Sibley put England in a commanding position against the Proteas with an unbeaten 133 as the tourists declared on 391-8, setting the home team a target of 438.
The Warwickshire man was playing just his fourth Test as he steered England towards victory, with the Proteas still 312 runs shy of victory heading into day five.
"It's probably one of the best days of my life," Sibley told Sky Sports. "I was a bit nervy on 95 when I nicked one off [Kagiso] Rabada and luckily turned around and saw it race away to the rope.
"It was nice to get one away off [Keshav] Maharaj and a nice big celebration."
The opener is now hopeful he can add further "addictive" tons in the remainder of the series, with England eight wickets away from winning the Test and drawing level in South Africa.
"Your first one makes you feel like you can do it here - especially against a really good attack," he said. "I just want to keep doing it, to be honest.
"That feeling was pretty addictive today, with the way the crowd was. It doesn't mean I'm going to rest on my laurels. I'll train hard and hopefully have another couple in this series."
Sibley was feeling the pressure overnight as he sat on 85, but Ben Stokes, a new partner on Monday morning, was in destructive mood - making 72 off 47 - to aid his team-mate.
The centurion added at a news conference: "I slept terribly, to be honest. I was up at like 2am, watching TV, thinking about the 15 runs.
"It feels amazing right now. I'm just glad that I got over the line.
"I think [Stokes] took the pressure off me, made it really easy to just go at my own tempo. He kept saying to me, 'Don't change what you're doing, just play the way you play'.
"So when he was whacking it everywhere and I was nurdling it around and playing and missing and stuff, it was nice that, at the other end, he was doing the scoring. I could just go about it in my own way."
The Leicestershire spinner was 18 years and 126 days old when he played against Pakistan in Karachi in December, taking seven wickets in the match as England completed a Test series clean sweep at the National Stadium.
He was left out of the squad heading to New Zealand for two Tests in February, but Ahmed will have the chance to make his debut in both short formats in March after being selected for the three-match ODI series against Bangladesh, which is followed by three T20I games.
England are World Cup holders in ODIs and T20Is, and Ahmed will be joined by a fellow uncapped player after Somerset batter Tom Abell was also included.
Lancashire paceman Saqib Mahmood features in the ODI squad as he returns to the England fold after recovering from a stress fracture of the back, while Jos Buttler captains the teams.
The series will see the teams play ODIs on March 1, 3 and 6, and T20Is on March 9, 12 and 14.
England ODI squad: Jos Buttler (captain), Tom Abell, Rehan Ahmed, Moeen Ali, Jofra Archer, Sam Curran, Saqib Mahmood, Dawid Malan, Adil Rashid, Jason Roy, Phil Salt, Reece Topley, James Vince, Chris Woakes, Mark Wood.
England T20I squad: Jos Buttler (captain), Tom Abell, Rehan Ahmed, Moeen Ali, Jofra Archer, Sam Curran, Ben Duckett, Will Jacks, Chris Jordan, Dawid Malan, Adil Rashid, Phil Salt, Reece Topley, Chris Woakes, Mark Wood.
The Proteas won the opener on a sweltering Tuesday at Chester-le-Street, but it was a very different story on a gloomy Friday at Old Trafford.
Liam Livingstone top-scored with 38 on his home ground and Sam Curran made a quickfire 35 from 18 balls as England were all out for 201 in a match reduced to 29 overs per side, Dwaine Pretorius taking 4-36.
Topley (2-17) and David Willey (1-9) were then outstanding with the new ball before spinners Adil Rashid (3-29) and Moeen Ali (2-22) did damage as South Africa were skittled out for 83 in 24.3 overs, setting up a decider at Headingley on Sunday.
Anrich Nortje removed Jason Roy in the third over after Keshav Maharaj won the toss and put England in. A delayed start occurred due to the miserable weather, but England were going well on 49-1 at the end of the powerplay.
The excellent Pretorius (4-36) then came into the attack to dismiss Phil Salt before getting Joe Root caught behind for only one and bowling a well-set Jonny Bairstow (28) in the same over.
