Manchester United manager Erik ten Hag was not particularly concerned about the injury suffered by Alejandro Garnacho on Sunday despite him requiring crutches as he left Old Trafford.

Garnacho was introduced in the second half of United's 0-0 draw with Southampton and went down hurt during the latter stages under a challenge from Kyle Walker-Peters.

The Southampton defender won the ball on the stretch in the penalty area, but Garnacho's right ankle appeared to get trapped between Walker-Peters' legs.

Garnacho looked to be in agony but managed to play on until he was withdrawn in stoppage time as Ten Hag sought to bolster 10-man United at the back.

He was subsequently spotted leaving the stadium with the support of crutches.

"He was a little bit limping after the bad tackle," Ten Hag told reporters.

"In the end they brought on another striker, a big and tall one [Paul Onuachu] and I don't want to go for risk, we were already downsized to 10 [men].

"I didn't want to go with players who were [just] 90 per cent [fit]. That's why I called him off, but I think it is not too bad."

United are next in action on Thursday as they go to Seville to face Real Betis in the second leg of their Europa League last-16 tie.

They take a 4-1 aggregate lead to the Benito Villamarin after a comprehensive win at Old Trafford in the first leg.

Reims are flying under head coach Will Still and remain undefeated in Ligue 1 since the Belgian-born Englishman took charge in October.

A goal from Arsenal loanee Folarin Balogun sealed a 1-0 win at Monaco on Sunday, taking Reims into eighth place and closer to European qualification.

Still is only the second boss to remain unbeaten in his first 17 games (W9 D8) in the top-five European leagues in the 21st century, after Tito Vilanova with Barcelona in 2012-13 (18).

The 30-year-old is astonishingly costing the French club €25,000 per game in fines due to not having a UEFA Pro Licence under Ligue 1 rules.

It is clearly worth it, though, with Reims having kept six consecutive clean sheets in the league, establishing their longest run without conceding a goal in their top-flight history. Only Serie A giants Juventus have had a better streak in the top-five European leagues this season (eight between October 2022 and January 2023).

Les Rouges et Blancs have also won three consecutive games in a single top-flight season for the first time since April 1978, while their 10 games unbeaten away from home in Ligue 1 (W2 D8) is their longest since May-December 1959 (13).

Still is not the only Englishman impressing at the club, with Balogun's goal against Monaco taking him to 16 in 26 league games for the season.

Aged 21 years and 252 days, Balogun became the youngest player to score at least 16 goals in his first season in Ligue 1 since Mohammed Salem with Sedan-Torcy in 1960-61.

The England Under-21 international is also the only player to score against each of the top five in Ligue 1 this season, having netted against Paris Saint-Germain, Marseille, Lens, Monaco and Rennes (twice).

Still has the chance to match Vilanova's record when his team host Marseille next Sunday.

Julen Lopetegui claimed Wolves were denied a "very, very clear penalty" by referee Andy Madley in Sunday's 2-1 defeat at Newcastle United.

Wolves were furious in January when they had a late goal disallowed for offside against Liverpool in the FA Cup at Anfield, and they remain convinced that was an injustice.

Madley was also the man in the middle that time, with Wolves denied what would almost certainly have been a winning goal as the game finished 2-2, with Liverpool going on to edge the replay 1-0 at Molineux.

That incident has not been forgotten by Lopetegui, and he was aghast at Wolves being denied a spot-kick early on against Newcastle at St James' Park.

Newcastle goalkeeper Nick Pope took a poor touch and gave away the ball to Wolves striker Raul Jimenez, before seeming to bundle the Mexican to the floor.

Wolves wanted a penalty and a red card but got neither, and Lopetegui said afterwards: "It's true that, for me, it was a very, very clear penalty for us. We are very unlucky with the referee. This is a pity for us.

"It doesn't matter what I think. The more important thing is that this is true that we have suffered a big mistake a lot of matches ago at Liverpool, and for me [Sunday's incident] was a penalty, but the VAR can't help in this case the referee. We were very unlucky with the decision. We didn't have a penalty since I arrived here."

Alexander Isak headed Newcastle ahead in the first half, but Hwang Hee-chan brought Wolves level in the 70th minute.

