Quinton de Kock and Aiden Markram paved the way for South Africa to claim their first Twenty20 series win since March 2019 as they held off West Indies to secure a 25-run victory.
Having decided to bat first in Grenada, Temba Bavuma's side went on to seal a decisive triumph to round off a 3-2 series success.
De Kock's 60 and Markram's 70 set the tone as the tourists reached 168-4 from 20 overs.
It proved the difference, with Evin Lewis' 52 not enough to inspire the Windies, who also lost the Test series against the Proteas 2-0.
South Africa could hardly have got off to a poorer start, however, with captain Bavuma dismissed on the third delivery of the day.
Yet thanks to the efforts of De Kock – who struck his third straight half-century – and Markram, the Proteas were on 128 by the time they next lost a wicket.
After helping to muster the highest partnership of the series for either side, De Kock picked out Andre Russell off Fidel Edwards' bowling, before Markram, who has now scored 50 or more in four of his last nine T20s, succumbed two overs later.
David Miller added 18 off 16 deliveries to ensure South Africa finished with a flourish.
Lewis went on the attack to get Windies off to a strong start, but by the time he was caught by Markram, the hosts were 75-3, having lost Lendl Simmons and Chris Gayle.
Shimron Hetmyer's 33 included two sixes, but the loss of Kieron Pollard and Andre Russell in swift succession ultimately left the Windies with too much to do, with Nicholas Pooran's dismissal the final blow to their hopes.
DE KOCK LEADS THE WAY
Though Markram was awarded with player of the match, De Kock has enjoyed a brilliant series.
His innings also included four boundaries along with a pair of sixes, while De Kock's total of 225 runs are also the most by a batter in a bilateral series.
Lungi Ngidi (3-32), was the pick of the bunch from South Africa's bowling attack.
BOUCHER GETS A MONKEY OFF HIS BACK
This was also a huge win for South Africa coach Mark Boucher. The Proteas have hardly had much in the way of consistent success under his coaching unit, albeit the coronavirus pandemic has certainly played a part in that.
Indeed, South Africa were on a five-series losing streak in T20s, but they may just have started to turn things around.