quarter-final spot.
The other shock result during the day came in the form of world number seven Zverev losing 7-5 6-3 to Alexander Bublik.
It was the biggest win of Bublik's career, with the world number 43 - a finalist at the Singapore Open on Sunday - having now triumphed in his last three matches against top-10 opponents.
Zverev was playing for the first time since a quarter-final defeat to Novak Djokovic in Melbourne last month.
Bublik will face American Tommy Paul in the next round, while David Goffin beat Jan-Lennard Struff and Alejandro Davidovich Fokina got the better of compatriot Roberto Bautista Agut.
The world number one, who reached the final at 's-Hertogenbosch last week only to suffer a shock defeat to Tim van Rijthoven, had not beaten Bautista Agut in three previous matches.
But his duck against the Spaniard is over following a 6-2 6-4 win, which set up a semi-final meeting with Oscar Otte after the German saw off Karen Khachanov in three sets.
"I remember all the matches we had… He was playing some [great] tennis and it was tough for me to win," Medvedev said of his previous meetings with Bautista Agut.
"Today I had my plan, managed to keep it going. Definitely got more edge on the most important points, because he had more break points than me. It was not easy, and I'm happy to win."
Hubert Hurkacz, a Wimbledon semi-finalist last year, is also into the last four after edging Felix Auger-Aliassime in two tie-breaks and will face Nick Kyrgios, who beat Paulo Carreno Busta in straight sets.
Elsewhere, Matteo Berrettini was victorious at the Stuttgart Open and is on course to go back-to-back at the Queen's Club Championships after seeing off Tommy Paul 6-4 6-2 to progress to the semi-finals.
Botic van de Zandschlup is his next opponent, the Dutchman overcoming Alejandro Davidovich Fokina 6-2 6-4.
Meanwhile, Filip Krajinovic had to come from a set down to end Briton Ryan Peniston's run at the quarter-final stage, with his reward a meeting with former US Open champion Marin Cilic, a straight-sets victor over Emil Ruusuvori.
The former world number one took just 82 minutes to win 6-1 6-2, converting six of 13 break points against his Bulgarian opponent.
Medvedev rises back up to 10th in the world rankings after the win, and will go ninth if he can claim the title.
"It was an amazing match," Medvedev said after his victory. "The score [looks] easy, but the match was not. I felt physically like I was playing five sets.
"It would be amazing [to win the tournament]. Every time I come here, and I think it is my fifth time here, everywhere there are photos of the winners and their names.
"I don't remember who won it first time, but then Arthur Ashe won it [twice]. Then [John] McEnroe, [Bjorn] Borg, [Stefan] Edberg, and I'm like, 'Well, that tournament has a history for sure'. To add my name there would be amazing, but for this I need to play well in the final."
That final will be against Jannik Sinner after the Italian overcame spirited home wildcard Tallon Griekspoor.
It was Sinner's impressive serve that saw him through 7-5 7-6 (7-5), not facing a single break point, and ruthlessly taking the only one he carved out all match to take the first set.
He kept his nerve to see out a second set tie-break, and now has the chance to follow up last week's Open Sud de France title with another in Rotterdam.
Former world number one Medvedev committed just five unforced errors in a 6-2 6-4 win on Friday that saw him progress to the semi-finals.
"Today was my best match of the week, but I have to build on this," Medvedev said afterwards.
"Usually, the best weeks you play, many times you're going to play your best tennis in the last match, so that's definitely a goal.
"But I'm happy with my level today, beating someone like Felix in straight sets."
He will next face Grigor Dimitrov, who needed three sets to see off Alex de Minaur.
Dimitrov saved two match points in claiming a 6-3 3-6 7-6 (8-6) victory but seemingly has an uphill challenge having lost four of his six matches against Medvedev.
"I kind of know the plan for the game,” Medvedev added of his clash with Dimitrov. "The thing is, he is going to try to do the same, to make up a good plan. If we take the last two matches, it's 1-1. So I always say a new match is a new match, no matter the head to head.
"I'm preparing for a tough one tomorrow, he's such a great player and today was a great match from him, a great comeback actually. So I'm ready for the tough fight tomorrow."
Jannik Sinner was just as impressive as Medvedev, cruising to a 6-1 6-3 victory over three-time grand slam champion Stan Wawrinka.
Sinner, who won the Open Sud de France last week and has already dumped out top seed Stefanos Tsitsipas, will face Tallon Griekspoor after the Dutchman's win over fellow home hope Gijs Brouwer.