Michail Antonio felt West Ham were up against 14 players as they bowed out of the Europa League to Bayer Leverkusen.

Antonio’s early header gave the Hammers hope of overturning a 2-0 first-leg deficit and inflicting a first defeat of the season on Xabi Alonso’s new Bundesliga champions.

But the bustling striker claimed he did not get a decision all night from card-happy Spanish referee Jose Maria Sanchez and his two assistants.

“It doesn’t feel like you’re playing against 11 men, it feels like you’re playing against 13 or 14 including the two linos,” Antonio told TNT Sports.

“You just have to keep pushing and try and make the decisions go your way. And they just weren’t. We had to keep playing our way and keep being professional.”

West Ham pushed gamely for a second goal to take the tie to extra-time, but as they inevitably flagged Leverkusen substitute Jeremie Frimpong scored with a deflected shot in the last minute to make it 1-1 on the night and 3-1 on aggregate.

It was a valiant effort but ultimately a sad end to another European adventure for last season’s Conference League winners.

“We’re very proud of ourselves, to achieve what we’ve achieved over the last few years is incredible,” added Antonio.

“Three back-to-back years in European quarter-finals I would never have thought that. We were a yo-yo team, fighting relegation, then into Europe.”

Sanchez booked 11 players and sent off West Ham coach Billy McKinlay, and Sebastian Parrilla from Leverkusen’s staff after a touchline altercation.

Asked if that skirmish had anything to do with some bad-tempered exchanges between the benches in last week’s first leg, Alonso said with a grin: “I wouldn’t say no.”

Hammers boss David Moyes was not keen to be drawn on the officiating, but he did say: “I watch a lot of Spanish football but if that’s the way it is you wouldn’t want to watch too many Spanish matches.”

On his side’s performance, he added: “It was a brilliant team performance, I have to say over the two games.

“We played a really good team and we had chances to be two or three up. I couldn’t fault the players at all. If I was going out of Europe I wanted to go out like that.”

In the first half Leverkusen looked as though they may have celebrated their first Bundesliga crown on Sunday a little too much, and Alonso admitted they needed to improve after the break.

“For sure it was a thrilling game,” he said. “Two different halves. First half we knew West Ham would come with high intensity and we were not comfortable with that.

“After they scored one we were lucky not to concede a second one. But we showed character in the second half and the substitutes had a good impact. It was a lesson for us.”

Liverpool crashed out of the Europa League after they failed to turn around their 3-0 first-leg defeat to Atalanta despite winning 1-0 at Gewiss Stadium.

Jurgen Klopp’s men took the lead from the spot in the seventh minute through Mohamed Salah but could not find the goals needed as they fell to a 3-1 aggregate loss in the quarter-finals.

West Ham were knocked out by Bundesliga champions Bayer Leverkusen at London Stadium, also going out 3-1 on aggregate.

The Hammers gave themselves hope, both in the tie and of inflicting a first defeat of the season on Leverkusen, courtesy of Michail Antonio’s first-half goal.

But it was not enough as Leverkusen scored late on through Jeremie Frimpong.

Roma held off AC Milan to advance to the semi-finals.

Daniele De Rossi’s side, who won the first leg 1-0, scored two quickfire goals through Gianluca Mancini and Paulo Dybala to strengthen their advantage.

Despite Mehmet Zeki Çelik’s red card for a late challenge on Rafael Leao and Matteo Gabbia pulling one back in the 85th minute, the hosts managed to see out the match.

Marseille had to rely on penalties to claim their last-eight win over Benfica.

Benfica went to Stade Velodrome with a 2-1 advantage.

Faris Moumbagna opened the scoring for the hosts but both defences proved to be stubborn as the match went the distance after extra-time.

Antonio Silva and Angel Di Maria missed from 12 yards before Luis Henrique scored the decisive spot-kick to send the French club through.

West Ham bowed out of the Europa League but only after giving new German champions Bayer Leverkusen an almighty fright.

Michail Antonio’s early goal had the Hammers, 2-0 down from the first leg, dreaming of inflicting a first defeat of the season on Xabi Alonso’s Leverkusen and of maybe reaching a third European semi-final in three years.

