Corentin Tolisso suffered a muscle strain in Bayern Munich's 4-1 win over Greuther Furth.
Bayern came from behind to see off the Bundesliga's bottom side with four second-half goals, including two from Robert Lewandowski.
Tolisso was withdrawn from the action in the 25th minute, having gone down in pain grabbing his left thigh after a challenge from Paul Seguin.
"Coco has strained a muscle. We were initially worried that it was something more, but luckily it's 'just' a muscle strain," Bayern boss Julian Nagelsmann said afterwards.
Nagelsmann said to DAZN: "How can we replace Coco? With Marcel Sabitzer, with Marc Roca, with Jamal Musiala and hopefully soon with Leon Goretzka again."
Centre-back Lucas Hernandez lasted just 53 minutes of Sunday's game at the Allianz Arena.
However, his issue was not as serious, with Naglesmann adding: "It's not bad with Luci, he has cramp."
Injuries have limited Tolisso to just 12 Bundesliga games this season, scoring two goals.
When the midfielder has played, he has done an excellent job of getting Bayern into attacking positions.
Indeed, only Mainz's Kevin Stoger (26.02) and Bayern team-mate Joshua Kimmich (20.42) have played more successful passes ending in the final third per 90 minutes than Tolisso (18.33) among players to have featured in at least 10 games.
Sabitzer (16.43) is fifth on that list while Musiala (15.99) is seventh, making them both excellent candidates to replicate the impact of Tolisso in that regard.
Tolisso's season-high for successful passes into the final third came when he played 32 against Arminia Bielefeld in November. He played 21 and scored the opening goal in last month's 4-1 win at Hertha Berlin and registered 13 in this month's 3-2 win over RB Leipzig, suggesting he was hitting his stride.
Bayern visit Eintracht Frankfurt in their next Bundesliga match on Saturday.