San Diego Padres' star Fernando Tatis Jr has been cleared to ramp up as he homes in on a playing return as early as next month following March wrist surgery.

The 2021 All-Star shortstop has not played at all this season, having undergone an operation to repair the fractured scaphoid bone in his left wrist on March 16.

Tatis Jr met with his surgeon on Tuesday and Padres manager Bob Melvin revealed that he has subsequently been cleared to ramp up "on the defensive end", although hitting is still to come.

"I know he's excited about the fact that he's going to be on the field with us, no restrictions as far as taking ground balls, throwing and so forth," Melvin said.

"Hitting's going to be the last thing."

It is anticipated he will return to hitting at full speed in a fortnight's time, with a playing return floated for late July or August.

"It depends on how we kind of configure it before he starts playing games," Melvin said.

"You certainly want him coming back when he feels good about how he’s swinging the bat. More days with us is probably better than less days with us."

Tatis Jr, 23, won the Silver Slugger Award in both 2020 and 2021 along with being last year's National League home run leader. He is a two-time All-MLB First Team selection (2020 and 2021).

Reigning National League MVP Bryce Harper was ruled out indefinitely by the Philadelphia Phillies after fracturing his left thumb during Saturday's win over the San Diego Padres.

Harper sustained the injury in the fourth inning when he was hit by a 97mph fastball from Padres pitcher Blake Snell.

Set to undergo further evaluation in the coming days, Harper said: "I've never had a hand injury like this.

"Never broken anything in my life. This is new to me, so I'm just gonna go day by day, see kind of where we're at, and see the specialist in Philly. And if I do need to see another specialist somewhere, then I will."

Harper joked: "I kind of wish it would've hit me in the face. I don't break bones in my face. I can take 98 to the face, but I can't take 97 to the thumb."

General manager Dave Dombrowski was unsure in the immediate aftermath whether Harper would require surgery.

"We will put him on the injured list [on Sunday]," Dombrowski said. "I was concerned at first he got hit in the face. I was concerned right off the bat because he is a tough guy and he walked off the field immediately."

Harper is fifth in the NL with a batting average of .318. He has 15 home runs this season and is tied sixth in the NL with 48 RBIs.

"He is a guy who really isn't replaceable on an individual basis, but we are going to have to be in a position that other people are going to have to step up," Dombrowski said.

"We will make a move to try and get someone here [on Sunday]."

Houston Astros pitchers Cristian Javier, Hector Neris and Ryan Pressly combined for a stunning no-hitter in their 3-0 win over the New York Yankees on Saturday.

Javier set career highs for pitches (115) and strikeouts (13) after walking Josh Donaldson on a full count in the first at-bat, before Astros manager Dusty Baker brought Neris in to start the eighth inning.

Pressly, who gave up the game-tying three-run home run to Aaron Hicks in Thursday's loss to the Yankees, retired three-straight in the ninth for his 15th save out of 18.

Astros rookie JJ Matijevic gave the Astros the lead in the seventh inning with his second homer in the major leagues, sending Gerrit Cole deep over right-field.

Jose Altuve followed that up with a home run of his own in the eighth but Yuli Gurriel added an RBI single in the ninth, as the Astros took their second game of three in the high-profile four-game series.

Harper breaks thumb as Appel makes Phillies roster

While Mark Appel's promotion to the Philadelphia Phillies' roster was the main topic pre-game, nine years after he was selected in 2013 MLB Draft, it was overshadowed by Bryce Harper's broken thumb in their 4-2 win over the San Diego Padres.

The reigning National League MVP will be out indefinitely after a wild fast-ball from Padres starter Blake Snell tagged him on the left hand.

Alec Bohm and JT Realmuto led the way in Harper's absence, with Bohm claiming two hits and RBI from four at-bats and Realmuto's home run off Snell setting up a three-run fifth inning.

Archer and Twins combine for one-hitter

Chris Archer was instrumental as the Minnesota Twins claimed top spot in the American League Central, as they secured a 6-0 victory against the Colorado Rockies.

On a limited pitch count, Archer gave up just one hit and struck out five over 78 pitches in five innings, before Jharrel Cotton, Griffin Jax and Tyler Thornberg shut the Rockies out.