The visitors sat deep and were punished by a fine finish from Miguel Almiron nine minutes later.

Newcastle head coach Eddie Howe told Sky Sports he felt there would have been no justification in awarding Wolves a penalty for the clash between Pope and Jimenez, which came when the game was goalless.

Howe said: "I didn't think it was a penalty at the time. You might say I was biassed, but I didn't. I thought it was Jimenez going down before the contact was made, that was my initial assessment."

Substitute Almiron delighted Howe with his contribution off the bench, having been a regular starter up to now.

"Not that he necessarily needed to give a response, it was a case of us just trying to freshen him up," Howe said. "It's an outstanding season that he's had, he's contributed in lots of different ways, and you see the work rate he gives every week. He made a massive impact, and I'm delighted for him."

Howe was glad to halt a five-game winless run, with the Magpies jumping above Liverpool into fifth place.

"I just think it reignites us," he said. "Hopefully it re-sparks us into action and restores confidence levels to where they should be."

Leandro Trossard and Casemiro were two of the standout players in Sunday's Premier League action – though for contrasting reasons.

Belgium international Trossard was inspirational as Arsenal's title tilt remained on track, while Casemiro was shown a second red card in three Premier League appearances as Manchester United slipped up again.

Miguel Almiron was Newcastle United's hero, Eddie Howe's men closing on the Champions League places again, and Ollie Watkins continued his fine form for Aston Villa in their draw with West Ham.

After the conclusion of the day's drama, Stats Perform highlights the pick of the Opta numbers.

Manchester United 0-0 Southampton: Another Casemiro red threatens to derail Ten Hag's men

Casemiro has undoubtedly been one of United's best players this season, but if they now miss out on the top four, the Brazil international will have to take part of the blame.

His sending off in the first half on Sunday for a heavy challenge on Carlos Alcaraz proved costly, with United only able to scrape a point thereafter.

That made him the first United player to receive two red cards in one Premier League season since Nemanja Vidic in 2013-14, and just the second to earn a pair of reds in his first campaign for the club after Darren Fletcher (2003-04).

He will now miss their next four matches – at the end of that run, he will have been suspended for eight games this year alone.

While some United fans might have had the perception this was always going to be the risk that came with signing a player like Casemiro, he had never been shown a straight red in his entire senior career before moving to Old Trafford.

Of course, for Southampton, Casemiro's dismissal proved helpful. While they could not get the win they might feel they deserved, Saints managed to keep a third clean sheet in four games under Ruben Selles – that is one more than in their previous 34 league games.

Fulham 0-3 Arsenal: Trossard inspirational as Gunners continue to deal out capital punishment

Arsenal's comprehensive win at Craven Cottage was their fifth successive away London derby win without conceding a goal.

That is a feat no club has managed previously in the Premier League.

Trossard played a vital role with a unique feat of his own, setting up all three of Arsenal's goals, with each one coming in the first half.

Thus, the Belgian became the first player to ever tally a hat-trick of assists in the first half of a Premier League away game.

Trossard's second was a looping cross that found Gabriel Martinelli for a close-range header, the Brazilian nodding in his 23rd top-flight goal for the club.

He is now only one away from surpassing Nicolas Anelka as the foreign player with the most Premier League strikes for the club before turning 22.

That first-half flurry keeps the Gunners on track in the title race, five points clear of Manchester City in second.

West Ham 1-1 Aston Villa: Watkins in a groove

Unai Emery has certainly managed to steady the ship at Aston Villa since replacing Steven Gerrard in the dugout, and the form of Watkins has been among the most notable improvements.

The striker netted again on Sunday, opening the scoring at London Stadium as he headed in from Alex Moreno's cross.

Since the World Cup, only Marcus Rashford (10), Erling Haaland (10) and Harry Kane (eight) have scored more Premier League goals than Watkins (seven).

That includes goals in each of his past four Premier League away games, which is the longest such scoring run by a Villa player since Dwight Yorke between March and May 1998 (also four).

Unfortunately for Villa, West Ham levelled just nine minutes later through Said Benrahma, who was lively throughout.

His penalty continued his 100 per cent record from the spot in English league football, with that his third from three for West Ham having also converted 4/4 at Brentford.

