Playing in his home city of Belgrade, world number one Djokovic will be expected by many to carry off the trophy for a third time.
He scored a 4-6 6-1 6-2 victory over Russian Karen Khachanov in the first of Saturday's semi-finals.
Djokovic has made a habit of losing opening sets this week, rebounding from early deficits to beat fellow Serbians Laslo Dere and Miomir Kecmanovic on his way through to the last four, where it happened again.
The 34-year-old was able to recover and improve his career win-loss record to 13-2 at the clay-court tournament.
Djokovic, who has been prevented from playing events in Australia and the United States this year after refusing to be vaccinated against COVID-19, believes he is gradually building up form and match fitness.
He said in an on-court interview: "I'm already feeling quite comfortable on the courts. I think the three matches that went all three sets gave me enough of the match play.
"I was running enough in order to be at my optimum best. I don't think the lack of matches now plays a role. Maybe it was the case three or four days ago, not today.
"But in terms of the audience, of course that's going to be a huge motivation boost for me, so I'm going to enjoy the crowd's support as much as I can and hopefully bring the title to Serbia."
Rublev, another Russian, beat Italian Fabio Fognini 6-2 6-2 in the second semi-final, saying it had been his best performance of the week.
The world number eight is relishing playing Djokovic, saying: "It's going to be fun. Tomorrow I have nothing to lose, I can go out and enjoy it. He plays at home, so it will be his moment. The best I can do is fight and try to do my best."
Zverev was enraged during a doubles clash with partner Marcelo Melo against Lloyd Glasspool and Harri Heliovaara, after the umpire over-ruled a decision from the line judge.
That subsequently handed Glasspool and Heliovaara match point in the super tie-break, which was decided by an ace on the next serve.
Zverev quickly walked off and smashed his racquet against the umpire's chair three times, before shouting at the umpire that he had "destroyed the whole f****** match" and striking the chair again.
The German was then withdrawn by the ATP due to "unsportsmanlike conduct" ahead of a second-round singles meeting with Peter Gojowczyk.
The Olympic champion has apologised for his actions, explaining his regret at letting his fans, the tournament, and the sport that he loves down, and Djokovic believes Zverev will learn from his mistake.
"I saw the video, I saw Sascha's [Zverev] statement," Djokovic told reporters at a news conference after cruising into the quarter-finals of the Dubai Tennis Championships.
"I think he said it all in that statement. He realises that it was a mistake. I understand the frustration. Sometimes on the court, you feel in the heat of the battle lots of different emotions, different things happening in your head.
"I've made mistakes in the past where I've had tantrums on the court, so I understand what the player is going through. Of course, I do not justify his actions, but that statement has handled it in the right way.
"He said he made a mistake and his actions were not appropriate. I think that the disqualification decision was not too harsh, I think it was correct under the circumstances.
"Of course, it can be harsh for a player to get disqualified from a tournament. I know a year-and-a-half ago, I had something - I can't say similar - but I was disqualified from a grand slam after unintentionally hitting the line umpire.
"I realised that it was a mistake and I had to take it. Hopefully, he can reflect on that and not let something like that happen again in his life. I'm sure that he's going to approach it maturely."
Djokovic enjoyed a much calmer outing in Dubai, where he overcame Karen Khachanov in just 98 minutes 6-3 7-6 (7-2) to tee up a quarter-final tie against qualifier Jiri Vesely.
He was then keen to stress that Zverev is not the first player to produce a raging response when on the court, and insisted that the 24-year-old will recover from the outburst.
"I'm sure that the ATP management and officials will look at the video, will probably interview the chair umpire, will take some time to decide what they want to do," he added.
"I'm never going to encourage the ATP disqualifying or fining a player because I'm not in a position to do that, why would I do that?
"Everyone is a human being, everyone is flawed and can make mistakes, but I wouldn't say that he was the only one that ever has done something like that.
"There were many examples of players hitting their racquet in the umpire's chair. It happens. Bottles, bags were thrown, a lot of things, a lot of bad words. It's not the only case."
The 20-time grand slam winner was deported from Australia on the eve of the Australian Open after his entry visa to the country was cancelled.
Djokovic, who told officials he was not vaccinated against COVID-19, believed he was still eligible to enter the country and compete after testing positive for coronavirus last month and making a full recovery.
