Jesus Corona salvaged a 1-1 draw away to Panama as Mexico dropped points for the first time in 2022 CONCACAF World Cup qualifying.

Mexico had won their opening two Octagonal fixtures to sit top of the CONCACAF standings on the road to Qatar 2022.

But Panama and Mexico shared the points at Estadio Rommel Fernandez Gutierrez in Panama City on Wednesday.

Panama – also unbeaten – had suffered four consecutive defeats to Mexico since earning a goalless draw against El Tri in World Cup qualifying in 2016.

However, hosts Panama opened the scoring through Rolando Blackburn approaching the half-hour mark in the 28th minute.

Mexico – again without head coach Tata Martino following eye surgery – had their chances in the opening half, but it was not until the 76th minute that El Tri found the back of the net.

After Sebastian Cordova hit the post, Corona was on hand to convert the rebound with a curled effort past Panama goalkeeper Luis Mejia.

The United States' stuttering start to World Cup qualifying continued after they were held to a 1-1 draw by rivals Canada.

Brendan Aaronson's 56th-minute opener was cancelled out within six minutes by Canada forward Cyle Larin as the USA drew consecutive games on the road to Qatar 2022.

Chelsea star Christian Pulisic returned to the starting line-up on Sunday after missing the USA's Octagonal opener against El Salvador following a positive coronavirus test.

Weston McKennie, though, was axed from the squad following a "violation of team policy", while Giovanni Reyna sat out due to a hamstring injury.

Canada made a lively start on the road in Nashville, where Larin checked his run and got on the end of Alphonso Davies' pass, but Matthew Turner somehow pushed the shot onto the crossbar in the 14th minute.

USA went close to breaking the deadlock five minutes before the break when Pulisic's shot hit the post from close-range.

CONCACAF Gold Cup champions the USA, though, did open the scoring via Aaronson, who slid onto the end of Antonee Robinson's cross 11 minutes into the second half.

The lead was short-lived however as Davies showed off his incredible pace, driving towards the penalty area before teeing up Larin for a simple tap-in just past the hour-mark.

Despite the draw, the USA extended their unbeaten streak to 11 matches across all competitions.

The United States and Canada both have two points from their opening two fixtures.

Mexico preserved their 100 per cent record in CONCACAF World Cup qualifying after edging Costa Rica 1-0 away from home.

Orbelin Pineda converted a penalty in first-half stoppage time and it proved to be enough on Sunday as Mexico made it two wins from two games in the Octagonal section of qualifying on the road to Qatar 2022.

Mexico head coach Gerardo Martino did not travel to Costa Rica after undergoing eye surgery and assistant Jorge Teller deputised in the absence of the former Barcelona and Argentina boss.

El Tri were underwhelming in their opening 2-1 win over Jamaica and they made another timid start on the road – Mexico goalkeeper Guillermo Ochoa forced into a save to deny Costa Rica captain Bryan Ruiz.

Mexico had a great chance to break the deadlock three minutes later in the 18th minute after Rogelio Funes Mori found himself in a one-on-one situation with Keylor Navas, who thwarted the forward from close range.

Visiting Mexico did draw first blood on the stroke of half-time – Pineda scoring from the spot after Bryan Oviedo was penalised for a foul on Andres Guardado.

Costa Rica continued to push numbers forward and almost salvaged a point at the death, however, Keysher Fuller's 92nd-minute effort rattled the woodwork.

Mexico clinched the start they wanted, opening their CONCACAF World Cup qualifying campaign with a dramatic 2-1 win over Jamaica. 

Henry Martin's 89th-minute strike was the difference at an empty Estadio Azteca, helping El Tri avoid an embarrassing result as they look to secure a spot at Qatar 2022. 

Mexico dominated possession throughout Thursday's fixture and out-shot Jamaica 27-5, but Reggae Boyz goalkeeper Andre Blake thwarted the hosts until Martin's last-gasp winner. 

A botched clearance by Jamaica in the 50th minute left the ball at Alexis Vega's feet, with multiple Mexico players in an offside position, he held the ball and worked his way toward the middle of the field along the top of the penalty area before sending a right-footed shot past a diving Blake.

Shamar Nicholson equalised 15 minutes later for Jamaica, firing a shot past Guillermo Ochoa after a poor clearance by Jorge Sanchez. 

