Adrian Mannarino won the second ATP Tour title of his career when he defeated Laslo Djere 7-6 (7-1) 6-4 in the final of the Winston-Salem Open on Saturday.

Mannarino, 34, entered the match with a 1-9 record from his 10 career final appearances, but capped off his incredible week with his fifth consecutive straight-sets win.

On his way to the decider, Mannarino eliminated ninth seed Emil Ruusuvuori, eighth seed Albert Ramos-Vinolas, fourth seed Maxime Cressy and second seed Botic van de Zandschulp.

Against Djere, Mannarino stuck to what he had done all week, which was limiting his own errors and taking advantage of his opponent's mistakes.

The Frenchman committed 12 less unforced errors (29-to-17), while also controlling the game with his serve, winning 78 per cent (49-of-63) of his service points compared to 63 per cent (45-of-71) for Djere.

It was actually the Serbian who secured the first break of the match, but it would also be his last break of the match as Mannarino tightened the screws, not allowing a single break point opportunity in the second set.

With the win, and the 250 ranking points, Mannarino will rise 20 places up to 45th in the world.

Botic van de Zandschulp is the only seeded player remaining at the Winston-Salem Open, advancing to the semi-final after winning a pair of tiebreakers against Benjamin Bonzi 7-6 (8-6) 7-6 (7-1).

Van de Zandschulp, the second seed, is yet to lose a set in the tournament after straight sets wins against Tallon Griekspoor and Jaume Munar, and he used his dominant serve to get the job done against France's Bonzi.

The Dutchman had 15 aces while Bonzi had three, and he posted 50 winners to Bonzi's 24 in a terrific exhibition of power tennis.

Van de Zandschulp, 26, will face Adrian Mannarino in the semi-final as the 34-year-old seeks his second career ATP Tour title, beating Maxime Cressy 6-4 7-6 (7-3).

Fourth seed Cressy was Mannarino's third consecutive seeded scalp, having also defeated ninth seed Emil Ruusuvuori and eighth seed Albert Ramos-Vinolas to make it this far.

Cressy's 10 double faults and 26 unforced errors shot himself in the foot, as the veteran Mannarino played a clean match, posting two double faults and eight unforced errors.

Serbia's Laslo Djere has taken the scenic route to the semi-final, winning his fourth three-set match of the week as he edged past Richard Gasquet 6-4 3-6 7-6 (8-6) in two hours and 43 minutes.

It comes after a three-hour-11-minute marathon against Jason Kubler in the previous round, and a two-hour-50-minute war of attrition against Joao Sousa prior to that.

Djere will hope to have some more gas in the tank when he meets Switzerland's Marc-Andrea Huesler in the semi-final after he upset 13th seed Jack Draper 6-4 6-4.

Dominic Thiem's run at the Winston-Salem Open came to a halt as Jack Draper claimed a comfortable straight sets victory on Wednesday.

In the first meeting between Draper and Thiem, it was the 20-year-old Brit who sealed his place in the last eight with a routine 6-1 6-4 victory.

Draper charged ahead in the first set, creating five chances to break and taking two of them, while his sole successfully converted break point in the second set paved the way for the Winston-Salem debutant to serve out the match.

World number 55 Draper has now reached three Tour-level quarter-finals this season, while 2020 US Open champion Thiem had been on a run of making it to the last eight in his last three tournaments, in Bastad, Gstaad (where he made the semis) and Kitzbuhel.

Draper did not offer up a single break opportunity, and said: "I was really good behind serve, really solid. In the second set it was tough because he was coming up with some amazing shots. It was a real honour to be on court with Dominic. He's an amazing player.

"I started confidently, I started well. I was hitting through the ball, felt good in the conditions. It was a difficult start because I felt like everyone was supporting Dominic and I knew that I needed to come out confidently and sharp, and that's what I did."

Draper will meet Marc-Andrea Huesler in the quarter-finals, after the world number 102 overcame Ilya Ivashka.

Botic van de Zandschulp is the favourite after Grigor Dimitrov's retirement due to illness with the Dutchman progressing to the last eight by defeating Spain's Jaume Munar in straight sets. He will face Benjamin Bonzi after the Frenchman's 7-5 6-2 defeat of Thiago Monteiro.

Maxime Cressy will face Adrian Mannarino after coming from a set down to beat Lorenzo Sonego 6-7 (4-7) 6-2 7-6 (7-3), while Richard Gasquet and Laslo Djere make up the other quarter-final tie after respective victories over Steve Johnson and Jason Kubler.

Top overall seed at the Winston Salem Open, Grigor Dimitrov, won the first set of his opening match against Dominic Thiem 6-0 before being forced to retire due to illness symptoms while trailing 4-2 in the second.

The first set was total domination from the Bulgarian, winning 80 per cent (12-of-15) of the points against Thiem's serve as he breezed through the opening frame in 25 minutes, but after experiencing dizziness and shortness of breath in the second set, he decided to pull the plug on his match after a visit from the doctor.

Thiem will play England's Jack Draper in the next round after he was too strong down the stretch for Italy's Fabio Fognini, winning 6-2 4-6 6-1.

Meanwhile, it was relatively smoother sailing for second second Botic van de Zandschulp in his all-Dutch matchup against Tallon Griekspoor, converting both of his two break point opportunities to win 7-6 (7-5) 6-3.

