Bayer Leverkusen suffered their first defeat in 36 Bundesliga matches, as Leipzig came from behind to stun Xabi Alonso's side 3-2 at BayArena.

Lois Openda struck twice for Marco Rose's, who recovered from 2-0 down to make it two wins from two and move to the summit of the table.

It looked like business as usual for the reigning Bundesliga champions when they scored twice in the last seven minutes of the first half through Jeremie Frimpong and Alejandro Grimaldo.

However, Leipzig replied deep into first-half stoppage time with Kevin Kampl reducing the deficit.

Openda then brought the visitors level in the 57th minute, before a stunning long-range strike completed the turnaround 10 minutes from time, condemning Leverkusen to their first league defeat in 15 months. 

Data Debrief: Leverkusen's long streak comes to a shuddering halt

Leipzig became the first side to beat Leverkusen in a Bundesliga match since Bochum achieved the feat a staggering 462 days earlier.  

The visitors have begun a Bundesliga season with two wins from two for only the second time, also doing so in 2019-20.

They are also now unbeaten in 13 league matches, their longest such streak since Rose took charge.

As for Leverkusen, their invincible streak is officially history, as is their 29-game unbeaten run on home soil.

Champions League semi-finalists Borussia Dortmund suffered a crushing 4-1 Bundesliga defeat at the hands of RB Leipzig on Saturday, denting their hopes of a top-four finish.

Manchester United loanee Jadon Sancho put Dortmund ahead after 20 minutes with a curling effort from the left corner of the box, but Edin Terzic's team couldn't hold on.

Lois Openda levelled within three minutes, and Benjamin Sesko pounced with a close-range finish to put Leipzig ahead on the stroke of half-time.

Mohamed Simakan made it 3-1 just one minute after the restart, then Christoph Baumgartner came off the bench to add a fourth with 10 minutes to play.

Dortmund, who host Paris Saint-Germain in the first leg of their Champions League semi-final tie on Wednesday, stay fifth, five points behind fourth-placed Leipzig.

They will likely have to wait on confirmation of Germany earning a fifth Champions League qualification place for next season, which was made more likely by a dismal set of results for England's clubs throughout the European quarter-finals earlier this month.

Data Debrief: Dynamic duo lead Leipzig to victory

Goals from Openda and Sesko ensured Leipzig turned Saturday's game around before the halfway point, both players netting in their fourth successive Bundesliga game together. 

They are the first pair of team-mates to achieve that feat since Dortmund's Marco Reus and Pierre-Emerick Aubameyang did so in February 2015.

Real Madrid endured a nervy night against RB Leipzig before they booked their place in the Champions League quarter-finals with a 2-1 win on aggregate after a 1-1 second-leg draw.

Carlo Ancelotti’s team held a one-goal lead from the first game in Germany on February 13, but came close to exiting in the last-16 stage only for Lois Openda to miss several chances while Dani Olmo hit the crossbar in stoppage time.

It meant Vinicius Junior’s 65th-minute opener, after a superb assist by Jude Bellingham, proved decisive with Leipzig’s equaliser via Willi Orban not enough to earn Marco Rose’s men a famous European victory.

Bellingham started days after his red card at Valencia following the controversial decision by referee Jesus Gil Manzano to blow for full-time before his headed effort could count as a last-gasp winner.

Leipzig had created plenty of chances in the first leg and should have put the ball in the net with 10 minutes played when Benjamin Sesko was sent through, but Andriy Lunin made a simple save and the offside flag was raised.

Vinicius diverted an effort over the crossbar with his chest soon after, which proved a rare venture into the Germans’ half in a one-sided first 45 minutes.

Openda curled wide moments later before his golden chance arrived in the 16th minute, but he dragged wide after an excellent ball by Olmo.

The Bernabeu crowd were already restless and a blocked Bellingham effort failed to turn the tide, with Paris St Germain loanee Xavi Simons next to test Lunin.

Simons was involved again three minutes before the break when his corner picked out Openda, who brushed the side-netting with his wayward shot from inside the area.

Whistles followed at half-time and Ancelotti reacted with Rodrygo introduced, but the visitors continued to create chances with Openda able to round Lunin before his decision to cut back inside allowed the Madrid goalkeeper to dive at his feet.

Madrid frustration boiled over when Vinicius was booked for shoving Orban to the ground, but he almost created the opener on the hour mark with a great run only for Bellingham’s scuffed effort to hit Rodrygo before a Toni Kroos shot was parried away.

Ancelotti’s team had finally started to move up the gears and the breakthrough occurred with 65 minutes played.

Bellingham was at the heart of the move, carrying the ball half the length of the pitch before he found Vinicius, who made an excellent run and rifled into the corner.

Any chance that Leipzig would fold was dispelled when Antonio Rudiger deflected a shot from Simons wide, which sparked big celebrations with Bellingham.

It was the visitors celebrating with 22 minutes left though when David Raum’s cross was headed in by Leipzig captain Orban to set up a grandstand finish.

Rose urged his team to press forward for a decisive second and Olmo sent a shot wide before Orban headed another chance over.

Leipzig pushed for a final opportunity, which did arrive in stoppage time but Olmo’s side-footed effort hit the top of the crossbar and bounced over to ensure Madrid progressed.

Manuel Akanji admits Manchester City need to cut our the errors after being exposed in their comeback victory over RB Leipzig at the Etihad Stadium.

The holders trailed 2-0 after a lacklustre first-half display in Tuesday’s Champions League encounter before a Phil Foden-inspired recovery saw them fight back to win 3-2.

With their place in the last 16 already secure, there was little cause for alarm on the night but, after recent Premier League draws against Chelsea and Liverpool, the champions are not fully firing.

