England fell foul of some contentious refereeing decisions and indiscipline as Wales clinched a Six Nations triple crown with a 40-24 bonus-point win in Cardiff.
Eddie Jones' team felt hard done by in the first half with referee Pascal Gauzere at the centre of the discussion, allowing questionable tries from Josh Adams and Liam Williams to stand.
Anthony Watson's try handed England some momentum heading into the second half, though Kieran Hardy's effort seemed to have put Wales back in control.
Owen Farrell moved onto 1000 points in international rugby either side of Ben Youngs' score to level proceedings, yet a trio of composed penalties from Callum Sheedy and a late Cory Hill try settled a topsy-turvy contest.
Biggar kicked Wales ahead in the fifth minute, though Williams just denied Mario Itoje an opening try after a charge down at the other end.
Farrell restored parity after Ben Youngs' break resulted in an England penalty, but the visiting captain was soon left seething with referee Gauzere soon after.
England were given little time to set from a penalty restart, and Biggar's kick found Adams, who raced over in the corner.
Farrell channelled his frustration as he slotted a long-range penalty between the posts, though another contentious call then went against the Red Rose as Williams went over.
Louis Rees-Zammit's fumble in the build-up was adjudged to have gone backwards, and Biggar's conversion clipped the post on its way through.
England hit back when Watson forced himself through a crowd of defenders, and though Farrell missed the kick, he atoned with a penalty on the stroke of half-time.
Hardy cruised through a gap to restore Wales' cushion, though Farrell's penalty pulled England to within seven points – the skipper then reached his milestone 1000 international points by converting Youngs' try.
But with the scores level, defensive errors cost England, and in the space of eight minutes, Sheedy had struck nine points.
It set the stage for Hill to add further gloss as he bundled over under the sticks to send Wales to the top of the standings in style.
Wales looking good in Wayne's world
It was a tough 2020 for Wayne Pivac, but the New Zealander now has his team playing with real confidence and belief.
England might point to the refereeing decisions going against them, but their own errors in the final stages ultimately proved decisive and Wales took full advantage. They now top the standings by two points, with France not playing this weekend due to a COVID-19 outbreak in their camp, and having wrapped up a triple crown, look well on course for a Grand Slam.
Farrell's landmark proves fruitless
It is now 1000 points from 91 caps for England captain Farrell, who appeared to be leading his side back into the contest until those costly defensive slip ups.
Farrell is just the second man to reach that tally for England after World Cup 2003 hero Jonny Wilkinson (1179).
What's next?
England face another huge test in the form of France in round four, while Wales travel to Rome to face lowly Italy.