Martin gave Mexico the three points in the end, collecting a pass from Luis Romo that was redirected by Cesar Montes and firing home just inside the top of the area.

Nearly four years after the infamous loss to Trinidad and Tobago that saw the United States fail to qualify for Russia 2018, a young USA side opened the final round of 2022 World Cup qualifying with a 0-0 draw at El Salvador on Thursday. 

USA head coach Gregg Berhalter's inexperienced team, missing star Christian Pulisic and goalkeeper Zack Steffen, managed to take a point before a raucous crowd in San Salvador following their CONCACAF Gold Cup success last month.

It might not have been a scintillating performance for a side coming off Gold Cup and CONCACAF Nations League triumphs, but the USA will take it after opening their 2018 qualifying campaign with successive losses. 

Nine players in the USA starting line-up were making their first appearance in a World Cup qualifier, with DeAndre Yedlin and Tim Ream the only exceptions, but the group did not appear rattled on the road. 

USA had a tantalising chance after eight minutes when Miles Robinson got free behind the El Salvador defence on a Gio Reyna free-kick, but saw his header sail over the goal. 

El Salvador's best opportunity of the first half came in the 33rd minute when California-born Alex Roldan cut in from the left after a short corner and curled a ball over USA goalkeeper Matt Turner that grazed the top of the crossbar. 

The home side had a chance to take the lead in the 57th minute, as Turner had to dive to his left to save a header from Eriq Zavaleta off a corner from Marvin Monterroza, the first and only shot on target for El Salvador. 

Weston McKennie had a clear header in the 72nd minute, however the USA and Juventus midfielder could not put home Reyna's cross, one of several missed opportunities for the visitors.

The result snapped the USA's nine-match winning streak, but they still have suffered only one defeat in their last 20 games dating to November 2019, a 2-1 friendly loss at Switzerland in May. 

The first international break of the 2021-22 campaign has arrived, and with it comes an opportunity for many national teams to start afresh.

Following the conclusion of the Copa America, Gold Cup and Euro 2020 in quick succession, all roads now lead to the 2022 Qatar World Cup.

For a number of players, the September qualifiers provide an opportunity to make an impression, while for others it is potentially a first taste of international football. 

With the games coming thick and fast over the next week or so, Stats Perform has looked at those in contention to make their senior international debuts.

Albert Sambi Lokonga (Belgium)

Belgium's golden generation of talent missed another opportunity to turn promise into something more tangible when losing to eventual winners Italy in the Euro 2020 quarter-finals.

Roberto Martinez has decided against wholesale changes after that disappointment, with Lokonga the only outfield player in line for his first cap, having failed to get further than the bench – against Greece in June – after previous call-ups.

A product of the same Anderlecht youth system that oversaw the development of Romelu Lukaku, Youri Tielemans and Leander Dendoncker, among others, Lokonga sealed a move to Arsenal in July after impressing in the Belgian top flight.

The £15million signing has not had the best of starts to life at Arsenal, the Gunners finding themselves bottom of the English top-flight table having played at least three league matches for the first time since October 1974.

Lokonga, noted for his ability to play in front of the defence, featured in just two of those games yet still trails Granit Xhaka alone in terms of passes (113 to 139) and successful passes (97 to 118) and is behind only Sead Kolasinac for interceptions.

Claudinho (Brazil)

Citing concerns over the availability of his European-based contingent due to clubs being reluctant to release players to red-list countries, Tite has named a bloated Brazil squad for this month's triple-header of World Cup qualifiers.

Those complications appear set to deny Raphinha a debut, having impressed during his first year in the Premier League with Leeds United. 

Raphinha ranks seventh in the division for dribbles attempted since the start of last season (142), completing 42.96 per cent of those. He also ranks in the top 10 for chances created over that period with 68.

But Claudinho remains in line to be capped for the first time, called up after helping his country secure Olympic gold at Tokyo 2020.

The midfielder, whose signing at Zenit was announced not long after the Olympic tournament had concluded, described his call-up as "a dream come true".

Theo Hernandez and Moussa Diaby (France)

It is out with the old and in with the new as far as France's first post-Euros squad is concerned – to an extent, at least, with Olivier Giroud one of nine players to make way from the previous group named by Didier Deschamps.

Injuries have also played a part in that, potentially giving a quartet of uncapped players the chance to impress in the upcoming qualifiers with Bosnia-Herzegovina, Ukraine and Finland.

