An electric first-half display from Rafael Leao steered AC Milan into the Europa League quarter-finals as 10-man Slavia Prague succumbed 3-1 on the night and 7-3 on aggregate.

Just as they had in the first leg, the Czechs paid the price for a red card, Tomas Holes dismissed after just 17 minutes for a dangerous tackle on Davide Calabria.

The Rossoneri cashed in three times before the break, Leao lending a helping hand as Christian Pulisic and Ruben Loftus-Cheek netted before bending in a spectacular strike of his own from distance.

Slavia had not lost at the Fortuna Arena all season but were unable to summon a serious battle for their Serie A opponents until Matej Jurasek grabbed a late consolation.

They did manage one attempt before the tie slipped irretrievably out of their grasp, Mojmir Chytil denied by the outstretched boot of Mike Maignan – the goalkeeper’s last real contribution before coming off injured.

Within a couple of minutes, Holes went studs first into a challenge with Calabria and saw red after a VAR check, leaving his side to face the majority of the match at a numerical disadvantage.

Jindrich Stanek kept the hosts in it with a pair of sharp saves but could not hold back the tide when Leao played in Pulisic, who rifled home after turning inside with a smart touch.

With the resistance broken, Milan wasted no time getting another, Loftus-Cheek providing the final touch after Theo Hernandez’s silky one-two with Leao put it on a plate for the Englishman.

With the pressure off, Fikayo Tomori will regret picking up a booking that will rule him out of the first leg of the quarter-finals but the celebrations resumed in added time before the break, the electric Leao letting fly with a beautiful curling effort from 30 yards.

The second half unfolded at a gentler pace, the home side focused on containment and the Italians emptying their bench in acknowledgement that they had wrapped things up.

Chances did occasionally appear, Lofus-Cheek slotting wide and Olivier Giroud aggrieved when he was unable to add his name to the scoresheet just after the hour mark.

To their credit, the Czech side did not lie down, firing a warning shot via Michal Tomic’s breakaway and then getting one back through Jurasek. He had only just come on when he picked up Christos Zafeiris’ pass and picked out the bottom corner of the net from the edge of the area.

AC Milan head coach Stefano Pioli says his side has the quality to finish the job against Slavia Prague and reach the Europa League quarter-finals.

The Italian side hold a two-goal advantage going into the second leg of their last-16 tie in Prague following last week’s 4-2 win at San Siro.

Pioli told reporters: “We knew this moment would arrive, a crucial point in the season. Tomorrow we have an aim we need to reach.

“There’s a lot of talk around our opponents having the game of their lives, but we can and want to do the same.

“Our opponents will bring all their quality to bear. They’ve only lost once at home all season, but we want to go through and we’re convinced that we can with the quality we’ve got.

“We don’t need to force it, nor can we afford to be too calm. We need to play our own game, which is at a high tempo, especially in Europe, where you come up against some really good teams, good in attack and defence.”

The Czech runners-up went toe-to-toe with Milan in the first leg, despite the 26th-minute dismissal of defender El Hadji Diouf.

Milan’s Christian Pulisic struck the all-important fourth goal for Pioli’s side with five minutes remaining.

Pioli, whose side are second in Serie A, 16 points behind leaders Inter Milan, added: “We weren’t pleased, especially with that second half.

“We need to be clear on the fact that at 11 versus 11, our opponents caused us problems.

“I honestly think they will change it up from the first leg, even though they did well for the first 30 minutes before the red card, but now they have to overturn a two-goal deficit.”

Slavia Prague, also second in their domestic league, one point behind city rivals Sparta, lost for the only time this season at home against Viktoria Plzen in November.

Slavia boss Jindrich Trpisovsky told a press conference: “We will play in a stadium full of fans, the whole country will be watching us.

“We will do everything we can. We want to continue playing as we did in the first leg. We want to be brave. We’ll see if we can stand up to Milan.”

AC Milan saw off 10-man Slavia Prague 4-2 at San Siro in the first leg of their Europa League last-16 tie.

