Stipe Miocic will face the winner of Saturday's heavyweight title fight between Jon Jones and Ciryl Gane, UFC president Dana White has announced.

Jones makes his long-awaited return to the UFC at heavyweight in Las Vegas.

A former two-time light heavyweight champion, Jones is facing Gane for the vacant heavyweight belt after Francis Ngannou left the UFC as a free agent.

Ngannou beat Miocic and Gane in his last two fights before quitting, and Jones will take on the same pair in reverse order if he comes through Saturday's bout at UFC 285.

"He's absolutely the next one," White said of Miocic. "So, whoever wins on Saturday night will face Stipe next."

But there will be no blockbuster return for Ngannou, who White says will not be allowed back into the UFC.

"We negotiated with him for years," he said. "It's over. That's over. He'll never be in the UFC again."

Francis Ngannou set his sights on Jon Jones after sealing a devastating knockout win in his rematch with Stipe Miocic to claim the heavyweight title at UFC 260.

Ngannou became the undisputed champion as he gained revenge after being outclassed by Miocic three years ago at UFC 220, the Cameroonian landing a brutal and decisive blow with a left hook in the second round.

And now the 34-year-old wants a shot at Jones, with the legendary American poised to step up to the heavyweight division later this year.

Ngannou lauded Jones as the GOAT of MMA, but declared he was ready for the challenge.

"In my opinion, Jon Jones is the greatest of all time in mixed martial arts. Him moving up is going to be a good thing," he said after his stunning victory in Las Vegas.

"He's a challenge I will take, and it will be a very good thing on the resume. But this time he is the challenger. I am the champ. He's coming up, looking for me.

"So I'm ready any time soon. Even summer, I will be here, ready to fight in July or August. Whenever they are ready, I'm ready.

"He said something, 'Show me the money'. Show the money and we'll go, baby. I'm here."

Miocic – who was coming off a unanimous decision win over Daniel Cormier at UFC 252 last August – was left stunned by an overpowering display from Ngannou, who got the job done 52 seconds into round two.

Francis Ngannou annihilated Stipe Miocic with a brutal second-round knockout in their blockbuster rematch to become the UFC heavyweight champion.

Ngannou was outclassed by Miocic three years ago, the Cameron fighter unable to take the title away from his opponent at UFC 220 in 2018.

But Ngannou (16-3) exacted revenge on Saturday thanks to his brutal KO of the titleholder at UFC 260 in Las Vegas, where a new champion was crowned.

Ngannou earned another title shot following knockout wins against Curtis Blaydes, Cain Velasquez, Junior dos Santos and Jairzinho Rozenstruik.

The 34-year-old dethroned Miocic (20-4) inside the UFC Apex, where he had the American fighter in trouble early in the second round after dropping the champion with a two-punch combination.

Miocic – who was coming off a unanimous decision win over Daniel Cormier at UFC 242 last August – was left stunned after being swarmed with punches on the chin and Ngannou followed with a hammer fist on the ground as the referee waved off the fight.

Afterwards, Ngannou talked up a showdown with former champion Jon Jones.

"It's a challenge that I'll take and a very good fight on my resume," Ngannou said post-fight.

"He's the challenger, I am the champion so he's looking for me. I'm ready to fight in July and August. Let's do it." 

In the co-main event, Vicente Luque stunned former welterweight champion Tyron Woodley, who was forced into submission in the opening round.

It condemned Woodley to a fourth consecutive defeat as Luque earned the biggest win of his career.

"I want to take this time also to call out Nate Diaz," Luque said. "I called him out in the past and he didn't respond. My style, it matches perfect. I'm going to go forward. I think Nate is a perfect fight."