Earlier in the day, in-form Belarusian and 11th seed Ilya Ivashka used his powerful serve to overwhelm Germany's Peter Gojowczyk 6-4 6-2. 

Ivashka will meet Switzerland's Marc-Andrea Huesler next after the world number 102 passed a stiff test against Sweden's Mikael Ymer, with his 6-4 6-4 win likely elevating him into the top-100 when the next rankings are released.

Richard Gasquet at 36 years young upset 20-year-old Italian Lorenzo Musetti 7-6 (7-5) 4-6 6-1, and he will play Steve Johnson next after the big American defeated Spain's Pedro Martinez 7-6 (7-2) 6-2.

Serbia's Laslo Djere needed almost three hours to get the better of Portugal's Joao Sousa 4-6 6-3 7-6 (7-5), and Djere will play Australia's Jason Kubler after he handled South Korea's Kwon Soon-woo 7-5 6-2.

The other two Aussies in action were less successful, as John Millman fell 6-4 6-4 to Spain's Albert Ramos-Vinolas, and James Duckworth went down 6-3 6-3 against Maxime Cressy.

Finland's rising star Emil Ruusuvuori was disappointing in his 6-4 6-1 loss to France's Adrian Mannarino, and fellow Frenchman Benjamin Bonzi also got the job done against England's Kyle Edmund 6-4 7-6 (7-5).

In the late session, 15th seed Jaume Munar defeated Tseng Chun-hsin 6-3 6-4, and in the last match of the night, Lorenzo Sonego beat Alejandro Tabilo 7-5 6-1.

Dominic Thiem defeated J.J. Wolf to set up a showdown with top seed Grigor Dimitrov in the second round of the Winston-Salem Open.

Thiem showed signs of returning to his best with runs to the last eight or better in three tournaments in July, but the 2020 US Open winner was in danger of falling at the first hurdle in North Carolina when he lost the first set against the American wildcard.

But Thiem, a debutant in the competition, bounced back, and after a long rain delay he prevailed 6-7 (5-7) 7-5 7-6 (8-6), and he will now face Dimitrov, who is seeking a first trophy since 2017.

The Austrian had to save two match points during a last-set tie-break, and said afterwards: "First of all I'm super happy to get that win, [my] first win on hard courts since a very long time, since March 2021, I guess.

"It was not easy at all today with the rain delay, coming back out there at 11:15 p.m. It was very late. I had trouble [getting] into the match again.

"But luckily I raised the level a little bit in the third-set tie-break and compared to Kitzbuhel, where similar stuff happened with the rain, the luck was on my side today."

Second seed Botic van de Zandschulp also learned of his last-32 opponent on Monday, with Tallon Griekspoor beating fellow lucky loser Taro Daniel 7-6 (7-3) 6-3.

Last year's beaten finalist Mikael Ymer ensured a safe passage through, meanwhile, thanks to a 6-2 6-3 victory against Federico Coria.

Australia's James Duckworth also advanced with a 4-6 6-3 7-5 (7-5) comeback win over compatriot Thanasi Kokkinakis, while Kyle Edmund saw off Michail Pervolarakis 6-2 7-5.

Sixth seed Nikoloz Basilashvili was a big-name exit, as he went down to Thiago Monteiro.

Andy Murray was left in "the strangest situation" he has experienced before a tour match at the Winston-Salem Open following Nick Kyrgios' withdrawal.

Murray had been due to face Kyrgios in an enticing first-round clash in North Carolina, only for the Australian to pull out due to a knee issue.

Former world number one Murray was then drawn against a lucky loser from qualifying, which had only been completed shortly before Murray was due to go on court on Sunday.

The tight turnaround prompted Pierre-Hugues Herbert and Max Purcell to decline the chance to take on Murray, while another option, Yosuke Watanuki, ended up with a direct path to the main draw.

Home hope Noah Rubin, who played his college tennis at the same venue having competed for Wake Forest University, stepped in shortly after his qualifying defeat to Lucas Pouille.

Despite Rubin's best efforts, the challenge proved too much for him as Murray swept to a 6-2 6-0 win, capping a bizarre evening for the three-time grand slam champion.

"It is, by far, the strangest situation I've ever been in before a match on tour," said Murray. "It's pretty rare that you experience something new when you're 17 years into your career.

"I sort of knew at 6:15 that Nick wasn't going to play, but the qualifying was still going on. I was told that if I played a lucky loser, I would play this evening, but if I played against a qualifier the match would be suspended until tomorrow [Monday].

"Then I was told that I drew a lucky loser and I was going to be playing this evening against Pierre-Hugues Herbert, that was like 15-20 minutes after the last qualifying match finished, then Herbert decided he didn't want to play.

"Then they went down the list and none of them, Purcell and Watanuki, they didn't want to play either. And Rubin, who had obviously just finished playing 20 minutes beforehand said, 'yeah I'll do it. I'll play'.

"I kind of had like three opponents in the space of 45 minutes, I was warming up for the match to start at seven and then stopped and then prepared to play Herbert then he didn't want to play then Noah obviously decided but he'd just finished so it was a break and it was just very, very odd sort of 45 minutes, an hour before we went on."

Murray is due to face 13th seed Frances Tiafoe in the second round.