The international break might bring respite from the packed club calendar, but with Qatar 2022 now just 20 months away, top players have little chance for rest.
Still, the start of the European World Cup qualifiers brings an opportunity for the new names on the international scene to impress, particularly with more established stars unlikely to be involved in every minute of matches over these two weeks.
Several of the continent's top teams have offered first-time call-ups to those enjoying fine form and, while some were anticipated, others have left even the players themselves surprised.
We have picked through a selection of the new faces to look out for, with a sprinkling of Opta data to highlight why they deserve a chance to impress for their country.
Belgium: Orel Mangala and Albert Sambi Lokonga
Stuttgart's Orel Mangala has been linked with Arsenal and RB Leipzig due to his performances for Stuttgart this season. Only three midfielders have regained possession more often in the Bundesliga than the 23-year-old (166).
Also hoping to make his senior Belgium debut at the heart of midfield is Albert Sambi Lokonga, who assumed the captain's armband at Anderlecht less than a month after turning 21.
Lokonga, who could get a chance in place of the injured Axel Witsel, has regained possession 35 more times than any team-mate this season (157) and is also fourth for chances created (22).
Croatia: Kristijan Lovric
With Ante Rebic and Bruno Petkovic injured, the coming matches could offer a real chance to impress for Kristijan Lovric.
The HNK Gorica star is second in the top scorer standings in Croatia's top flight, with 15 goals in 24 appearances. With four assists also to his name, Lovric is behind only Tottenham's Europa League slayer Mislav Orsic and Ramon Mierez (both on 20) for direct goal involvements this season.
It's a seriously impressive return for the 25-year-old, particularly as he plays predominantly wide on the left of the Gorica attack.
England: Ollie Watkins
West Brom goalkeeper Sam Johnstone may get the chance to win a first senior England cap, but a man almost certain to be given a chance in attack is Ollie Watkins.
The Aston Villa forward became the 10th Premier League player to score a hat-trick against Liverpool, and the first in a decade, in October's extraordinary 7-2 win over the reigning champions.
He has 10 in the top flight this term, while only captain Jack Grealish (17) has had more direct goal involvements than Watkins (15) in all competitions for Villa this season. Not bad for a man who was playing in England's sixth tier just six years ago.
Germany: Florian Wirtz and Jamal Musiala
Rising Bayern Munich star Jamal Musiala was expected to be named in Joachim Low's squad after he pledged his international future to Germany rather than England.
The 18-year-old, who only signed his first professional contract this month, is Bayern's youngest ever Champions League goalscorer and has already played 18 times in the Bundesliga this season.
Bayer Leverkusen's Florian Wirtz has also earned the right to shine on the senior stage. He is one of just two players under the age of 20 to be directly involved in at least eight goals across the top-five European leagues this season.
Italy: Rafael Toloi and Matteo Ricci
Brazilian-born Rafael Toloi has made it to the age of 30 without a senior international appearance, but his performances for Gian Piero Gasperini's outstanding Atalanta side made him hard to overlook.
Toloi averages seven possession regains per match for Atalanta this season and is comfortable when using the ball, completing 493 passes in the opposition half, the most of any Atalanta defender barring Berat Djimsiti.
Spezia midfielder Matteo Ricci, meanwhile, boasts 19 chances created in Serie A this season as well as 151 times winning back the ball, by far the highest tally for his team.
Netherlands: Jeremiah St Juste
Jeremiah St Juste has impressed at the back for Mainz this season, despite their involvement in a tense battle to avoid the drop.
There are only five Bundesliga defenders to win more tackles and duels combined than the 24-year-old this season (he has managed 165).
Previously a full-back with Feyenoord, St Juste brings a vital commodity to modern central defending: speed. Last season, he clocked a sprint of 22.1 miles per hour, bettered only at the time by Bayern winger Kingsley Coman.
Poland: Kacper Kozlowski
A relative unknown outside Poland, even Kacper Kozlowski himself was shocked to be called up to Paulo Sousa's squad this month.
Clearly, though, he has caught the eye for some all-action displays in the top flight for Pogon Szczecin. The 17-year-old averages 8.3 duels won and 17 passes ending in the final third per 90 minutes, each the most of any teenage midfielder in the competition.
Kozlowski, who is also renowned for a fierce long-range shot, has been linked with some of the world's biggest clubs since making his senior debut at just 15, with Manchester United said to be among them.
Portugal: Joao Palhinha and Nuno Mendes
Linked with Manchester City (among others), Sporting CP full-back Nuno Mendes has been described as the standout young talent in Portugal's top flight.
Only Wilson Manafa (49) has completed more dribbles among defenders this season than Mendes (29), who has played in all but four of the unbeaten leaders' league matches.
The 18-year-old is joined in the Portugal squad by team-mate Joao Palhinha, a robust midfielder who has won 208 duels in the Primeira Liga in 2020-21 – no player in his position has won more.
Spain: Bryan Gil and Pedri
Pedri has been a revelation for Barcelona in his first season at Camp Nou, establishing himself as a key part of Ronald Koeman's midfield despite only turning 18 last November.
He has played 42 times already in 2020-21, the most of anyone at the club, and became the youngest player to record 100 touches in a single LaLiga game for at least 15 years against Osasuna this month.
Bryan Gil, meanwhile, has been thriving on loan at Eibar from Sevilla and in January became the second player born this century to score twice in the same LaLiga match, following in the footsteps of Ansu Fati.