Leading the major leagues in batting average (.347) and OBP (.426), Luis Arraez claimed two hits and an RBI from five at-bats to help secure the win, moving the Twins to 40-33 for the year.

Mark Appel could be about to end his long, long wait to play in the major leagues after being called up by the Philadelphia Phillies.

Appel is joining the Phillies after the team put Connor Brogdon on the COVID injured list, according to MLB.com and The Athletic.

The 30-year-old pitcher is yet to make a single MLB appearance, despite being taken with the first overall draft pick by the Houston Astros in 2013.

That was the third time Appel had been selected – and second time in the first round – but the first time he was signed.

However, Appel never played for the Astros and was traded to the Phillies after the 2015 season, having struggled in the minor leagues.

He was designated for assignment in 2017 and announced his retirement in 2018, admitting he could "probably" be considered "the biggest draft bust".

Yet Appel returned to the Phillies last year and could now get his opportunity in place of Brogdon. The team are in the middle of a four-game series against the San Diego Padres.

Appel is one of four first overall picks never to have made it to MLB, along with Steve Chilcott, Brien Taylor and Brady Aiken.

The Astros also selected Aiken – in 2014, when Appel was still a part of the organisation – but a bonus dispute saw him become the first number one pick to be left unsigned since Tim Belcher in 1983.

Aiken was drafted again in 2015 by the Cleveland Indians, this time 17th overall, yet he still did not play and was released last year.

Austin and Aaron Nola made MLB history on Friday – to the frustration of the Philadelphia Phillies pitcher.

The brothers faced one another for only the second time in their major league careers as the Phillies visited the San Diego Padres' Petco Park.

The first meeting, in 2021, had gone the way of Phillies right-hander Aaron, as three fastballs saw Austin struck out swinging despite a 4-3 Padres win.

Given the baseball Aaron threw for strike three made its way to Austin for Christmas, revenge could well have been on the agenda this time.

And Austin delivered and then some.

Another Padres win was settled in the battle between the Nola brothers, as Austin drove in the RBI for the only run in a 1-0 victory.

It was the first ever example of a major league player having an RBI off his brother in a 1-0 win.

"Of all the people... do it to somebody else," Aaron said afterwards, knowing he was in store for a tough evening.

"He'll talk about it obviously. It is what it is. Yeah, I'll hear about it tonight. He runs his mouth a lot."

The Phillies had plenty of opportunities to rescue their pitcher, with Kyle Schwarber finally flying out with bases loaded in the ninth.

"I'm beating myself up about that one," Schwarber said. "I can't believe I let his brother beat him. Gosh."

At least in front of the media, Austin was magnanimous in victory, saying: "I'm glad we got the win, but then your brother gets the loss.

"He pitched an unbelievable game. It's fun to watch him. There's no doubt about it.

"He's done it twice to us. He threw seven innings, threw eight innings last year. What a performance by him."

San Diego Padres ace and NL Cy Young Award candidate Joe Musgrove put in another quality start to help his side to a 6-4 away win against the Chicago Cubs.

While Musgrove finished with a great game, it was a rough beginning, with Christopher Morel hitting a home run from the Cubs' first at-bat of the game.

The Padres took the lead in the second inning as Nomar Mazara connected on a two-run home run, before Jake Cronenworth's RBI double a couple of batters later made it 3-1.

Andrelton Simmons pulled one run back with a base hit later in the second inning, and that would be the last run Musgrove gave up, holding the Cubs scoreless for the next five innings.

Musgrove finished with nine strikeouts from seven complete innings, giving up two earned runs from five hits and one walk.

His dominance through the middle innings allowed the Padres to open up some breathing room, with MVP candidate Manny Machado tacking on a run with an RBI single in the fourth, before Austin Nola made it 5-2 with a sacrifice fly an inning later.

Jurickson Profar completed the away side's scoring with a solo home run in the eighth inning, before the Cubs added a pair of consolation runs with RBIs to Frank Schwindel and Ian Happ.

Machado finished with three hits – all singles – from five at-bats, taking his batting average for the season up to .328.

Yankees walk it off

The New York Yankees came out on top in a hard-fought pitching duel, defeating the Tampa Bay Rays 2-1 thanks to a walk-off home run by Anthony Rizzo.

