Bayer Leverkusen twice took the lead but conceded a 90th-minute equaliser to draw 2-2 at Werder Bremen.

Victor Boniface, playing with a bandaged hand, flicked in a Jeremie Frimpong cutback in the 30th minute to put the champions in the driving seat.

He had missed Wednesday's Champions League 1-1 draw at Brest after suffering minor hand and foot injuries as a passenger in a car crash on Sunday, a day after he had scored the winner in Leverkusen's victory over Eintracht Frankfurt.

Boniface, who has now scored six league goals this season, had a chance to add another on the hour but Bremen goalkeeper Michael Zetterer pulled off a stunning save.

Instead, it was Bremen who scored with Marvin Duksch's powerful header in the 74th to level. Their joy only lasted three minutes, though, as Felix Agu, under pressure, spectacularly miskicked for an own goal.

Bremen, however, came back again, and Romano Schmid fired in a 90th-minute equaliser to snatch a point.

Leverkusen are third on 15 points, two behind second-placed Bayern Munich, who are in action on Sunday. 

Data Debrief: Ducksch comes up trumps

Duksch accumulated the second-highest expected goals (xG) total in the game (0.65) and took the most shots in the match (seven).

That tally of shots is the most by a Bremen player in a Bundesliga match this term.

Lukas Hradecky, meanwhile, was making his 200th Bundesliga appearance for Leverkusen, becoming the first non-German player to hit that milestone for the club.

Despite Bremen's late equaliser, they have now won just one of their last 15 competitive matches against Leverkusen.

Paulo Fonseca viewed Milan's display in their Champions League defeat to Bayer Leverkusen as their best performance of the season.

Milan went down 1-0 at BayArena on Tuesday, meaning they have now lost both of their matches so far in the new-look competition.

The seven-time European champions are now winless across their last six matches against German opposition in major competitions (D4 L2) since a 2-0 victory over Bayern Munich in April 2007.

Milan came on strong after Victor Boniface's goal early in the second half, though prior to that had been by far second best, mustering only one shot and 0.04 expected goals (xG) in the opening 45 minutes.

They hit the woodwork in the second half while Lukas Hradecky made a smart stop to deny Ruben Loftus-Cheek, and despite the rather grim match statistics, Fonseca believes his team turned in their best display of the campaign.

"We didn't win, but it's the game I've liked the most since I arrived here," Fonseca told Sky Sport.

"Especially in the second half. We played a fantastic game, it's not easy against a team like Leverkusen.

"We are sad and disappointed with the result, but I am satisfied with the courage and form shown.

"It was difficult for us. In the first half we suffered on the wings."

In the closing minutes, Leverkusen defender Piero Hincapie made a challenge on Loftus-Cheek at the edge of the area, which the Milan boss believes should have resulted in a penalty.

"For me it's a penalty, it's an intervention on the line," Fonseca said. "What's strange is that they haven't even reviewed the situation. The referee during the game had no doubts, but I don't like to talk about the referee."

Speaking to Milan TV, Fonseca said his side deserved to get something from the game.

"I honestly think the result is not fair, in the second half we created many clear chances," he said.

"It's true that we didn't win, but there was an improvement in our growth. It was evident. This is why we must move forward, because the growth is evident." 

Xabi Alonso believes Bayer Leverkusen passed their challenge to bounce back from defeat with flying colours after their 4-1 victory at Hoffenheim on Saturday.

Victor Boniface scored twice and set up Martin Terrier, with Florian Wirtz adding the other after Mergim Berisha had pulled one back for the hosts.

It was an important win for last season's domestic double-winners as they recovered from their loss to RB Leipzig in the Bundesliga before the international break.

"It was an important test for us to not concede a second goal after going 2-0 up," said Alonso, whose team had taken a two-goal lead at home against Leipzig before eventually losing 3-2.

"We reacted well and this time we controlled the game better and were more stable until the end. We know we will get our chances if we are patient and that is what we have to patiently work towards."

Leverkusen's defeat by Leipzig was their first in the Bundesliga in over a year (462 days) after winning last year's title undefeated.

However, they proved a threat on Saturday, having 20 shots, getting eight of those on target, while accumulating 3.62 expected goals.

"We were ready today to show our highest level," said Alonso. "We were serious and very professional.

"Hoffenheim made it difficult for us in the 10 minutes before the break but we came back after half-time to show sufficient energy."

Leverkusen, who have six points from three games, kick off their Champions League campaign on Thursday at Feyenoord.

Champions Bayer Leverkusen cruised to a 4-1 victory at Hoffenheim on Saturday thanks to a dazzling performance by Victor Boniface.

The Nigerian scored two goals and laid on an assist, ensuring Leverkusen got back to winning ways in their first game since the international break.

The visitors struck twice in the first half an hour for a 2-0 lead, with Boniface setting up Martin Terrier for a tap-in in the 17th minute before turning scorer with a clever finish.

Mergim Berisha, making his first appearances since a knee ligament tear last November, cut the deficit for Hoffenheim just before the break from close range.

Leverkusen restored their two-goal lead courtesy of a penalty, buried by Florian Wirtz in the 72nd minute, after Dennis Geiger fouled Alex Grimaldo in the box.