Tabraiz Shamsi (2-39) ended a scratchy knock from Jos Buttler to reduce the world champions to 101-6, but Livingstone and Curran cut loose before Willey chipped in with a run-a-ball 21.
The Proteas made a nightmare start to their run chase, Topley sending Janneman Malan and Rassie van der Dussen on their way without scoring in a brilliant third over.
Willey got in on the act by getting Quinton de Kock caught by Livingstone and the tourists were in disarray on 6-4 when Aiden Markram was superbly run out by Buttler without facing a ball.
Heinrich Klaasen (33) was starting to motor before he was stumped when charging Moeen, and Rashid tormented South Africa as they were bowled out for their joint-second lowest ODI total, having also been skittled out for 83 by England at Trent Bridge in 2008.
Pretorius takes his chance
All-rounder Pretorius was a concussion replacement for Andile Phehlukwayo in the first match of the series on Tuesday and was given the nod to play in Manchester.
The 33-year-old took his opportunity with both hands by recording his best ODI bowling figures, settling on a good line and length as he dismissed the clean-striking Salt before claiming the big scalps of Root and Bairstow.
Paceman becoming England's Top man
Topley almost retired due to injury, but the left-arm paceman is very much making up for so much lost time.
After claiming the best bowling figures by an Englishman in the 50-over format with 6-24 against India at Lord's, he returned to the side after missing out in Durham and set the tone with the ball along with Willey.
Silverwood paid the price for a 4-0 Ashes thrashing in Australia when he was relieved of his duties early in February.
Joe Root then quit as Test captain before Rob Key was appointed as managing director of England men's cricket this month.
Key replaced Andrew Strauss, who took the role on an interim basis following the sacking of Ashley Giles in the wake of a nightmare tour Down Under.
Former England batter Key was expected to revert to different coaches for the red and white-ball sides and advertisements have now been posted for those roles.
The England and Wales Cricket Board (ECB) set a deadline of May 6 for applications, with the first interviews to take place on May 9 and 10.
Gary Kirsten, Simon Katich, Tom Moody are Graham Ford are among the names to be linked with the Test job.
England start their next Test against New Zealand on June 2 and begin an ODI series versus Netherlands on June 17.
Illness swept through the England camp during a successful recent tour of South Africa.
Captain Root says they will be taking no chances in Sri Lanka, where they start a two-match Test series in Galle on March 19.
Speaking before England boarded the plane for their latest tour, the batsman said: "After South Africa we are well aware of the importance of keeping contact to a minimum and we've been given some really sound and sensible advice from our medical team to help prevent spreading germs and bacteria.
"We are not shaking hands with each other – using instead the well-established fist bump – and we are washing hands regularly and wiping down surfaces using the antibacterial wipes and gels we've been given in our immunity packs.
"There is no suggestion that the tour will be affected.
"But of course, it is an evolving situation, so we are in regular contact with the authorities and will proceed as advised."
Pace bowler Archer made his comeback in domestic action for Sussex this week after undergoing surgery on his right hand at the end of March.
However, a persistent elbow issue flared up while in action against Kent, with Archer unable to bowl during the final two days of the County Championship fixture.
England confirmed on Sunday that the 26-year-old will now seek further medical advice over the next course of action, meaning he will not feature in either game against the Black Caps on home soil.
"England and Sussex seamer Jofra Archer has been ruled out of the Test series against New Zealand starting next month," an England and Wales Cricket Board statement read.
"Archer, who returned to action for Sussex in the LV= Insurance County Championship against Kent this week at Hove, only bowled five overs in Kent’s second innings. He was suffering from pain in his right elbow when bowling and was unable to bowl in the final two days of the match.
"The England and Sussex medical teams will now seek guidance, and Archer will see a medical consultant later this week to determine the next course of action on the management of his elbow."
Archer bowled 13 overs in Kent’s first innings, taking 2-29 in a rain-hit contest that finished as a draw.
