Harris English won his first PGA Tour title at TPC Southwind eight years ago, and he has another triumph in his sights after opening with a 62 at the WGC-FedEx St. Jude Invitational.
The American has a two-stroke lead over four pursuers, as Ian Poulter, Carlos Ortiz, Jim Herman and Matthew Wolff carded six-under-par 64s Thursday in Memphis, Tennessee.
Bryson DeChambeau, Scottie Scheffler and Marc Leishman were three shots back after shooting 65, with DeChambeau making his first start since missing the Tokyo Olympics following a positive COVID-19 test.
Among the group two shots behind them at five under were defending champion Justin Thomas, Open Championship winner Collin Morikawa and the red-hot Louis Oosthuizen, who has top-three finishes in four of his last five starts.
Among other notables, Patrick Reed and Hideki Matsuyama are at two under, with Phil Mickelson, Dustin Johnson and Olympic champion Xander Schauffele at one under, and Brooks Kopeka and Sergio Garcia at even par.
Jordan Spieth is at one over and Rory McIlroy at two over, leaving him 62nd in the 66-player field.
But they will all start Friday chasing English. The 32-year-old carded seven birdies on a blistering front nine, then faltered a bit with bogeys at 10 and 12 before closing his round with birdies at three of the last four holes.
"It was one of those rounds where I was hitting it really good off the tee and making a lot of good putts," English told reporters.
English won at Memphis in its previous incarnation as the Tour's St. Jude Classic in June 2013, then added another title that fall.
That was his last PGA Tour win before this year, which has seen him take the Tournament of Champions in Maui in January and the Travelers Championship in June.