Warren Gatland has left experienced trio Alun Wyn Jones, Taulupe Faletau and Justin Tipuric out of Wales' starting line-up for Saturday's Six Nations clash against Scotland.

Wales were beaten 34-10 on home soil by Ireland in their tournament opener last weekend as Gatland's first game back in charge after replacing Wayne Pivac ended in defeat.

Gatland has rung the changes to his pack ahead of facing Scotland at Murrayfield, with British and Irish Lions veterans Jones, Faletau and Tipuric making way.

Jones and Tipuric have been left out of the matchday squad entirely, while Rhys Davies could make his Test debut from the replacements' bench.

Dafydd Jenkins and Christ Tshiunza will make their first starts for Wales, who have also added Tommy Reffell to their back row.

"We created opportunities last week but weren't clinical enough in terms of finishing them off," said Gatland, who has won all 10 matches against Scotland as Wales head coach.

"We need to start better. We gave away stupid penalties and unforced penalties when we weren't really under a lot of pressure so that's been an area that we've spoken about."

Wales have won 13 of their past 15 matches against Scotland in the Six Nations (L2), including six of their seven matches at Murrayfield during that run (L1).

Scotland also named their 15-man team on Thursday, with Zander Fagerson returning to the front row in the only change from the 29-23 victory over England.

Fagerson, who missed the win at Twickenham having only recently recovered from a hamstring injury, replaces the benched WP Nel.

Last week's Calcutta Cup hero Duhan van der Merwe is joined in the back three by Kyle Steyn and Stuart Hogg, who continues at full-back.

Gregor Townsend has also named an unchanged bench, meaning no place in the squad for Hamish Watson, despite recovering from concussion.

Scotland have won their opening Six Nations fixture in each of the past three years, but they went on to lose to Wales in round two in both 2021 and 2022.

However, since beating Scotland in that most recent meeting 12 months ago, Wales have gone on to win just twice in 11 matches, losing their last three in a row.

Scotland XV: Stuart Hogg, Kyle Steyn, Huw Jones, Sione Tuipulotu, Duhan van der Merwe; Finn Russell, Ben White; Pierre Schoeman, George Turner, Zander Fagerson; Richie Gray, Grant Gilchrist; Jamie Ritchie (c), Luke Crosbie, Matt Fagerson.

Replacements: Fraser Brown, Jamie Bhatti, WP Nel, Jonny Gray, Jack Dempsey, George Horne, Blair Kinghorn, Chris Harris.

Wales XV: Liam Williams; Josh Adams, George North, Joe Hawkins, Rio Dyer; Dan Biggar, Tomos Williams; Wyn Jones, Ken Owens (c), Dillon Lewis, Dafydd Jenkins, Adam Beard, Christ Tshiunza, Tommy Reffell, Jac Morgan.

Replacements: Scott Baldwin, Rhys Carre, Leon Brown, Rhys Davies, Taulupe Faletau, Rhys Webb, Rhys Patchell, Alex Cuthbert.

Manu Tuilagi and captain Courtney Lawes will make their returns from injury in England's Six Nations showdown with Wales at Twickenham, while forward Taulupe Faletau will make his first appearance since last year's competition for the visitors on Saturday.

Both sides have posted a win and a loss in their two games so far to trail early leaders France in the table.

England bounced back from a 20-17 loss to Scotland by thrashing Italy 33-0 last time out, while Wales beat Scotland 20-17 after opening their title defence with a 29-7 defeat in Ireland.

Lawes returns from a concussion-enforced layoff which has kept him out of action since January, and regains the captaincy he held against South Africa last Autumn, replacing stand-in Tom Curry in the role.

Tuilagi also makes a welcome return from injury, but Ben Youngs will have to wait to win a record 115th cap after being named on the bench, as Eddie Jones makes four changes to the team which impressed in Rome, with Luke Cowan-Dickie and Kyle Sinckler also coming in.