He has 42 wickets at an average of 31.04 in 13 Test appearances for England, who have a home series to come against India later in the year.
Livingstone has not played international cricket since June 2017, when he scored 16 runs in a pair of T20 appearances against South Africa on English soil.
However, the 27-year-old was part of the group for the one-day series at home to Ireland last year, as well as the tour to South Africa that was cut short in December due to coronavirus concerns.
His selection comes after an impressive Big Bash tournament in Australia, though Hales – who finished as the competition's leading scorer, managing 543 at a strike-rate of 161.60 for Sydney Thunder – continues to be overlooked by the national selectors.
Root is also not included for the five-match series that offers Eoin Morgan's side further opportunities to prepare ahead of the ICC T20 World Cup, which takes place in India during October and November.
Jos Buttler – who has returned home for a scheduled break after helping England win the first Test against India in Chennai – will travel back for the white-ball games.
As well as the players in the squad, the England and Wales Cricket Board announced Jake Ball and Matt Parkinson as reserves. The party will depart on February 26, with all games to be played at the Sardar Patel Stadium in Ahmedabad.
England T20 squad for the tour to India:
Eoin Morgan (captain), Moeen Ali, Jofra Archer, Jonny Bairstow, Sam Billings, Jos Buttler, Sam Curran, Tom Curran, Chris Jordan, Liam Livingstone, Dawid Malan, Adil Rashid, Jason Roy, Ben Stokes, Reece Topley, Mark Wood.
Reserves: Jake Ball, Matt Parkinson.
The Group B match will take place in Barbados on Thursday, June 4.
Australia, Namibia and Oman complete the group in a tournament which has been expanded to 20 teams and will take place in the Caribbean and the United States throughout June.
ICC chief executive Geoff Allardice said: “The ICC Men’s T20 World Cup 2024 marks an exciting expansion of our sport with more teams than ever before set to compete in this event.
“It’s going to be an incredible spectacle bringing together 20 international teams from Africa, the Americas, Asia, East-Asia Pacific and Europe.
“The release of the fixtures is made even more exciting for fans as we enter a new frontier, with the USA hosting a major ICC event for the first time.
“With 16 matches being played across three venues in the USA, it allows us to make a statement in the world’s biggest sports market.
“It will also be great to have an ICC event back in the West Indies, which has such a rich history of the game.
“It has hosted World Cups with great success in the past and this tournament will certainly provide a boost to the game there, especially with the final being played in Barbados.”
England will remain in Barbados to play Australia on June 8 before heading to Antigua to take on Oman (June 13) and Namibia (June 15).
Scotland meet Namibia in Barbados on June 6 ahead of playing Oman in Antigua (June 9) and Australia in St Lucia (June 15).
Ireland have been drawn in Group A alongside India, Pakistan, Canada and the US, with two games in New York and two in Florida.
India and Pakistan meet in arguably the most anticipated group match in New York on June 9.
The fixture will be played in a 34,000-seat modular stadium just 30 miles east of downtown Manhattan in Nassau County.
Group C consists of New Zealand, the West Indies, Afghanistan, Uganda and Papua New Guinea, while South Africa, Sri Lanka, Bangladesh, the Netherlands, Nepal make up Group D.
Dallas’ Grand Prairie Cricket Stadium will host the tournament opener between the US and Canada on June 1.
The top two in each group progress to the Super Eights between June 19 and June 24.
The semi-finals will be held in Guyana on June 26 and Trinidad on June 27, with the final in Barbados on June 29.
England captain Morgan hit an unbeaten 75 to return to form at The Oval in the second ODI of the three-match series, leading England to an eight-wicket triumph.
The hard work had been done by Sam Curran, whose maiden ODI five-for dismantled Sri Lanka's top order, with David Willey (4-64) more than chipping in to limit the tourists to 241.
Jason Roy's superb 60 got England going before Morgan and his Test counterpart Joe Root (68) guided the hosts over the line with 42 deliveries to spare.