Over the course of the 90 minutes, Benrahma had 10 shots, which is the joint-most on record (since the 2003-04 season) for a West Ham player in a single Premier League game.

He could not single-handedly inspire a turnaround, however.

Newcastle United 2-1 Wolves: Almiron comes up trumps yet again

Almiron has stepped up this season, becoming a key player for Newcastle and a regular source of goals.

A recent dip in form saw him dropped from the starting XI for the visit of Wolves on Sunday, but he responded well.

Eleven minutes after his second-half introduction, he found space in the right side of the box and saw a deflected effort beat Jose Sa following Joe Willock's well-timed pass.

That was his fourth winning goal of the season – the most among Newcastle players – and his 11th goal in total in the Premier League, which is four than his previous four campaigns combined.

Earlier, Hwang Hee-chan had equalised just 57 seconds after coming off the bench, making it the second-fastest substitute goal of the season.

But the day belonged to Almiron as Newcastle ended a five-match winless streak.

Gabriel Jesus has given Mikel Arteta "a great problem" after the Arsenal forward returned from injury with a cameo appearance in Sunday's 3-0 victory at Fulham.

Manager Arteta saw Jesus impress in the opening months of the season as the Gunners began their title challenge, but they have learned to cope without him since the former Manchester City man suffered a knee injury on Brazil duty at the World Cup.

There is still no mistaking Jesus has a role to play in the Premier League run-in, but Arteta, while delighted to have the £45million man back, said the 25-year-old "needs to earn his place".

Arteta brought on Jesus as a 77th-minute substitute at Craven Cottage, in place of Leandro Trossard, whose three first-half assists paved the way for the London derby victory.

"We didn't know whether it was the right game for him today," Arteta said. "A few days ago, he told me he was missing something, and then yesterday he looked me in the eyes and told me he was ready.

"Today we had the opportunity to throw him in because it's that first step to give him the boost. He looked free and generated two big chances straight away, and it's great to have him back.

"Now he needs to earn his place like anyone else in the team. We have alternatives that can play in different positions, and we have different roles to fill in relation to the chemistry of the players and what we ask them to do. It's a great problem to have, believe me.

"I was so happy. He put a lot in the last few months, and all the staff spent so many hours together to try to fulfil all his needs. He wanted more and more and more, and he was very willing to get back. Just to see him there with a smile on his face was just a joy."

Jesus shared that emotion, writing on Twitter that he was "so happy to be back".

Arteta praised his team's "love for defending" after the clean sheet and called it an "outstanding performance", with Arsenal reasserting their five-point advantage over Manchester City, with 11 rounds of games remaining.

Trossard, a January recruit from Brighton and Hove Albion, set up the goals for Gabriel Magalhaes, Gabriel Martinelli and Martin Odegaard.

Arteta commended the Belgian winger, saying: "When we talk about composure and finding the right pass, and looking to the right player in the box, it's very blurry and some other players make rash decisions, and he created three goals.

"He could have scored two – I think he was really impressive. His contribution was superb."

Victory took Arteta to 100 wins as manager of Arsenal, and the former club captain said: "Hopefully there will be many more."

Thomas Muller will be left out of Hansi Flick's upcoming Germany squad, but the head coach has not "shut the door" on the Bayern Munich forward.

Muller is fourth on his nation's all-time caps list (121) behind only Lothar Matthaus (150), Miroslav Klose (137) and Lukas Podolski (130), while his tally of 44 goals puts him seventh.

A World Cup winner in 2014, the 33-year-old said he would contemplate his international future following Germany's group-stage exit from the 2022 tournament in Qatar.

Muller has been directly involved in 11 goals for Bayern this season (scored four, assisted seven), with only Jamal Musiala (eight) registering more assists for the Bundesliga leaders.

However, Flick revealed the forward will play no part in the friendlies against Belgium and Peru later this month, though the head coach has left the door open for a potential return with Germany hosting next year's European Championship.

"I discussed with Thomas that he will not be called up to the games in March and June," Flick told Suddeutsche Zeitung.

"I want to give younger players a chance with the national team. But that doesn't mean that his Germany career is over or that he won't play a role at the Euros.

"He sees things the way I do. As a national team player, you don't retire. You either get a call-up or you don't, and he's now on hold until the summer.