Howe taking plenty of positives despite frustrating Newcastle campaign
Eddie Howe was keen to look at the positives after Newcastle United secured seventh place in the Premier League on Sunday.
Alexander Isak and Bruno Guimaraes were among the goalscorers as Newcastle won 4-2 at Brentford to finish their Premier League campaign.
The victory ensured a seventh-place finish, and a Manchester City victory over Manchester United in next Saturday's FA Cup final will confirm Newcastle's place in next season's Europa Conference League.
While this season did not quite live up to the heroics of last term, which saw the Magpies finish in the Champions League spots, Howe still feels it has been a successful campaign.
"It summed up our season," Howe told BBC Sport. "We weren't totally secure at the back, but great credit to the players. They've done their job - now we wait and see.
"We anticipated after losing against Manchester United that our control of the [European] situation had gone. It's never a nice situation, but whatever happens, happens.
"We have issues to solve defensively. If we can do that, next season could be another season of really strong performances. This was a season that could have been better, but a good season overall.
"We're a really united club. I think we're still moving forward, so there's a lot to be positive about."
Postecoglou will not settle until Tottenham hit his 'lofty ambitions'
Ange Postecoglou warned Tottenham he will not settle until the club hits the "lofty ambitions" targeted in his mind.
Spurs were 3-0 victors over Sheffield United at Bramall Lane on Sunday, ending their Premier League season with a convincing win to finish fifth in the table.
Postecoglou voiced his frustrations after Tuesday's 2-0 defeat to Manchester City ended their hopes of Champions League football next term.
The Spurs head coach was far more relaxed after his side performed well in Sheffield, with Dejan Kulusevski twice on target, along with a goal for Pedro Porro against the relegated Blades.
Yet Postecoglou insisted his ambitions remain high as the Australian attempts to take Tottenham to the next level.
"Contrary to my general demeanour, I have loved every minute of it," former Celtic boss Postecoglou said of his first season in charge of Tottenham.
"It is a great challenge in the Premier League and taking over a big club that didn't have a great year last year. You understand it is not going to run smoothly, but I have enjoyed the whole season.
"I have got some lofty ambitions for the football club and until we reach that point I am not going to be smiling too much.
"As I said, all any manager wants is maximum effort and I have got that from everyone involved. I have enjoyed it and looking forward to pushing on from here."
Asked to summarise his first campaign in England's top league, Postecoglou continued: "It's been good, it's been eventful, it's had a bit of everything.
"I am obviously not delighted with the way we finished the season but in fairness to the players and staff we have been in the top five all season, in a year where there was a fair bit of upheaval.
"We finished eighth last year, player turnover, different football, different way of training, it is not easy to maintain a level when you are trying to do that.
"Even in our tough periods this year we have still been competitive for the most part."
Kulusevski scored his seventh and eighth Premier League goals of the season (36 outings), more than he managed in his first two league campaigns with Tottenham combined (seven across 48 games).
Only in the 2019-20 season with Parma has the Sweden winger scored more times in a league season (10 in Serie A), and Postecoglou hailed Kulusevski's returns.
He added: "I thought Deki was good. He's worked awfully hard this year without a lot of reward in the front third.
"We thought playing him through middle today would help us with his mobility and ability to run in behind. He did well.
"He always works hard but it's that sort of final third where we need him to get rewards and he got them today so he did well."
Walker: Man City driven on by creating history
Kyle Walker believes Manchester City were spurred on by creating history to a fourth straight Premier League title.
A Phil Foden double and a Rodri strike saw City beat West Ham 3-1 on Sunday as they claimed a fourth consecutive Premier League crown, finishing two points above Arsenal.
In doing so, City became the first team ever to win England's top division four times in a row, and Walker feels that was one of the key motivations behind the team finishing top of the Premier League pile yet again.
When asked if creating history had driven him and his team-mates on, Walker told Sky Sports: "I think so, I think so. We went out of the Champions League, got into the FA Cup final, but to do this, make it four in a row, it made it something special.
"It has been spoken about all year what we can achieve and the history we can make. But it is about the finer details. It was down to just one game and that game was West Ham United. We get past that then we make history, but more importantly we claim the Premier League again.
"It is a very, very tough league to win. I looked at the Italian league, German league, Spanish league, the winners are 10, 15 points clear. Fair play to Arsenal and Liverpool for what they have done throughout the season, making sure they push us right to the limit."
Walker turns 34 later this month but has shown little signs of slowing down, playing an integral role again this season on his way to a sixth Premier League title of his decorated career.
Walker still feels he is capable of playing at the top level, saying: "I feel young. I don't know if that is a good thing or a bad thing. I feel young, I feel great, I still have my pace.
"I come to training every day wanting to learn. Once that goes then it is probably time to pack up, but this group of lads keeps you on your toes. They keep on you to keep improving every day."
Walker has been City's captain this season, making his 300th appearance for the club in the title-securing win over West Ham.
The defender was keen to emphasise that it has been a collective effort this term, though, explaining: "I am the man at the front and I wear the armband, but I don't put myself above anyone else. We are a team.
"There are four captains including myself, and we all pull our weight. I am just the man they've picked to wear the armband which I am very grateful for. To be able to lift the trophy in this scenario, the four in a row, it is a dream come true."
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