Boniface then single-handedly dismantled the Hoffenheim defence with a strong run down the left, powering a shot past keeper Oliver Baumann three minutes later to lift Leverkusen to fourth place on six points.

Data Debrief: Normal business resumed

It came as quite a shock before the international break when Leverkusen's 35-game unbeaten streak in the Bundesliga ended, with RB Leipzig handing them their first defeat in 462 days.

But Xabi Alonso's side quickly shook that result off, and extended their impressive unbeaten run on the road - they are now unbeaten in 19 such matches (W16 D3). It is also the first time they have won their first two away games in a Bundesliga season.

Meanwhile, Baumann made his 464th Bundesliga appearance in this match, drawing him level with Toni Schumacher and Lothar Matthaus. This was his 92nd consecutive game in the competition.

David Moyes insists West Ham still have “half a chance” to reach the Europa League semi-finals despite an agonising 2-0 first-leg defeat at Bayer Leverkusen.

The Hammers defended heroically for 83 minutes of a one-sided encounter against the Bundesliga leaders in Germany.

But late goals from substitutes Jonas Hoffman and Victor Boniface left West Ham with it all to do in next week’s second leg against a team yet to lose a match this season.

Moyes told TNT Sports: “Leverkusen have a good record of scoring late. We were aware of that. We did a great job but we played against a Champions League side and we’re not quite at that level.

“We’re still in the tie and we have half a chance in the second leg.

“We’d like to have played more attacking. The players did a brilliant job with the structure. We got done by two corner kicks. The second one was really poor from our point of view.

“It’s going to take some performance because they’re a really good team. You never know what’s going to happen. Let’s try to get one and then see if we can get two. We’ll pick ourselves up for next week and hopefully get the crowd behind us.

“This team we’re playing will be Champions League next year. We have to recognise what we’re playing against. We’ll have to do exceptionally well to get that result.”

Goalkeeper Lukasz Fabianksi made a string of excellent saves to keep the hosts at bay.

The former Poland international, who turns 39 next Thursday, added: “We are very disappointed.

“We worked hard for 80 minutes and then we gave two goals away from set-pieces. Usually defending set-pieces is our strength but you have to give a lot of credit to the opposition because they pushed the whole game.

“The more disappointing thing is that we conceded the second goal. It gives them a bit more confidence. We won’t give up. We have to believe and respond in the second leg.

“I wouldn’t say we ran out of energy. Both teams did their best. In the end the second set-piece felt too easy. It felt like the striker had too much space.

“We have a really good record at home. They’re special magical nights and hopefully the second leg will be the same.”

To make matters worse, West Ham will be without Lucas Paqueta through suspension for the return leg.

Leverkusen’s former Arsenal midfielder Granit Xhaka said: “We knew before the game West Ham would be deep, but we showed one more time we have the quality to beat these teams.

“The second goal helps a lot for the second leg and we’ll have to be focused from the beginning.”

West Ham were breached by two late goals as they slipped to a 2-0 defeat in the first leg of their Europa League quarter-final at Bayer Leverkusen.

The Hammers had defended heroically for 83 minutes before goalkeeper Lukasz Fabianski was finally beaten by substitute Jonas Hoffman.

A one-goal deficit might have given David Moyes’ side hope going into next week’s second leg at the London Stadium, despite facing a side unbeaten all season.

But disaster struck in stoppage time when a second substitute, Victor Boniface, headed home Hofmann’s cross, to leave West Ham’s hopes of a third consecutive European semi-final looking horribly slim.

A yellow card for Lucas Paqueta, ruling the Brazil international out of the second leg, only adds to the task facing the east Londoners.

The Hammers, without injured top scorer Jarrod Bowen and defensive midfield linchpin Edson Alvarez through suspension, were almost undone in the seventh minute when Josip Stanisic’s wayward shot was flicked towards goal by Patrik Schick but the ball went straight to Fabianski.

But Leverkusen were given a warning of West Ham’s prowess on the counter-attack moments later when Michail Antonio outstripped Jonathan Tah on the left wing and produced the best chance of the first half.

The burly frontman squared the ball to Mohammed Kudus, but the Ghana winger’s first-time strike was comfortably held by Matej Kovar.

However, West Ham were largely camped in their own penalty area and Fabianski palmed away Jeremie Frimpong’s curler before Exequiel Palacios’s drive was deflected over.

Paqueta’s over-enthusiastic challenge on Amine Adli earned him his booking – the Brazilian survived a red card check – and provoked a mild skirmish on the touchline.

Fabianski might have suspected he was in for a busy evening and he was proved right, making big saves to keep out dangerous efforts from Alejandro Grimaldo, Shick and Edmond Tapsoba.

Early in the second half Emerson Palmieri was shown a yellow card after catching Adli on the ankle, meaning the left-back will also sit out next week’s return leg.

Frimpong, a former Manchester City youngster, hit a low angled drive straight at Fabianski, before the 38-year-old Pole made a stunning save to tip Shick’s instinctive header over the crossbar.

But with seven minutes remaining Fabianski was powerless to prevent Hoffman’s shot bouncing through a sea of white shirts and into the net after a corner was only half-cleared.

Tomas Soucek cleared two Tah efforts off the line in a desperate finale before Boniface headed the second to leave the Hammers devastated.