"Why would I shut the door on a player like that forever? Look at his current importance for Bayern. He's totally important again, and I'm very happy for him."

Flick also insists there are no guarantees that Manuel Neuer will remain his first-choice goalkeeper upon his return from injury, with Marc-Andre ter Stegen or Kevin Trapp likely to be handed opportunities in the friendlies.

The Bayern captain, and Germany's most-capped goalkeeper with 117 appearances, is out for the season having broken his leg during a skiing trip shortly after the World Cup.

"The performance concept is in the foreground," Flick added. "There's nothing set in stone — Manu knows that.

"I am convinced that he will reach his performance limit when he becomes 100 per cent fit again."

Erik ten Hag bemoaned a lack of consistency in refereeing decisions after he was left frustrated by the performance of Anthony Taylor in Manchester United's draw with Southampton on Sunday.

United could only scrape a 0-0 draw at Old Trafford after Casemiro was shown a straight red card in the first half – the Brazilian given his marching orders for a tough challenge on Carlos Alcaraz.

Taylor initially showed Casemiro a yellow card, but it was upgraded to a red following a VAR review, leaving the United midfielder clearly despondent after replays showed he won the ball before catching Alcaraz.

It means Casemiro is the first United player to receive two red cards in a single Premier League season since Nemanja Vidic in 2013-14, and he will serve a ban of four matches rather than three due to it being his second dismissal.

The tackle was not too dissimilar to an incident on Saturday when Ricardo Pereira caught Joao Felix with his studs and escaped punishment entirely, and this is the crux of Ten Hag's frustration, having also seen a couple of penalty appeals fall on deaf ears.  

"What I think is the inconsistency; players don't know anymore what is the policy, and I think it's all across [every competition]," Ten Hag told reporters.

"We see it with the Premier League yesterday: Leicester-Chelsea, the VAR is not coming online. Today, it's coming online.

"And then it's two penalty situations, but they don't come online. Especially the first one, it was clear and obvious handball, so what is the policy?"

Ten Hag was asked if he sought that clarification from Taylor afterwards, though he was seemingly dissatisfied with the outcome.

"Of course, we talk but not a lot, so some questions we [still] have," he continued.

"There's another one: inconsistent. The referee is coming in the start of the season with a policy; we are [in the] Premier League, it's coming strong here, we want intensity [in the play]."

Ten Hag also feels the slow-motion and freeze-frame nature of VAR reviews does not help because he believes it makes everything look worse than in reality.

"Everyone who knows something about football, and of course, when you freeze it, it looks bad," Ten Hag said. "But everyone who knows something about football, who was acting on top football, they know what is bad, what isn't bad and what is fair.

"And I tell you: Casemiro is a really fair player. Tough but fair.

"Casemiro is across European games, over 500 games he never had a [straight] red card. Now he has two.

"Think about that. He plays tough, but he plays fair. And also in this, he's playing fair, same as against Crystal Palace, so it's very debatable.

"And if they isolate one [incident] – it's a little bit the same as against Crystal Palace, definitely.

"When you saw that incident, you should have sent off three or four players and not only one [Casemiro], if you're really consistent."

Real Madrid are ready to appear at any trial that stems from the complaint filed by Spanish prosecutors against Barcelona.

Last month, broadcaster SER Catalunya alleged Barca had paid €1.4million to the company of Jose Maria Enriquez Negreira – the former vice-president of Spain's Technical Committee of Referees (CTA) – between 2016 and 2018.

Newspaper El Pais claimed Negreira's company – DASNIL 95 SL – produced written reports and DVD assessments of referees prior to games.

The public prosecutor's office said on Friday that Spanish prosecutors had filed a complaint against Barca and two of their ex-presidents, Josep Maria Bartomeu and Sandro Rosell, over the alleged payments. It has been claimed the total payments exceeded €7m, dating back to 2001.

The saga may end up being resolved in court, although that is not certain at this stage. Madrid's board met on Sunday and expressed their "utmost concern regarding the gravity of the facts".