Dubai does not have the same conditions for entry as Australia, and Djokovic will be free to compete at the tournament he has won five times previously provided that he can produce a negative PCR test result on arrival.
His place in the field was confirmed by tournament organisers on Thursday, with Djokovic joined by defending champion Aslan Karatsev and last year's beaten semi-finalists Andrey Rublev and Denis Shapovalov. The tournament runs from February 21 to 26.
After strong Australian Open campaigns, Felix Auger-Aliassime, Jannik Sinner and Gael Monfils have also entered the Dubai event, which will be staged for a 30th time.
Djokovic won a hat-trick of Dubai titles from 2009 to 2011, adding further triumphs in 2013 and 2020. Only Roger Federer, with eight titles, has had more success at the tournament.
Serbian superstar Djokovic is not entered for the ATP 500 events in Rotterdam or Rio de Janeiro that precede the Dubai tournament.
Unlike in Australia, the 34-year-old can likely expect the red-carpet treatment in Dubai, where Colm McLoughlin, CEO of tournament sponsors Dubai Duty Free, said: "We are delighted to see Novak back in Dubai for the 12th time when he will be seeking his sixth title and we wish him the best of luck."
The Serbian picked up his 19th consecutive victory midway through his record 378th week as world number one, settling his last-16 clash in straight sets.
Griekspoor, at a career-high position of 39th in the ATP rankings himself, proved no match for the 22-time grand slam winner, who dismantled him inside an hour and 22 minutes.
Djokovic had looked poised for a near-flawless performance, with a late lost service game at 5-1 up in the second set the only major blemish on his display.
"It's been a great evening for me," Djokovic said in his post-match interview.
"Yesterday [against Tomas Machac], I really had to work hard to get a win. Tonight, right from the blocks, I think I was sharp. I definitely played better than I did last night.
"Maybe the last three or four games weren't the best to close the match, but I managed to find a good serve in the end.
"I'm very pleased with the performance and with the way I felt on the court, and hopefully things can go in the right direction for tomorrow."
Djokovic, who remains undefeated in 2023, is bidding to win the Dubai title for a sixth time, in what represents his first tournament since he won the Australian Open in January.
Elsewhere, second and third seeds Andrey Rublev and Daniil Medvedev joined Djokovic in easing their way into the last eight.
The former was made to work by Spain's Alejandro Davidovich Fokina however, recovering for a 1-6 7-6 (8-6) 7-6 (7-3) win, while the latter saw off Alexander Bublik 6-4 6-2.
Fourth seed Felix Auger-Aliassime crashed out with a surprise 7-6 (7-4) 6-4 loss to Italy's Lorenzo Sonego, who is rewarded with a last-eight clash against seventh seed Alexander Zverev.
The Serbian also secured a place at next month's ATP Finals in Turin after prevailing 6-3 6-4 in just 75 minutes.
It was Djokovic's fourth piece of silverware of the season – adding to his triumphs in Wimbledon, Rome and Tel Aviv – and stretched his winning streak to nine matches.
The 21-time major winner had prevailed in each of his last six encounters with Tsitsipas and claimed a crucial break in game eight of the opening set, before serving it out to draw first blood.
Seeking his maiden ATP 500 title at the ninth attempt, Tsitsipas was aiming to join Djokovic in becoming only the second male player to win a tour-level title on all three surfaces this season.
However, the Greek ace hit 25 unforced errors throughout the contest to his opponent's seven and was broken again in game five of the second set.
Djokovic, who won 33 of his 38 first-serve points and did not face a single break point, subsequently sealed victory with a brilliant backhand winner to make it back-to-back titles following last week's triumph in Tel Aviv.
"I always hoped that I would be going to have a great career. Obviously, [I] didn't know the amount of finals I was going to play, the amount of tournaments I was going to win, but my intention was always to reach the highest heights in our sport.
"I'm just very grateful and blessed to be able to play this well at this stage of my life. I think the experience, probably, in these kinds of matches and big occasions helps as well to approach mentally in the right way.
"I could not ask for a better restart of the season. I'm super-pumped and motivated to end the season as well as I have done these past couple of weeks."
Last month, the world number one and 20-time grand slam winner was deported from Australia on the eve of the Australian Open after his entry visa to the country was cancelled due to him not being vaccinated against coronavirus.
Djokovic believed he was still eligible to enter the country and compete after testing positive for coronavirus in December and making a full recovery.