It marked Morgan's first big score since he hit 106 against Ireland in August 2020, with the one-day skipper having scored 23, 42, 23, 22 and six in his five innings between then and Thursday.
"Nice to score some runs and make a contribution to a series win," Morgan said at the post-match presentation.
"It's worked in my favour, distractions as a captain, to not think about your batting for some time.
"The game was set up by the bowling unit, two left-armers swinging it early, and then the wicket became a bit flatter and slower and we had to sit in and build pressure to create chances."
"I think we'll see more changes, it's only three days away but we also have an eye on the Pakistan series, 50-over cricket is a chance to bring guys in," Morgan added when asked if he would look to introduce fresh players into the XI for the final match in Bristol.
"We're always looking to grow and get better.
"I still don't think I'm striking it that well but [it was] nice to get some time in the middle."
Curran was awarded the Player of the Match prize for his efforts of 5-48 on his home ground.
"Really special, to be playing in front of the fans, you can hear them now – an awesome atmosphere, to do it on my home ground us really special," said the Surrey bowler.
"I feel I've played a lot of cricket, feel like I'm learning, picking the brains of other guys. The more I play and fail I learn from those experiences."
The England and Wales Cricket Board has announced the schedule for the trip in February and March of next year, with games to be staged at three bio-secure venues amid the ongoing coronavirus pandemic.
Instead of returning home after completing the two-Test tour of Sri Lanka in January, England's squad will travel straight to Chennai from Colombo.
There they will play two Tests at the MA Chidambaram Stadium as part of a four-match series in the longest format.
The teams then move on to Ahmedabad, with the Sardar Patel Stadium - a 110,000-capacity venue opened earlier this year - hosting the first day-night Test between the countries. That February 24-28 contest will be the first of two Tests between the teams at the ground.
After the Test action, England will be involved in a five-match Twenty20 series with India in March, followed by a trio of ODI fixtures - all to be staged in Pune - at the end of the same month.
"International cricket between India and England is a highlight of the cricketing calendar and always attracts significant levels of interest from fans around the world," ECB chief executive Tom Harrison said in a statement confirming the fixtures.
"We have been delighted with the planning that has been undertaken by the BCCI [Board of Control for Cricket in India] to ensure the three venues in Chennai, Ahmedabad and Pune will be ready to host international cricket in a bio-secure environment and look forward to working closely with them over the coming weeks to finalise those plans.
"The prospect of becoming the first international side to play at the magnificent Sardar Patel Stadium in Ahmedabad adds an extra dimension to the tour and I know will be something that is a highlight for both the players and management."
Jay Shah, honorary secretary for the BCCI, made clear player safety is paramount as India deals with the effects of the COVID-19 health crisis.
India is only behind the United States in terms of total number of coronavirus cases, with the country seeing over 141,000 deaths so far.
"The BCCI prioritises health and safety of both teams and will leave no stone unturned to make sure that the tour is held adhering to all safety protocols agreed by the BCCI and ECB medical teams," Shah said.
"Both boards have worked closely to put together an exciting series that promises to provide high octane action between two powerhouses of world cricket.
"This will be India's first bilateral series at home since the outbreak of COVID-19 pandemic and the home season will bring back joy to cricket fans."
England have not toured Pakistan since 2005 due to security concerns, but will return for a seven-match T20 series in September.
Pakistan Cricket Board (PCB) chairman Ramiz Raja confirmed last month that an England tour of the country was in the works, with ESPNcricinfo having reported that an England and Wales Cricket Board (ECB) security team were to assess security arrangements.
The tour, which was originally set to be played in October 2021 but was cancelled after New Zealand withdrew from a series citing security issues, has now been confirmed. It will take place between September 20 and October 2, prior to the T20 World Cup, which is to be held in Australia.
England will then return to Pakistan for a three-match Test series in December.
Karachi will host the opening four T20s, taking place on September 20, 22, 23 and 25, with Lahore staging the final three, on September 28, 30 and October 2.
Zakir Khan, the PCB's director of international cricket, said: "We are absolutely delighted to confirm hosting England for seven T20Is in Karachi and Lahore as a curtain-raiser to a busy, entertaining and exciting season of home internationals.