A Real Madrid statement read: "In their meeting held today, the Real Madrid CF board of directors have inspected the serious accusations brought by the Barcelona prosecution service against FC Barcelona, two of its former presidents, Josep Maria Bartomeu and Sandro Rosell, and executives Albert Soler and Oscar Grau, on the basis of alleged offences of corruption in sports, among others, all related to the relationship the club maintained with the former vice-president of the CTA, Jose Maria Enriquez Negreira.

"Real Madrid wishes to express its utmost concern regarding the gravity of the facts and reiterates its confidence in the legal system. The club has agreed that, in defence of its legitimate rights, it will appear at the trial when the judge opens it up to the affected parties."

Barcelona's current president Joan Laporta used Twitter on Sunday to attempt to reassure fans, writing: "Culers [Barca fans], you can be calm. Barca is innocent of the accusations made against it and is the victim of a campaign, that now involves everyone, to harm its honourability.

"It is no surprise, and we will defend Barca and prove that the club is innocent. Many will be forced to rectify."

Stefano Pioli wants Rafael Leao to lead a Milan resurgence as he warned his team their Champions League run must not come at the expense of a top-four finish.

The Milan head coach said Zlatan Ibrahimovic is not yet ready to start games after making two substitute appearances since returning from major knee surgery.

They cannot therefore look to the inspirational Swedish veteran, but in 23-year-old Portuguese winger Leao they have a proven match-winner and last season's Serie A MVP.

Beaten by Fiorentina in the last round of games, Milan host Salernitana on Monday, and victory would vault them back into the top four.

The Rossoneri were on a high after booking a Champions League quarter-final spot on Wednesday, edging through at Tottenham's expense.

Now Pioli wants them to book another adventure in that competition with a strong finish to their domestic campaign.

"We are aware that we have to focus on the league with attention and determination," Pioli said. "To repeat the feelings we are experiencing in the Champions League, we need to finish in the top four in Serie A, and we are focused on achieving this.

"We need to find the consistency that we have lacked so far. The team is doing well physically, mentally and also tactically. We can still improve a lot and performances like the one in London help us to grow."

Milan drew 0-0 with Tottenham to win through 1-0 on aggregate, and they will learn their next Champions League opponents in Friday's draw.

"Tomorrow we have to be the best Milan possible because it's an important match," Pioli said. "As a team, we must and can improve in our choices.

"Ibra will not start against Salernitana. He is improving his fitness and will be ready to help us.

"Leao is giving us a lot, and he played well in the last few games. We have to serve him better. Rafa is the player with the most freedom of movement, and he has to look for spaces to harm the opponent's defence."

Leao had 11 goals and eight assists in Serie A last term, and he has eight goals and six assists this time around, with ample time to top his 2021-22 totals.

Pioli, quoted on Milan's website, said his Serie A champions of last season need to collectively find some of that Scudetto-winning spark again.

"Compared to last season, we are doing better in Europe, not so much in the league," he said. "The goal is to finish in the Champions League places, and every game will be crucial from now on, because there are fewer and fewer to go.

"Before the quarter-finals, we have four matches – difficult and important ones – to play in Serie A; we cannot look beyond that."

David de Gea appealed for "more consistency" from referees after Manchester United had Casemiro sent off in their 0-0 draw with Southampton.

United failed to get back to winning ways in the Premier League following their 7-0 thrashing by Liverpool last week.

They spent much of a home game with the division's bottom club on the back foot, especially after Casemiro became the first United player to receive two red cards in the same league season since Nemanja Vidic in 2013-14.

Casemiro was initially booked by Anthony Taylor for his challenge on Carlos Alcaraz, but the referee was instructed by VAR to consult the pitch-side monitor.

Having looked at replays that showed Casemiro going over the top of the ball and sending his studs high into Alcaraz's leg, Taylor changed his decision and showed the Brazil midfielder a red.

United claimed a point despite Southampton attempting 17 shots, with De Gea called into action to preserve their clean sheet on several occasions.

Speaking to Sky Sports, De Gea said: "It should be a game to win today, but the game changed when we lost a man in the team.

"We tried our best to score, but it was difficult. They had some chances, but in the end we showed good team spirit. We have to take the point and keep going.

"I think Casemiro was unlucky. He tried to touch the ball and his foot came up high. I think the referees need to show more consistency. Sometimes they show a red card, and sometimes they don't."