The Serbian was subsequently sent home as he lost the legal battle that dominated much of the sports news agenda during the early weeks of 2022.
Djokovic is set to make his return to the court at the Dubai Duty Free Tennis Championships later this month, with vaccination not a requirement.
But it is at Indian Wells, where the five-time champion has been announced as a competitor, prompting curiosity about whether more legal battles await or if Djokovic has since been jabbed.
An Indian Wells statement read: "With health and safety as the tournament's top priority, the BNP Paribas Open will require valid proof of full vaccination to enter the Indian Wells Tennis Garden for the tournament.
"For the second consecutive year, the BNP Paribas Open has partnered with CLEAR, the secure identity company, to facilitate the implementation of the venue's mandatory vaccination policy ahead of the 2022 tournament.
"The guidelines for the players are governed by the protocols established by their respective governing bodies, the WTA and ATP, as well as any restrictions established by the United States of America in regard to the vaccination status of international travellers entering the country."
Images of Djokovic do not appear any of the tournament's build-up social media posts nor the website's promotional announcement, while his entry-list inclusion is little more than a footnote – but, crucially, it does include him.
The statement continued: "A power-packed line-up of ATP top-10 players will join [Rafael] Nadal in looking to put together a breakthrough performance in Tennis paradise.
"2021 US Open champion and 2022 Australian Open finalist Daniil Medvedev (world no. 2), 2021 ATP Finals winner Alexander Zverev (world no. 3), and 2021 French Open finalist Stefanos Tsitsipas (world no. 4) will each be in search of their maiden title in the desert.
"Reigning BNP Paribas Open champion Cameron Norrie (world no. 13) will look to replicate his extraordinary 2021 title run, in which he won his first Masters 1000 crown.
"World no. 1 and five-time Indian Wells champion Novak Djokovic is also on the tournament entry list."
The world number one cruised in the opening set, before Hurkacz put up more of a fight in the second.
Djokovic eventually prevailed to seal a 6-3 7-5 win, successfully seeing off his opponent despite Hurkacz valiantly throwing everything at him.
The 35-year-old Serbian has now won 15 consecutive matches in 2023, with his latest impressive display including just seven unforced errors, less than half Hurkacz's 15 as Djokovic's clinical edge proved decisive.
Fifteen successive victories is the fourth-best start to a season in Djokovic's career, though he remains some way off the 41-0 record he began 2011 with.
A semi-final clash against Daniil Medvedev awaits following the Russian's comfortable 6-3 6-2 victory against Borna Coric, which clocked in at one hour and 21 minutes.
Medvedev is also in the midst of an impressive winning streak, rattling off 12 consecutive successes since being eliminated by Sebastian Korda at the Australian Open in January.
Andrey Rublev booked his spot in the final four with a 6-3 7-6 (7-3) victory over Botic van de Zandschulp to maintain his title defence.
He will face seventh seed Alexander Zverev in the semi-final, the German having seen off Lorenzo Sonego 7-5 6-4.
Djokovic, who is celebrating a record 378th week as world number one, had to rely on a third-set tie-break to finally get over the line, defeating his Czech opponent 6-3 3-6 7-6 (7-1) on Tuesday.
Machac is ranked 130th in the world, but caused Djokovic plenty of problems, earning 10 break points across the match, though he was only able to convert three.
Djokovic had a 4-1 lead in the deciding set before Machac fought back to force a tie-break, but the Australian Open champion ultimately had few problems at 6-6 as he won seven of the eight points played to clinch the win.
"Tomas certainly didn't play like the No. 130 in the world today," Djokovic said of his opponent. "He was giving me all kinds of trouble. But I guess when it mattered, I found another gear."
Djokovic, who is still undefeated in 2023, will face Tallon Griekspoor in the second round.
Elsewhere, fresh off two titles in as many weeks, third seed Daniil Medvedev eased past Matteo Arnaldi 6-4 6-2 to tee up a tie with Alexander Bublik next after his opponent Alexandar Lazarov retired hurt with Bublik leading 6-1 1-0.
Felix Auger-Aliassime defeated Maxime Cressy 7-6 (7-4) 3-6 6-3, but sixth seed Karen Khachanov is out after he was beaten 7-5 6-2 by Botic van de Zandschulp.
The Dutchman will take on Mikael Ymer in the second round after his 6-2 6-3 win against Francesco Passaro, while eighth seed Borna Coric and Dan Evans played just four games before the latter retired hurt.