"England [are] one of the top-ranked T20I teams and them playing the shortest format in the lead up to the ICC Men's T20 World Cup in Pakistan will not only help the team management to finalise their preparations, but will also set the tone for December's three-Test series.
"We demonstrated our event planning and operational skills in the highly successful series against Australia in March/April and I am confident we will be able to replicate these when England visit us for the first time since 2005."
ECB managing director of England men's cricket, Rob Key, added: "We have been liaising closely with the PCB over arrangements for this visit and the Tests later in the year, and will continue to work closely with the PCB, British High Commission and other relevant authorities as we continue to prepare for these tours."
Pakistan will also host New Zealand in December and January, as well as in April, with West Indies also set to tour the nation next year.
England head to Southampton with a 1-0 lead in the three-match series despite frustration for Anderson at Old Trafford.
The 38-year-old seamer - closing in on 600 Test wickets - returned underwhelming match figures of 1-97 and subsequently fielded questions on whether he was set to retire.
Anderson insisted that was not an option, though, and he has the support of captain Joe Root, who intends to keep faith with England's record Test wicket-taker.
"Jimmy's likely to play," Root told reporters on Wednesday ahead of the second Test, which starts on Thursday. "I can't tell you who else is likely to play.
"The only other player I can guarantee if he's fit and well and doesn't get food poisoning tonight is probably me."
Pressed on Anderson getting an immediate opportunity to bounce back, Root replied: "Wouldn't you give him the opportunity with nearly 600 wickets under his belt?"
The captain, who welcomed "very exciting" Sussex seamer Ollie Robinson to the squad, revealed he had a private conversation with Anderson during the Old Trafford Test.
Having told the veteran to "remember how good a player you are", Root offered a firm defence of his most senior star.
"I think to question Jimmy's ability and his record... do that at your own peril," the skipper said.
"There's a reason he's got so many wickets over such a long period of time. It's because he's a consistent performer. I don't think it'll be long before he's back in the wickets big time.
"It would be very silly for us to write someone like Jimmy off. He's still as dedicated as ever, working very hard at his game, and looking very good in practice.
"I don't think it'll be long before he's got another five-fer next to his name."
He added: "It just shows that even the greats of the game and the greats of English cricket still have those days where it doesn't always come as naturally to you, it doesn't always feel the easiest game in the world.
"You know it can be a struggle sometimes. That's just the way it goes.
"I think with Jimmy, you know it won't be long before he's right back at the top, at the peak of his powers, and I'm very much looking forward to seeing him perform again this week."
Anderson's long-time colleague Stuart Broad had a more prominent role in proceedings with figures of 6-91 in Manchester, yet his send-off of Yasir Shah saw him fined by the match referee, his father Chris.
Root said: "It was disappointing for that to happen. It just shows the frustrations that Test cricket can throw at you sometimes.
"You know how much it means to Stuart, and over the past couple of weeks he's made it clear how much it means for him to play for England and do well. That probably just slightly boiled over.
"I'm sure that was a frosty conversation with his dad at some point last week. But he'll look to move on. He knows he's got to set an example and I can't see that being a major talking point dragging over into this week.
"Ultimately, we want to make sure none of our players are missing games through avoidable incidents like that."
The ECB released the men's international fixture list on Wednesday, which launches with a three-match Test series against world champions New Zealand in June.
The Black Caps – winners of the inaugural World Test Championship earlier this year – face England at Lord's (June 2-6), Trent Bridge (June 10-14) and Headingley (June 23-27).
Joe Root's side then welcome India for a three-match T20 series beginning at Old Trafford on July 1, before a three-match ODI series follows from July 9 at Edgbaston.
South Africa then arrive for a three-match ODI series starting at Riverside on July 19, before a three-match T20 series between the sides begins in Bristol eight days later.
The Proteas will also provide the opposition as England conclude their calendar year on home soil with a three-match Test series played at Lord's (August 17-21), Edgbaston (August 25-29) and the Oval (September 8-12).
