Spain and Italy have joined fellow heavyweights Netherlands and Germany in the European Under-21 Championship quarter-finals.

All four sides picked up the results they required in Tuesday's final round of fixtures in Groups A and B to advance through to the knockout stages later this year.

Germany were pushed all the way by Romania in one of the early kick-offs, a goalless draw in Budapest enough to send the 2019 runners-up through on goal difference at Romania's expense.

Romania, now unbeaten in their last seven group matches in the competition, hit the post through Alexandru Matan in the first half and had a shot blocked on the line.

But a point apiece was just about the right outcome in the end as Amos Pieper was also denied by the frame of the goal in the second half and Lukas Nmecha missed a penalty.

The Netherlands had far less trouble seeing off tournament joint-hosts Hungary as they ran out 6-1 winners at MOL Arena Sosto to pip Germany to top spot in Group A by virtue of a superior head-to-head record.

Dani de Wit opened the scoring three minutes before half-time and Cody Gakpo, who set up that goal, scored two of the Netherlands' five second-half goals

Myron Boadu was also on target from the penalty spot for the Netherlands, before Sven Botman and substitute Brian Brobbey got in on the act late on, rendering Bendeguz Bolla's own spot-kick little more than a consolation. 

Holders Spain had a couple of second-half Dani Gomez goals to thank for their 2-0 win over the Czech Republic, who required a victory in Celje to keep their tournament participation alive.

The Levante forward was brought on with 65 minutes played and did not take long to do what his team-mates could not in breaking down a stubborn Czech side after being teed up by Ander Barrenetxea.

Gomez volleyed in a second nine minutes later and that proved enough to seal first place in Group B, despite an emphatic 4-0 win for Italy in their meeting with Slovenia at Stadion Ljudski vrt.

Record five-time winners Italy were two goals ahead inside 19 minutes via clinical finishes from Giulio Maggiore and Giacomo Raspadori, which Patrick Cutrone added to from the penalty spot six minutes later.

Cutrone missed a second spot-kick on the verge of half-time, though it ultimately mattered little as he bagged an impressive second five minutes into the second period.

The only negative for Italy was substitute Riccardo Marchizza's late dismissal after receiving two yellow cards - the centre-back's second sending-off in this year's tournament.

Spain, Italy, Germany and the Netherlands will discover their quarter-final opponents on Wednesday when the final round of group fixtures take place, with the knockout stages to begin in late May.

Spain were made to wait for a place in the quarter-finals of the European Under-21 Championship as they were held to a goalless draw by nine-man Italy after Romania broke Hungary hearts.

Holders Spain had not failed to score in 26 Euro U21 matches, but the holders fired a blank at Stadion Ljudski vrt in Maribor on Saturday.

Italy had Gianluca Scamacca and Nicolo Rovella dismissed for second bookable offences in a dramatic finale, while Spain's Oscar Mingueza was also sent off as tempers flared.

Davide Frattesi's shot was tipped onto the crossbar by Spain goalkeeper Alvaro Fernandez in a stalemate that leaves Spain two points clear of Italy and the Czech Republic in Group B.

The Czech Republic needed a late Nik Prelec own goal to secure a 1-1 draw that was a hammer blow to co-hosts Slovenia after Aljosa Matko opened the scoring in the first half.

Spain will be expected to get the job done when they face the Czech Republic on Tuesday, with battling Italy well placed to advance ahead of their encounter with Slovenia.

Romania shattered Hungary's hopes of qualifying by coming from behind to beat the co-hosts 2-1, moving up to second in Group A.

Andras Csonka put Hungary in front after 56 minutes at the Bozsik Arena despite Adrian Szoke's first-half dismissal for two bookable offences, but Alexandru Matan and Alex Pascanu won it late on.

Germany lead the way after Lukas Nmecha salvaged a 1-1 draw against the Netherlands, who took the lead through Justin Kluivert at Sostoi Stadion in Szekesfehervar.

The Netherlands are two points adrift of Germany and Romania, who meet on Tuesday when the Dutch take on Hungary.

Spain and Germany eased to 3-0 wins over Slovenia and Hungary respectively in their opening 2021 European Under-21 Championship fixtures on Wednesday.

Holders Spain found Slovenia tough to break down before Javier Puado and Gonzalo Villar struck in the space of 108 seconds early in the second half.

Igor Vekic made eight saves to keep Slovenia in the game, but Juan Miranda added a late third to get Spain's title defence off to a positive start in Maribor.

Germany's clash with Slovenia's fellow co-hosts Hungary panned out in a similar manner, with the 2019 runners-up failing to find a way through until just after the hour mark.

Anderlecht's on-loan Manchester City forward Lukas Nmecha continued his fine form by powering in a header to break Hungary's resolve and Bote Baku, who assisted that goal, added a quickfire double to seal the win.

The other Group A fixture between Romania and the Netherlands finished 1-1 thanks to Andrei Ciobanu's impressive free-kick to cancel out Perr Schuurs' opener.

The Netherlands, competing in this tournament for the first time in eight years, had to hold on towards the end to claim a point against the 2019 semi-finalists in a cagey contest.

Wednesday's other match also finished 1-1, although Italy had two players sent off late on against the Czech Republic.

Gianluca Scamacca opened the scoring with a composed finish after 31 minutes, but the Czechs fought back well and levelled through an unfortunate Giulio Maggiore own goal.

Italy then had Sandro Tonali sent off six minutes from time for kicking out at Ondrej Sasinka, while Riccardo Marchizza followed in added time for a foul on Vaclav Drchal, earning a second yellow card.

The disappointing stalemate for the nine-man Azzurri leaves them two points behind early Group B leaders Spain.