Christopher O'Connell set up a match against Alexander Zverev in the next round after he overcame Emil Ruusuvuori 7-5 6-4.
The two played out a thrilling first two sets, with Medvedev taking the lead before Djokovic fought back to level the match via a tie-break.
However, the Russian was unable to continue after sustaining a leg injury, keeping Djokovic in the hunt for back-to-back titles when he competes in the showpiece, where he will face Stefanos Tsitsipas.
"I really hope that his injury is nothing too serious,” said Djokovic. "I know Daniil, he's a great guy, he's a fighter, he's a big competitor.
"He wouldn't retire a match if he didn't feel that he [could] continue or [if it wouldn't] worsen his injury. He told me that he pulled an adductor muscle in his leg.
"It was such a close match, particularly in the second set. I would probably say he was a better player on the court in both sets. I was fighting and trying to find a way.
"I found a way to win the second, but I'm just sad for the tournament and for these people who were enjoying the battle, and for Daniil that it had to end this way."
Third seed Tsitsipas started slowly in the first set against Andrey Rublev but managed to triumph 4-6 6-4 6-3 in Saturday's other semi-final.
"My mentality kind of changed," said Tsitsipas, who will seek his first ATP 500 title at the ninth attempt. "I played with more of an aggressive game style and didn’t have anything by luck."
At the Japan Open, Taylor Fritz battled back from 3-1 down in the deciding set against Denis Shapovalov to claim a 6-3 6-7 (5-7) 6-3 semi-final victory and book his place in his third ATP Tour final this season.
Third seed Fritz faces an all-American clash in Sunday's final against Frances Tiafoe, who dropped his first set of the week as Soonwoo Kwon bageled him, but the US Open semi-finalist recorded a 6-2 0-6 6-4 win.
"It was a weird match, but I'm happy to get through," said Tiafoe, who progressed into his second final of the season and fifth overall.
"It's not always going to be pretty, it's not always going to be the best stuff, but a win is what matters."
World number one Djokovic was in danger of losing three straight ATP Tour matches for the first time in over four years when he surrendered the opening set to his fellow Serbian in front of an adoring crowd.
The 20-time grand slam winner was two points away from defeat in the second-set tie-break but managed to force a decider by converting set point at the sixth attempt.
And Djokovic needed another tie-break to get the job done, with Djere paying the price for a series of errors as he missed out on a chance to claim a famous victory.
Next up for Djokovic, who bounced back from successive defeats to Jiri Vesely and Alejandro Davidovich Fokina in Dubai and Monte Carlo respectively, is Miomir Kecmanovic.
Seventh seed Kecmanovic faced little resistance from John Millman as he claimed a 6-4 7-6 (7-5) success, while Karen Khachanov was granted a walkover against Roman Safiullin.
At the Barcelona Open, Carlos Alcaraz advanced to the third round courtesy of a 6-1 2-6 6-2 victory over Kwon Soon-woo.
He will face Jaume Munar for a place in the quarter-finals following the wildcard's 6-1 6-4 triumph against ninth seed Nikoloz Basilashvili.
Felix Auger-Aliassime was taken the distance by Carlos Taberner but eventually closed out a 6-1 3-6 6-4 success. His reward is a meeting with Frances Tiafoe, who beat Hugo Dellien 7-6 (7-3) 6-1.
Lloyd Harris defeated Albert Ramos Vinolas 6-3 6-4, while Alex De Minaur, Emil Ruusuvuori, Pablo Carreno-Busta and Marton Fucsovics also advanced.
Inclement weather brought a halt to top seed Stefanos Tsitsipas' meeting with Ilya Ivashka after just one game, while Grigor Dimitrov was up a break in the third set of a clash with Federico Coria.
Djokovic needed to win just two matches in Austria to guarantee he will end the year as world number one, unless Rafael Nadal takes up an unlikely wildcard for the Sofia Open.
After defeating Filip Krajinovic in the first round, Djokovic took a vital step towards cementing his name in the record books with a 7-6 (13-11) 6-3 victory over Coric on Wednesday.
Pete Sampras is the only previous player to have claimed the year-end number one spot on six occasions, doing so between 1993 and 1998.
