Naomi Osaka and Victoria Azarenka withdrew from their respective tournaments on Saturday due to injuries.

Osaka, a three-time grand slam champion, opted out of her Gippsland Trophy semi-final against Elise Mertens.

Azarenka, meanwhile, was due to face Anett Kontaveit in the Grampians Trophy quarter-finals.

Osaka said her move was a cautious one ahead of the Australian Open, which begins on Monday.

"Sorry to Tennis Australia and the fans to have to withdraw today," she said, via the WTA.

"I have a niggling injury and in light of the Australian Open on the horizon, I need to be cautious. I look forward to competing next week."

It continues what has been a difficult build-up to the first grand slam of the year.

On Friday, Serena Williams withdrew from her semi-final at the Yarra Valley Classic due to a right shoulder injury.

It comes amid a busy schedule for players after Thursday's action was called off due to a coronavirus scare.

One in eight women in the Australian Open draw have already won a grand slam title.

One in eight. It is staggering that of the 128 players who set out in the hope of singles glory at Melbourne Park, there are 16 major champions among them, and perhaps never has it been so difficult to predict who will carry off the title.

Compare it to the men's draw, where there are just five grand slam singles winners, and where you would struggle to make a compelling case for any more than three of those this year, with apologies to Stan Wawrinka and Marin Cilic.

As long-running dynasties near their end on the men's and women's tours, the WTA is a lengthy step ahead of the ATP with a cast of appealing characters already assuming leading roles.

The leader of the pack

Three-time grand slam champion Naomi Osaka is at the forefront of a school of rising stars, but she has impressive rivals for company.

The last four years have seen the 15 women's majors won by 12 different players, whereas in the men's game, Rafael Nadal (6), Novak Djokovic (5), Roger Federer (3) and Dominic Thiem (1) have creamed off all the top prizes in the same period.

Often criticised in the past for a perceived lack of depth, in the years when Serena Williams won seemingly at will, the women's tour has exploded with a rush of bright and young talent.

Osaka is a revelation and a leader, on and off the court. Twice a US Open champion now, and a winner in Australia two years ago, the 23-year-old Japanese star took a powerful stance for racial equality at Flushing Meadows back in September, at the height of Black Lives Matter protests. She wants to achieve even more off the court than on it, where she looks assured of one day leaving an impressive legacy.

If there is any area where Osaka's game falls down it is consistency. She has surprisingly not passed the fourth round in 14 of her 17 grand slam appearances, but on every occasion she has gone beyond that stage it has been en route to lifting a trophy.

In hot pursuit

Last year's three slam champions were, at the times of their triumphs, just 21 (Sofia Kenin - Australian Open), 19 (Iga Swiatek - French Open) and 22 (Osaka - US Open).

The women's game has not seen anything comparable in terms of youthful winners of its blue riband tournaments since 2004, when the 21-year-old Justine Henin won in Australia, Anastasia Myskina landed the Roland Garros title at 22, Maria Sharapova was a 17-year-old bolter to Wimbledon glory and 19-year-old Svetlana Kuznetsova scored a stunning Flushing Meadows victory.

Last year does not touch the 1997 season, when a 16-year-old Martina Hingis won the Australian Open, Wimbledon and US Open, denied a grand slam clean sweep by 19-year-old Iva Majoli's shock French Open final win over the Swiss.

But women's tennis is still seeing a remarkable shift to relative youth.

The 2019 season saw a then 19-year-old Bianca Andreescu scoop a stunning US Open win, while Ash Barty took the French Open.

Andreescu has been sidelined with a knee injury since the 2019 WTA Finals, but she is back for Australia, where Queenslander Barty, now 24, is the home hero.

Brace for the prospect of Andreescu and Barty joining Kenin, Swiatek and Osaka in a group of five who can take the women's game boldly into the post-Williams era.

But the Williams era isn't over

This is true, and again Serena will make another attempt to land that elusive 24th grand slam, the one that would move her level with Margaret Court on the all-time list.

She remains, at the age of 39, a magnificent competitor and a beguiling player, as does sister Venus, who turns 41 in June.

