Manchester United full-back Noussair Mazraoui will be absent for several weeks after undergoing a minor heart procedure.

Mazraoui joined United from Bayern Munich in a deal worth an initial £12.8million (€15m) in August and has quickly established himself as the Red Devils' first-choice right-back.

He has started all seven of their Premier League games this season, with Erik ten Hag's men taking just eight points to record their worst-ever start to a campaign in the competition.

On Monday, he withdrew from Morocco's squad for two Africa Cup of Nations qualifiers against the Central African Republic, having experienced heart palpitations.

Widespread reports on Thursday then said Mazraoui had successfully undergone a corrective procedure and would return within a few weeks.

Mazraoui was withdrawn at half-time in United's goalless draw with Aston Villa on Sunday, with Harry Maguire also replaced at the interval.

Leny Yoro, Luke Shaw and Tyrell Malacia are long-term absentees, meanwhile, leaving Ten Hag's men short in defence ahead of their return to action against Brentford on October 19.

Manchester United have confirmed that Luke Shaw will miss the start of the Premier League season with a calf injury.

The left-back sustained the injury in pre-season training and is set to be out until at least the September international break.

He is expected to miss the Red Devils' matches against Fulham, Brighton and Liverpool.

Shaw struggled with injuries last season and was limited to just 15 appearances in all competitions and missed the last three months of the campaign with a hamstring problem.

However, he recovered from that injury in time to represent England in the latter stages of Euro 2024.

United are also still without long-term absentee Tyrell Malacia, leaving Erik ten Hag without a natural left-back, though new signing Noussair Mazraoui, who joined from Bayern Munich on Tuesday, can also operate on that side. 

Erik ten Hag expects Tyrell Malacia to end up missing the entire season through injury as the Manchester United manager’s left-back frustrations continue.

The Red Devils have been beset by problems during a bumpy second term for Ten Hag, who is fighting for his job over the coming weeks and months.

United have had to deal with key absentees and been left light in certain areas, most problematically left-back as Luke Shaw’s issues have compounded the season-long absence of Malacia.

Ten Hag said just under a month ago that he soon hoped to have the Netherlands international back from a knee complaint, having dealt with some setbacks during rehab.

But the United boss will have to keep muddling through at left-back for the foreseeable future after he revealed Malacia’s return is unlikely to come this season.

“We talk about one of my biggest frustrations is there,” Ten Hag said.

“You can accept in a position that a player is not available, but when two players are not available over the course of the season that is very frustrating.

“Because that is also very difficult to catch up as a team, but we dealt with it in the best way, but of course it is a disadvantage.”

Asked how far away Malacia is from returning, the United boss said: “I think it’s going to be difficult for this season to be available.

“He will fight, he’s back on the pitch, but not in the team and the process had some setbacks and is still going really slowly forward, and the season is going to an end.”

That blow puts United’s decision to allow Sergio Reguilon to return to Tottenham midway through a season-long loan in the spotlight.

Signed in September to provide back-up with Malacia lied low, the Spain international was sent back to Spurs in January and has since made a temporary switch to Brentford.

Asked if it was a mistake letting Reguilon go back, frustrated Ten Hag said: “I think it’s a good question because in December I had the talks internally with, of course, medical and performance (staff).

“They assured me they (injured defenders) will be fit in January, they will be both fit in January, so you have two left full-backs.

“Then when you have two left full-backs and you have a third one, that means I always have to disappoint one full-back.”

Malacia was undergoing rehab at that point and Shaw was recovering from an injury issue that kept him out for five weeks, returning in late January against Newport in the FA Cup.

That was one of five appearances the England international managed before sustaining a muscle injury that is expected to rule him out until mid-May.

“I think it’s the same,” Ten Hag said of Shaw. “Maybe for the last games of the season, but we don’t expect him back this or next month.”

The duo are among a number of injuries at a key time for United, with Everton arriving in the Premier League on Saturday lunchtime before hosting Liverpool in next weekend’s FA Cup quarter-final.