Casemiro is now set to miss the next four domestic games for United. He will be unavailable for the FA Cup quarter-final with Fulham as well as Premier League clashes with Newcastle United, Brentford and Everton.

"It's going to be tough, he's a big player," De Gea said. "We will miss him for four games, but we have a big squad. We have players coming from the bench who do well. We will keep working hard."

Martin Odegaard declared Gabriel Jesus' long-awaited return from injury was "a massive boost" for Arsenal following their 3-0 win over Fulham.

The Premier League leaders took a step closer to the title, regaining their five-point lead at the top thanks to first-half goals from Gabriel Magalhaes, Gabriel Martinelli and Odegaard at Craven Cottage.

Mikel Arteta also welcomed Jesus back for his first Arsenal appearance since the win at Wolves in November, the Brazil international appearing as a late substitute for the impressive Leandro Trossard, who chalked up three assists.

Captain Odegaard was delighted to see his team-mate back in action, but insists the Gunners are not getting carried away despite moving within 10 wins of Premier League glory.

"It's a massive boost," he told Sky Sports about Jesus' return. "He's been out for a while now.

"We know what he’ll give to the team and we are excited to have him back."

Odegaard added: "We did really well from the start. We controlled the game and scored some good goals in the first half. The second half was a bit different, but very good.

"[We have the] same focus. We've said all season we’ll take it game by game. We'll do the same things, keep working hard and see where it takes us."

Odegaard also praised the performance of January arrival Trossard, after the former Brighton and Hove Albion man became the first player in Premier League history to register a hat-trick of first-half assists away from home.

"He has brought some amazing things to the team," Odegaard said. 

"I love playing with him. He's good to find the right pass and we're really happy to have him on the team."

Trossard himself could find few faults with the performance.

He said: "When we win, we're always happy. We knew it would be a tough game. We did really well and kept a clean sheet as well.

"[It was] a perfect win for us. I'm really happy with it [the hat-trick of assists], I always try to contribute and today it went my way. I'm just really happy we won, now there are 11 finals to go for us."

Arsenal became the first side in the history of English league football to win five successive away London derbies without conceding a single goal, while Arteta chalked up his 100th win in charge of the Gunners.

"I'm really happy to win and get three points away from home, especially with a clean sheet," the Spaniard said. 

"It's great to see the goals distributed through the team. Leandro laid on three assists and could also have scored too.

"Every time we put the ball in the net, it's great. We practice lots of things and we scored beautiful goals."

Lois Openda scored a hat-trick in Lens' 4-0 win at Clermont on Sunday in just four minutes and 30 seconds, the fastest in Ligue 1 since 1967.

The 23-year-old grabbed his first goal in the 30th minute at the Stade Gabriel Montpied after racing onto a lofted pass from the left from Angelo Fulgini before putting the ball through the legs of Clermont goalkeeper Mory Diaw.

In the 34th minute he took advantage of a defensive error from the hosts as he finished off a neat square pass from Adrien Thomasson, before completing his hat-trick just 66 seconds later when Mateusz Wieteska underhit a backpass, allowing Openda to round Diaw and finish.

The Belgian striker also managed to add an assist in the second half as he pulled the ball back from the right for substitute Alexis Claude-Maurice to make it 4-0 to the visitors.

Openda's treble was just the second this century to be achieved in under five minutes, beating Matt Moussilou's for Lille against Istres in April 2005 by four seconds.

According to Opta, he is only the third Ligue 1 player to score a hat-trick inside five minutes in the last 75 years, along with Moussilou and Michel Margottin for Angers against Rouen in February 1967. The exact hat-trick time for Margottin in that match 56 years ago was not recorded.

Only Manchester City's Erling Haaland has scored more hat-tricks this season in the top five European leagues (four) than Openda, whose treble against Clermont was his second of the season after also hitting three goals against Toulouse in October.

Manchester United failed to bounce back from their historic defeat to Liverpool as Casemiro was sent off in a 0-0 draw with Premier League strugglers Southampton.

United suffered the largest loss in the history of their great rivalry with Liverpool last Sunday, going down 7-0 on Merseyside.

Seven days on, Erik ten Hag's men were again disappointing, and Casemiro's red card for a bad foul on Carlos Alcaraz allowed the relegation-threatened visitors to dominate.