Serena has lost her last four grand slam finals, however, and the most recent run to a title match came almost 18 months ago in New York, where Andreescu had her number.

As the new gang of five threaten to pull away from the old establishment, perhaps Williams is now in the next group, along with the likes of Simona Halep, Victoria Azarenka and Petra Kvitova: still perfectly capable of winning another slam or even multiple slams, but it feels important to strike now.

Serena has not won any of her last 10 slams, making it the longest span in her professional career without winning a major.

Barty party, or Sofia the second?

Osaka begins the Australian Open as favourite with bookmakers, but world number one Barty will have home support and could make that count. How she performs will be keenly watched, given she chose not to travel once the COVID-19 pandemic hit last year, sitting out 11 months.

Should Barty get on a roll, hopes will be high she can become the first Australian woman to take the title since Chris O'Neil in 1978. Last year, Barty fell in the semi-finals to Kenin, and she will be eager to land a second slam title.

Kenin, whose intense concentration and steely resolve helped her pull off last year's shock Melbourne win, and follow up with a run to the French Open final, can be a match for anyone. She will be aiming to become the first woman to win back-to-back Australian Open titles since Azarenka in 2012 and 2013.

Success on this level has come perhaps ahead of schedule for the American, and the same can be said for Swiatek, whose demolition of the field at Roland Garros in October made a mockery of her being ranked number 53 in the world.

The teenage Polish player became her country's first grand slam singles champion, and with that status comes the expectation she will follow it up. How that turns out for her will be one of the most intriguing of sub-plots in the new season.

Changing priorities

Halep said in a recent WTA interview that winning an Olympic medal was her "main goal" for 2021, although Osaka will also have the Tokyo Games firmly circled in her diary.

For the likes of those other players among the 16 slam winners in the Melbourne draw, there will be differing targets this year, too.

Angelique Kerber, Sloane Stephens, Jelena Ostapenko and particularly Garbine Muguruza may yet come good again on the big stage at some point this season.

For Venus Williams, Kuznetsova and Samantha Stosur, it may be a case of one final hurrah.

As the likes of Coco Gauff emerge as potential future big-stage winners, and fledgling ambassadors, the women's game looks in safe hands.

Victoria Azarenka called for greater understanding from players stuck in hotel quarantine ahead of the Australian Open.

After being exposed to coronavirus on flights, 72 players – including Azarenka – have been forced into a two-week quarantine ahead of the tournament beginning on February 8.

Novak Djokovic reportedly made several requests, which were rejected, of officials for players in quarantine, while Roberto Bautista Agut compared the conditions to prison.

But amid complaints on social media, two-time Australian Open champion Azarenka pleaded for players to be more understanding in a measured statement.

"Dear players, coaches, entourage and Australian community. I would like to take a moment and address some of my colleagues as well as the media around the world," the Belarusian wrote on Twitter.

"This has been a very difficult time for a lot of us that did not expect to end up in the situation we are in today, myself included. To be in a 14-day hard quarantine is very tough to accept in terms of all the work that everyone has been putting in during their off-season – to be prepared for playing our first grand slam of the year. I understand all the frustration and feeling of unfairness that has been coming and it is overwhelming.

"We have a global pandemic, nobody has a clear playbook of how to operate at full capacity and without a glitch, we all have seen it last year. Sometimes things happen and we need to accept, adapt and keep moving.

"I would like to ask all my colleagues for cooperation, understanding and empathy for the local community that has been going through a lot of very demanding restrictions that they did not choose, but were forced to follow.

"I would like to ask to be sensitive as well to the people who have lost their jobs and loved ones during this horrible time for all of us around the world. I would like to ask all of us to have respect for people who work tirelessly to try to make our lives easier.

"I would like to ask the media to please have consciousness on the impact and influence you bring to this situation and to the community. I would like for the people in the community to know and understand that we have it as our top priority to ensure the health [and] safety of all the people.

"Lastly, I would like for us to please try to support each other as much as someone can or is willing to. Things are always easier when you have a compassionate environment and work together."

Victoria endured tough restrictions after a second coronavirus wave last year.

On Tuesday, the state recorded its 13th consecutive day of no locally acquired cases of COVID-19.