Djokovic is tied with fellow modern greats Rodger Federer and Nadal, who the Serbian lost to in the French Open earlier in October, and Jimmy Connors, but is now set to nose ahead of his rivals, having previously secured top spot in 2011, 2012, 2014, 2015 and 2018.
His latest win did not come easy, though, with the 33-year-old made to work by world number 24 Coric.
The pair traded blows in an epic opening set which lasted just under two hours – Djokovic eventually coming out on top in a thrilling tie-break after Coric dropped serve for a third time.
A first break in set two handed Djokovic the advantage and he then held his nerve to take the eighth game with some wonderful shots in an exhilarating rally, making it 5-3.
Djokovic's sublime volley close to the net set the tone in the next game and while Coric saved two match points, it was only a case of delaying the inevitable.
Earlier, Stefanos Tsitsipas opted to switch his shoe in the third set of his match with Jan-Lennard Struff, though the third seed ultimately came through the contest to tee up a tie with Grigor Dimitrov.
With the third set tied at 1-1, Nitto ATP Finals champion Tsitsipas changed his footwear and subsequently broke serve, going on to record a 6-7 (7-3) 6-3 6-4 triumph.
Daniil Medvedev, meanwhile, is enjoying the hospitality in Austria as he eased past Jason Jung 6-3 6-1 in his first-round match.
"It's great. The hotel is good, the food is amazing, maybe the best of the year," said the world number six.
"These small things make tennis players happy all the time. The most important is to play good on the tennis court, so the organisation is very good."
Djokovic's 86-week reign at the top of the ATP rankings will end on Monday, after the Serbian lost to qualifier Jiri Vesely 6-4 7-6 (7-4) in the Dubai Tennis Championships.
That means that Daniil Medvedev will leapfrog Djokovic regardless of whether or not he wins in Acapulco.
Using his official Twitter account, Djokovic congratulated both Vesely – who won his only previous meeting with the 20-time grand slam champion back in 2016 – and Medvedev.
"Well played @jiri_vesely, that was a great game. Wish you the best of luck for the rest of the tournament," Djokovic wrote, accompanying his post with a thumbs up emoji.
"Congratulations also to a very deserving @DaniilMedwed, who will now become world number one."
His appearance in Dubai was Djokovic's first competitive action of 2022, after he was unable to feature at the Australian Open due to his refusal to be vaccinated against COVID-19.
While suggesting he is still working his way back to full sharpness after not playing since December, Djokovic insisted he is fully motivated to carry on playing.
"My goal is to keep on playing tennis," Djokovic said in his post-match news conference.
"That's the ultimate goal. For as long as I really feel like it and as long as I can play. As long as my body allows me, as long as the circumstances in my life as well, the people that surround me [and] support me.
"I'm still motivated and I'm still p***** off when I lose a match. I care about it. I care about winning every match, as anybody else on the Tour, regardless of the age. I'm actually glad that I'm feeling a lot of emotions every single day because it means that I really want to be part of this sport, part of the Tour.
"Unfortunately, [it] wasn't my day. I congratulate Jiri. He played better.
"The more matches I play, the more comfortable I get on the court. I need the match play. I didn't have many matches at all last few months.
"I don't look at the age really as a restricting factor for my career. I still feel great in terms of my body and the way it's holding on, the way it's recovering. It's been serving me well, so to say. That's something that obviously encourages me to keep going."
Djokovic complemented a fine display of serving by converting three of his five break points in a 6-4 6-3 victory, recording his seventh consecutive win following his absence from the US Open.
The 21-time grand slam champion has now reached six semi-finals this year, but saw room for improvement in his performance after beating the world number 18.
"I didn't play as well from the baseline as I did in the first two matches, but still it was enough," Djokovic said. "I managed to produce some good tennis when it was most needed in both sets."
Looking ahead to his final-four match, the Serb added: "I always expect highs from myself. Hopefully I can elevate still the level of my game for tomorrow, because it's going to be needed."
Djokovic will face an 11th tour-level meeting with Medvedev in the next round after his fellow former world number one recorded a dominant 6-1 6-1 win over Roberto Bautista Agut.
On the other side of the draw, third seed Stefanos Tsitsipas beat Hubert Hurkacz 7-6 (10-8) 6-3, and will now face Andrey Rublev after he eased to a 6-1 6-2 win over Adrian Mannarino.
