West Ham will face Gent in the Europa Conference League quarter-finals as they bid to reach a European semi-final for the second straight year.
The Hammers made it to the Europa League final four last season, suffering a heartbreaking 3-1 aggregate defeat to eventual champions Eintracht Frankfurt.
But they thumped Cypriot side AEK Larnaca 4-0 at home on Thursday to seal a 6-0 aggregate win, before being matched with Belgian club Gent in Friday's quarter-final draw.
If they can get past Gent, David Moyes' men will face either AZ or Anderlecht to reach the final on June 7 after those two were pitted against each other in the last eight.
AZ have avoided defeat in seven of their last eight European clashes with Belgian opponents, with Anderlecht looking to win their first game against the Eredivisie side in three attempts having lost their previous two meetings.
On the other side of the draw, Lech Poznan stand between Fiorentina and their first European semi-final since the 2014-15 season.
History does not bode well for Poznan, with Fiorentina winning four of their six encounters with Polish clubs in European competitions.
The winner of that tie will play either Basel or Nice to see who will take their place in the showpiece match in Prague's Fortuna Arena.
The first legs of the quarter-finals will be played on April 13 before the return fixtures on April 20.