But they were unable to find a second and were then left crastfallen when a deflected goal from Jeremie Frimpong a minute from time made it 1-1 on the night and 3-1 on aggregate to end the Hammers’ hopes.

Few gave David Moyes’ side any chance of overturning the deficit against one of the best teams in Europe, even if they were a little jaded after celebrating their first Bundesliga crown on Sunday.

At the very least West Ham knew they needed a fast start, and both the team and the crowd were instantly unrecognisable from the meek 2-0 home defeat by Fulham four days earlier.

The first shot in anger did come from Leverkusen’s Florian Wirtz, whose 20-yard effort was acrobatically saved by Hammers keeper Lukasz Fabianksi despite it being his 39th birthday.

But the first goal was always going to have to come from West Ham if they were going to make anything resembling a contest out of it, and it arrived in the 14th minute when Jarrod Bowen swung a cross into the box.

Antonio got above Leverkusen centre-half Odilon Kossounou and in front of keeper Matej Kovar to guide his header into the net as a raucous home crowd genuinely started to believe something special could be in the air.

It was almost two four minutes later when Mohammed Kudus shook off the attentions of Kossounou and hit a deflected shot which Kovar did well to smother.

It was enough to rattle Alonso, who removed Kossounou from the firing line with less than half an hour gone, the Ivory Coast defender heading straight down the tunnel.

Tempers flared between the benches moments later with the Hammers’ mild-mannered first-team coach Billy McKinlay sent off along with Sebastian Parrilla from Leverkusen’s bench.

Still West Ham attacked and Edson Avarez’s shot looked goalbound until it hit Antonio’s backside, with Kovar holding Bowen’s follow-up.

Alonso made two further changes at the break, with big guns Victor Boniface and Frimpong called into action.

After the break Bowen, still a lively presence despite only passing a late fitness test, robbed Piero Hincapie in the area only to pull his shot across goal.

But Leverkusen were finding their rhythm. Frimpong should have wrapped up the tie with 10 minutes left when he raced through one-on-one with Fabianski, only to lift his shot way over the crossbar.

But with two minutes left Frimpong did strike, his shot taking a huge deflection off Aaron Cresswell to end West Ham’s European adventure.

Xabi Alonso insists Bayer Levekusen’s focus is solely on West Ham on Thursday night despite a potentially historic weekend on the horizon.

Leverkusen, unbeaten in all 41 of their matches this season, look set to wrap up a first Bundesliga title on Saturday or Sunday.

All they need to do is match Bayern Munich’s result to be confirmed as champions.

Should Bayern lose to Cologne then Leverkusen will be crowned as title winners without having to kick a ball.

Either way, Alonso’s side will claim the title if they beat Werder Bremen at home on Sunday afternoon.

But Leverkusen are still in the hunt for a treble – they are already in the German Cup final – and first up is the Europa League quarter-final first leg against the Hammers.

Speaking at his pre-match press conference, Alonso said: “We know what West Ham can do. They have experience in Europe, last season they were champions of the Conference League.

“We want to go further and starting tomorrow and then next week in London, we have to play to our own game. We are ready.”

Former Liverpool midfielder Alonso was reportedly among the contenders to replace Jurgen Klopp as Anfield boss.

But the 42-year-old Spaniard has opted to stay at the BayArena, a decision which has thrilled the players according to defender Jeremie Frimpong.

“Everyone has a good feeling,” he said. “We love the coach and we are happy, you see it on the pitch. We simply have this great connection.”

Leverkusen reached the semi-finals of the same competition last season, but were edged out 1-0 on aggregate by Roma.

“When we lost last season in the Europa League semi-final it was difficult, but this season is different, we don’t like losing,” added Frimpong.

“It’s the quarter-finals so we are obviously excited for tomorrow. It’s what football is about, playing against the top teams so we are looking forward to it.”

West Ham have a major doubt over top scorer Jarrod Bowen for the match in Germany, but Leverkusen have also been dealt an injury blow in attack.

They will have to manage without striker Adam Hlozek, who injured his left ankle in the first half of Saturday’s 1-0 win away to Union Berlin.

Bayer Leverkusen stayed on course for a German league and cup double by thumping Fortuna Dusseldorf 4-0 to reach the DFB-Pokal final.