ECB chief executive officer, Tom Harrison, said: "It has been a scintillating summer of cricket and so good to see crowds back packing out venues later this summer.
"For next summer, I am pleased to be able to confirm three high-quality men's international touring teams for 2022, starting with a three-Test series against World Test champions New Zealand.
"We also look forward to India returning for two white-ball series before we host South Africa for what promises to be hard-fought series across three formats, including three Test matches."
The England men's and women's teams are due to face Pakistan next month, with Eoin Morgan's side set for a two-match T20I series starting on October 13.
However, New Zealand's series against Pakistan was called off on Friday amid growing worries over player safety, and England are now assessing the situation.
The England and Wales Cricket Board said in a statement: "We're aware of New Zealand's decision to pull out of the Pakistan tour due to a security alert.
"We are liaising with our security team who are on the ground in Pakistan to fully understand the situation.
"The ECB board will then decide in the next 24-48 hours whether our planned tour should proceed."
Friday's decision by New Zealand Cricket to pull the ODI and T20I series, hours before the first match was due to be played, was met with disappointment from the Pakistan Cricket Board.
Pakistan captain Babar Azam echoed the PCB's sentiments, indicating that he trusted the security services would have ensured it took place in safe conditions.
"Extremely disappointed on the abrupt postponement of the series, which could have brought the smiles back for millions of Pakistan cricket fans," Babar wrote on Twitter.
"I've full trust in the capabilities and credibility of our security agencies. They are our pride and always will be! Pakistan Zindabad!"
The opening match of the three-game series last Friday was postponed after a positive test for COVID-19 was returned in the hosts' camp.
Two "unconfirmed" positives within the England party saw the rescheduled match in Paarl cancelled just 30 minutes before its scheduled start time on Sunday.
The second ODI in Cape Town was later postponed as a precaution while players and team management went into self-isolation in their hotel rooms.
It had been hoped that back-to-back ODIs could be played at Newlands in Cape Town on Tuesday and Wednesday before the tourists returned to England on Thursday.
However, on Monday, the England and Wales Cricket Board (ECB) confirmed the tour was off "to ensure mental and physical health and welfare of players from both teams".
ECB CEO Tom Harrison said: "We have always maintained that the welfare of our players and management is paramount.
"We were concerned about the potential impact that recent developments might have on the wellbeing of the touring party, and so after consultation with Cricket South Africa [CSA], we have jointly made the decision to postpone the remaining matches in this series, in the best interest of the players' welfare.
"I would like to thank Cricket South Africa for their support and understanding on this matter and look forward to working with them to identify a time when we can return to play these fixtures in the future."
CSA acting CEO Kugandrie Govender said: "The concern over the mental health impact of recent events on all involved is not one that we as CSA or the ECB take lightly, and the decision to postpone the tour is the most responsible and reasonable course of action for us.
"I would like to thank the ECB for the continued positive relations, and we look forward to hosting the England men's team in the near future."
England won the three-match Twenty20 series between the sides 3-0.
Ben Stokes' side took an unassailable 2-0 lead in the three-match series last week, claiming a comfortable 241-run victory at Trent Bridge.
Ollie Pope (121, first innings), Joe Root (122, second innings) and Harry Brook (109, second innings) all made centuries in that contest as the hosts sealed their first series win since they triumphed in Pakistan in 2022-23.
There are no changes for the upcoming match in Birmingham, which begins on Friday, with Mark Wood retaining his place after returning to the side last time out.
Shoaib Bashir, meanwhile, will look to build on a brilliant outing in Nottingham, where he managed a five-for including a spell of 3-8 within 15 second-innings deliveries.
England team to face West Indies: Zak Crawley, Ben Duckett, Ollie Pope, Joe Root, Harry Brook, Ben Stokes, Jamie Smith, Chris Woakes, Gus Atkinson, Mark Wood, Shoaib Bashir.