Those matches could also go a long way to deciding the future of Ten Hag, who he believes Sir Jim Ratcliffe’s Ineos understands the issues he has had to contend with this season.

“They are aware of it,” the Dutchman said. “We talk a lot with each other, talk a lot about processes and the way we want to go for the future.”

Pushed on whether they appreciate the difficulties and are understanding, Ten Hag added: “That is what they’re telling me but I’m independent, I’m here to win.

“I’m in a process and we keep going in this process. We know which direction we want to go.

“We have now big setbacks, we’ve had big setbacks but we keep going and have a strong mentality. We keep fighting and keep pushing the team in the right direction.”

Sergio Reguilon will return to Tottenham after Manchester United exercised a break clause in his loan deal.

The 27-year-old Spanish left-back made 12 appearances for United after joining in September following injuries to Luke Shaw and Tyrell Malacia.

But the PA news agency understands United have now chosen to cut short the deal with Shaw having returned to action, although he is currently out with a slight injury, and Malacia also nearing a comeback.

It is understood United included the break clause in the original deal as it was always seen as a strong possibility that Reguilon would return to London during this window.

With United having been eliminated from European competition and the Carabao Cup, it was felt there would be fewer opportunities for Reguilon to feature in the second half of the season.

He has only played for United so far this season, so could play for another club if he left Spurs during the January window.

Tottenham are looking to strengthen their defence and PA understands they have stepped up their pursuit of a new centre-back by opening talks with Genoa over the signing of Radu Dragusin.

Spurs head coach Ange Postecoglou has been in need of reinforcements, especially defensively with Micky Van de Ven absent since November and Cristian Romero now sidelined until February with a hamstring injury.

Postecoglou has repeatedly made clear his desire for any January recruits to arrive during the early part of the transfer window and could get his wish with talks progressing well with Genoa.

Romania international Dragusin, 21, has established himself as a regular in Serie A during the past two seasons at Genoa after he initially came through Juventus’ academy.

If Dragusin was to arrive, it could open the door for Eric Dier to depart during the January transfer window with the versatile 29-year-old now into the final six months of his deal and the club willing to listen to offers.

Midfielder Pape Sarr, meanwhile, is poised to extend his contract with the club until 2030, PA understands.

The 21-year-old Senegal international has made 33 appearances for Spurs in all competitions since signing from French club Metz in 2021.

He claimed his second goal for the Premier League side during Sunday’s 3-1 win over Bournemouth before leaving the field in tears due to a hamstring problem.

That injury had cast doubt on his participation in the upcoming Africa Cup of Nations in the Ivory Coast, which Senegal begin against Gambia on January 15, but following the match Sarr expressed a confidence that he would be fine to compete in the tournament.

After completing his transfer to north London, Sarr was initially loaned back to Metz for the 2021-22 campaign, but he has excelled this term and established himself as one of Postecoglou’s key men, starting 16 of Tottenham’s 20 top-flight league games to date.

His maiden goal in English football came in Spurs’ 2-0 victory over Manchester United in August.

Manchester United boss Erik ten Hag has defended under-fire Andre Onana and insisted the Cameroon international is among the best goalkeepers in the Premier League.

Onana has repeatedly been in the spotlight since United spent £47million on the 27-year-old this summer to replace David De Gea, and although it had been felt his form was improving in recent weeks, Wednesday’s 3-3 draw against Galatasaray was a clear setback as he was at fault for two goals.

Onana also made a mistake for a goal in United’s Champions League defeat against Bayern Munich, but while he has struggled in Europe, Ten Hag pointed to the statistics that say Onana is second in saves made, save percentage and goals prevented in the Premier League.

“If you analyse it well then you see he is the second best goalkeeper in the Premier League based on stats, so his expected defending goals is the second best in the Premier League,” Ten Hag said.

“He’s doing well. Also he knows that in the Champions League he makes some mistakes but all over you see the first five months he is doing particularly well.”