After Slavia defender El Hadji Malick Diouf was shown a straight red card in the 26th minute, the Rossoneri made the most of their advantage with first-half goals from Olivier Giroud, Tijjani Reijnders and Ruben Loftus-Cheek.

David Doudera had earlier given the Czech side hope with an fine strike to make it 1-1 and Ivan Schranz reduced the deficit midway through the second half before Christian Pulisic’s close-range effort late on gave Milan breathing space heading into the return leg.

Having dropped out of the Champions League, Stefano Pioli’s men came through the play-off round, beating Rennes 5-3 on aggregate, while Slavia had finished first in Group G ahead of Roma.

It had been a bright start by the home side, with right-back Alessandro Florenzi clipping a free-kick from the edge of the penalty area just over the crossbar.

Slavia Prague, though, created the clearest opening of the early exchanges when an angled ball picked out Diouf in the left side of the penalty area, but the defender completely missed his kick.

The Czech visitors continued to offer a threat on the counter attack, and in the 15th minute Doudera sliced his shot wide after breaking into the right side of the box.

Slavia Prague found themselves down to 10 men after just 26 minutes when Diouf was shown a straight red card for catching Pulisic on the ankle with his late sliding challenge.

Milan broke the deadlock in the 34th minute when Giroud headed in at the far post from Rafael Leao’s deflected curling cross out on the left.

Slavia, however, hit back straight away as Doudera fired a superb right-footed volley in off the post when the ball dropped to him at the edge of the penalty area following a corner.

Giroud saw his effort saved by Slavia keeper Jindrich Stanek, who then got down to palm away Matteo Gabbia’s header.

Milan’s pressure finally told just before the break when Reijnders drove in a low shot from 20 yards after a quick corner was pushed out to the left side of the penalty area.

It was 3-1 in first-half stoppage time when England midfielder Loftus-Cheek powered in a header from a corner.

Soon after the restart, Leao flashed a low drive across the face of goal and Slavia continued to sit deep looking to limit further damage.

The Czechs, though, reduced the deficit in the 65th minute when Schranz fired in an angled strike after Milan again failed to clear a free-kick.

Frustration started to creep in from the home crowd as the Rossoneri failed to break down Slavia’s resolute backline.

Milan eventually restored some breathing space with five minutes left when Leao’s angled chip across goal was touched over the line by Pulisic.

AC Milan boss Stefano Pioli has called on his side to meet a pivotal stage of the season “head on”.

Milan host Czech side Slavia Prague on Thursday in the first leg of their Europa League last-16 tie.

They go into the match on the back of a last-gasp 1-0 win at Lazio in Serie A, their first victory in four matches.

“We didn’t play at our best, technically, at the Olimpico, but we showed great character,” Pioli said at his pre-match press conference.

“The only game we let ourselves down in was against Monza, but over the last few months and in this recent period the team has kept up a certain level.

“The decisive part of the season is upon us and we’re ready to meet it head on.”

Milan dropped into the Europa League after finishing third in their Champions League group behind Borussia Dortmund and Paris St Germain.

“The Champions League is no longer part of our campaign after a few details got away from us,” Pioli added.

“Now, we must focus on just doing well in this competition. We must have the mindset that we can win the trophy.

“Firstly, we will need to be at out best to get through this round and take it one step at a time, albeit with awareness and enthusiasm.

“We have to make the most of home advantage; it is a key period of the season because it’s not easy for anyone to be competitive in Europe and in the league.

“Slavia lost only to Roma in the group stage. They are an intense, direct and energetic team. They play with three players up top – all close to each other – and like to threaten in behind; they have strong and physical forwards.

“It’s not the badge that goes out onto the pitch, but the players and they have reached the quarter-finals twice in recent years. We respect our opponents.”

French midfielder Yacine Adli knows Milan are among the favourites to lift the trophy in Dublin in May.

He said: “We know we’re coming up against a strong side. We’re playing the first leg in front of our fans and we’ll try to bring an intensity onto the pitch from the first minute.

“When AC Milan play in any competition, the aim is to always go and win it; we have a big opportunity. We are a top side and we want to prove it.”