India are favourites to carry on where they left off in Australia and spoil England captain Joe Root's 100th Test in Chennai.
Depleted India defied the odds to come from behind and secure a 2-1 series win in Australia despite being without a host of key players, including captain Virat Kohli.
Kohli returns from paternity leave to lead the side after Ajinkya Rahane filled in superbly in his absence, while Jasprit Bumrah, Ishant Sharma and Ravichandran Ashwin have recovered from injuries but Ravindra Jadeja (broken thumb) misses out.
India are in pole position to seal their place in the inaugural ICC World Test Championship final against New Zealand, but England and Australia can also qualify.
In-form skipper Root will become the 15th England player to win a century of Test caps when the four-match series starts at the M. A. Chidambaram Stadium on Friday.
Ben Stokes, Jofra Archer and Rory Burns return, while Jonny Bairstow, Mark Wood and Sam Curran have been given a rest following the recent 2-0 whitewash of Sri Lanka.
The tourists could be without Zak Crawley after the batsman injured his right wrist when slipping outside the changing room, but Ollie Pope is poised to make his comeback from a shoulder injury.
England have won just one Test series in India since 1984-85, losing four and drawing one since then other than a triumph in 2012.
What are the Test Championship permutations?
The postponement of the series between South Africa and Australia ensured the Black Caps will play in the first Test Championship final.
Kane Williamson's side will face India at Lord's if they beat England 2-0, 2-1, 3-0, 3-1 or 4-0.
England must win at least three matches in India to set up another final against New Zealand, so Root's men are very much outsiders.
Australia will qualify if England win the series without winning three matches, while they will also take on their trans-Tasman rivals if the series is drawn or India come out on top 1-0.
Centurion Root leading by example
Root failed to make a hundred for England last year, but the prolific captain showed class is permanent in Sri Lanka.
The 30-year-old made a magnificent 228 in his first innings of the series and struck a brilliant 186 in the second Test, making a strong statement at the start of a hectic year for England.
Root averaged 106.50 as he delivered a masterclass of how to bat against spin and will be relishing the battle with the India attack.
He is just one win away from matching Michael Vaughan's record of 26 Test wins as England skipper and achieving that feat in the Yorkshireman's 100th match would be extra special.
KEY MATCH FACTS
- Four of the last five Test series between the two sides have been won by England, who eased to a 4-1 victory when they last did battle in 2018.
- India have won their last 10 multi-game bilateral Test series on home soil, that run beginning after they suffered a 2-1 defeat at the hands of England in 2012.
- India have recorded five wins to England's three when facing off against each other at M.A. Chidambaram Stadium. India have won three in a row at the Chennai venue.
- No touring side has won at M.A. Chidambaram Stadium during the 21st century (D3 L5) – Pakistan being the last team to do so in the format (1999).
- England are on a run five away Test wins in succession – their longest such run since 1914 (seven in a row between 1911 and 1914).