Onana will face another major test on Saturday evening when United travel to Newcastle, who are on a five-game winning streak at St James’ Park.

But Ten Hag does not expect Onana to suffer any hangover from Wednesday night.

“You have seen how he is reacting on a bad performance like in Munich,” Ten Hag said.

“At Burnley (three days later) he was outstanding. He is a strong character, he is a personality and he will deal with it.”

United said on Friday that left-back Tyrell Malacia, yet to feature this season after knee surgery, is on course to return early next year after requiring a second operation.

Mason Mount was also back in training on Friday but there is no timeframe yet for the midfielder’s return.

Mount’s absence has helped open the door for 18-year-old Kobbie Mainoo, who excelled in last weekend’s 3-0 win over Everton at Goodison Park and was impressive again in Istanbul.

“He showed on Sunday (at Everton) he was ready,” Ten Hag said. “It looks like he always has time.

“He is scanning, he is running free, he is scanning to see the options and make the right decisions. He can delay, can speed up, he makes the right decisions.”

Saturday’s trip to the north east is a third straight away game for United, and another intimidating atmosphere after they faced an angry Goodison Park and the bear pit that is Galatasaray’s Rams Park.

“I really respect them,” Ten Hag said of Newcastle. “It’s a difficult team to play but it’s a good challenge and I like to play against it.

“We have to rise to the occasion, be our best against them because the way they play is very organised.”

United go into the game on the back of five wins in their last six Premier League games, having put a rocky run of domestic form behind them to close in on the top four.

It stands in contrast to their European form, but Ten Hag believes performances have been good across the board.

“On Wednesday, we played very good, also in Copenhagen,” he said. “Even in Bayern Munich we played very good. But we have to do some things better.

“Eliminate individual errors, defensive transition, but we can sort this out and I would be more concerned if we didn’t play well.”

Casemiro is set to miss a key stretch of Manchester United’s season after Erik ten Hag revealed the midfielder will be sidelined with a hamstring injury until after Christmas.

The 31-year-old midfielder has struggled for form and fitness in his second season since his eye-catching switch to Old Trafford from Real Madrid.

Casemiro sustained an ankle injury on Brazil duty last month and returned against Newcastle last Wednesday, only to be taken off at half-time of the 3-0 Carabao Cup defeat.

United confirmed the Brazil international had sustained a hamstring that would keep him out for “several weeks”, but Ten Hag has now suggested the midfielder may struggle to play again this year.

Left-backs Luke Shaw and Tyrell Malacia may return in the coming weeks but Casemiro and Lisandro Martinez, who is out with a foot injury, are set to miss the 10 matches before Christmas.

“I have some time schedules, yeah,” Ten Hag said. “But it’s always difficult to project that because there can always be setbacks during the rehab period.

“I’m always a little bit holding back on such issues.

“I expect some back but, for instance, Casemiro and Martinez are really strong injuries and I don’t expect them back before Christmas.”

Among the 10 matches Casemiro is expected to miss before Christmas is Wednesday’s key Champions League group game at Copenhagen.

The 31-year-old was suspended for the reverse fixture two weeks ago, when Andre Onana’s stoppage-time penalty save and Harry Maguire’s header secured a 1-0 win at Old Trafford.

The latter has enjoyed a resurgence of late and Brain injury charity Headway questioned the decision to allow him to continue playing after a head collision in Saturday’s 1-0 win at Fulham.

Maguire completed the match and is in United’s 23-man squad to face the Danish champions.

“So, we did all the protocols during and after the game, so he is ready to play,” Ten Hag said. “There is not any indication (of concussion).

“He was fine in the game so no problems. He played a very good game.”

United’s squad also includes Victor Lindelof and Marcus Rashford, who missed the trip to Craven Cottage through illness and a leg issue respectively.

“100 per cent (fit),” the United boss said. “Rashy missed one game out. A small knock but he’s back.”