Switzerland defender Akanji said: “We didn’t play well in the first half. We did a lot of mistakes, (in) a lot of duels.

“We had it change it in the second half. We spoke in half-time that we needed to do better. It still wasn’t great but we improved a lot, we didn’t do many of the mistakes.

“It happens sometimes. We didn’t plan to go into the game like this. The first goal was me losing a duel off the long ball, the second one was Ruben (Dias) after the pass and it happens sometimes.

“Normally we don’t do these mistakes but the good thing is we’ve got a good team.

“Now we have important games before the Club World Cup against Spurs and Villa and we need to really focus on these games. We need points because we drew twice so it’s really important to get winning again.”

Akanji was indeed at fault for the first of Lois Openda’s two first-half goals, with Dias caught out for the second.

Foden sparked the comeback when he teed up Erling Haaland to become fastest player to reach 40 Champions League goals in just his 35th appearance.

The England midfielder then scored a sublime equaliser before showing further nimble footwork to set up the late winner for substitute Julian Alvarez.

The victory ensures City, who travel to Red Star Belgrade next month, will finish top of Group G.

With John Stones again not fit enough to feature, Akanji played in the defence-midfield hybrid role his colleague has excelled in.

“I like it,” Akanji said. “I play wherever the manager puts me but also in the Chelsea game and the weekend against Liverpool I felt more comfortable in there because I got used to the position.

“When you come from defence into midfield it’s a big difference because normally you have all the game in front of you and suddenly there are players coming from all angles.

“But I got a better orientation with the game set-up so I felt more confident. I can adapt pretty good. I play in different positions. I try to listen and do what the manager wants from me.”

Phil Foden felt Manchester City were at their worst before recovering from 2-0 down to secure top spot in their Champions League group with a 3-2 win over Leipzig.

The holders trailed to two breakaway Lois Openda goals at half-time of Tuesday’s clash at the Etihad Stadium.

Foden sparked their recovery after the interval, teeing up goals for Erling Haaland and substitute Jeremy Doku either side of scoring a sublime effort himself.

The England midfielder told TNT Sports: “First half was the worst I’ve seen us. Courage and motivation courage changed it around. This team has great mentality and it’s so nice to see.

“We just needed that goal to get going. Even the fans were a lot louder after the goal. Once the first went in the motivation was there. We’ve got a great record at the Etihad and it only takes one goal to change things.”

City’s victory not only made certain of preferential seeding in the last 16 for a seventh successive season but extended their English record unbeaten run in European competition to 19 games.

Manager Pep Guardiola was pleased with that achievement but admitted concern about the performance.

The Spaniard said: “If we talk about the qualification it is a great night. If we talk about the game, we could do better.

“Sloppy goals – in football you have to win duels and it was quite similar against Chelsea. We were solid and now we’ve had two warnings already.

“It’s the same up front. We’ve had chances and missed them.

“But maybe for the future it’s good to win not comfortably, to show we are able to make a comeback.

“When we scored early in the second half, 45 minutes was a long time for them. It was not easy because they defended really well and they were strong, but we are there.

“Now we have five days to recover for the game against Spurs.”

Leipzig’s display was a huge improvement on their 7-0 loss at the same venue last season and coach Marco Rose felt his side were unfortunate not to get more from the game.

Rose said: “We knew we made them angry in the first half. It got more difficult.

“If we kept the clean sheet a little bit longer, maybe then the chance would become bigger and bigger to win or to take something home, but at the end you need a little bit of luck and that is what we missed maybe.

“We played a really good game, but this is City.”

Harry Kane was on target as Bayern Munich came from two goals down draw 2-2 at RB Leipzig in the Bundesliga.

Leipzig struck early through Lois Openda and Castello Lukeba but Kane and Leroy Sane replied in the second half to earn the reigning champions a point.

But the draw saw Thomas Tuchel’s men end the day in third, two points behind leaders Bayer Leverkusen.

Bayern almost scored inside three minutes when Kane’s smart pass in midfield played in the elusive Jamal Musiala but the attacking midfielder failed to hold his nerve and his shot was saved by Janis Blaswich.

Straight after, Bayern goalkeeper Sven Ulreich was nearly caught outside his box, but Leipzig took their second opportunity to open the scoring after 20 minutes.

Xaver Schlager retrieved the ball in midfield and he slipped through Openda who sped away from his man before his deflected effort nestled in the corner to give the hosts a 1-0 lead over the German champions.

And in the 26th minute Bayern shipped another goal as Leipzig stormed into a 2-0 lead.

Ulreich misjudged the flight of David Raum’s whipped corner and a knockdown in the box found the alert Lukeba who scored and stunned Tuchel’s side at Red Bull Arena.

Leipzig played with a higher intensity and quality which forced fouls from Kane and Dayot Upamecano who received bookings as Bayern searched for a way back.

And they brought one back in the 57th minute from the spot through Kane.

Musiala’s free-kick cannoned off the elbow of Benjamin Henrichs and after a VAR review the referee pointed to the spot which allowed Kane to bury his eighth Bundesliga goal.

Bayern grew in confidence and completed the comeback in the 70th minute.

Musiala showed his explosive pace when he countered from a Leipzig corner before he slipped in Sane who opened his body up and slid his effort home.

With 10 minutes to go Bayern searched for a winner and were camped in Leipzig’s final third, looking for openings to complete the turnaround.

Sane enjoyed touches of the ball in dangerous positions but Leipzig’s Schlager was quick to tackle and drive his team forward before he nearly picked out Benjamin Sesko in the 88th minute against the run of play.

Ulreich sensationally rushed out and beat Sesko to the ball in a 50-50 when the striker was played through and the game ended level after six minutes of added time.