England triumphed by eight wickets in the first of three Tests in Christchurch, with debutant Jacob Bethell hitting an unbeaten half-century to guide the tourists over the line in their second innings.
Pope, meanwhile, was faultless behind the stumps as he stood in for the injured Jordan Cox and also made 77 with the bat in the first innings, hitting his first half-century since September.
Team-mate Chris Woakes told BBC Sport he was impressed by the way Pope had taken on the role, saying: "They always say when you don't notice a keeper he's done a good job.
"Ollie certainly did that. He was brilliant last week, stepping into a role he hasn't done a lot of.
"Obviously he can keep and has done previously for England, but to step up at short notice like that and do the job he did was fantastic.
"For him to score runs just shows his character, putting his hand up for the team without any fuss and cracking on. To move to number six, get such a good score for us and contribute to a big partnership was massive."
Captain Ben Stokes, meanwhile, keeps his place as an all-rounder after overcoming an injury scare in the first Test,
England team: Zak Crawley, Ben Duckett, Jacob Bethell, Joe Root, Harry Brook, Ollie Pope (wk), Ben Stokes (c), Chris Woakes, Gus Atkinson, Brydon Carse, Shoaib Bashir.
The Windies captain returned career-best figures of 6-42 while Shannon Gabriel weighed in with 4-62 as the tourists' quicks dismissed England for 204 under gloomy skies before tea on the second day.
Ben Stokes, captaining England for the first time in Joe Root's absence, top-scored with 43 but was one of half a dozen Holder victims as the giant seamer continued his fine form in Tests.
England could only remove John Campbell (28) before bad light stopped play, with West Indies 57-1, 147 runs behind.
Wet weather meant just 17.4 overs were possible on the first day of Test cricket following the worldwide coronavirus-enforced break, and England resumed on 35-1.
Rory Burns (30) soon went past 1,000 Test runs before Gabriel found his rhythm, Joe Denly the first to depart with one that nipped back between bat and pad and clattered into his stumps.
Burns and Zak Crawley were both removed lbw following successful West Indies reviews and England lost their fourth wicket of the session when Ollie Pope edged Holder behind.
Stokes was dropped either side of lunch and he was closing in on a half-century following a 67-run partnership with vice-captain Jos Buttler.
Yet Holder struck once more to send back Stokes, Shane Dowrich taking a catch behind the stumps, as he did again with a dive to his right to oust Buttler (35).
Another successful Windies lbw review accounted for Jofra Archer and, despite some late resistance from Dom Bess (31 not out), England only just snuck beyond past 200.
Windies opener Campbell then overturned two lbw decisions awarded to James Anderson, for whom it was a case of third time lucky, and it was not long before Kraigg Brathwaite and Shai Hope came off due to the poor light.
HOLDER'S HOT STREAK
It was Gabriel who did the damage in the morning but Holder grabbed the ball and took charge after lunch with the dismissals of Stokes and Buttler.
His figures were the best for a West Indies captain in England and he has now taken at least five wickets in an innings in six of his past 10 Tests.
REVIEWS PRODUCE REWARDS
Holder's brilliance was not only restricted to his bowling endeavours as he also successfully overturned three lbw decisions given not out on the field in England's innings.
Campbell survived, twice, after being given out by the standing umpires too, before eventually unsuccessfully reviewing a third time. Home umpires are being used in this Test due to COVID-19 restrictions but, to be fair to Richard Kettleborough and Richard Illingworth, they were a series of marginal calls.
MOMENT OF THE DAY - HOLDER WINS BATTLE OF THE CAPTAINS
Stokes was playing his usual talismanic role after lunch, utilising his feet to disrupt the bowlers' lines and producing a crucial sixth-wicket alliance with his deputy Buttler.
But in the battle of the all-round skippers, it was Holder who eventually came out on top from around the wicket, as Stokes prodded at a fuller delivery and got an outside edge.
Faced with the unenviable task of overturning a 190-run first-innings deficit, the tourists reached 172 for five at tea, with Ollie Pope unbeaten on 67.
