Carlos Alcaraz finished the job against Brazilian wild card Mateus Alves to set up a second-round meeting with Fabio Fognini at the Rio Open.
Alcaraz's first-round meeting with Alves was halted on Tuesday due to heavy rain with the 2022 US Open champion leading 6-4 5-3, but the Spaniard clinched victory on Wednesday 6-4 6-4.
The top seed will take on 35-year-old Italian Fognini, who also was made to wait to secure his progress due to the Tuesday rain, eventually triumphing 6-2 6-3 over Chilean qualifier Tomas Barrios Vera.
Second seed Cameron Norrie endured a tough second-round tussle with local Thiago Monteiro, needing two hours and 30 minutes to triumph 7-5 7-5.
The Briton prevailed in one hour and 25 minutes in the first set against the 83rd-ranked Brazilian, while he was broken when serving for the match at 5-4 in the second frame.
Norrie, however, rallied to break straight back before securing victory after successfully serving the match out on the second attempt.
Fifth seed Diego Schwartzman was the major casualty of the day's play, going down 6-1 6-4 to Serbia's Dusan Lajovic in one hour and 29 minutes.
Brazilian veteran Thomaz Bellucci farewelled the ATP Tour after losing 6-3 6-2 to sixth seed Sebastian Baez.
Albert Ramos Vinolas, Bernabe Zapata Miralles and Hugo Dellien were also winners on Wednesday, with the latter progressing into the quarter-finals to face Norrie.