South Africa emphatically consigned England to a first Test defeat of their new era as Ben Stokes' side were thrashed by an innings and 12 runs inside three days at Lord's.
The potent Proteas pace attack did much of the damage once again, bowling a fragile England out for only 149 in 37.4 overs on Friday.
Dean Elgar's men dominated from start to finish in London, taking a first innings lead of 161 by posting 326 all out in reply to England's 165.
The tourists wrapped up the victory just over two-and-half days into the first of three Tests in the series to go 1-0 up, with the wickets shared between magnificent quicks Anrich Nortje (3-27), Kagiso Rabada (2-27), Marco Jansen (2-13) and Lungi Ngidi (1-15) after Keshav Maharaj took 2-27.
It was a chastening defeat for England, Stuart Broad and Alex Lees the joint top-scorers with 35 as they lost their perfect record since Stokes was appointed captain and Brendon McCullum head coach.
Broad took a brilliant one-handed catch for Matthew Potts to dismiss Rabada after South Africa resumed on 289-7, before claiming two wickets of his own to end the innings and leave Nortje unbeaten on 28.
Spinner Maharaj had England in trouble on 38-2 at lunch, dismissing the out-of-sorts Zak Crawley (13) leg before and trapping Ollie Pope (five) in front with the last ball of the morning session.
The Proteas pace attack again came to the fore in the afternoon session, Ngidi getting rid of Joe Root (six) before a fired up Nortje had Jonny Bairstow (18), Lees and Ben Foakes (nought) caught behind.
Broad came out swinging (35) as he put on 55 with Ben Stokes for the seventh wicket before he was deceived by a slower ball from Rabada and Jansen cleaned up Potts.
Stokes (20) picked out Maharaj in the deep knowing he was almost out of partners to become Rabada's second victim and Jansen bowled James Anderson with a quick yorker to put England out of their misery.
Proteas fire to blow England away
England had won all four Tests under their new coach and captain, whitewashing New Zealand 3-0 and beating India in a rearranged match at Edgbaston.
They were brought down to earth by a ruthless South Africa, who showed why they are top of the World Test Championship. Their fast bowlers fired on all cylinders as England were beaten by an innings at Lord's for only the second time in 52 Tests since June 1993.
Left-arm tweaker Maharaj was not required to bowl in the first innings, but he set the ball rolling in England's second innings before the quicks ripped through the hosts.
Crawley could pay the price
Opener Crawley has been backed by Stokes and McCullum, but he could pay the price for two more failures.
England must regroup before the second Test at Old Trafford, where Crawley may have to step aside.