Bumrah took the lead with a magical spell of pace bowling on a pitch that has largely rendered the seamers as an afterthought, removing the fluent Ben Duckett and key man Joe Root.
Pairing speed through the air with devilish reverse swing he sent Duckett’s off-stump flying for 47 and then trapped Root lbw for just two to reassert India’s strong position.
England had enjoyed a positive start to the day, taking three quick wickets in the morning session to bowl India out before reaching a promising 113 for one at a lively scoring rate.
Bumrah’s classy intervention knocked the stuffing from their burgeoning counter-attack and when captain Ben Stokes was beautifully bowled by Ravichandran Ashwin late in the afternoon session the net closed further still.
Play began with India on 421 for seven, adding another 15 before losing their remaining wickets without scoring.
Root snapped up two in two balls, Ravindra Jadeja lbw for 87 and Bumrah castled for a golden duck. Rehan Ahmed provided the finishing touch, zipping one low through Axar Patel and ushering the game along to its decisive moment.
Zak Crawley and Duckett made a typically positive start, zoning out the precarious match situation to clear 45 from the deficit despite considerable scoreboard pressure.
After a couple of polite new-ball overs from Bumrah it was spin at both ends and the initial signs were good.
Crawley sent a couple of reverse sweeps to the boundary boards before trying something even more expansive, moving his feet to the pitch and lifting Patel for six down the ground.
He hurried along to 31 in 33 balls but his fun was shut down in the 10th over, Ashwin clipping the outside edge with a precise delivery that nestled in Rohit Sharma’s hands.
Pope started sketchily, busy but uncertain in his movements, while Duckett was poised. Trusting his arsenal of sweeps and reverses he guided the score to 89 for one at lunch, with the hosts’ lead just into three figures.
England continued chipping away until Bumrah returned to the fray early in the afternoon. He should have had Duckett lbw for 39 but saw his appeal shrugged away by the on-field umpire and his captain, who declined to call for DRS.
Undeterred he came again, shaping the ball through the air, through the gap that Duckett’s lavish drive left and violently into the off stump.
Root was next to succumb, beaten on the crease after just six balls and trapped in front. He sent the decision upstairs but found no reprieve.
Pope was still making the odd mistake but he rode his luck and continued scoring briskly as he brought up his first half-century in India at nearly a run-a-ball.
England still needed a big partnership and were unable to find one as the spinners found their rhythm.
Jonny Bairstow was bowled for 10 offering no stroke to Jadeja, mis-reading one that skidded on with the arm, and Stokes saw Ashwin clip the top of off with a ball that snaked past his outside edge.
The start of the final match in the series had been in doubt after India cancelled a practice session on Thursday as a result of a member of their support staff testing positive for COVID-19.
England had been hopeful of the contest, which was due to begin at 11:00BST on Friday, going ahead as planned.
But after talks between the England and Wales Cricket (ECB) board and their Board of Control for Cricket in India (BCCI) counterparts, the match has been cancelled.
"Following ongoing conversations with the BCCI, the ECB can confirm that the fifth LV= Insurance Test between England and India men due to start today at Emirates Old Trafford, will be cancelled," an ECB statement read.
"Due to fears of a further increase in the number of COVID cases inside the camp, India are regrettably unable to field a team.
"We send our sincere apologies to fans and partners for this news, which we know will cause immense disappointment and inconvenience to many."
The statement initially said India had forfeited the final Test and the series was drawn at 2-2, but that was later removed.
India head coach Ravi Shastri tested positive for coronavirus ahead of last week's 157-run win at The Oval, which gave his side a 2-1 lead in the five-Test series, while bowling coach Bharat Arun, fielding coach R Sridhar and physio Nitin Patel isolated as a precautionary measure.
The overall number of positive cases climbed this week after another backroom staff member, reported to be a junior physio, also contracted the respiratory disease.
The entire India squad returned negative PCR Tests on Thursday, though any hopes of rescheduling the match appear unlikely given the start of the Indian Premier League on September 19, four days after the England series was due to finish.
