Brighton were taught a harsh lesson on their Europa League debut as Greek champions AEK Athens ran out 3-2 winners after a pulsating encounter at the Amex Stadium.

Substitute Ezequiel Ponce struck the winner on the counter-attack six minutes from the end of normal time as Roberto De Zerbi’s side failed to heed the signs after falling behind twice previously in the first half.

Joao Pedro equalised from the penalty spot in the first period then again in the second, both times after VAR had intervened in Brighton’s favour.

The hosts had the better of the play but they lacked the clinical edge of AEK, who scored with two excellent finishes from set-pieces. The first goal was a superb header from Djibril Sidibe, followed by a sliding finish from Mijat Gacinovic as Brighton were undone by nerves and their own naivety.

The opening goal came after 11 minutes and was against the early run of the play.

AEK’s first attack saw them win a corner on the left after a low cross was turned behind. As the ball was whipped in, no one had picked up the lurking Sidibe who with a late dash into the box caught Brighton out with a superb 15-yard diving header that whistled past Jason Steele.

De Zerbi’s side had been badly caught out, and seconds later it could have been two. Levi Garcia, who would torment Brighton in the first period with pace and clever movement, raced beyond the defence and went through on goal, but Garcia’s tame finish was too close to Steele.

Garcia wasted another glorious chance to double the lead from an almost identical position, this time slipping his effort just beyond the far post.

Pedro nodded wide from a free header inside the six-yard box as Brighton finally put together an attack to concern the AEK defence, but within a minute he had made amends for his profligacy.

When defender Ehsan Hajsafi dangled a leg as Pedro looked to cut inside to shoot the referee initially booked the striker for diving. But after a pitchside VAR review the booking was rescinded, Pedro stepped up and coolly rolled his penalty beyond Cican Stankovic to score Brighton’s first European goal.

At that stage it appeared that they had had their reprieve for the way they had left themselves vulnerable to AEK’s threat, but five minutes before the break there was another fine delivery from a set-piece and another critical lapse in concentration.

Brighton held a high line on the edge of their own box as a free-kick was whipped in from 40 yards out, but as blue shirts charged back towards their own goal none could prevent Gacinovic from sliding to get a foot on the ball to turn it beyond Steele.

There was still time for Jan-Paul Van Hecke to deny Orbelin Pineda what would have been a deserved third for AEK on the stroke of half-time.

There was relief then around the Amex when the referee was directed pitch-side for another VAR review after Pedro’s tumble inside the box under Damian Szymanski’s challenge had at first been waved on.

As in the first half, the decision was overturned, and Pedro got to his feet to replicate his earlier composed finish to draw Brighton level again.

De Zerbi was booked for remonstrating too forcefully on the touchline, before Pedro was handed the chance to seal his hat-trick and an opening night win when he spring the offside trap and went one-on-one with Stankovic. This time the goalkeeper got the better of their duel.

Then came AEK’s final sting. A raking ball from the back was nodded out wide by Ponce to Niclas Eliasson, who returned the ball to his fellow substitute. Although Steele blocked Ponce’s shot, the rebound ricocheted off the Argentinian and into the net for the winner.

Eddie Howe admits defeat at Brighton is a warning Newcastle cannot allow their Champions League adventure to distract from the “ruthless” Premier League.

The Magpies are back in the group stage of European football’s premier competition for the first time in 20 years and travelled to the Amex Stadium having been drawn to face heavyweights AC Milan, Paris St Germain and Borussia Dortmund.

But anticipation of those upcoming fixtures was swiftly tempered by a third successive top-flight loss as a hat-trick from 18-year-old Evan Ferguson earned the Seagulls a 3-1 success.

Manager Howe, whose side were beaten 2-1 at home by 10-man Liverpool last weekend following a 1-0 defeat at Manchester City, accepts responsibility for the mini slump but insists he will not over-react.

“It’s never been lost on me how difficult the Premier League is,” he said.

“I know how tough a league it is, it’s ruthless, so if you get your focus swayed, you’re going to have big problems – I don’t think our focus has been.

“We’ve tried to very much concentrate on our next match, that will always be our focus and we’re determined to be successful in the league this year and win as many games as possible.

“But we know the demands placed upon us are going to be extreme so this is a warning, I think, that we can’t be swayed and the Premier League is a very tough division.