United will hope the pair’s return can help continue their revival after making hard work of beating Copenhagen on home soil, having lost their Group A openers against Bayern Munich and Galatasaray.

“They played a very decent game and I thought we didn’t play a good game,” Ten Hag added.

“But, still, we won. I think it was a deserved win but we have to do things better.

“We are aware of that because you have to lift the performance if you want to get the result in.”

Tyrell Malacia says there is no chance of Manchester United’s focus wavering as the mouth-watering FA Cup final against Manchester City draws closer.

Erik ten Hag has overseen an impressive turnaround in culture and quality at Old Trafford since taking over last summer.

United are pushing for a top-four finish, having already won the Carabao Cup, and June 3 offers another shot at silverware against potentially treble-chasing rivals City.

The all-Manchester FA Cup final may be looming large, but Malacia says it will not distract the squad from their final Premier League push.

“No, I think we have a lot of experienced players who have been in these kind of situations,” the full-back said ahead of Thursday’s trip to Brighton.

“We keep each other like a team and we focus on qualification for the Champions League.

“I think Brighton are a good team, very good football, quality players, so it’s going to be a tough game.

“We have to focus on ourselves now, watch game-to-game and we need to win.”

Brighton will be looking for revenge just 11 days after their FA Cup semi-final penalty shoot-out defeat to United, who have since drawn 2-2 with Tottenham before beating Aston Villa 1-0 on Sunday.

Bruno Fernandes’ strike at Old Trafford ended Villa’s 10-match unbeaten run and strengthened the Red Devils’ grip on a Champions League qualification spot with six matches left to play.

“I think from now until the last game of the season it’s important points, so we have to win every game now,” Malacia said.

“It’s not good that we dropped points (at Tottenham), but (against Villa) we played good and (won) important points.”

As well as picking up three points, United recorded a 15th Premier League clean sheet – no mean feat given Villa’s form and the absence of first-choice centre-backs Raphael Varane and Lisandro Martinez.

“We have a lot of quality in the team, so if someone drops out we know we have someone there with quality,” Malacia said, who played left-back as Luke Shaw impressed centrally once again.

“Yeah (they are big players missing), but still we are Man United so we have a lot qualities and that’s important.”

On Shaw, the Netherlands international said: “We’re helping each other before the game, before training. We always talk to each other, so it’s good.

“From the beginning when I came here he always talked to me and spoke with me.”

Sunday was Malacia’s 19th Premier League appearance for United and he has played 36 matches in all competitions since joining last July.

The 23-year-old became the first signing of the Ten Hag era after moving from Feyenoord for 15million euros (£12.95m), plus 2m euros (£1.7m) in add-ons.

“I said to myself maybe 20 games this season and I’ve played more than 20,” Malacia said.

“I’m happy I’m here, I’m learning a lot. My first year in the Premier League, I’ve played a lot of games. I’ve learnt a lot of things, so happy to be here.”

Asked if he has felt extra pressure playing for United, he said: “All good. I don’t feel the pressure. For me, it’s OK.

“I’m just happy to be on the pitch and play football. That’s what I want to do and that’s what I dream all of my life, so why should I be pressured?”

Malacia’s delight to be playing at United comes with gratitude to Ten Hag, whose meticulous nature and approach the squad have bought into.

Put to Malacia that the manager seems demanding, he said: “Always, always (with) everyone.

“It’s a good thing because it keeps us sharp and you have to be on your A-game, especially because he said we are a big club so we need to win prizes. Then we have to be on our A-game.

“Everything (he is demanding about). It’s good because you see it work, so it’s always good then.”

Villa have their own demanding manager in impressive Emery, whose side will look to get back to winning way at Wolves on Saturday.

Leander Dendoncker told VillaTV ahead of the trip to his former club: “I don’t think we played a bad game here.

“The next game is an away game as well, which is going to be tough as well.

“We just have to keep going, we have been outstanding in the last few weeks and we just have to keep going.”