Looking ahead to the match, Jones told England Rugby that he was content with his side's preparation, and was excited ahead of the showdown.

"We've prepared very well for this game, the squad have really come together on and off the pitch," said Jones. 

"Wales are a good, tough side and Six Nations champions, and it will make for an exciting Test match in front of a full Twickenham crowd.

"We've got a talented, young, hungry squad who have trained with real intensity this week. We're ready to go at them and can't wait to play in front of our supporters again."

The British and Irish Lions will repeat a feat last achieved back in 1959 if they avoid a series defeat in South Africa.

Warren Gatland's side drew with New Zealand four years ago after a 2-1 triumph in Australia in 2013.

It is 62 years since the Lions were able to avoid defeat in a third consecutive tour and they will have to face the world champions without Alun Wyn Jones, who was replaced as captain by Conor Murray after he suffered a dislocated shoulder in the win over Japan.

Confirmation on Sunday that three members of the Springboks squad have tested positive for coronavirus was a concern before the Lions boarded the plane to South Africa.

They are due to play five tour matches before the first Test against the Springboks at Cape Town Stadium on July 24.

Stats Perform picks out some of the standout Opta numbers for such an eagerly-awaited tour.

BOKS TO GO BACK-TO-BACK?

South Africa were 2-1 winners the last time the Lions toured in 2009, but they have not won back-to-back series since coming out on top in 1962 and 1968.

The Springboks have won eight, lost four and tied one of their previous series against the Lions.

South Africa can boast 23 victories to the Lions' 17, with six of the 46 previous showdowns ending in a draw.

There have been alternate winners in the past five series between the Lions and South Africa, a sequence the Lions will be hoping continues.

SOUTH-AFRICA-BORN FLYER AMONG DEADLY DEBUTANTS

While the loss of Jones and Justin Tipuric to injury in the win over Japan at Murrayfield were big blows, Gatland will have been encouraged by the performances of his debutants.

Three of the four try-scorers in Edinburgh were making their Lions bows, with Josh Adams, Duhan Van Der Merwe and Tadhg Beirne crossing.

South-Africa born Scotland wing Van der Merwe was the leading try-scorer in the Six Nations this year with six and beat 31 defenders in the tournament, breaking a record set by Brian O'Driscoll.

He can make a big impact against his country of birth along with Adams, the leading try-scorer at the 2019 World Cup with seven.

South Africa must also be wary of Louis Rees-Zammit, the youngest tourist aged 20, after he scored four Six Nations tries and had the most clean breaks (nine) in the competition, also gaining the most metres per carry (9.9m from 27 carries).

Beirne caught the eye against Japan and can play a big part in South Africa. He affected the most turnovers in the Six Nations with nine and was the first man to 87 rucks - the same number as Gregory Alldritt.

PASS MASTER MURRAY CAN DICTATE

Murray was surprised to be given the honour of skippering the Lions in the absence of the most-capped player in the history of international rugby.

The Ireland scrum-half has vast experience and can lead by example in his third Lions tour.

Murray has won two, lost two and drawn one of his previous Lions Tests and will look to pull the strings for the tourists.

The 32-year-old pivot has assisted 25 Six Nations tries, eight more than any other player, and holds the record for the most passes in the competition with 3,527. Peter Stringer is next on the list with 2,539.

KEY MEN CAN ROAR AGAIN

There were some outstanding performances in the Lions' tour of New Zealand as they drew 1-1 with the All Blacks.

Maro Itoje was among the heroes of that tour and the England lock will embrace the battle with the Springboks. He hit more rucks (162) than any other player in the Six Nations this year and amassed 16 turnovers.

Versatile back Liam Williams made the most metres by a Lions player on the tour in New Zealand four years ago with 344 from six games.

Gatland has been able to rely on Taulupe Faletau time and again over the years. The back-row made the most tackles (76) in New Zealand and beat more defenders (14) than any other forward.