Francisco Mejia finally broke the deadlock with a solo home run to give the Rays a 1-0 lead in the fifth inning, before Rizzo tied things up with an RBI single an inning later.

Yankees starting pitcher Clarke Schmidt only went three innings before he was withdrawn, while Rays starter Jalen Beeks pitched just two innings without allowing a baserunner before he was also pulled, with the two teams trusting their bullpens in long-relief.

With the scores tied in the bottom of the ninth inning, with one out, Rizzo cleared the fence with the game-winning homer, moving the Yankees' league-leading record to 47-16.

Phillies stay hot

It's now 12 wins from their past 14 games for the Philadelphia Phillies after a dominant 10-1 win against the Washington Nationals.

Phillies starting pitcher Zack Wheeler was lights-out on the mound, giving up just one run from four hits and no walks in seven complete innings, while his side were just as impressive with the bat.

Five Phillies drove in at least one run each, with Kyle Schwarber the star, hitting two massive home runs, with both travelling further than 415 feet.

St Louis Cardinals pitcher Miles Mikolas fell agonisingly short of a career-first no-hitter as his side won 9-1 over the Pittsburgh Pirates on Tuesday.

Mikolas came within one strike of the rare feat, achieved only 10 times in Cardinals' history, with two outs and two strikes against the Pirates in the ninth inning.

It was Cal Mitchell who denied Mikolas in his no-no bid with a center-field hit that eluded Harrison Bader by inches and bounced over the wall.

Mikolas tossed down a season-high 129 pitches throughout the game, with six strikeouts.

"It kinda stinks to not finish that out," Mikolas said after the game. "I don’t have one yet. I've got friends who have one, it would’ve been nice to join that conversation but I can't say enough about our defense. I kinda feel like I let them down."

Mikolas overshadowed Mike Goldschmidt who had a four-hit, two-homer and five-RBI display in the second game of the double-header.

Goldschmidt sits atop the National League (NL) rankings for batting average (.349) and on-base plus slugging (1.073). He is second in the NL for RBIs (56) and tied for second for home runs (16).

The Cardinals won both games, triumphing 3-1 in the earlier match-up, with Yadier Molina reaching 14,865 putouts which is the most by a catcher in MLB history.

Voit leads Padres' turnaround against Cubs

The Chicago Cubs' slide continued despite boasting a 5-0 lead heading into the sixth inning as Luke Voit turned things around for the San Diego Padres in a 12-5 win.

Willson Contreras enjoyed his 10th career multi-home run game to help the Cubs lead 5-0 before Voit's two-run blast narrowed the gap, followed by another two runs in the sixth for the Padres.

Voit emptied the bases in the seventh inning, finishing the game with five RBIs along with his two hits and two runs from six at-bats.

Astros launch with eighth-inning rearguard

The Texas Rangers blew their shot at a fourth consecutive win after poor fielding cost them in the eighth inning, losing 4-3 to the Houston Astros.

The Rangers were leading 3-0 in the eighth when third baseman Ezequiel Duran misplayed, allowing Jose Altuve to get home despite a mix-up between bases from Alex Bregman's hit.

Two batters later, with Michael Brantley having added a second run, Kyle Tucker hit a two-run blast to clinch a 4-3 victory for the Astros. Tucker extended his active hitting streak to 13 games.

All-Star Fernando Tatis Jr. is closing in on a return but has still not been cleared to swing a bat following wrist surgery in March.

The 2020 and 2021 All-MLB First Team shortstop had a follow-up exam on Monday after an operation on his broken wrist in March.

The San Diego Padres had initially placed a three-month timeframe on his recovery but general manager A.J. Preller said in an update after his latest exam that he has not yet been cleared to bat.

"Another MRI scan continues to show healing, but it was not quite at the level for ... a full green light," Preller said.

"Basically we're in a spot where we're going to progress week to week."

Tatis has resumed some baseball activities, including taking ground balls, throwing and running.

The 23-year-old has not played at all this season for the Padres, who held a 38-24 record prior to Tuesday's games, sitting second in the NL West behind the Los Angeles Dodgers.

The Los Angeles Angels tied their longest single-season losing streak in franchise history, going down 1-0 at home to the Boston Red Sox on Monday.