Jeremie Frimpong, Amine Adli and Florian Wirtz scored first-half goals as runaway Bundesliga leaders Leverkusen made light work of second-tier opponents at the BayArena.

Wirtz added a fourth from the penalty spot as Xabi Alonso’s side – who are also in the quarter-finals of the Europa League – made it 40 games unbeaten in all competitions this season.

Dusseldorf’s away form in Bundesliga – seven wins and four draws from 14 games – had given them semi-final hope, but this was a much tougher challenge than they were accustomed to.

The size of their task was laid bare within four minutes when Emmanuel Iyoha’s last-ditch tackle prevented Frimpong from opening the scoring.

Marlon Mustapha instantly managed a weak shot at the other end, but the unmarked Frimpong rifled Leverkusen ahead after seven minutes with a ferocious shot into the roof of the net.

Leverkusen doubled their lead after 20 minutes from a lightning counter-attack launched from deep inside their own penalty area.

Wirtz released Adli and his unerring low finish into the corner of the net gave goalkeeper Florian Kastenmeier no chance.

There was a massive chasm between the sides and Leverkusen rammed home their superiority after 35 minutes.

Dusseldorf were caught out playing from the back and Adli repaid the compliment as Wirtz finished in style.

Wirtz saw another effort tipped over by Kastenmeier before Andre Hoffmann and Christos Tzolis threatened for Dusseldorf.

But Matej Kovar stood firm in the home goal and Leverkusen added a fourth on the hour mark.

Patrik Schick’s header was going wide, but the ball clipped the hand of Matthias Zimmermann to be diverted on to the post.

It was definitely not an intentional intervention from Zimmerman, but the referee was sent to the monitor for a VAR review and a penalty awarded.

Wirtz, fresh from scoring after six seconds for Germany against France, sent his devastating spot-kick in to the corner.

Dusseldorf wanted their own penalty after 74 minutes when Tzolis tangled with Frimpong in the box.

On first glance it looked as if Tzolis had got there first, but on closer examination Frimpong’s challenge was shown to be legitimate.

Leverkusen welcomed back Victor Boniface for the final 15 minutes, the 16-goal Nigeria striker having not played since December 20 because of a muscle injury.

Substitute Nathan Tella was denied a late fifth, but the party had already started with flares lighting up the BayArena.

Leverkusen – 13 points clear of Bayern Munich at the top of the Bundesliga – will play second-tier Kaiserslautern in the DFB-Pokal final in Berlin on May 25.

Jeremie Frimpong fired into an empty net in stoppage time to cap Bayer Leverkusen’s outstanding 3-0 win over Bayern Munich as they celebrated carnival weekend in the Rhineland by moving five points clear at the top of the Bundesliga.

Josip Stanisic, the man on loan from Bayern, opened the scoring in the 18th minute before Alex Grimaldo doubled the advantage five minutes into the second half, but Frimpong added an exclamation mark after Manuel Neuer came up for a corner and Leverkusen broke to punish him.

Bayern had more of the ball but throughout the night it always felt as though Xabi Alonso’s side were the more dangerous, and this was a huge statement in their bid to win a first Bundesliga title and banish the nickname Vizekuzen – a mark of the five times they have finished runners-up.

The match at the BayArena kicked off eight minutes late after fans threw toy balls and other items onto the pitch as part of ongoing protests against the prospect of outside investment into the Bundesliga, and once play began it was Bayern who appeared to be on the front foot.

But while Leverkusen were happy to invite the visitors on to them, they were simply waiting for the moment to counter.

Their first shot at goal came in the 11th minute but Amine Adli’s effort lacked the power to trouble Neuer. Adli threatened again seven minutes later before Kim Min-jae got a foot in just in time, but Bayern were asleep from the resulting throw-in and were made to pay.

Robert Andrich drilled in a low ball across the face of goal and the Bayern defence stood still as Stanisic arrived to fire home, left all alone by Sacho Boey, usually a right-back but deployed on the left here in his second appearance since joining from Galatasaray last month.

Adli had a superb chance to get a second just before half-time as Granit Xhaka’s pin-point pass put him clean through on goal, but Dayot Upamecano recovered to get a toe on the ball, poking it back to Neuer.