Southampton failed to take their chances, however, left to settle for a well-earned point that keeps them bottom of the table but only two points adrift of safety.

United initially looked in the mood to set things right after their Anfield humbling and Marcus Rashford was denied by Gavin Bazunu after a fine give and go with Bruno Fernandes. 

But Fernandes would spend much of the rest of the first half aiming protestations at referee Anthony Taylor as United struggled to exert control on the game.

They were grateful to David de Gea for turning over Theo Walcott's close-range header but then had to face up to playing with 10 men as Casemiro was shown a straight red after Taylor went to the VAR monitor following a high challenge on Alcaraz.

Raphael Varane nearly bundled home at the far post from a Fernandes free-kick soon after, with United subsequently seeing two penalty appeals correctly waved away at the end of a frustrating 45 minutes for the hosts.

Southampton twice went agonisingly close to capitalising on their one-player advantage after the restart.

Aaron Wan-Bissaka was forced to clear off the line after Scott McTominay deflected a Kyle Walker-Peters cross towards goal. James Ward-Prowse then clipped the top of the crossbar as he narrowly missed out matching David Beckham's Premier League record for goals from free-kicks.

Walcott was again thwarted by De Gea after going through one on one with the United goalkeeper on the counter, before Bazunu produced heroics at the other end to turn Fernandes' curling effort against the inside of the post.

Walker-Peters saw a swerving effort clatter the left-hand post with De Gea well beaten, with fortune favouring a United side that is now 16 points adrift of leaders Arsenal.

Leandro Trossard played a starring role as Premier League leaders Arsenal restored their five-point lead at the summit with a 3-0 victory over Fulham.

The Belgium international claimed a hat-trick of assists at Craven Cottage, with Gabriel Magalhaes, Gabriel Martinelli and Martin Odegaard all profiting.

Mikel Arteta's side subsequently became the first side in the history of English league football to win five successive away London derbies without conceding a single goal.

Arsenal, who welcomed Gabriel Jesus back from injury, also made it five straight Premier League victories in all as they took another step towards the title.

The Gunners thought they had taken the lead when Antonee Robinson put through his own net in the 16th minute, but the VAR ruled Martinelli had strayed offside before Bernd Leno parried his shot against the Fulham defender. 

However, Arsenal broke through five minutes later as Gabriel, who scored the winner in the reverse fixture in August, climbed to head in Trossard's corner.  

Trossard was the provider again when his cross was nodded in by Martinelli at the far post after 26 minutes, while Odegaard tucked away another precise centre from the former Brighton and Hove Albion man in first-half stoppage time.

Fulham were far more positive after the break. Bobby De Cordova-Reid drew a smart reflex save from Aaron Ramsdale, while Aleksandar Mitrovic's header hit the crossbar.

But Arsenal stood firm to deny their opponents a potential route back into the contest and went close to increasing their margin of victory through Odegaard and the returning Jesus.

Paul Pogba was not included in Juventus' squad for Sunday's Serie A meeting with Sampdoria in another setback for the midfielder.

The France international has had a torrid time of things since returning to Juve from Manchester United last July, appearing for just 34 minutes across two substitute appearances.

Pogba appeared to have put his injury issues behind him when featuring in back-to-back games against Torino and Roma, but he was dropped for Thursday's match with Freiburg.

That was down to Pogba turning up late for a team meeting ahead of the Europa League tie, but Massimiliano Allegri said on Saturday he would be involved against Sampdoria.

However, the 29-year-old was not included on the 21-man squad list published by Juve on Sunday, with reports suggesting he sustained another muscular injury in training.

Angel Di Maria, Federico Chiesa, Alex Sandro, Arkadiusz Milik and the suspended Moise Kean were the other notable absentees from the Bianconeri squad.

Allegri said on the eve of the game that goalkeeper Mattia Perin and forward Dusan Vlahovic would both start against Sampdoria at the Allianz Stadium.

Juve's loss to Roma last time out ended a four-game winning run in the Italian top flight, but a home match against bottom side Samp provided a chance to respond.

The Bianconeri had won their past seven home league meetings against Sampdoria, who went into Sunday's game with just two wins in 25 Serie A matches this season.