Michael Wacha pitched for his first shutout in five years, extending the Angels' losing streak to 12 games, matching the run to end the 1988 season.

Wacha pitched the full nine innings for only the second time in his career, giving up only three hits and striking out six over 105 pitches.

In a thin silver lining to a rather sizeable cloud for the Angels, Mike Trout went one-of-two off Wacha to end a hitless streak of 26 at-bats, the longest in the 30-year-old's career.

The Red Sox confirmed a fifth consecutive victory, moving past .500 ball at 28-27, but they remain fourth in the American League East.

Escobar and Carrasco lead Mets to series-opening win

The New York Mets kicked off a three-game series with a victory over fellow National League contenders in the San Diego Padres, winning 11-5.

After splitting the four-game series in their high-profile National League matchup with the Los Angeles Dodgers, the Mets scored a combined seven runs in the opening and closing innings to pick up the win on Monday.

Eduardo Escobar went four-of-five at the plate, including a home run and six RBIs, while Carlos Carrasco pitched seven innings, striking out 10 and giving up five hits over 105 pitches.

Mariners beat AL West leaders

In Monday's divisional ball, the Seattle Mariners defeated the AL West-leading Houston Astros in a heated contest.

Mariners manager Scott Servais was ejected after the benches cleared when Astros reliever Hector Neris zipped a pitch into the back of Ty France.

Rookie center-fielder Julio Rodriguez hit a two-run home run in the ninth inning, while Cal Raleigh added four RBIs in the win.

Luis Severino combined with two relievers for a one-hitter to hand the New York Yankees a 3-0 win over the Detroit Tigers on Saturday.

Along with the solitary hit, Severino struck out 10 over 92 pitches, before being pulled after the seventh inning for Michael King and Clay Holmes to close the game out.

Tigers pitcher Beau Brieske struck out seven and gave up three hits in six innings, while Miguel Cabrera claimed his 3,033rd career hit, but the damage for the Yankees was done early.

Aaron Judge went deep off Brieske, mashing the rookie on the first pitch in the bottom of the first inning for his 21st home run for the season, before Anthony Rizzo followed suit.

The Pinstripes moved to 38-15 for the season with their fifth consecutive win, extending their lead over the Toronto Blue Jays atop the American League East.

Gore and Cronenworth propel Padres

MacKenzie Gore and Jake Cronenworth were vital for the San Diego Padres as they won their high-profile National League match-up, defeating the Milwaukee Brewers 4-0 on the road.

Gore continued the impressive start to his rookie season, striking out 10 and giving up only three hits over an astounding 108 pitches in six innings.

Cronenworth homered off Aaron Ashby meanwhile, as well as driving in three runs for the important win.

Pivetta continues impressive form for Red Sox

Nick Pivetta pitched for his fifth consecutive win as the Boston Red Sox won their third straight, defeating the Oakland Athletics 8-0.

Pivetta allowed only two hits and struck out seven over 100 pitches in seven innings, before Tanner Houck and Hirokazu Sawamura closed out for the Red Sox.

Alex Verdugo claimed three hits and two RBIs while Trevor Story doubled twice, as Boston moved to within a game from .500.

Luis Severino combined with two relievers for a one-hitter to hand the New York Yankees a 3-0 win over the Detroit Tigers on Saturday.

Along with the solitary hit, Severino struck out 10 over 92 pitches, before being pulled after the seventh inning for Michael King and Clay Holmes to close the game out.

Tigers pitcher Beau Brieske struck out seven and gave up three hits in six innings, while Miguel Cabrera claimed his 3,033 career hit, but the damage for the Yankees was done early.

Aaron Judge went deep off Brieske, mashing the rookie on the first pitch in the bottom of the first inning for his 21st home run for the season, before Anthony Rizzo followed suit.

The Pinstripes moved to 38-15 for the season with their fifth consecutive win, extending their lead over the Toronto Blue Jays atop the American League East.

Gore and Cronenworth propel Padres

MacKenzie Gore and Jake Cronenworth were vital for the San Diego Padres as they won their high-profile National League matchup, defeating the Milwaukee Brewers 4-0 on the road.