It took only five minutes of the second half for the second to arrive. Grimaldo played a neat one-two with Nathan Tella to carve open the Bayern defence before beating Neuer at his near post with a rising shot.

Bayern were rocking, and there was chaos in their penalty area soon after, with Eric Dier’s cross hitting the arm of Leon Goretzka before bobbling back to Neuer, with a VAR check for handball coming to nothing.

Grimaldo hit the crossbar direct from a corner just after the hour as the ball dramatically dipped, but it bounced to safety.

Bayern tried to up the ante as Thomas Tuchel turned to his bench but struggled to create any real opportunities for a frustrated Harry Kane.

Instead, Leverkusen looked more likely to score again. Frimpong had already hit a post at the end of one late counter-attack, but had the final say after Neuer failed to get on the end of the corner and he raced down the pitch to fire into the unguarded net.

Bayer Leverkusen returned to the Bundesliga summit with a 3-0 win at Werder Bremen to ensure boss Xabi Alonso enjoyed a memorable 42nd birthday.

Bayern Munich had taken over at the top on Friday night with a narrow victory at Cologne, but Alonso’s unbeaten team provided the perfect response.

An own goal by Olivier Deman broke the deadlock after nine minutes and then it was all about the visitors’ wing-backs.

Jeremie Frimpong made it 2-0 before half-time with a thumping finish from close range and Alex Grimaldo wrapped up a comprehensive win with Leverkusen’s third in the 76th minute to make it 12 league games without defeat.

Stuttgart are third in Bundesliga after goals at either end of the first half from Deniz Undav helped them to a 2-1 victory away to Frankfurt.

Borussia Dortmund make up the top four after they fought back from two down to beat Borussia Monchengladbach in a thriller.

Goals from Rocco Reitz and Manu Kone put Monchengladbach 2-0 up inside 28 minutes, but Marcel Sabitzer started the comeback before further efforts by Niclas Fullkrug, Jamie Bynoe-Gittens and Donyell Malen inspired an excellent 4-2 triumph for the hosts.

Elsewhere, Wolfsburg got the better of RB Leipzig 2-1 and Union Berlin started the post-Urs Fischer era with a 1-1 home draw with Augsburg.

Barcelona lost more ground in the LaLiga title race after they were forced to settle for a point at Rayo Vallecano.

Unai Lopez fired Vallecano ahead six minutes before half-time with a superb strike from range and Xavi’s side struggled to make their dominance count until the 82nd minute when Florian Lejeune put through his own net.

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Barca substitute Raphinha had strong penalty appeals turned down in stoppage time as it finished 1-1.

Atletico Madrid leapfrogged Barca to move into third after a 1-0 victory at home to Mallorca.

In-form Antoine Griezmann grabbed the only goal of the game with 64 minutes on the clock when he headed home Mario Hermoso’s deep cross to send Diego Simeone’s team into the top three.

Mason Greenwood found the net in Getafe’s 2-1 win at home to Almeria, while Rafael Benitez celebrated a point on his return to Valencia after his Celta Vigo side battled to a goalless draw.

AC Milan returned to winning ways in Serie A against Fiorentina thanks to a Theo Hernandez penalty on a historic night at the San Siro.

Hernandez won a spot-kick in first-half stoppage time and converted from 12 yards to end a four-match winless run in the division for Stefano Pioli’s team.

Pioli helped Milan make history with seven minutes of the match remaining when he introduced 15-year-old forward Francesco Camarda for Luka Jovic to make the teenager the youngest ever player to appear in Serie A.

Napoli got the Walter Mazzarri reign under way with a 2-1 win at Atalanta after goals by Khvicha Kvaratskhelia and Eljif Elmas, but Lazio suffered a surprise defeat by the same scoreline at Salernitana.

Ciro Immobile put Lazio ahead in the 43rd minute but Grigoris Kastanos’ equaliser and Antonio Candreva’s long-range rocket earned Salernitana a first league victory of the season at the 12th time of asking.

Patrick Vieira’s Strasbourg held Marseille to a 1-1 draw in Ligue 1, while Lens claimed an excellent 3-0 win at Clermont where both teams finished the match with 10 men.