Jamie Gittens scored twice as Borussia Dortmund opened their Champions League campaign with a 3-0 victory away at Club Brugge.

Serhou Guirassy added a late penalty for last season's finalists, who netted three times in the final quarter of an hour at Jan Breydelstadion.

Brugge carried the greater attacking threat for most of the contest, going closest to scoring when Hugo Vetlesen rattled the crossbar, but they were made to pay for their profligacy.

Gittens entered the action as a 68th-minute substitute and broke the deadlock eight minutes later—albeit in fortuitous circumstances—with his shot taking two deflections before nestling in the top-left corner.

The 20-year-old doubled his and Dortmund's tally with four minutes remaining, cutting inside before firing past Simon Mignolet in the Brugge goal.

Guirassy added further gloss to the scoreline from the penalty spot deep into stoppage time, slotting home from 12 yards after he was fouled by Brandon Mechele.

Data Debrief: Super sub Gittens stars in historic win

Keeping Brugge at bay, Dortmund became the first team in Champions League history to play a single opponent five times without conceding a goal.

Gittens got the ball rolling at the other end. At 20 years and 41 days old, he is the second-youngest player to score two or more goals as a substitute in a Champions League game, older than only Monaco's David Trezeguet, who was just 34 days younger when he struck against K. Lierse SK in October 1997.

Guirassy completed the victory from the spot, meaning Dortmund have now converted each of their last six Champions League penalties, last failing from 12 yards against Barcelona in September 2019 through Marco Reus.

The second set of Champions League last-16 fixtures to take place this week is full of intrigue, with the continent's biggest-spending club of the January transfer window in need of a result.

Graham Potter's Chelsea forked out an estimated £291million to reshape their squad last month, but the misfiring Blues have won just one of their eight games this calendar year. 

For all his struggles on the domestic front, Potter has yet to suffer a Champions League defeat with Chelsea, and maintaining that record at Borussia Dortmund would give them an excellent chance of reaching the last eight.

Potter is not the only under-fire English boss to take centre stage on Wednesday, with former Fulham and Bournemouth head coach Scott Parker overseeing Club Brugge's clash with Benfica.

With just one win in nine games since the World Cup, Brugge will be considered outsiders against the Lisbon giants, who were outstanding as they finished above Paris Saint-Germain and Juventus in Group H.

Stats Perform has taken a look at the key Opta numbers ahead of Wednesday's first-leg match-ups. 

Borussia Dortmund v Chelsea

Somewhat surprisingly given their statuses as European regulars, Dortmund and Chelsea will do battle for the first time in continental competition on Wednesday.

The omens are not particularly good for either side, as a BVB team without a win in their last 10 European meetings with English opponents (D2 L8) face a Chelsea side with just three victories in 11 previous away games in Germany (D3 L5).

Dortmund's last win over Premier League opponents came against Tottenham in the Europa League in 2016, with current Chelsea striker Pierre-Emerick Aubameyang netting twice in a 2-1 triumph.

Aubameyang will not be welcomed back by the yellow wall on Wednesday, however, having been left out of Chelsea's Champions League squad following their huge spending spree.

Instead, Germany international Kai Havertz may lead the line as he bids for a first career goal against BVB – his seven appearances without netting against Dortmund are more than he has managed against any other club.

Dortmund, meanwhile, could hand Sebastien Haller his first Champions League appearance for the club following his recovery from testicular cancer. The former Ajax man has more goals in his first eight games in the competition (11) than any other player.

Additionally, Haller has averaged a goal every 61 minutes of Champions League football, the best ratio in the competition's history (minimum 250 minutes played).

Should Chelsea keep Haller quiet en route to victory, Potter would become the first English manager to win five consecutive Champions League matches, with a 1-1 draw against Salzburg in his first game at the helm the only blot on his European record with the Blues.

Club Brugge v Benfica

Two of the group stage's surprise packages meet in Belgium, with Brugge having escaped Group B at the expense of Bayer Leverkusen and Atletico Madrid, while Benfica bested PSG and Juventus.

Brugge boss Parker has struggled since replacing Carl Hoefkens, but he will join an exclusive club on Wednesday as just the third English coach to lead a non-English team in the Champions League, after Bobby Robson (Porto and PSV) and Gary Neville (Valencia).

In Parker and Potter, meanwhile, two different English managers will coach in the same Champions League campaign for the first time in the competition's history.