“We’ve lost three in a row and we have to take responsibility for that. It’s important that I don’t over-react.”

Newcastle had the better of the early chances on the south coast but fell behind to Ferguson’s 27th-minute opener following defensive errors.

The Republic of Ireland striker doubled his tally with a stunning long-range effort before becoming only the fourth teenager to register a Premier League treble thanks to an effort which deflected in off Fabian Schar.

Howe, who revealed sidelined midfielder Joe Willock will be out for a further six weeks after his hamstring issue was compounded by a fresh Achilles problem, is itching for a swift return to action going into a two-week international break.

“I’d like a game pretty quickly, if I could,” said Howe, whose team host Brentford on September 17.

“We have some great games to come and we’re looking forward to that challenge.

“I think the challenge to me is to lift everybody and keep our confidence levels because we are a very good team and we have to always have that in the back of our minds as we go into the next two weeks.

“The lads are very disappointed. Collectively we’ve got an outstanding group of individuals, great mentalities and we know what we’ve got to do.”

Ferguson’s first senior hat-trick, which was followed by Callum Wilson’s consolation, was the third in the Premier League on Saturday after trebles for Manchester City’s Erling Haaland and Tottenham forward Son Heung-min.

“It’s a good day,” he told Brighton’s website. “It’s an unbelievable feeling.

“It’s not bad company to be in; Haaland’s record last season (52 City goals in all competitions) and Son’s been doing it for a number of years, so it’s good company to be in.”

Ahead of kick-off, the Seagulls paraded 20-year Spain forward Ansu Fati following his deadline-day loan switch from Barcelona.

“He’s going to be great for the squad, especially as competition,” said Ferguson.

“It’s tough up that area of the pitch and he’s going to be another one chucked in there and I reckon he’ll be very good for it.”

David Moyes was delighted to see West Ham end their Brighton hoodoo with a convincing 3-1 win at the Amex Stadium which took them top of the table.

Summer signing James Ward-Prowse scored his first Hammers goal in only his second start to set the visitors on course for a first ever Premier League win over the south coast side.

Manager Moyes said: “I’m thrilled with the three points because usually we come here and struggle to get any points.

“We haven’t won here for years. It’s been the same coming here and not getting the results.

“Today was a well-deserved three points. Brighton did a good job, but we also did a good job in other parts of the game.

“Brighton have got an extremely good manager and his side are causing problems to plenty of teams, not just us.

“They are going to be hard for any manager to play against.

“They are very offensive, which is great, but that also means it can open up and give you chances on the counter.

“We worked hard on not getting picked off easily and we defended really well.

“Our counter-attacks were really good. Two or three years ago we were really good on the counter and we showed that. All the forward players made a really good contribution today.”

Moyes led West Ham to their first trophy in more than 40 years by winning last season’s Europa Conference League.

On their surprise early-season surge to the Premier League summit, the Scot said: “I didn’t realise we had gone top. It has been a long time since any West Ham manager did that also.”

Ward-Prowse got West Ham off to the perfect start when he opened the scoring after 19 minutes, following on from his two assists in last weekend’s debut win over Chelsea.

Michail Antonio was too strong for Brighton defender Adam Webster and picked out England international Ward-Prowse to tap in from two yards.

Jarrod Bowen added a second 13 minutes into the second half – expertly controlling Said Benrahma’s cross before firing into the bottom corner.

Bowen then teed up Antonio to seal the points in the 63rd minute with a drilled shot into the corner.

Brighton, who had 79 per cent of the possession, got a goal back with nine minutes to play when German midfielder Pascal Gross chopped back onto his right foot to rifle home through a crowded penalty area.

West Ham goalkeeper Alphonse Areola made two crucial saves in the dying stages to keep out Joel Veltman’s volley and Ferguson’s fierce drive.

Brighton manager Roberto De Zerbi said: “I’m disappointed with the result. It wasn’t the best performance in my time at the club, but we didn’t play badly.

“We shot 27 times and created 11 chances to score. In the second half I’m disappointed because we lost the balance of the game.

“I’m very proud of the performance, the attitude, the passion and the mentality to play well and get points.

“I can analyse how we conceded the goals and how we made a lot of mistakes in the last 20 metres and how we conceded so many counter-attacks, but it is not a problem.

“We will start on Monday working on the last week.”