Hernandez, a more natural left-back option than brother Lucas, will feel his first call-up is long overdue following back-to-back campaigns as a regular for Milan, whom he joined from Real Madrid. 

Since making his Rossoneri bow in September 2019, no defender in Serie A has completed more dribbles than Hernandez (133), while only Federico Dimarco (87) and Juan Cuadrado (107) have created more chances than his 86.

Monaco midfielder Aurelien Tchouameni and Roma's Jordan Veretout may also feature during this international break, but perhaps the most exciting of the new additions is Bayer Leverkusen winger Diaby.

The Paris Saint-Germain product scored twice and assisted another in Leverkusen's opening two Bundesliga games of 2021-22, while Alphonso Davies is the only player in the division to have attempted more dribbles this term (24 to his 22).

Known for his blistering pace and ability to take on opponents, Diaby could well provide Deschamps with a different option in an attack already packed full of talent.

Otavio (Portugal)

Three new players have been called up by Fernando Santos, who is looking to the future after his Portugal side's reign as European champions came to an end in July.

Goncalo Inacio is injured, but Diogo Costa and Otavio could each make their senior debuts during this international window, with the latter the name on many lips right now.

Otavio has tallied 11 goal involvementss in each of the past two Primeira Liga campaigns for Porto and has made a fast start to the new season with two assists in his first four games.

Since the start of last season, only team-mate Mehdi Taremi has provided more assists (12) in the Portuguese top flight than Otavio's 10, coming from 51 chances created.

The Brazilian-born attacking midfielder was granted Portuguese citizenship earlier this year and will be eager to show that Brazil's loss is very much Portugal's gain should he get some minutes over the next week.

Ricardo Pepi (United States)

The dual-national drama surrounding Pepi appears to have reached a resolution as the FC Dallas forward has seemingly pledged his allegiance to the United States over Mexico.

After breaking into the Dallas side two years ago and featuring regularly last year, 2021 has been quite the season for the El Paso-born youngster.

Pepi, who does not turn 19 until next January, has 11 goals and two assists in 21 games this term and scored the decisive kick in last week's penalty shoot-out win for MLS against their Liga MX counterparts in the All-Star Game.

He has 13 MLS goals in total, the fourth-most ever by a teenager – ahead of Freddy Adu – and just nine short of the record held by Diego Fagundez.

On the basis of the past four months in particular, the USMNT could have a potentially world-class player to lead their line for a number of years to come.

Karim Adeyemi (Germany)

For the first time in 17 years, Germany will play a match without Joachim Low in their dugout either as assistant or head coach when they face Liechtenstein on Thursday.

Hansi Flick is tasked with ushering in a new generation of German talents, with help from the old guard, many of whom were key to his successful spell at Bayern Munich.

Away from regulars such as Thomas Muller, Leon Goretzka, Joshua Kimmich and Manuel Neuer, Flick has included four uncapped players in his first squad – David Raum, Nico Schlotterbeck, Florian Wirtz and Adeyemi.

A technically gifted and supremely fast winger, Adeyemi has long been considered one of Germany's most promising young players, having cost Salzburg a reported €3m when he was 16.

Adeyemi, who left Bayern six years earlier, has been given the chance to spread his wings with Salzburg and has been strongly linked with Red Bull sister club RB Leipzig.

He already has six goals in six Austrian Bundesliga appearances this term, just one less than he managed in 29 top-flight appearances last time out – a return he will be looking to build on if he is given the nod by Flick.

Justin Bijlow (Netherlands)

The Netherlands are another European heavyweight going through a transitional period of sorts after turning to veteran coach Louis van Gaal for a third stint in charge.

Frank de Boer failed to get the most out of this talented Dutch squad and already Van Gaal has put his own mark on the team by calling up a few newbies.

There will be plenty of focus on the goalkeeping position as, with Jasper Cillessen not fully fit and Maarten Stekelenburg recently retiring, Joel Drommel and Bijlow can stake a claim to be the long-term number one.

Bijlow is considered one of the finest young goalkeepers in Europe and already has 45 Eredivisie games under his belt for Feyenoord, where he is a real fan favourite.

The 23-year-old has kept 15 clean sheets across those appearances and boasts a save percentage of 72.16. Van Gaal can seemingly rely on the young stopper, as he has made just one error leading to a goal.