Gore continued the impressive start to his rookie season, striking out 10 and giving up only three hits over an astounding 108 pitches in six innings.

Cronenworth homered off Aaron Ashby meanwhile, as well as driving in three runs for the important win.

Pivetta continues impressive form for Red Sox

Nick Pivetta pitched for his fifth consecutive win as the Boston Red Sox won their third straight, defeating the Oakland Athletics 8-0.

Pivetta allowed only two hits and struck out seven over 100 pitches in seven innings, before Tanner Houck and Hirokazu Sawamura closed out for the Red Sox.

Alex Verdugo claimed three hits and two RBIs while Trevor Story doubled twice, as Boston moved to within a game from .500.

The best team in baseball put on a show for their home fans on Friday as the New York Yankees hammered the Detroit Tigers 13-0.

The Yankees did it with bat and ball, with ace pitcher Gerrit Cole taking a perfect game into the seventh inning before it was finally broken up by a Jonathan Schoop single.

Cole finished with nine strikeouts, no walks and just two hits in seven full innings, while with the bat the Yankees hit four big home runs.

After a couple of scoreless innings to begin the game, Jose Trevino got things started with a 405-foot homer in the third inning, with MVP candidate Aaron Judge knocking his own 378-footer just three batters later to make it 2-0.

Trevino stayed hot with a two-run triple in the fourth inning, before Anthony Rizzo crushed the biggest hit of the game with a three-run, 430-foot home run to right-field to make it 8-0 in the fifth.

Recent signing Matt Carpenter got in on the fun as well, hitting a 386-foot blast later in the fifth inning. For Carpenter, it was his fourth home run for the Yankees in just seven appearances.

Judge finished with four hits from five at-bats, and the home run was his 20th of the season. Nobody else in the majors has more than Mookie Betts' 16.

Machado shows MVP power

In a battle between the National League's top MVP and Cy Young candidates, San Diego Padres slugger Manny Machado got the better of Milwaukee Brewers ace Corbin Burnes in a 7-0 win.

With the Padres leading 2-0 in the fourth inning, Machado put his stamp on the game by taking Burnes deep, connecting on a three-run home run to make it 5-0 and signal the end of Burnes' night, getting pulled just two batters later.

Joe Musgrove was the real star for the Padres, though, taking a no-hitter into the eighth inning before it was finally broken up. He finished with six strikeouts in eight innings, giving up one hit and three walks.

Twins order homers with extra Garlick

Jose Miranda and Kyle Garlick hit two home runs each for the Minnesota Twins in their 9-3 away win against the Toronto Blue Jays.

Garlick hit his first as the third batter of the game, giving the Twins a 2-0 lead in the first inning, and as soon as the Blue Jays were able to tie it back up, it was Miranda's turn, putting Minnesota back up 3-2 in the second frame.

Garlick's second came in the third inning, with Toronto's Vladimir Guerrero answering in the same frame, before Miranda finally gave the Twins some breathing room with his two-run blast in the sixth, pulling ahead 6-3 to grab a winning buffer.

The St. Louis Cardinals received strong performances from two rookies as they defeated the San Diego Padres 6-3 on Monday.

After the Padres took an early 1-0 lead, rookie second-baseman Nolan Gorman hit his second career home run with a 403-foot, two-run shot to right-field.

Tommy Edman was the player who trotted the bases along with Gorman for his home run, and he added another run himself with an RBI single in the fifth inning to make it 3-1.

Austin Nola pegged one back for the Padres with a base hit in the sixth frame, before the red-hot Paul Goldschmidt gave the Cardinals some breathing room with a two-run home run, crushing one 414 feet over the left-field wall to extend the lead to 5-2. It also extended Goldschmidt's hitting streak to 21 consecutive games.

Future Hall-of-Famer and 39-year-old Cardinals legend Yadier Molina capped off a fun night for the home faithful with an RBI double to center-field in the seventh inning.

Packy Naughton gave the Cardinals a decent start on the mound, striking out four batters and allowing one run in his two-and-a-third innings, before rookie Andre Pallante came in and earned his first career win, pitching three-and-a-third frames for one earned run and five strikeouts.

Both the Padres and the Cardinals remain three-and-a-half games off the leaders in their respective divisions.