At the Japan Open, a knee injury forced Wimbledon runner-up Nick Kyrgios to withdraw from his meeting with Taylor Fritz, with the American set to take on Denis Shapovalov in the semi-finals.
Seventh seed Shapovalov saw off Borna Coric 6-4 6-3 to reach the final four, while fourth seed Frances Tiafoe advanced with a 6-0 6-4 win against Miomir Kecmanovic.
South Korea's Kwon Soon-woo claimed the final place in the semi-finals in Tokyo, beating Spain's Pedro Martinez 6-3 6-0
After dominating his first-round encounter against Malek Jaziri in one hour, Djokovic won a similarly straightforward contest with Philipp Kohlschreiber 6-3 6-1 in just 59 minutes on Wednesday.
In the build-up, Djokovic had pointed to his loss against Kohlschreiber at Indian Wells last year on the previous occasion they had met on a hard court as evidence he was facing a big test.
But the Serbian triumphed without facing a break point, hitting 23 winners and just 10 unforced errors in improving his 2020 record to 15-0.
Khachanov, who has won one of his three meetings with Djokovic, moved through after seeing off Dennis Novak 6-3 6-4.
"I've had some interesting battles with him," Djokovic said of Khachanov. "He is a great guy, a very powerful player.
"He is one of the guys who is a pretender to be top five, top 10. He is very dedicated, so hopefully I'll be as sharp as I have been in the past two matches and start well."
Djokovic felt he had barely put a foot wrong against Kohlschreiber, who at 36-years-old is now ranked at number 80.
"It was a great performance," said the Australian Open champion. "I enjoyed the way I played, coming out with the right focus and tactics.
"Knowing Philipp beat me 12 months ago in Indian Wells, I needed to approach this match very seriously regardless of his ranking."
Second seed Stefanos Tsitsipas joined Djokovic in the quarter-finals at the ATP 500 event, beating Alexander Bublik – a player he also got the better of en route to Open 13 Marseille glory last week - 7-6 (7-1) 6-4.
Tsitsipas will now play Jan-Lennard Struff, who defeated Nikoloz Basilashvili.
Andrey Rublev saw off Filip Krajinovic 7-6 (7-3) 6-0 to book a clash with Dan Evans, who was on the brink of elimination but saved three match points in a thriller against Pierre-Hugues Herbert, eventually winning 7-5 3-6 7-6 (9-7).
Richard Gasquet eliminated fellow Frenchman and eighth seed Benoit Paire 6-4 6-4, while in-form Gael Monfils was a comfortable 6-1 6-2 winner over Yasutaka Uchiyama.
Djokovic, who last month won the Australian Open to move level with Rafael Nadal on 22 grand slam titles, has not played since claiming the title in Melbourne.
The world number one was nursing a hamstring issue throughout the season's first major, but he confirmed at a press conference in Belgrade on Wednesday that he will return to action at the Dubai Tennis Championships next week.
Djokovic could not compete in the United States last season due to his COVID-19 vaccination status, though his brother Djordje has claimed the 35-year-old has applied for a "special permit" to enter the country.
He has received clearance from the tournament organisers to play at the two Masters 1000 events at Indian Wells and in Miami but now faces a wait to find out if the U.S. government will grant him entry.
"The process for that has started. It is out of my control now," Djokovic said.
"I'd love to play and I'm glad I received the approval of directors in Miami and Indian Wells. I hope the decision makers will give the approval."
On his progress on the injury front, Djokovic explained: "As for the injury I sustained at the Australian Open, it's healed, but I'm not 100 per cent yet.
"Things are looking very good. As a team, we made the decision to go to Dubai."
Djokovic has won the Dubai Tennis Championships five times, though the last of those titles came in 2020.
He was knocked out by Jiri Vesely in the quarter-finals last year.
Djokovic this week tied Steffi Graf on 377 weeks spent as world number one.
The outright record is set to become his next week, with Carlos Alcaraz unable to surpass him even if the young Spaniard wins the Rio Open.
Djokovic, whose decision not to be vaccinated against COVID-19 caused him to be deported from Australia on the eve of the year's first grand slam, eased to a 6-3 6-3 win over Lorenzo Musetti in just 74 minutes at the Dubai Tennis Championships.
Djokovic spoke publicly about his vaccination status for the first time in a BBC interview last week, while rival Andy Murray, who has spoken about his support for vaccination on numerous occasions, said that he "didn't like seeing" Djokovic's ordeal in Australia after his own win in Dubai.
