Freddie Freeman hit the first game-ending grand slam in World Series history with two outs in the 10th inning, giving the Los Angeles Dodgers a 6-3 victory over the New York Yankees in a dramatic opener Friday night.

Hobbled by a badly sprained ankle, Freeman homered on the first pitch he saw - an inside fastball from Nestor Cortes - and then dropped his bat before beginning a trot while greeted with a roar from the sellout crowd of 52,394.

It was reminiscent of Kirk Gibson's game-ending homer that lifted Los Angeles over the Oakland Athletics in Game 1 of the 1988 World Series at Dodger Stadium - one of the most famous swings in baseball lore.

Gibson, sidelined by leg injuries, came off the bench and connected off Hall of Fame closer Dennis Eckersley.

Freeman, who missed three games during the National League playoffs because of an injury to his right ankle, didn't have an extra-base hit this postseason until legging out a triple earlier on Friday.

In this much-hyped, star-studded World Series between two of baseball's most storied and successful franchises, Game 1 certainly delivered.

In the top of the 10th, Anthony Volpe grounded into a fielder's choice to shortstop, scoring Jazz Chisholm Jr. from third after he stole two bases, to give the Yankees a 3-2 lead.

It was the third straight World Series opener to go extra innings.

The speedy Chisholm singled off Blake Treinen and then stole second and third for a Yankees team not known for speed.