Valdez pitches complete game for Astros

Houston Astros starting pitcher Framber Valdez needed no help on the mound, pitching nine complete innings in his side's 5-1 win against the Oakland Athletics.

Valdez gave up just two hits and three walks, striking out seven, and was able to finish the job in 114 pitches.

With the bat, star Jose Altuve collected two hits, including a 394-foot, two-run homer in the fifth inning, while teammate Yordan Alvarez also had two hits, and both were massive.

Alvarez's first home run travelled 469 feet to center field, and his second was a 444-foot bomb to right-center – but he was not even close to Tuesday's biggest blast.

Sanchez crushes year's longest home run

The Miami Marlins lost 7-1 away against the Colorado Rockies, but the visiting side's one run was a memorable one, coming from the longest home run of the season.

With both sides still scoreless in the second inning, Marlins center-fielder Jesus Sanchez hooked a monstrous 496-foot solo home run deep over the right-field wall and over the third deck.

It was one of only four hits given up by Rockies starting pitcher Ryan Feltner, who finished with seven complete innings for one run and six strikeouts.

No Rockies hit home runs in the game, but both Connor Joe and Garrett Hampson hit triples.

DJ LeMahieu's early grand slam propelled the New York Yankees to a 7-5 win over the Chicago White Sox on Saturday as tempers flared again.

A week after Josh Donaldson and Tim Anderson scrapped in Chicago, the two resumed hostilities in the third inning as the former American League MVP, in his first season with the Yankees, rounded second base.

The benches were then cleared in the fifth inning, when the Yankees' designated hitter faced off with White Sox catcher Yasmani Grandal.

The Pinstripes started strong early and took the lead in the second with a five-run inning, on the back of LeMahieu going deep off Dallas Keuchel with two out.

Nestor Cortes struck out seven and gave up six hits over 100 pitches in five innings, as the Yankees moved to 29-10.

Musgrove muzzles Giants in Padres win

Joe Musgrove was in fine form as the San Diego Padres defeated the San Francisco Giants 2-1 in a big National League West matchup.

Musgrove pitched seven scoreless innings, striking out four and giving up only four hits over 100 pitches.

Manny Machado scored the eventual winning run for the Padres, sending Carlos Rodon's fast-ball back over his head.

Varsho drives Diamondbacks to extra-innings victory

The Arizona Diamondbacks staged a late comeback to defeat the Chicago Cubs, winning 7-6 in an extra inning on the road.

Daulton Varsho was pivotal for the D-Backs, forcing the 10th inning with a two-out, three-RBI double.

Varsho then scored the winning run on the back of a throwing error by Andrelton Simmons in the 10th inning, before Mark Melancon made his ninth save of the season.

The Atlanta Braves came out best after an action-packed eighth inning to defeat the San Diego Padres 6-5 on Saturday.

Down 5-2 in the bottom of the eighth following a four-run inning from the Padres, the defending World Series champions responded with a four-run inning of their own to split the opening two games of a three-game series.

Marcell Ozuna scored a home run and Austin Riley hit the go-ahead double in the response to hand the Braves the win, in what has been a sputtering start to the season.

Charlie Morton pitched solidly, striking out nine and giving up two hits over 83 pitches in six innings.

Atlanta have now won four of their past six games to move to a 16-18 record for the season.

Robert ruins Yankees win streak

Luis Robert drove home the winning run in the ninth inning to hand the Chicago White Sox a 3-2 win over the American League East-leading New York Yankees.

The Yankees were relentless at the plate over the opening two games of the series, scoring 25 runs but faced difficulty against Dallas Keuchel, who struck out three and gave up only four hits over 86 pitches.

While New York still hold the best record in baseball at 24-9, the loss ends a five-game winning streak.

Marte mashes Mariners

Patrick Mazeika hit the game-winning home run in the seventh inning, but Starling Marte was the star for the New York Mets in their 5-4 win over the Seattle Mariners.

Marte tripled, doubled, singled and claimed three RBIs from four at-bats for the Mets, who let a 4-0 lead slip when Jesse Winker tied with a three-run home run in the seventh inning.

Batting ninth, Mazeika had the final say however, mashing Andres Munoz inside the right-field foul pole for his second home run in the major leagues.