Serbia's 20-time Grand Slam winner says that most of his fellow professionals have been supportive upon his return to action.
"So far here most of the players that I’ve seen – I haven’t seen too many players – but most of the players that I've seen have been positive and welcoming", he said after his round-of-32 win.
"It's nice to see, obviously. I can't say that was the case in Australia. It was a little bit strange. But here, it's gone well so far."
The 34-year-old impressed against Musetti, serving five aces, winning 71 per cent of his second serves (17 out of 24) and saving each of the seven break points he faced during his first outing of the year, and Djokovic was also pleased with the reception he received from the fans in Dubai, as well as with his performance.
"I couldn't ask for a better reception," he added.
"It's been a while since I played, and I couldn't think of a better place to kick-start the season. Thank you for the reception and for welcoming me on court the way you did.
Ranked 42 in the world, Sonego had failed to win a single set in his three previous meetings with players inside the top 10.
But the 25-year-old Italian produced a scintillating performance against the top seed as he became the first lucky loser to beat Djokovic.
"It's unbelievable. It's amazing," Sonego said in an interview on court after wrapping up the win in 68 minutes.
"For sure, it's the best victory of my life. Novak is the best in the world. I played so, so good."
Djokovic's surprise exit at the Wiener Stadthalle meant the Serbian missed the opportunity to guarantee top spot in the year-end ATP Rankings this week.
The 33-year-old is still poised, however, to tie Pete Sampras' record of six year-end number one finishes unless Rafael Nadal takes up an unlikely wildcard for next month's Sofia Open, with reports indicating the Spaniard has already rejected such an opportunity.
At the age of 27, and with little warning, Karatsev has hurtled from obscurity before tennis went into lockdown 12 months ago to real prominence.
A 6-3 6-2 victory over South African Lloyd Harris on Saturday gave him a trophy for his efforts and he will enter the top 30 on Monday, having never had a double-digit ranking before this season.
Karatsev reached the Australian Open semi-finals last month, having had to win three qualifying rounds to make the main draw, and it took Novak Djokovic to stop that charge in Melbourne.
Now Vladikavkaz-born Karatsev is back in another winning routine, with Andrey Rublev, Jannik Sinner and Dan Evans having figured among his victims en route to the Dubai final.
The first-time champion said on Amazon Prime: "I am super happy. It was a tight match. [I was] really nervous. I want to congratulate my opponent for the final [run]. He did a great week. Every final is different, so I am happy that I won."
Karatsev had some promising results at Challenger Tour level last year but had never shown form on the main circuit until the start of 2021, and suddenly he looks a major force to be reckoned with.
He said of the rush of success: "You never know when it is coming. I did a good job with my team, with my coach and it has happened now."
The broadcast camera shook mid-point during the all-German semi-final encounter.
A 5.7 magnitude earthquake was registered to the north of Marquelia, which is to the east of Acapulco.
Zverev went on to secure a 6-4 7-6 (7-5) victory over Koepfer to reach the final.
Federer has endured two torrid years on the ATP Tour, missing most of 2020 due to double knee surgery.
The 20-time grand slam champion had then been limited to six matches this season heading into this week.
Having finally found some momentum at the French Open, Federer withdrew from his fourth-round match and explained: "It's important that I listen to my body and make sure I don't push myself too quickly on my road to recovery."
But the Swiss great was fit to finally step back out on a grass court for the first time since coming up short against Novak Djokovic at the All England Club.
And it was a winning return as Federer battled past Ilya Ivashka 7-6 (7-4) 7-5 in Germany.
Ivashka squandered two break point opportunities early in the opener and was quickly on the back foot after the set went to a tie-break, saving three set points but not a fourth.
Federer stayed patient in a second that stayed on serve initially, belatedly piling on the pressure to break in the final game having earlier passed up a match point at 5-4.
Fifth seed Federer was the only seed to win on Monday, however, as Sebastian Korda upset Roberto Bautista Agut in straight sets and David Goffin gave Corentin Moutet a walkover.
There was a standout shock at the Queen's Club Championships, too, as talented teenager Jannik Sinner was pipped by home hopeful Jack Draper 7-6 (8-6) 7-6 (7-2).
Draper's compatriot Cameron Norrie joined him in the last 16, battling back to beat Albert Ramos-Vinolas in three.
