Wales were forced to make a late change for the decisive third Test against South Africa when Gareth Anscombe was ruled out due to a rib injury.
Anscombe came off the bench to kick the conversion that sealed a dramatic first win for Wales against the Springboks on South African soil last weekend, levelling the series at 1-1.
He will not feature at the DHL Stadium on Saturday after suffering an injury blow, so Rhys Patchell takes his place on the bench.
Captain Dan Biggar was passed fit to start at number 10 after recovering from a shoulder problem.
Wales are eyeing a first series win in South Africa after Wayne Pivac's side snatched their historic success over the world champions in Bloemfontein.