Benfica are sure to make things difficult for Parker's team. The Portuguese giants are unbeaten in their last seven Champions League games (W4 D3) and are chasing three consecutive wins in the competition for the first time since the 2005-06 campaign.

In the group stage, Benfica generated more shots (14) and scored more goals (five) following high turnovers (open-play sequences starting within 40 metres of the opponent's goal) than any other team, showing their devastating counter-attacking abilities.

Benfica also have the highest conversion rate of any team, netting with 20 per cent of their shots in the Champions League this term (16/80).

Home goalkeeper Simon Mignolet, then, could be in for a busy outing. Fortunately for Brugge, he has prevented more goals than any other goalkeeper in the Champions League this season (6.3) – being beaten four times from 10.3 expected goals on target faced.

Diego Simeone insisted Atletico Madrid had produced one of their best displays this season in Wednesday's goalless Champions League draw with Club Brugge.

Atleti recorded 21 shots to Brugge's five as they dominated at the Civitas Metropolitano, but their poor European form continued as they failed to make the breakthrough.

The result ensured Brugge will progress to the Champions League's knockout stages for the first time in their history, but Atletico's chances of joining them are in doubt after taking just four points from four games in Group B.

Atleti have now failed to score in five of their last six Champions League matches, including each of their last three, but Simeone refused to criticise their performance.

"We had important situations, well generated, we played one of the best games of this season, due to our rhythm, intensity, the rival," Simeone said. "Many good things were seen, but the goal did not come. 

"Morata's chance is the one that remains in all of our minds, but the goalkeepers are here to stop and the players are here to be forceful or not.

"This round we did things very well, better than in the first leg against them. I keep a lot of good things, honestly."

However, with Atletico rounding off their Group B campaign with tough tests against Porto and Bayer Leverkusen, Simeone is under no illusions as to what is now required.

"The classification was complicated, and we are in a place where the only good thing is that we have to win both games," he added.

Brugge goalkeeper Simon Mignolet was the star of the show on Wednesday, denying Atleti on nine occasions.

The former Liverpool shot-stopper has now made 14 saves across two appearances against Atleti in the Champions League this season – the most any goalkeeper has made against a single opponent without conceding in a single campaign since records began (in 2003-04).

Speaking to Club RTL after the match, Mignolet said helping Brugge to the knockout stages ranked among the highlights of his career, saying: "I have already done a lot of things, but it was an incredible feeling with the team. A first in the history of the club. It's a great moment.

"We needed everything to keep the clean sheet today. I had a good match, I made my saves but it was just necessary to keep the clean sheet."

Simon Mignolet hopes Belgium can learn from their shock 4-1 defeat to the Netherlands, who outclassed the world's second-ranked team in Brussels.

The form book was on Belgium's side heading into their Nations League opener at home to the Oranje on Friday.

The Red Devils had not lost to their neighbours since September 1997 and had not lost to any side at home since September 2016.

But both of those runs came to an end as Belgium were blown away, with Mignolet – in for Champions League final hero Thibaut Courtois – left horribly exposed.

Nine of the Netherlands' 15 shots came over a 25-minute first-half stretch in which Belgium did not attempt one.

Steven Bergwijn netted the opener shortly after that onslaught, before Memphis Depay scored twice either side of a simple Denzel Dumfries finish in the second half.

It was the first time Belgium had conceded four goals at home since October 2010, but Mignolet had no complaints about the scoreline.

"There are no excuses for this defeat," the goalkeeper said. "You get the chance to play against the Netherlands and you have to grab that opportunity with both hands.

"In the run-up to the World Cup, tonight's game and the remaining matches in the Nations League were good opportunities to measure ourselves.

"We have to learn from this and take things forward to the preparations for the World Cup in Qatar."

The mood in the Dutch camp was rather more cheerful, as captain Virgil van Dijk told NOS: "It was a good win with good football. Everyone was good today.

"Steven Bergwijn in particular was excellent – they couldn't get a grip on him – but also Steven Berghuis and Frenkie de Jong. Actually, I can be positive about everyone. It was a great team performance.

"We did an excellent job, we forced them to make mistakes and we scored good goals."

Van Dijk came straight from playing against Courtois in the Champions League final and will now bring his long season to an end while the Netherlands turn their focus to further Nations League matches.

"It's time to recover," the centre-back added. "I'm going on holiday now and the rest can prepare for Wales [on Wednesday]."